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The map label for this gene is gpo [H]

Identifier: 86749020

GI number: 86749020

Start: 2171722

End: 2172198

Strand: Direct

Name: gpo [H]

Synonym: RPB_1897

Alternate gene names: 86749020

Gene position: 2171722-2172198 (Clockwise)

Preceding gene: 86749019

Following gene: 86749021

Centisome position: 40.73

GC content: 59.75

Gene sequence:

>477_bases
ATGGCGTCGATTTATGATTTTTCGGCCAGGACGCTTGCGGGCGAAGAGCTGCCGCTGAAGCGGTTCGAGGGGCAGGTGCT
GCTGATCGTCAACACCGCCAGTGCCTGCGGATTCACGCCGCAATACAAGGGCCTCGAAGCACTACAGCAGAAATACGGCG
CGCGCGGATTTTCGGTGCTCGGCTTCCCCTGCAACCAGTTCGGCGCGCAGGAATCCGGCAGCGAGGCGCAGATCGCGCAA
TTCTGCTCGACCCATTACGGCGTCAGTTTCCCGATGTTCGCCAAGATCGACGTCAATGGCGCGCAGGCGCATCCGCTGTA
CACATTTCTCAAGGACGAGAAGGGCGGGTTGCTCGGCTCGGCGATCAAATGGAATTTCACCAAATTTCTGGTCGATCGGT
CCGGCCATGTGATATCGCGGCACGCGCCGACGACCACGCCGGAGTCGCTCGCAAAGGATATCGAGACCTTGCTATGA

Upstream 100 bases:

>100_bases
GGCCGCTATCGCGAAGATCTGTGCCTGCTCGCCGGCGAGGCGATCGAGGCCGGCGGCACGCCGGCGTCGCCGATCGATCC
GGTGCGGTAGGGCGGCGACG

Downstream 100 bases:

>100_bases
CCGATAAAACCACGACCGCTGCGCCTGCTATCGAATTCCCGGACCGTCTCTCGATCGAGCCGAACAGCCCGTACTACAAT
GAAGCGATCCTCGAACTCGA

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MASIYDFSARTLAGEELPLKRFEGQVLLIVNTASACGFTPQYKGLEALQQKYGARGFSVLGFPCNQFGAQESGSEAQIAQ
FCSTHYGVSFPMFAKIDVNGAQAHPLYTFLKDEKGGLLGSAIKWNFTKFLVDRSGHVISRHAPTTTPESLAKDIETLL

Sequences:

>Translated_158_residues
MASIYDFSARTLAGEELPLKRFEGQVLLIVNTASACGFTPQYKGLEALQQKYGARGFSVLGFPCNQFGAQESGSEAQIAQ
FCSTHYGVSFPMFAKIDVNGAQAHPLYTFLKDEKGGLLGSAIKWNFTKFLVDRSGHVISRHAPTTTPESLAKDIETLL
>Mature_157_residues
ASIYDFSARTLAGEELPLKRFEGQVLLIVNTASACGFTPQYKGLEALQQKYGARGFSVLGFPCNQFGAQESGSEAQIAQF
CSTHYGVSFPMFAKIDVNGAQAHPLYTFLKDEKGGLLGSAIKWNFTKFLVDRSGHVISRHAPTTTPESLAKDIETLL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=155, Percent_Identity=45.1612903225806, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI90903240, Length=155, Percent_Identity=45.1612903225806, Blast_Score=136, Evalue=7e-33,
Organism=Homo sapiens, GI15618997, Length=155, Percent_Identity=43.2258064516129, Blast_Score=129, Evalue=9e-31,
Organism=Homo sapiens, GI192455698, Length=159, Percent_Identity=36.4779874213836, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI90903238, Length=140, Percent_Identity=45.7142857142857, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI6006001, Length=174, Percent_Identity=39.0804597701149, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI41406084, Length=182, Percent_Identity=37.9120879120879, Blast_Score=103, Evalue=8e-23,
Organism=Homo sapiens, GI4557629, Length=173, Percent_Identity=36.9942196531792, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI33186887, Length=172, Percent_Identity=38.3720930232558, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=32.5966850828729, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI41406082, Length=75, Percent_Identity=52, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788003, Length=167, Percent_Identity=47.3053892215569, Blast_Score=152, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17535473, Length=159, Percent_Identity=50.9433962264151, Blast_Score=167, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17506887, Length=159, Percent_Identity=47.1698113207547, Blast_Score=160, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI193210707, Length=162, Percent_Identity=46.9135802469136, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71993584, Length=157, Percent_Identity=40.7643312101911, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193209493, Length=164, Percent_Identity=37.1951219512195, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550320, Length=164, Percent_Identity=36.5853658536585, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193210709, Length=72, Percent_Identity=50, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17507603, Length=101, Percent_Identity=39.6039603960396, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993573, Length=95, Percent_Identity=34.7368421052632, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=36.8421052631579, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322228, Length=159, Percent_Identity=53.4591194968553, Blast_Score=187, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6319721, Length=158, Percent_Identity=53.7974683544304, Blast_Score=187, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6322826, Length=159, Percent_Identity=45.9119496855346, Blast_Score=150, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24656777, Length=160, Percent_Identity=49.375, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24656767, Length=160, Percent_Identity=49.375, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24656772, Length=160, Percent_Identity=49.375, Blast_Score=163, Evalue=3e-41,
Organism=Drosophila melanogaster, GI85726443, Length=158, Percent_Identity=43.6708860759494, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17214; Mature: 17083

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIYDFSARTLAGEELPLKRFEGQVLLIVNTASACGFTPQYKGLEALQQKYGARGFSVL
CCCCCCCCCHHCCCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEE
GFPCNQFGAQESGSEAQIAQFCSTHYGVSFPMFAKIDVNGAQAHPLYTFLKDEKGGLLGS
CCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCEECC
AIKWNFTKFLVDRSGHVISRHAPTTTPESLAKDIETLL
HHHHHHHHEEECCCCCEEECCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
ASIYDFSARTLAGEELPLKRFEGQVLLIVNTASACGFTPQYKGLEALQQKYGARGFSVL
CCCCCCCCHHCCCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEE
GFPCNQFGAQESGSEAQIAQFCSTHYGVSFPMFAKIDVNGAQAHPLYTFLKDEKGGLLGS
CCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCEECC
AIKWNFTKFLVDRSGHVISRHAPTTTPESLAKDIETLL
HHHHHHHHEEECCCCCEEECCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]