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The map label for this gene is glcD [H]

Identifier: 86748950

GI number: 86748950

Start: 2088731

End: 2090224

Strand: Direct

Name: glcD [H]

Synonym: RPB_1827

Alternate gene names: 86748950

Gene position: 2088731-2090224 (Clockwise)

Preceding gene: 86748949

Following gene: 86748951

Centisome position: 39.18

GC content: 66.06

Gene sequence:

>1494_bases
ATGACGATTCTGATGCCCGAGCCGGACCAGGCCGTGCTGGCGCGCCGCGACGAGATCGTCGCGAGCCTGCGCAAGATCGT
GCCGGGCGAGGGCGTGATCTCCAGCGCCGCCGAAATGAAGCCCTATGAGTCCGACGGGCTGATGGCGTATCGGCAGCCGC
CGATGGTGGTCGTGCTGCCCGACACCACCAAGCAGGTTTCCGAAGTACTGCGCTATTGCCACAAGAACGGCATCAAGGTG
GTGCCGCGCGGCTCCGGCACGTCGCTGTCCGGCGGCGCGCTGCCGCTCGCCGACGGCGTGCTGCTCGGCCTCGGCAAGTT
CAAGCGGATCCGCGAGATCGACTTCGACAACCGCGCCGTCGTGGTCGAGCCCGGCGTCACCAATCTGGCGATCAGTCAGG
CGGTCGATCATGCCGGCTTTTACTACGCGCCCGACCCGTCGTCGCAGATCGCCTGCTCGATCGGCGGCAACATCGCCGAG
AATTCCGGCGGCGTGCATTGCCTGAAATACGGCATGACCACCAACAACGTGCTCGGCTGCGAGATCGTGCTGATGACCGG
CGAGATCCTGCGCATCGGCGGCAAGGCCGCCGAATGCGCGGGTTACGACCTGATGGGCGTGATCACCGGCTCCGAAGGCC
TGCTCGGCGTCATCACCGAAGTCACCGTCCGCATCCTGCGCAAGCCGGAGACGGCGCGGGCGCTGATGGTCGGCTTCACC
GACGTCGAGGCCGCCGGCCGATGCGTCGCCGACGTGATCAGCGCCGGCATCATTCCCGGCGGCATGGAGATGATGGACCG
CCCCGCGATCCACGCCGCCGAAGCCTTCGTCCACGCCGGCTATCCGCTCGACGTCGAGGCGCTGCTGATCATCGAGCTCG
ACGGCCCGCAAGTCGAGGTCGACGAACTGATCACCCGCGTAGAGGCGATCGCGCTCGGCTGCGGCTCGACCACCTGCCAG
ATCTCGACGTCGGAACAGGAGCGGCTGCTGTTCTGGTCCGGCCGCAAGGCCGCGTTTCCGGCAGTCGGCCGGATCTCGCC
GGACTATCTGTGCATGGACGGCACCATTCCGCGCGCGCAACTGCCGCTGGTGCTGCGGCGGATGACGCAGATGTCGGAAA
AATACGGGCTGCGCGTCGCCAATGTGTTTCACGCCGGTGACGGCAATCTTCACCCTCTCATCCTGTACGACGCCAACAAG
CCCGGCGAGCAGGACAGGGCGGAGGCGTTCGGCGCCGACATCCTGCGGCTGTGCGTCGAGGTCGGCGGCGTGCTGACCGG
CGAGCATGGGGTCGGCATCGAGAAACGCGACCTGATGCCGGAGATGTTCTCCGATATCGATCTCAATCAGCAGCAGCGAT
TGAAATGCGCGTTCGATTCCGAGGGCCTGCTCAATCCCGGCAAGGTGTTTCCGACGCTGCACCGCTGTGCCGAGCTCGGC
CGCATGCACGTCCACGGCGGCAAATTGCCATTCCCGGATATTCCGCGGTTTTGA

Upstream 100 bases:

>100_bases
TAAGGGTTGAGGGCGTACCCCGATCCCGGCCTGTTGCGCTGTTGCGGCAGACGCGCCAGCCACGCTCGACGAATCAGCGG
GCCGCGCAGGAGTATCTCGC

Downstream 100 bases:

>100_bases
ACCTGGTAGTTTGATGGTCGATGGACGAAGCACAACCTTTCAACGTCATTGCGAGCGAAGCGAAGCAATCCAGCGTCGTG
CACCGGCTGGATTGCTTCGT

Product: FAD linked oxidase-like

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MTILMPEPDQAVLARRDEIVASLRKIVPGEGVISSAAEMKPYESDGLMAYRQPPMVVVLPDTTKQVSEVLRYCHKNGIKV
VPRGSGTSLSGGALPLADGVLLGLGKFKRIREIDFDNRAVVVEPGVTNLAISQAVDHAGFYYAPDPSSQIACSIGGNIAE
NSGGVHCLKYGMTTNNVLGCEIVLMTGEILRIGGKAAECAGYDLMGVITGSEGLLGVITEVTVRILRKPETARALMVGFT
DVEAAGRCVADVISAGIIPGGMEMMDRPAIHAAEAFVHAGYPLDVEALLIIELDGPQVEVDELITRVEAIALGCGSTTCQ
ISTSEQERLLFWSGRKAAFPAVGRISPDYLCMDGTIPRAQLPLVLRRMTQMSEKYGLRVANVFHAGDGNLHPLILYDANK
PGEQDRAEAFGADILRLCVEVGGVLTGEHGVGIEKRDLMPEMFSDIDLNQQQRLKCAFDSEGLLNPGKVFPTLHRCAELG
RMHVHGGKLPFPDIPRF

Sequences:

>Translated_497_residues
MTILMPEPDQAVLARRDEIVASLRKIVPGEGVISSAAEMKPYESDGLMAYRQPPMVVVLPDTTKQVSEVLRYCHKNGIKV
VPRGSGTSLSGGALPLADGVLLGLGKFKRIREIDFDNRAVVVEPGVTNLAISQAVDHAGFYYAPDPSSQIACSIGGNIAE
NSGGVHCLKYGMTTNNVLGCEIVLMTGEILRIGGKAAECAGYDLMGVITGSEGLLGVITEVTVRILRKPETARALMVGFT
DVEAAGRCVADVISAGIIPGGMEMMDRPAIHAAEAFVHAGYPLDVEALLIIELDGPQVEVDELITRVEAIALGCGSTTCQ
ISTSEQERLLFWSGRKAAFPAVGRISPDYLCMDGTIPRAQLPLVLRRMTQMSEKYGLRVANVFHAGDGNLHPLILYDANK
PGEQDRAEAFGADILRLCVEVGGVLTGEHGVGIEKRDLMPEMFSDIDLNQQQRLKCAFDSEGLLNPGKVFPTLHRCAELG
RMHVHGGKLPFPDIPRF
>Mature_496_residues
TILMPEPDQAVLARRDEIVASLRKIVPGEGVISSAAEMKPYESDGLMAYRQPPMVVVLPDTTKQVSEVLRYCHKNGIKVV
PRGSGTSLSGGALPLADGVLLGLGKFKRIREIDFDNRAVVVEPGVTNLAISQAVDHAGFYYAPDPSSQIACSIGGNIAEN
SGGVHCLKYGMTTNNVLGCEIVLMTGEILRIGGKAAECAGYDLMGVITGSEGLLGVITEVTVRILRKPETARALMVGFTD
VEAAGRCVADVISAGIIPGGMEMMDRPAIHAAEAFVHAGYPLDVEALLIIELDGPQVEVDELITRVEAIALGCGSTTCQI
STSEQERLLFWSGRKAAFPAVGRISPDYLCMDGTIPRAQLPLVLRRMTQMSEKYGLRVANVFHAGDGNLHPLILYDANKP
GEQDRAEAFGADILRLCVEVGGVLTGEHGVGIEKRDLMPEMFSDIDLNQQQRLKCAFDSEGLLNPGKVFPTLHRCAELGR
MHVHGGKLPFPDIPRF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=459, Percent_Identity=30.5010893246187, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI37595754, Length=482, Percent_Identity=29.045643153527, Blast_Score=219, Evalue=7e-57,
Organism=Homo sapiens, GI119964728, Length=467, Percent_Identity=28.4796573875803, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI4501993, Length=250, Percent_Identity=26.8, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1789351, Length=499, Percent_Identity=56.312625250501, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1787977, Length=504, Percent_Identity=24.8015873015873, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI48994907, Length=488, Percent_Identity=24.3852459016393, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71992373, Length=474, Percent_Identity=28.0590717299578, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71992381, Length=471, Percent_Identity=28.0254777070064, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71992392, Length=371, Percent_Identity=27.7628032345013, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17534361, Length=494, Percent_Identity=26.3157894736842, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17556096, Length=261, Percent_Identity=23.7547892720307, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320027, Length=479, Percent_Identity=28.1837160751566, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320764, Length=485, Percent_Identity=26.8041237113402, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320023, Length=467, Percent_Identity=25.4817987152034, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI18921117, Length=464, Percent_Identity=25.6465517241379, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24639277, Length=464, Percent_Identity=25.6465517241379, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24639275, Length=464, Percent_Identity=25.6465517241379, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24653753, Length=231, Percent_Identity=25.974025974026, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 53386; Mature: 53254

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILMPEPDQAVLARRDEIVASLRKIVPGEGVISSAAEMKPYESDGLMAYRQPPMVVVLP
CEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEEECCCCEEEEEC
DTTKQVSEVLRYCHKNGIKVVPRGSGTSLSGGALPLADGVLLGLGKFKRIREIDFDNRAV
CCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHCCHHHCCHHHHHHHHCCCCCCEE
VVEPGVTNLAISQAVDHAGFYYAPDPSSQIACSIGGNIAENSGGVHCLKYGMTTNNVLGC
EECCCCCHHHHHHHHHHCCCEECCCCCCCEEEEECCCEECCCCCEEEEEECCCCCCEEEE
EIVLMTGEILRIGGKAAECAGYDLMGVITGSEGLLGVITEVTVRILRKPETARALMVGFT
EEEEEECCEEEECCCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHCEEEEEEC
DVEAAGRCVADVISAGIIPGGMEMMDRPAIHAAEAFVHAGYPLDVEALLIIELDGPQVEV
CHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCCCH
DELITRVEAIALGCGSTTCQISTSEQERLLFWSGRKAAFPAVGRISPDYLCMDGTIPRAQ
HHHHHHHHHHEEECCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCHHH
LPLVLRRMTQMSEKYGLRVANVFHAGDGNLHPLILYDANKPGEQDRAEAFGADILRLCVE
HHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
VGGVLTGEHGVGIEKRDLMPEMFSDIDLNQQQRLKCAFDSEGLLNPGKVFPTLHRCAELG
HCCEEECCCCCCCCHHHCCHHHHHCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHC
RMHVHGGKLPFPDIPRF
CEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TILMPEPDQAVLARRDEIVASLRKIVPGEGVISSAAEMKPYESDGLMAYRQPPMVVVLP
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEEECCCCEEEEEC
DTTKQVSEVLRYCHKNGIKVVPRGSGTSLSGGALPLADGVLLGLGKFKRIREIDFDNRAV
CCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHCCHHHCCHHHHHHHHCCCCCCEE
VVEPGVTNLAISQAVDHAGFYYAPDPSSQIACSIGGNIAENSGGVHCLKYGMTTNNVLGC
EECCCCCHHHHHHHHHHCCCEECCCCCCCEEEEECCCEECCCCCEEEEEECCCCCCEEEE
EIVLMTGEILRIGGKAAECAGYDLMGVITGSEGLLGVITEVTVRILRKPETARALMVGFT
EEEEEECCEEEECCCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHCEEEEEEC
DVEAAGRCVADVISAGIIPGGMEMMDRPAIHAAEAFVHAGYPLDVEALLIIELDGPQVEV
CHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCCCH
DELITRVEAIALGCGSTTCQISTSEQERLLFWSGRKAAFPAVGRISPDYLCMDGTIPRAQ
HHHHHHHHHHEEECCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCHHH
LPLVLRRMTQMSEKYGLRVANVFHAGDGNLHPLILYDANKPGEQDRAEAFGADILRLCVE
HHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
VGGVLTGEHGVGIEKRDLMPEMFSDIDLNQQQRLKCAFDSEGLLNPGKVFPTLHRCAELG
HCCEEECCCCCCCCHHHCCHHHHHCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHC
RMHVHGGKLPFPDIPRF
CEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]