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The map label for this gene is tdcB [H]

Identifier: 86748747

GI number: 86748747

Start: 1828537

End: 1829523

Strand: Direct

Name: tdcB [H]

Synonym: RPB_1623

Alternate gene names: 86748747

Gene position: 1828537-1829523 (Clockwise)

Preceding gene: 86748746

Following gene: 86748749

Centisome position: 34.3

GC content: 70.82

Gene sequence:

>987_bases
ATGATGGATTCAGTCTCGTTCCCGATCACCGCCGCAGATATCGACGCGGCGGCCGATGTGCTCGCGCCCTATGCGGTGCG
CACGCCGCTGCTGACCTCGCCGGCGCTCGACGCCGCCACCGGGGCGCGCGTCTTTCTGAAGCCGGAGATGCTGCAGCGGA
CCGGCTCGTTCAAATTTCGCGGCGCCTTCAACAAGCTGTCGTCGATCCCGCAAGCGGCGCGCGGCGGCGGCGTGGTGGCG
TTCTCGTCCGGCAATCACGCCCAGGGCGTCGCCGCGGCGGCGCAGATCCTCGGCATGCGCGCCACCATCGTGATGCCGGC
CGATGCGCCGGCCTCGAAGCGTGAGCGCACCAAGGGCTACGGCGCCGAGGTGGTGCTGTACGATCGCGACCGCGAGGATC
GCGAGGCGATCGCGCGCGGCATCGCCGGCCCCCGCGGCGCGACGCTGGTGCCGCCTTATGACGATGCCAAGGTGATCGCG
GGGCAGGGCACCGTCGGCCGCGAGATTGCCGCCGATCTCGCCGCGCTCGGCGTCACGCCGGATATCGTCGTCGCGCCGGC
CTCCGGCGGCGGGCTGGTCGCCGGCATTGCCGTCGCGGTGACGACGCGCTTCCCGGAAGCGGCGGTGATGTCGGCGGAGC
CGGAGGCGTTCGACGACCATGCCCGCTCCATCGCCGCCGGCCGCCGTGAGCCGCACAAGGCCGAAGGCCGCACCATCTGC
GACGCGCTGATGGCGTCGATCCCAGGCGAACTCACCTTCGCGATCAATCAGCAGCTTCTGACGCGCGGCGTCACCGCCTC
CGATGCCGAGGTGACCAAGGCGGTGGCCTTGGTGTTTCGCGAGCTGAAGCTGGTGGTCGAGCCCGGCGGCGCGGTGGCGC
TGGCGGCACTGCTGGCAGGCCGCATCGATGCGCGCGGCAAGACCATCGCGATCGTACTGTCGGGCGGCAATGTCGACGCC
GATCTGTTCGCGAAGCTGATCGCTTAG

Upstream 100 bases:

>100_bases
GACGCGAAGGCGCGCCGGCTGGTCGCCTGAGCAGGCGAGTCGCCGTGCCTCAAGGCAACGTGCATTGCCGGGCCGCGCGG
GGCTGCGGTATTGTCGCCCC

Downstream 100 bases:

>100_bases
TGCAGTCCTGCTTTTGATGGAATCTGAGCTCGCGATCCGATTGCCGCCGTCATCCTGAGGTGCCCGCTGGGCCGCGCTGT
GCGCGGCGCGGCGGGCCTCG

Product: pyridoxal-5'-phosphate-dependent enzyme, beta subunit

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MMDSVSFPITAADIDAAADVLAPYAVRTPLLTSPALDAATGARVFLKPEMLQRTGSFKFRGAFNKLSSIPQAARGGGVVA
FSSGNHAQGVAAAAQILGMRATIVMPADAPASKRERTKGYGAEVVLYDRDREDREAIARGIAGPRGATLVPPYDDAKVIA
GQGTVGREIAADLAALGVTPDIVVAPASGGGLVAGIAVAVTTRFPEAAVMSAEPEAFDDHARSIAAGRREPHKAEGRTIC
DALMASIPGELTFAINQQLLTRGVTASDAEVTKAVALVFRELKLVVEPGGAVALAALLAGRIDARGKTIAIVLSGGNVDA
DLFAKLIA

Sequences:

>Translated_328_residues
MMDSVSFPITAADIDAAADVLAPYAVRTPLLTSPALDAATGARVFLKPEMLQRTGSFKFRGAFNKLSSIPQAARGGGVVA
FSSGNHAQGVAAAAQILGMRATIVMPADAPASKRERTKGYGAEVVLYDRDREDREAIARGIAGPRGATLVPPYDDAKVIA
GQGTVGREIAADLAALGVTPDIVVAPASGGGLVAGIAVAVTTRFPEAAVMSAEPEAFDDHARSIAAGRREPHKAEGRTIC
DALMASIPGELTFAINQQLLTRGVTASDAEVTKAVALVFRELKLVVEPGGAVALAALLAGRIDARGKTIAIVLSGGNVDA
DLFAKLIA
>Mature_328_residues
MMDSVSFPITAADIDAAADVLAPYAVRTPLLTSPALDAATGARVFLKPEMLQRTGSFKFRGAFNKLSSIPQAARGGGVVA
FSSGNHAQGVAAAAQILGMRATIVMPADAPASKRERTKGYGAEVVLYDRDREDREAIARGIAGPRGATLVPPYDDAKVIA
GQGTVGREIAADLAALGVTPDIVVAPASGGGLVAGIAVAVTTRFPEAAVMSAEPEAFDDHARSIAAGRREPHKAEGRTIC
DALMASIPGELTFAINQQLLTRGVTASDAEVTKAVALVFRELKLVVEPGGAVALAALLAGRIDARGKTIAIVLSGGNVDA
DLFAKLIA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=320, Percent_Identity=36.875, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI19923959, Length=152, Percent_Identity=36.8421052631579, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI33469958, Length=156, Percent_Identity=34.6153846153846, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1789505, Length=322, Percent_Identity=41.304347826087, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1790207, Length=299, Percent_Identity=33.4448160535117, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=31.3291139240506, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71991565, Length=319, Percent_Identity=32.2884012539185, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17537387, Length=317, Percent_Identity=32.1766561514196, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322631, Length=319, Percent_Identity=41.3793103448276, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320930, Length=300, Percent_Identity=34.6666666666667, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319788, Length=290, Percent_Identity=26.2068965517241, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355833, Length=320, Percent_Identity=33.4375, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24645328, Length=224, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 33604; Mature: 33604

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDSVSFPITAADIDAAADVLAPYAVRTPLLTSPALDAATGARVFLKPEMLQRTGSFKFR
CCCCCCCCEEEHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEECHHHHHHCCCEEEE
GAFNKLSSIPQAARGGGVVAFSSGNHAQGVAAAAQILGMRATIVMPADAPASKRERTKGY
HHHHHHHCCCHHHCCCCEEEECCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCC
GAEVVLYDRDREDREAIARGIAGPRGATLVPPYDDAKVIAGQGTVGREIAADLAALGVTP
CCEEEEECCCCHHHHHHHHHCCCCCCCEECCCCCCCEEEECCCCCHHHHHHHHHHHCCCC
DIVVAPASGGGLVAGIAVAVTTRFPEAAVMSAEPEAFDDHARSIAAGRREPHKAEGRTIC
CEEEEECCCCCHHHHHEEEEEECCCCHHEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
DALMASIPGELTFAINQQLLTRGVTASDAEVTKAVALVFRELKLVVEPGGAVALAALLAG
HHHHHHCCCCEEEHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
RIDARGKTIAIVLSGGNVDADLFAKLIA
CCCCCCCEEEEEEECCCCCHHHHHHHHC
>Mature Secondary Structure
MMDSVSFPITAADIDAAADVLAPYAVRTPLLTSPALDAATGARVFLKPEMLQRTGSFKFR
CCCCCCCCEEEHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEECHHHHHHCCCEEEE
GAFNKLSSIPQAARGGGVVAFSSGNHAQGVAAAAQILGMRATIVMPADAPASKRERTKGY
HHHHHHHCCCHHHCCCCEEEECCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCC
GAEVVLYDRDREDREAIARGIAGPRGATLVPPYDDAKVIAGQGTVGREIAADLAALGVTP
CCEEEEECCCCHHHHHHHHHCCCCCCCEECCCCCCCEEEECCCCCHHHHHHHHHHHCCCC
DIVVAPASGGGLVAGIAVAVTTRFPEAAVMSAEPEAFDDHARSIAAGRREPHKAEGRTIC
CEEEEECCCCCHHHHHEEEEEECCCCHHEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
DALMASIPGELTFAINQQLLTRGVTASDAEVTKAVALVFRELKLVVEPGGAVALAALLAG
HHHHHHCCCCEEEHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
RIDARGKTIAIVLSGGNVDADLFAKLIA
CCCCCCCEEEEEEECCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA