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The map label for this gene is aphA [H]

Identifier: 86748777

GI number: 86748777

Start: 1883709

End: 1884734

Strand: Direct

Name: aphA [H]

Synonym: RPB_1654

Alternate gene names: 86748777

Gene position: 1883709-1884734 (Clockwise)

Preceding gene: 86748776

Following gene: 86748778

Centisome position: 35.33

GC content: 66.76

Gene sequence:

>1026_bases
GTGAAGGCCGTCTACAGCGAACTGCATCGAAGCCACGACCCGCAATTCTTTCTGGTTCGCGGGATCGTCCAGCGCACTAC
CGAACAACCCGAACGTGCCGACCGGCTGCTGGCGGGACTGAAGGCCGGCGGTCATTCGCTCGTCGAGCCGACGGCGTTCG
GACAGGGCCCGCGCGCCAGGGTGCATAGTCCGGAGTATCTCGGCTTTCTCGCCGAGGCCTGGGACGCCTGGGCGGCGCTG
GGCAATTCCGGCCCCGAGATGATCGCCAACATCCATCCCGTCCGCAACGAGGCGACGTATCCGACGCACATCGTCGGCCG
CCTCGGCTGGCACACGATCGATACGTCCTGCCCGATCGGACCCGGCACCTGGGCCGCGGTCTGCGCCGCGACCGATGTCG
CGACCTCGGCAGCCCAACTCGTGATGGACGGGGAAGACGCCGCCTACGCGCTGTGTCGTCCGCCGGGGCACCACGCCTAT
CGCGATCTCGCCAGCGGCTTCTGCTTTCTCAACAACAGCGCGATCGCGGCCGCCCATCTGCGGCTGAAGCACGAGCGCGT
CGCGATCCTCGACGTCGACGTTCATCATGGCAACGGCACGCAGGGCATCTTCTACGAGCGGCCCGACGTGCTCACCGTTT
CGATTCACGCCGACCCGACCTTCTTCAACCCCTTTGTCTGGGGCTACGCGCACGAACGCGGCGCGGGTCCGGGGCTCGGC
GCCAATCTGAACATCCCGCTGGCGAAGGGCACCGACGATGACGGCTATATCGAGGCGCTCGGTGTCGCGGAAAAGACGAT
TCGCGCTTTTGCGCCCGGCGCTCTGGTCGTCGCGCTCGGCCTCGATGCATCCGAGCATGACCCGCTTGCGGGGCTGGCCG
TCACGACCGATGGATTCCATCGCATCGGTGGCGCCATCGCGCGGTTGGGGCTGCCCACCGTGTTCGTTCAGGAAGGCGGA
TATCTGTCGGAGATTCTCGGACCCAACCTGACGTCGGCGCTCGCCGGCTTCGAGCAGGTTCGCTAG

Upstream 100 bases:

>100_bases
GGTGCGGGAGATTCCTCCCGCGACTGCCGGCGGCAAAATACGATCCGTGTGATGCCGACGAACGCCCGACGATTGATCAT
CAAGCCATGGGAGTCTCTGC

Downstream 100 bases:

>100_bases
GTAGCGGGCTTCCGACATCGACGTGACCTCGAGAACCCCGGTCCGCGACCGGGGTTTTTTGCTATCGGGCGGATCGATCG
CCGCGGTGGTGCGGACCCGC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKAVYSELHRSHDPQFFLVRGIVQRTTEQPERADRLLAGLKAGGHSLVEPTAFGQGPRARVHSPEYLGFLAEAWDAWAAL
GNSGPEMIANIHPVRNEATYPTHIVGRLGWHTIDTSCPIGPGTWAAVCAATDVATSAAQLVMDGEDAAYALCRPPGHHAY
RDLASGFCFLNNSAIAAAHLRLKHERVAILDVDVHHGNGTQGIFYERPDVLTVSIHADPTFFNPFVWGYAHERGAGPGLG
ANLNIPLAKGTDDDGYIEALGVAEKTIRAFAPGALVVALGLDASEHDPLAGLAVTTDGFHRIGGAIARLGLPTVFVQEGG
YLSEILGPNLTSALAGFEQVR

Sequences:

>Translated_341_residues
MKAVYSELHRSHDPQFFLVRGIVQRTTEQPERADRLLAGLKAGGHSLVEPTAFGQGPRARVHSPEYLGFLAEAWDAWAAL
GNSGPEMIANIHPVRNEATYPTHIVGRLGWHTIDTSCPIGPGTWAAVCAATDVATSAAQLVMDGEDAAYALCRPPGHHAY
RDLASGFCFLNNSAIAAAHLRLKHERVAILDVDVHHGNGTQGIFYERPDVLTVSIHADPTFFNPFVWGYAHERGAGPGLG
ANLNIPLAKGTDDDGYIEALGVAEKTIRAFAPGALVVALGLDASEHDPLAGLAVTTDGFHRIGGAIARLGLPTVFVQEGG
YLSEILGPNLTSALAGFEQVR
>Mature_341_residues
MKAVYSELHRSHDPQFFLVRGIVQRTTEQPERADRLLAGLKAGGHSLVEPTAFGQGPRARVHSPEYLGFLAEAWDAWAAL
GNSGPEMIANIHPVRNEATYPTHIVGRLGWHTIDTSCPIGPGTWAAVCAATDVATSAAQLVMDGEDAAYALCRPPGHHAY
RDLASGFCFLNNSAIAAAHLRLKHERVAILDVDVHHGNGTQGIFYERPDVLTVSIHADPTFFNPFVWGYAHERGAGPGLG
ANLNIPLAKGTDDDGYIEALGVAEKTIRAFAPGALVVALGLDASEHDPLAGLAVTTDGFHRIGGAIARLGLPTVFVQEGG
YLSEILGPNLTSALAGFEQVR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI169234807, Length=210, Percent_Identity=39.0476190476191, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI148539870, Length=210, Percent_Identity=39.0476190476191, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI8923769, Length=206, Percent_Identity=32.5242718446602, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI30795204, Length=196, Percent_Identity=39.7959183673469, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI30795202, Length=196, Percent_Identity=39.7959183673469, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI17158039, Length=184, Percent_Identity=40.2173913043478, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI13128864, Length=229, Percent_Identity=36.2445414847162, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI13128860, Length=213, Percent_Identity=30.9859154929577, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI153085395, Length=185, Percent_Identity=38.9189189189189, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI262073088, Length=176, Percent_Identity=35.2272727272727, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI13128862, Length=280, Percent_Identity=26.7857142857143, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI20070354, Length=189, Percent_Identity=37.5661375661376, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI293336691, Length=242, Percent_Identity=27.6859504132231, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI62750349, Length=197, Percent_Identity=35.5329949238579, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI62750347, Length=197, Percent_Identity=35.5329949238579, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI226529806, Length=116, Percent_Identity=44.8275862068966, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI262073092, Length=143, Percent_Identity=34.2657342657343, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17540332, Length=197, Percent_Identity=38.0710659898477, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193206283, Length=197, Percent_Identity=38.0710659898477, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17540334, Length=197, Percent_Identity=38.0710659898477, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17537347, Length=217, Percent_Identity=34.5622119815668, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193209491, Length=271, Percent_Identity=32.4723247232472, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17508561, Length=265, Percent_Identity=28.3018867924528, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17561978, Length=265, Percent_Identity=27.5471698113208, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17534739, Length=216, Percent_Identity=29.6296296296296, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25154022, Length=180, Percent_Identity=28.3333333333333, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25154020, Length=180, Percent_Identity=28.3333333333333, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321244, Length=217, Percent_Identity=29.4930875576037, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323999, Length=168, Percent_Identity=33.9285714285714, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324307, Length=202, Percent_Identity=33.6633663366337, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325325, Length=185, Percent_Identity=29.1891891891892, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641720, Length=186, Percent_Identity=41.9354838709677, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI281360801, Length=186, Percent_Identity=41.9354838709677, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI281360799, Length=186, Percent_Identity=41.9354838709677, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24642146, Length=205, Percent_Identity=40.9756097560976, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24642144, Length=205, Percent_Identity=40.9756097560976, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24642142, Length=205, Percent_Identity=40.9756097560976, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360899, Length=218, Percent_Identity=38.9908256880734, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24644244, Length=263, Percent_Identity=28.5171102661597, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24657891, Length=214, Percent_Identity=32.2429906542056, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36283; Mature: 36283

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVYSELHRSHDPQFFLVRGIVQRTTEQPERADRLLAGLKAGGHSLVEPTAFGQGPRAR
CCHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VHSPEYLGFLAEAWDAWAALGNSGPEMIANIHPVRNEATYPTHIVGRLGWHTIDTSCPIG
CCCHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCCCHHHHHHCCCEEECCCCCCC
PGTWAAVCAATDVATSAAQLVMDGEDAAYALCRPPGHHAYRDLASGFCFLNNSAIAAAHL
CCHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHHHHHHHCCEEEECCCCEEEEEE
RLKHERVAILDVDVHHGNGTQGIFYERPDVLTVSIHADPTFFNPFVWGYAHERGAGPGLG
EEECCEEEEEEEEEECCCCCCCEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
ANLNIPLAKGTDDDGYIEALGVAEKTIRAFAPGALVVALGLDASEHDPLAGLAVTTDGFH
CCEEEEECCCCCCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCHH
RIGGAIARLGLPTVFVQEGGYLSEILGPNLTSALAGFEQVR
HHHHHHHHHCCCEEEEECCCHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKAVYSELHRSHDPQFFLVRGIVQRTTEQPERADRLLAGLKAGGHSLVEPTAFGQGPRAR
CCHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VHSPEYLGFLAEAWDAWAALGNSGPEMIANIHPVRNEATYPTHIVGRLGWHTIDTSCPIG
CCCHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCCCHHHHHHCCCEEECCCCCCC
PGTWAAVCAATDVATSAAQLVMDGEDAAYALCRPPGHHAYRDLASGFCFLNNSAIAAAHL
CCHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHHHHHHHCCEEEECCCCEEEEEE
RLKHERVAILDVDVHHGNGTQGIFYERPDVLTVSIHADPTFFNPFVWGYAHERGAGPGLG
EEECCEEEEEEEEEECCCCCCCEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
ANLNIPLAKGTDDDGYIEALGVAEKTIRAFAPGALVVALGLDASEHDPLAGLAVTTDGFH
CCEEEEECCCCCCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCHH
RIGGAIARLGLPTVFVQEGGYLSEILGPNLTSALAGFEQVR
HHHHHHHHHCCCEEEEECCCHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]