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The map label for this gene is lpxK

Identifier: 86748979

GI number: 86748979

Start: 2121497

End: 2122513

Strand: Direct

Name: lpxK

Synonym: RPB_1856

Alternate gene names: 86748979

Gene position: 2121497-2122513 (Clockwise)

Preceding gene: 86748978

Following gene: 86748981

Centisome position: 39.79

GC content: 70.4

Gene sequence:

>1017_bases
GTGCGTGAGCCGGGCTTCTGGCACAGGCCGCCTTCTTGGCTGTCGCGTCTGCTGCTGCCGCTCGGCGCCGTGTATGGCGA
AATCACCTCCTGGCGAATGCGCAAGACCGGCGTCGAGGCCGGCGCGCCGGTGATCTGCGTCGGCAATTATCATCTCGGCG
GCGCCGGCAAGACGCCGACGACGCTGGCGCTGGTCCGGCTGCTTCGTGACCTCGATGAACAGCCGATCGTGCTCAGCCGC
GGCTATGGCGGCCGGCTGAAAGGGCCAATCCTGGTCGATCCGCAACGTCACGACGCGGCGGATGTCGGTGACGAGCCGCT
GATGATGGCGCGCCGCGTGCCGGTGGTGGTGGCGCGCGACCGCGTCGACGGCGCCGCGCTGGCGCGATCGCAGGGCGCGA
GCCTCCTCGTGATGGACGACGGTTTCCAGAATCCGGCGCTGGTCAAACACCTCTCGCTGATCGTGATCGACAGCCGGCGC
GGCGTCGGCAATGGCTGCGTGTTCCCGGCCGGCCCGTTGCGCGCGCCGCTGCCGCTGCAGATCGAACGCACCGACGCGCT
GATCATCATCGGCGACGGCACCGCGGCCGATGAAGTCGCCGCTGCGATCGCCACGCGAGGCGGCGTCGTTCTGCGGGCGC
GGCTGCGGCCCGACGCGGCGTCGGTGGAGCGGCTGAAAGGCCAGCGCGTGCTGGCCTTCGCCGGCATCGGCGACCCGGCG
CGGTACTTCGCGACGCTGCGCGCCAGCGGCATCGACGTCGCGGATCAGCGCGCGTTCGCCGATCATCATCCGTTCACGGT
GGCCGAGCTCGAGAGTCTCGCCGAAACCGCGCGCCGCGAAGGCCTGACGCTGGTGACGACCGAGAAGGATCTGGCGCGCA
TCGGGGCCGCCGCGGCAACGCTCGGCAGCGCCATCGTTCCGTTCGCGGTGACATTGGCGGTCGAGGACGAACCCAGCTTG
CGGTTGTTTCTGCTGGAGCAGATCAATCGCGCGCGCACCAAGCCGCGCGCCGGATAG

Upstream 100 bases:

>100_bases
GCCACCCGCGTGGTCGATCGGCTCGGCGGCGCGCTGGACCGCACCGTCGCGGCGCTGGAACCCTATCTGCTGCAATTGCG
CATCGAGCAGGGCGCCGCCG

Downstream 100 bases:

>100_bases
CGCGCGTATCAGCCCAGCGGCTTTGCCGCCGCTGGAAAATGCCGCTGCAGCACCGCGATCGGCGTGGCGTAGGCTTCCTT
GAGATCGACGCTCCAATATT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MREPGFWHRPPSWLSRLLLPLGAVYGEITSWRMRKTGVEAGAPVICVGNYHLGGAGKTPTTLALVRLLRDLDEQPIVLSR
GYGGRLKGPILVDPQRHDAADVGDEPLMMARRVPVVVARDRVDGAALARSQGASLLVMDDGFQNPALVKHLSLIVIDSRR
GVGNGCVFPAGPLRAPLPLQIERTDALIIIGDGTAADEVAAAIATRGGVVLRARLRPDAASVERLKGQRVLAFAGIGDPA
RYFATLRASGIDVADQRAFADHHPFTVAELESLAETARREGLTLVTTEKDLARIGAAAATLGSAIVPFAVTLAVEDEPSL
RLFLLEQINRARTKPRAG

Sequences:

>Translated_338_residues
MREPGFWHRPPSWLSRLLLPLGAVYGEITSWRMRKTGVEAGAPVICVGNYHLGGAGKTPTTLALVRLLRDLDEQPIVLSR
GYGGRLKGPILVDPQRHDAADVGDEPLMMARRVPVVVARDRVDGAALARSQGASLLVMDDGFQNPALVKHLSLIVIDSRR
GVGNGCVFPAGPLRAPLPLQIERTDALIIIGDGTAADEVAAAIATRGGVVLRARLRPDAASVERLKGQRVLAFAGIGDPA
RYFATLRASGIDVADQRAFADHHPFTVAELESLAETARREGLTLVTTEKDLARIGAAAATLGSAIVPFAVTLAVEDEPSL
RLFLLEQINRARTKPRAG
>Mature_338_residues
MREPGFWHRPPSWLSRLLLPLGAVYGEITSWRMRKTGVEAGAPVICVGNYHLGGAGKTPTTLALVRLLRDLDEQPIVLSR
GYGGRLKGPILVDPQRHDAADVGDEPLMMARRVPVVVARDRVDGAALARSQGASLLVMDDGFQNPALVKHLSLIVIDSRR
GVGNGCVFPAGPLRAPLPLQIERTDALIIIGDGTAADEVAAAIATRGGVVLRARLRPDAASVERLKGQRVLAFAGIGDPA
RYFATLRASGIDVADQRAFADHHPFTVAELESLAETARREGLTLVTTEKDLARIGAAAATLGSAIVPFAVTLAVEDEPSL
RLFLLEQINRARTKPRAG

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=295, Percent_Identity=35.5932203389831, Blast_Score=141, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_RHOP2 (Q2IYZ6)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_485475.1
- STRING:   Q2IYZ6
- GeneID:   3908051
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1856
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   PRK00652
- BioCyc:   RPAL316058:RPB_1856-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36103; Mature: 36103

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREPGFWHRPPSWLSRLLLPLGAVYGEITSWRMRKTGVEAGAPVICVGNYHLGGAGKTPT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECEEECCCCCCHH
TLALVRLLRDLDEQPIVLSRGYGGRLKGPILVDPQRHDAADVGDEPLMMARRVPVVVARD
HHHHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCHHHHCCCCEEEEEC
RVDGAALARSQGASLLVMDDGFQNPALVKHLSLIVIDSRRGVGNGCVFPAGPLRAPLPLQ
CCCHHHHHHCCCCEEEEEECCCCCCHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
IERTDALIIIGDGTAADEVAAAIATRGGVVLRARLRPDAASVERLKGQRVLAFAGIGDPA
EECCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCEEEEEECCCCHH
RYFATLRASGIDVADQRAFADHHPFTVAELESLAETARREGLTLVTTEKDLARIGAAAAT
HHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHH
LGSAIVPFAVTLAVEDEPSLRLFLLEQINRARTKPRAG
HHHHHCCEEEEEEECCCCCEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MREPGFWHRPPSWLSRLLLPLGAVYGEITSWRMRKTGVEAGAPVICVGNYHLGGAGKTPT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECEEECCCCCCHH
TLALVRLLRDLDEQPIVLSRGYGGRLKGPILVDPQRHDAADVGDEPLMMARRVPVVVARD
HHHHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCHHHHCCCCEEEEEC
RVDGAALARSQGASLLVMDDGFQNPALVKHLSLIVIDSRRGVGNGCVFPAGPLRAPLPLQ
CCCHHHHHHCCCCEEEEEECCCCCCHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
IERTDALIIIGDGTAADEVAAAIATRGGVVLRARLRPDAASVERLKGQRVLAFAGIGDPA
EECCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCEEEEEECCCCHH
RYFATLRASGIDVADQRAFADHHPFTVAELESLAETARREGLTLVTTEKDLARIGAAAAT
HHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHH
LGSAIVPFAVTLAVEDEPSLRLFLLEQINRARTKPRAG
HHHHHCCEEEEEEECCCCCEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA