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The map label for this gene is adh [H]

Identifier: 86748994

GI number: 86748994

Start: 2134880

End: 2135932

Strand: Direct

Name: adh [H]

Synonym: RPB_1871

Alternate gene names: 86748994

Gene position: 2134880-2135932 (Clockwise)

Preceding gene: 86748993

Following gene: 86748996

Centisome position: 40.04

GC content: 67.71

Gene sequence:

>1053_bases
ATGAAGAGCTTTCGCGTCTCGGGCTTCGGCCAGCCGCTTAGCGAAGACAACCGGCCGACGCCGGAATTGACCGGCACGCA
GGTGCTGCTGCGCGTCAAGGCCGCCGGCATCTGCCACAGCGATCTGCACATCTGGGAGGGCGGCTACGAACTCGGCCACG
GCCGCAAGAAGCTGTCGCTGGCCGATCGCGGCGTGGCATTGCCGCTGACGATGGGGCACGAGACCGTCGGCGAGATCGTC
GCCGCAGGACCCGACGCCAAGGATGCGAAGATCGGCGATGTCGCGCTGGTGTATCCGTGGATCGGCTGCGGCCAATGCGC
GGTGTGTCGCGAAGGCGACGAGAACATGTGCCTCAAGCCGCGGTTCCTCGGCGTGTATTGCGACGGCGGCTATTCCGACG
AACTGATCGTGCCGCATCCGCGCTATCTGCTCAGCCTCGACGGGCTCGATCCGGTGACCGCGGCGCCGTATGCGTGTTCG
GGCGTCACCACCTACAGCGCGCTGAAGAAGCTGGAATTCGCCTTCGACGGTCCGATCGTGATGTTCGGCGCCGGCGGGCT
CGGGCTGATGGCGCTGTCGCTGCTGAAGGCGATGGGCGGCAAGGGCGCGATCATGGTCGATATCGACGCCAGGAAGCGCG
AGGCGGCGGAGCAGGCCGGCGCGATGGCGACGGTCGACGGCGCGGCGCCCGACGCGCTGGAGCAAATCGCCAAGAAGGCC
GGCGCGCCGGTGCGTGGCGCGCTCGACCTCGTCGGCAATTCGCAGACCGCGCAACTCGGCTTCGACTGTCTCACCAAAGG
CGGCAAGCTGGTGATCGTCGGCCTGTTCGGCGGCGGCGCGCCATGGGCGCTGCCGTTCATCCCGATGCGCGCGATCACGA
TTCAGGGCTCGTATGTCGGCAATCTGCGCGAGACCCAGGAACTGCTCGATCTGGTGCGCGCCAACAAGATCGCGCCGATT
CCGGTGACGCCGCTGCCGCTGCCCAAGGCCAACGAGGCGCTGATGGATCTGCAGAAGGGGCGGTTGGTCGGCCGCGCGGT
GCTGACGCCGTGA

Upstream 100 bases:

>100_bases
GGAATTCCGCACTGCAGGATGAGCGCATTGTCGCGCCAGTCGACGGCTGTGCTGCGCCATGTCATATCTAGACGATAAGA
AAAATCGGGGAGACCACGCC

Downstream 100 bases:

>100_bases
TCGCCGTCGTCAGTCCGGCTCGCGCATGGCGAGCCCCTCCGCCTCGGCGAGGTCCTGCGGCGTGTTGGCGTTGAAGAACG
GATCGGCCGGCTCGACCGGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKSFRVSGFGQPLSEDNRPTPELTGTQVLLRVKAAGICHSDLHIWEGGYELGHGRKKLSLADRGVALPLTMGHETVGEIV
AAGPDAKDAKIGDVALVYPWIGCGQCAVCREGDENMCLKPRFLGVYCDGGYSDELIVPHPRYLLSLDGLDPVTAAPYACS
GVTTYSALKKLEFAFDGPIVMFGAGGLGLMALSLLKAMGGKGAIMVDIDARKREAAEQAGAMATVDGAAPDALEQIAKKA
GAPVRGALDLVGNSQTAQLGFDCLTKGGKLVIVGLFGGGAPWALPFIPMRAITIQGSYVGNLRETQELLDLVRANKIAPI
PVTPLPLPKANEALMDLQKGRLVGRAVLTP

Sequences:

>Translated_350_residues
MKSFRVSGFGQPLSEDNRPTPELTGTQVLLRVKAAGICHSDLHIWEGGYELGHGRKKLSLADRGVALPLTMGHETVGEIV
AAGPDAKDAKIGDVALVYPWIGCGQCAVCREGDENMCLKPRFLGVYCDGGYSDELIVPHPRYLLSLDGLDPVTAAPYACS
GVTTYSALKKLEFAFDGPIVMFGAGGLGLMALSLLKAMGGKGAIMVDIDARKREAAEQAGAMATVDGAAPDALEQIAKKA
GAPVRGALDLVGNSQTAQLGFDCLTKGGKLVIVGLFGGGAPWALPFIPMRAITIQGSYVGNLRETQELLDLVRANKIAPI
PVTPLPLPKANEALMDLQKGRLVGRAVLTP
>Mature_350_residues
MKSFRVSGFGQPLSEDNRPTPELTGTQVLLRVKAAGICHSDLHIWEGGYELGHGRKKLSLADRGVALPLTMGHETVGEIV
AAGPDAKDAKIGDVALVYPWIGCGQCAVCREGDENMCLKPRFLGVYCDGGYSDELIVPHPRYLLSLDGLDPVTAAPYACS
GVTTYSALKKLEFAFDGPIVMFGAGGLGLMALSLLKAMGGKGAIMVDIDARKREAAEQAGAMATVDGAAPDALEQIAKKA
GAPVRGALDLVGNSQTAQLGFDCLTKGGKLVIVGLFGGGAPWALPFIPMRAITIQGSYVGNLRETQELLDLVRANKIAPI
PVTPLPLPKANEALMDLQKGRLVGRAVLTP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=354, Percent_Identity=25.7062146892655, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4501933, Length=375, Percent_Identity=24.2666666666667, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI34577061, Length=375, Percent_Identity=24.2666666666667, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI71743840, Length=374, Percent_Identity=23.5294117647059, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI262073058, Length=374, Percent_Identity=23.5294117647059, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=28.4829721362229, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI226510992, Length=303, Percent_Identity=30.3630363036304, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790045, Length=336, Percent_Identity=23.8095238095238, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082125, Length=271, Percent_Identity=32.1033210332103, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788073, Length=278, Percent_Identity=27.6978417266187, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1786518, Length=357, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082401, Length=363, Percent_Identity=26.7217630853994, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=23.9393939393939, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787863, Length=241, Percent_Identity=29.045643153527, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=23.8095238095238, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788075, Length=273, Percent_Identity=26.007326007326, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=349, Percent_Identity=27.7936962750716, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17562584, Length=345, Percent_Identity=27.2463768115942, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=28.6549707602339, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562876, Length=348, Percent_Identity=25, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=209, Percent_Identity=28.2296650717703, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=344, Percent_Identity=29.9418604651163, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324486, Length=341, Percent_Identity=29.0322580645161, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323961, Length=341, Percent_Identity=28.7390029325513, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319621, Length=341, Percent_Identity=27.8592375366569, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319258, Length=322, Percent_Identity=26.3975155279503, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=25.4691689008043, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=359, Percent_Identity=26.4623955431755, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=342, Percent_Identity=23.6842105263158, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=320, Percent_Identity=25, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=320, Percent_Identity=25, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=341, Percent_Identity=25.8064516129032, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17137530, Length=263, Percent_Identity=26.2357414448669, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17737897, Length=265, Percent_Identity=24.5283018867925, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36729; Mature: 36729

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFRVSGFGQPLSEDNRPTPELTGTQVLLRVKAAGICHSDLHIWEGGYELGHGRKKLSL
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCEEECCCEEECCCCEEEEE
ADRGVALPLTMGHETVGEIVAAGPDAKDAKIGDVALVYPWIGCGQCAVCREGDENMCLKP
CCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCEECC
RFLGVYCDGGYSDELIVPHPRYLLSLDGLDPVTAAPYACSGVTTYSALKKLEFAFDGPIV
EEEEEEECCCCCCCEECCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCEE
MFGAGGLGLMALSLLKAMGGKGAIMVDIDARKREAAEQAGAMATVDGAAPDALEQIAKKA
EEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCEEEECCCCHHHHHHHHHHC
GAPVRGALDLVGNSQTAQLGFDCLTKGGKLVIVGLFGGGAPWALPFIPMRAITIQGSYVG
CCCCCCHHEECCCCCCHHHCHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCC
NLRETQELLDLVRANKIAPIPVTPLPLPKANEALMDLQKGRLVGRAVLTP
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCEECEEECCC
>Mature Secondary Structure
MKSFRVSGFGQPLSEDNRPTPELTGTQVLLRVKAAGICHSDLHIWEGGYELGHGRKKLSL
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCEEECCCEEECCCCEEEEE
ADRGVALPLTMGHETVGEIVAAGPDAKDAKIGDVALVYPWIGCGQCAVCREGDENMCLKP
CCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCEECC
RFLGVYCDGGYSDELIVPHPRYLLSLDGLDPVTAAPYACSGVTTYSALKKLEFAFDGPIV
EEEEEEECCCCCCCEECCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCEE
MFGAGGLGLMALSLLKAMGGKGAIMVDIDARKREAAEQAGAMATVDGAAPDALEQIAKKA
EEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCEEEECCCCHHHHHHHHHHC
GAPVRGALDLVGNSQTAQLGFDCLTKGGKLVIVGLFGGGAPWALPFIPMRAITIQGSYVG
CCCCCCHHEECCCCCCHHHCHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCC
NLRETQELLDLVRANKIAPIPVTPLPLPKANEALMDLQKGRLVGRAVLTP
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCEECEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]