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The map label for this gene is penA [H]

Identifier: 86749111

GI number: 86749111

Start: 2257126

End: 2258880

Strand: Direct

Name: penA [H]

Synonym: RPB_1988

Alternate gene names: 86749111

Gene position: 2257126-2258880 (Clockwise)

Preceding gene: 86749110

Following gene: 86749112

Centisome position: 42.33

GC content: 65.98

Gene sequence:

>1755_bases
ATGACCGAACCGTCGGTGCCGCTCGTCGGCCATCACGTCAATTGGCGCCAGCGGCTGGTGCGCAGCCTGATCTACGGCCG
CGACGTCGATCGCGACGCCAAGGCGCGCGCCCGCGTCGGTCTGGCGATGCTGGCCTTCGCCGCGGTCTATGGCGTGATCG
CGTTCAAGCTGACCTTCATCGCGGTGGTCGGCGACAGCCACGGCACGCGGCGCACCGCGTCGCAGGACGCGATCGCCACC
GCGCGGCCCGACATCGTCGACCGCAACGGCACCATCCTGGCCACCGACGTCAAATCGCCGTCGCTGTTCGGCGAGCCGCG
CCGCATCATCGATCAGGATGAAGCGGTCGAATTGCTCACCGCGACGCTGCCGGACCTCGAGACCCCGGAGGTCCGCGAGC
GGCTGGCCTCGAAGAAGGGCTTCGTCTGGCTGAAGCGAGAGATCACGCCGCGGCAGCAGGCCGACATCAAGAAGCTCGGT
ATTCCCGGCATCGGCTTCCTGCGCGAGAACAGGCGCATCTACCCCACCGGCACCGAGGTCTCGCACCTCATCGGCCTCGT
CAATATCGACAACCAGGGCATCGCCGGCATCGAGAAGTGGCTCGACCACAACGGACTCGCCGATCTGCATCGCGCCGGCT
TCGCCTCCGACCGGCTGCAGAAGCCGGTGGAGCTCGCGGTCGACATCCGCGTCCAGCACGCGCTGCGCGATGAATTGCTG
AAGGCGAAGGACAAGTACAAGGCCAAGGCGGCGTCCGGTCTCGTCTCCAACGTCAACACCGGCGAGATCGTCGCGATGGT
GTCGCTGCCGGATTTCGATCCGAACAATCCGCGCGAGGCCAACGACCCGGACCGCATCAACCGGCTCACCACCGGCGTCT
ACGAGATGGGCTCGACCTTCAAGACGCTGACGCTGGCGATGGCGCTCGACTCGGGCAAGGCGACGCTGAATTCGATGTAC
GACGCCCGCGGCGCGTTGCGCTACGGCAAGTTCGCGATCCACGACACCCATCCGCTCGGCCGCGCGATCTCGCTGTCGGA
AGTGTTCACCTTCTCGTCCAACGTCGGCGCTGCACGGATCGCGCTGTCGATGGGCGTCGACGCGCACAAGGCGTTCCTCA
AGAAGGTCGGCCAGCTCGACCGGCTGCGCACCGAACTGCCCGAGAGTGCCTCGCCGATCGTGCCGAAGCGCTGGGGCGAA
CTCAACACCATCACCATCTCGTTCGGCCACGGCGTCGCGGTGGCGCCGCTGCAGGCGGTGATGGGCATCAACGCGATGGT
CAATGGCGGCTATCTGATCCCACCGACCTTCCACCGGCGCAGCGAAGACGAAGCGCAGAAGATGGCCAAGCGCGTGGTCA
AGAAGGAGACCAGCGACAAGATCCGCTATCTGATGCGCCTGAACGCCGAAATCGGCACCGCCAGGACGGCGGATCAGATC
GCCAAGGGCTACTACATCGGTGGCAAGACCGGAACCTCGGAAAAGGTGATCAACGGCCGCTACGCCAAGAAGCAGGTGTT
GAACTCGTTCACCGCCGTGCTGCCGGCCGACCATCCGCAATTCCAGGTGCTGATCATGCTCGACGAGCCCAAGCCGCTGC
CGGAAACCCACGGCTTCATCACCTCGGGCTGGAACGCGGTGCCCACCGGTGGCAAGGTGATCGAGCGAATCGCGCCGCTG
CTGGGGATCGAGCCGCGGTTCGATCTGCCGCCGCCCGACCGCCTCATTCTTGCGTCATCGAGGGCGGCCCAGTAG

Upstream 100 bases:

>100_bases
GCATCGTCAACCCGAACGATCCCGACCCGATCGCCTCGATGATCGAGAAGATCGATCCCGACATCGTCACCGGCGCGCTG
CCGGCCAGGGAGGCCGCGCA

Downstream 100 bases:

>100_bases
GTCGCGGGCCACGCGGGGCGGCAATGCGTCAGTCGTGTTGCACCGGGGCGCGCTTGCGCTAAAAGCCCGGTCTGCGTGCG
AACTCCCTTCGGACCGACCG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 584; Mature: 583

Protein sequence:

>584_residues
MTEPSVPLVGHHVNWRQRLVRSLIYGRDVDRDAKARARVGLAMLAFAAVYGVIAFKLTFIAVVGDSHGTRRTASQDAIAT
ARPDIVDRNGTILATDVKSPSLFGEPRRIIDQDEAVELLTATLPDLETPEVRERLASKKGFVWLKREITPRQQADIKKLG
IPGIGFLRENRRIYPTGTEVSHLIGLVNIDNQGIAGIEKWLDHNGLADLHRAGFASDRLQKPVELAVDIRVQHALRDELL
KAKDKYKAKAASGLVSNVNTGEIVAMVSLPDFDPNNPREANDPDRINRLTTGVYEMGSTFKTLTLAMALDSGKATLNSMY
DARGALRYGKFAIHDTHPLGRAISLSEVFTFSSNVGAARIALSMGVDAHKAFLKKVGQLDRLRTELPESASPIVPKRWGE
LNTITISFGHGVAVAPLQAVMGINAMVNGGYLIPPTFHRRSEDEAQKMAKRVVKKETSDKIRYLMRLNAEIGTARTADQI
AKGYYIGGKTGTSEKVINGRYAKKQVLNSFTAVLPADHPQFQVLIMLDEPKPLPETHGFITSGWNAVPTGGKVIERIAPL
LGIEPRFDLPPPDRLILASSRAAQ

Sequences:

>Translated_584_residues
MTEPSVPLVGHHVNWRQRLVRSLIYGRDVDRDAKARARVGLAMLAFAAVYGVIAFKLTFIAVVGDSHGTRRTASQDAIAT
ARPDIVDRNGTILATDVKSPSLFGEPRRIIDQDEAVELLTATLPDLETPEVRERLASKKGFVWLKREITPRQQADIKKLG
IPGIGFLRENRRIYPTGTEVSHLIGLVNIDNQGIAGIEKWLDHNGLADLHRAGFASDRLQKPVELAVDIRVQHALRDELL
KAKDKYKAKAASGLVSNVNTGEIVAMVSLPDFDPNNPREANDPDRINRLTTGVYEMGSTFKTLTLAMALDSGKATLNSMY
DARGALRYGKFAIHDTHPLGRAISLSEVFTFSSNVGAARIALSMGVDAHKAFLKKVGQLDRLRTELPESASPIVPKRWGE
LNTITISFGHGVAVAPLQAVMGINAMVNGGYLIPPTFHRRSEDEAQKMAKRVVKKETSDKIRYLMRLNAEIGTARTADQI
AKGYYIGGKTGTSEKVINGRYAKKQVLNSFTAVLPADHPQFQVLIMLDEPKPLPETHGFITSGWNAVPTGGKVIERIAPL
LGIEPRFDLPPPDRLILASSRAAQ
>Mature_583_residues
TEPSVPLVGHHVNWRQRLVRSLIYGRDVDRDAKARARVGLAMLAFAAVYGVIAFKLTFIAVVGDSHGTRRTASQDAIATA
RPDIVDRNGTILATDVKSPSLFGEPRRIIDQDEAVELLTATLPDLETPEVRERLASKKGFVWLKREITPRQQADIKKLGI
PGIGFLRENRRIYPTGTEVSHLIGLVNIDNQGIAGIEKWLDHNGLADLHRAGFASDRLQKPVELAVDIRVQHALRDELLK
AKDKYKAKAASGLVSNVNTGEIVAMVSLPDFDPNNPREANDPDRINRLTTGVYEMGSTFKTLTLAMALDSGKATLNSMYD
ARGALRYGKFAIHDTHPLGRAISLSEVFTFSSNVGAARIALSMGVDAHKAFLKKVGQLDRLRTELPESASPIVPKRWGEL
NTITISFGHGVAVAPLQAVMGINAMVNGGYLIPPTFHRRSEDEAQKMAKRVVKKETSDKIRYLMRLNAEIGTARTADQIA
KGYYIGGKTGTSEKVINGRYAKKQVLNSFTAVLPADHPQFQVLIMLDEPKPLPETHGFITSGWNAVPTGGKVIERIAPLL
GIEPRFDLPPPDRLILASSRAAQ

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=557, Percent_Identity=29.0843806104129, Blast_Score=185, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 64034; Mature: 63902

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPSVPLVGHHVNWRQRLVRSLIYGRDVDRDAKARARVGLAMLAFAAVYGVIAFKLTFI
CCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AVVGDSHGTRRTASQDAIATARPDIVDRNGTILATDVKSPSLFGEPRRIIDQDEAVELLT
EEECCCCCCCCCCCCCCHHHCCCCEECCCCCEEEECCCCCCCCCCCHHHCCHHHHHHHHH
ATLPDLETPEVRERLASKKGFVWLKREITPRQQADIKKLGIPGIGFLRENRRIYPTGTEV
HHCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEECCCEEECCCCCH
SHLIGLVNIDNQGIAGIEKWLDHNGLADLHRAGFASDRLQKPVELAVDIRVQHALRDELL
HHHEEEEEECCCCHHHHHHHHCCCCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
KAKDKYKAKAASGLVSNVNTGEIVAMVSLPDFDPNNPREANDPDRINRLTTGVYEMGSTF
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
KTLTLAMALDSGKATLNSMYDARGALRYGKFAIHDTHPLGRAISLSEVFTFSSNVGAARI
HHEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEHHHHHEECCCCCCEEE
ALSMGVDAHKAFLKKVGQLDRLRTELPESASPIVPKRWGELNTITISFGHGVAVAPLQAV
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
MGINAMVNGGYLIPPTFHRRSEDEAQKMAKRVVKKETSDKIRYLMRLNAEIGTARTADQI
HCCHHEECCCEECCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHH
AKGYYIGGKTGTSEKVINGRYAKKQVLNSFTAVLPADHPQFQVLIMLDEPKPLPETHGFI
HCCEEECCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCE
TSGWNAVPTGGKVIERIAPLLGIEPRFDLPPPDRLILASSRAAQ
ECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCC
>Mature Secondary Structure 
TEPSVPLVGHHVNWRQRLVRSLIYGRDVDRDAKARARVGLAMLAFAAVYGVIAFKLTFI
CCCCCCEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AVVGDSHGTRRTASQDAIATARPDIVDRNGTILATDVKSPSLFGEPRRIIDQDEAVELLT
EEECCCCCCCCCCCCCCHHHCCCCEECCCCCEEEECCCCCCCCCCCHHHCCHHHHHHHHH
ATLPDLETPEVRERLASKKGFVWLKREITPRQQADIKKLGIPGIGFLRENRRIYPTGTEV
HHCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEECCCEEECCCCCH
SHLIGLVNIDNQGIAGIEKWLDHNGLADLHRAGFASDRLQKPVELAVDIRVQHALRDELL
HHHEEEEEECCCCHHHHHHHHCCCCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
KAKDKYKAKAASGLVSNVNTGEIVAMVSLPDFDPNNPREANDPDRINRLTTGVYEMGSTF
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
KTLTLAMALDSGKATLNSMYDARGALRYGKFAIHDTHPLGRAISLSEVFTFSSNVGAARI
HHEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEHHHHHEECCCCCCEEE
ALSMGVDAHKAFLKKVGQLDRLRTELPESASPIVPKRWGELNTITISFGHGVAVAPLQAV
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
MGINAMVNGGYLIPPTFHRRSEDEAQKMAKRVVKKETSDKIRYLMRLNAEIGTARTADQI
HCCHHEECCCEECCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHH
AKGYYIGGKTGTSEKVINGRYAKKQVLNSFTAVLPADHPQFQVLIMLDEPKPLPETHGFI
HCCEEECCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCE
TSGWNAVPTGGKVIERIAPLLGIEPRFDLPPPDRLILASSRAAQ
ECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]