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The map label for this gene is mraY

Identifier: 86749114

GI number: 86749114

Start: 2261901

End: 2262986

Strand: Direct

Name: mraY

Synonym: RPB_1991

Alternate gene names: 86749114

Gene position: 2261901-2262986 (Clockwise)

Preceding gene: 86749113

Following gene: 86749115

Centisome position: 42.42

GC content: 64.64

Gene sequence:

>1086_bases
ATGCTCTATTGGCTGATCGATTTTTCCAGCTCGTTTCCTGCTTTCAACGTCTTCCGTTACATCACCTTCCGCACCGGCGG
CGCGGTGGTGACCGGCGCGTTGTTCGTGTTTCTGTGCGGGCCGTGGATCATCGACAATCTGCGACTGCGCCAGGGCAAGG
GGCAACCGATCCGCGCCGACGGTCCGCAATCGCATCTGGTGACCAAGCGCGGCACGCCGACGATGGGCGGCCTGATGATC
CTGTCGGGCCTGACGGTCGGCACCGTGCTGTGGGCCAATCCGCTCAATCCCTATGTGTGGATCGTGCTGGCGGTGACGCT
CGGCTTCGGCTTCGTCGGCTTCTACGACGACTACATGAAAGTCACCAAGCAGACCCACGCCGGCATCTCCGGCCGCACCC
GGCTGCTGATCGAATTCGCGATCGCGGGCGCGGCGTGTTTCGCGCTGGTGTGGCTCGGCCGCGGCTCGCTGTCGAGTTCG
CTGGTGATCCCGTTCTTCAAGGAAGTGGTGCTCAATCTGGGCTGGTACTTCGTGATCTTCGGCGCCTTCGTGATCGTCGG
CGCCGGCAATGCGGTGAACCTCACCGACGGCCTCGACGGCCTCGCCATCGTGCCGGTGATGATCGCGGCCGCGAGCTTCG
GCATGATCTCCTATCTGGTCGGCAACGCGGTGTTCGCCGAATATCTGCAAATCAACTACGTCGCCGGCACCGGCGAACTG
GCGGTGCTGTGCGGCGCGCTGCTCGGCGCCGGCCTCGGTTTTCTGTGGTTCAACGCGCCGCCGGCCTCGATCTTCATGGG
CGACACCGGCTCGCTGGCGCTCGGCGGGATGCTCGGCTCGATCGCGGTGGCGGTGAAGCACGAGATCGTGCTGGCGGTGA
TCGGCGGGCTGTTCGTGCTCGAGGCGGTGTCGGTGATCGTGCAGGTGGCGTCGTTCAAGCTGACCGGCAAGCGCGTGTTC
CGGATGGCGCCGATCCATCACCATTTCGAGCAGAAGGGCTGGACCGAGCCGCAGATCGTGATCCGGTTTTGGATCATCGC
CGTGATCCTGGCGCTCGCCGGCCTGTCGACGCTGAAGCTGCGGTGA

Upstream 100 bases:

>100_bases
GGCTCGCTCGGCTCGCGCATGAAAACGATTGTCACCGCGCTCGAGAAGCGCTTTCCCGGCAAGGCCGCGCTCGACGACGC
TGCGGTGTGAGGCGGCTTCA

Downstream 100 bases:

>100_bases
AGTTGGATATGTGCGCCGTCAGCCTTCACGCCGATTGCAGCGTCATCCTGAGGTGCGAGCCCTTGCGAGCCTCGAAGGAT
GGCCACGGGCACGCGCGGCC

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MLYWLIDFSSSFPAFNVFRYITFRTGGAVVTGALFVFLCGPWIIDNLRLRQGKGQPIRADGPQSHLVTKRGTPTMGGLMI
LSGLTVGTVLWANPLNPYVWIVLAVTLGFGFVGFYDDYMKVTKQTHAGISGRTRLLIEFAIAGAACFALVWLGRGSLSSS
LVIPFFKEVVLNLGWYFVIFGAFVIVGAGNAVNLTDGLDGLAIVPVMIAAASFGMISYLVGNAVFAEYLQINYVAGTGEL
AVLCGALLGAGLGFLWFNAPPASIFMGDTGSLALGGMLGSIAVAVKHEIVLAVIGGLFVLEAVSVIVQVASFKLTGKRVF
RMAPIHHHFEQKGWTEPQIVIRFWIIAVILALAGLSTLKLR

Sequences:

>Translated_361_residues
MLYWLIDFSSSFPAFNVFRYITFRTGGAVVTGALFVFLCGPWIIDNLRLRQGKGQPIRADGPQSHLVTKRGTPTMGGLMI
LSGLTVGTVLWANPLNPYVWIVLAVTLGFGFVGFYDDYMKVTKQTHAGISGRTRLLIEFAIAGAACFALVWLGRGSLSSS
LVIPFFKEVVLNLGWYFVIFGAFVIVGAGNAVNLTDGLDGLAIVPVMIAAASFGMISYLVGNAVFAEYLQINYVAGTGEL
AVLCGALLGAGLGFLWFNAPPASIFMGDTGSLALGGMLGSIAVAVKHEIVLAVIGGLFVLEAVSVIVQVASFKLTGKRVF
RMAPIHHHFEQKGWTEPQIVIRFWIIAVILALAGLSTLKLR
>Mature_361_residues
MLYWLIDFSSSFPAFNVFRYITFRTGGAVVTGALFVFLCGPWIIDNLRLRQGKGQPIRADGPQSHLVTKRGTPTMGGLMI
LSGLTVGTVLWANPLNPYVWIVLAVTLGFGFVGFYDDYMKVTKQTHAGISGRTRLLIEFAIAGAACFALVWLGRGSLSSS
LVIPFFKEVVLNLGWYFVIFGAFVIVGAGNAVNLTDGLDGLAIVPVMIAAASFGMISYLVGNAVFAEYLQINYVAGTGEL
AVLCGALLGAGLGFLWFNAPPASIFMGDTGSLALGGMLGSIAVAVKHEIVLAVIGGLFVLEAVSVIVQVASFKLTGKRVF
RMAPIHHHFEQKGWTEPQIVIRFWIIAVILALAGLSTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=362, Percent_Identity=51.1049723756906, Blast_Score=361, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_RHOP2 (Q2IYL1)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_485610.1
- STRING:   Q2IYL1
- GeneID:   3909497
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1991
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- ProtClustDB:   PRK00108
- BioCyc:   RPAL316058:RPB_1991-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 38699; Mature: 38699

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1bdf6af4)-; HASH(0x1d5d8910)-; HASH(0x1d5cbd24)-; HASH(0x1d5cec94)-; HASH(0x1d5d8ab4)-; HASH(0x1d5d527c)-; HASH(0x1cc5a4cc)-; HASH(0x1d606810)-; HASH(0x1d5cbd6c)-; HASH(0x1d5d530c)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYWLIDFSSSFPAFNVFRYITFRTGGAVVTGALFVFLCGPWIIDNLRLRQGKGQPIRAD
CEEEEEECCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
GPQSHLVTKRGTPTMGGLMILSGLTVGTVLWANPLNPYVWIVLAVTLGFGFVGFYDDYMK
CCCCCEEECCCCCCCCHHHHHHCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VTKQTHAGISGRTRLLIEFAIAGAACFALVWLGRGSLSSSLVIPFFKEVVLNLGWYFVIF
HHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHH
GAFVIVGAGNAVNLTDGLDGLAIVPVMIAAASFGMISYLVGNAVFAEYLQINYVAGTGEL
HHHHHEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHH
AVLCGALLGAGLGFLWFNAPPASIFMGDTGSLALGGMLGSIAVAVKHEIVLAVIGGLFVL
HHHHHHHHHCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVSVIVQVASFKLTGKRVFRMAPIHHHFEQKGWTEPQIVIRFWIIAVILALAGLSTLKL
HHHHHHHHHHHHEECCHHHHEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHEEC
R
H
>Mature Secondary Structure
MLYWLIDFSSSFPAFNVFRYITFRTGGAVVTGALFVFLCGPWIIDNLRLRQGKGQPIRAD
CEEEEEECCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
GPQSHLVTKRGTPTMGGLMILSGLTVGTVLWANPLNPYVWIVLAVTLGFGFVGFYDDYMK
CCCCCEEECCCCCCCCHHHHHHCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VTKQTHAGISGRTRLLIEFAIAGAACFALVWLGRGSLSSSLVIPFFKEVVLNLGWYFVIF
HHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHH
GAFVIVGAGNAVNLTDGLDGLAIVPVMIAAASFGMISYLVGNAVFAEYLQINYVAGTGEL
HHHHHEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHH
AVLCGALLGAGLGFLWFNAPPASIFMGDTGSLALGGMLGSIAVAVKHEIVLAVIGGLFVL
HHHHHHHHHCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVSVIVQVASFKLTGKRVFRMAPIHHHFEQKGWTEPQIVIRFWIIAVILALAGLSTLKL
HHHHHHHHHHHHEECCHHHHEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHEEC
R
H

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA