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The map label for this gene is capL [H]

Identifier: 86748678

GI number: 86748678

Start: 1750581

End: 1751852

Strand: Direct

Name: capL [H]

Synonym: RPB_1553

Alternate gene names: 86748678

Gene position: 1750581-1751852 (Clockwise)

Preceding gene: 86748676

Following gene: 86748679

Centisome position: 32.83

GC content: 60.46

Gene sequence:

>1272_bases
ATGCGGAAGATTGCGGTCGTCGGTCTCGGATATGTGGGCTTGCCAGTTGCTATTGGATTTGCCCGTTCGTACCAGGTGGT
CGGCTTCGATGTCGATCGCGTGCGGATCTCCGAGCTGAATGAAGGCTTCGACCGAACGCGCGAGGTCGAGCCGGACGCGC
TGCGCGGCGCCTCGATCAAGTTCACCAGTGTCGTCGCCGAATTGTCGGGATGCGATTTCTACATTGTGGCGGTCCCCACG
CCGCTCGATGACGCGCGTCGGCCCGACCTCGGTGCGATGTTGTCCGCCTCGCGCGCGGTGGGGTCGGTCCTGAAGAAAAA
CGATATCGTCGTCTACGAGTCGACCGTCTATCCGGGCGCAGTCGAAGAAGAGTGTCTTCCCGTTCTCGAGCAGGCGTCGG
GACTCCTGGCGGGAGTCGACTTCAAGGTCGGATACTCGCCGGAGCGGATCAATCCCGGCGACAAGAACCACAGGTTCGAA
ACCATCACCAAAGTCGTCTCGGCCCAGGACGCCGAATCTCTCGACATCGTCGCCGACGTCTATGGTTCGGTCGTCACCGC
CGGCATCTACCGGGCGCCCTCGATCAAGGTCGCGGAAGCCGCCAAGGTCATCGAGAATACTCAGCGCGACCTCAACATCG
CTTTCATGAACGAGCTGGCTCTGATCTTCCAGTCTCTGGAAATCGATACCGATGACGTTCTTGCGGCGGCGAGAACGAAA
TGGAATTTCCTGCCGTTTCAGCCCGGACTGGTGGGTGGACACTGCATCGGCGTGGACCCTTACTATCTGACCTTCCGGGC
GGAAAAAGCAGGCTATCATCCTGAAGTCATCCTGGCGGGTCGCCGGATCAACGACGCCATGGGAGCGGAGATTGCCCGTC
AGTGCATCCGCCGGATGATGCGGTGCCGATATCGGAGCGAAACCGTGACGATCCTCGGCCTGACGTTCAAGGAGAACGTT
CCCGACATCCGCAACACCAAAGTGGTGGACATCGTGCGTGAGCTGGAATCGTTCGGCGTTGCAGTTCAGATCTGCGATCC
TTGGGCGAACCCCGGCGACGCTTCGCGGGAGTACGGGATCGAGCCGGTCGATCTGGACAAGCTGCAGCCGGCCGACGCCG
TGATCGTTGCTGTTGCTCACGACGATTTTCTGCAACTCGGGTGGCCGCGGATCCAGACATTGCTTCACGGCGGCAAGGGC
ATCGTGTTCGACGTCAAGGCCAAATTGGATCGAAGCGCAAAGCCCGCCGATATCGAGCTGCTGCGGCTCTAA

Upstream 100 bases:

>100_bases
CGGCGCGCAGATTGCTATTGCCCTCGCCGCGGCACAAAGGCTAACGATGGCAGCGTTTTGGCCGTCATCGACGGCCCCGC
GGCTCGGAGTTTGATCGAAT

Downstream 100 bases:

>100_bases
CGAAAGCGTCATTCATGGGAACTCCGCCCGTTCTGGTGACCGGCGCTGCCGGCTTTATCGGCTTCCACGTCACGCAGCAA
TTGCTGGCCAAGGGAAGCAA

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MRKIAVVGLGYVGLPVAIGFARSYQVVGFDVDRVRISELNEGFDRTREVEPDALRGASIKFTSVVAELSGCDFYIVAVPT
PLDDARRPDLGAMLSASRAVGSVLKKNDIVVYESTVYPGAVEEECLPVLEQASGLLAGVDFKVGYSPERINPGDKNHRFE
TITKVVSAQDAESLDIVADVYGSVVTAGIYRAPSIKVAEAAKVIENTQRDLNIAFMNELALIFQSLEIDTDDVLAAARTK
WNFLPFQPGLVGGHCIGVDPYYLTFRAEKAGYHPEVILAGRRINDAMGAEIARQCIRRMMRCRYRSETVTILGLTFKENV
PDIRNTKVVDIVRELESFGVAVQICDPWANPGDASREYGIEPVDLDKLQPADAVIVAVAHDDFLQLGWPRIQTLLHGGKG
IVFDVKAKLDRSAKPADIELLRL

Sequences:

>Translated_423_residues
MRKIAVVGLGYVGLPVAIGFARSYQVVGFDVDRVRISELNEGFDRTREVEPDALRGASIKFTSVVAELSGCDFYIVAVPT
PLDDARRPDLGAMLSASRAVGSVLKKNDIVVYESTVYPGAVEEECLPVLEQASGLLAGVDFKVGYSPERINPGDKNHRFE
TITKVVSAQDAESLDIVADVYGSVVTAGIYRAPSIKVAEAAKVIENTQRDLNIAFMNELALIFQSLEIDTDDVLAAARTK
WNFLPFQPGLVGGHCIGVDPYYLTFRAEKAGYHPEVILAGRRINDAMGAEIARQCIRRMMRCRYRSETVTILGLTFKENV
PDIRNTKVVDIVRELESFGVAVQICDPWANPGDASREYGIEPVDLDKLQPADAVIVAVAHDDFLQLGWPRIQTLLHGGKG
IVFDVKAKLDRSAKPADIELLRL
>Mature_423_residues
MRKIAVVGLGYVGLPVAIGFARSYQVVGFDVDRVRISELNEGFDRTREVEPDALRGASIKFTSVVAELSGCDFYIVAVPT
PLDDARRPDLGAMLSASRAVGSVLKKNDIVVYESTVYPGAVEEECLPVLEQASGLLAGVDFKVGYSPERINPGDKNHRFE
TITKVVSAQDAESLDIVADVYGSVVTAGIYRAPSIKVAEAAKVIENTQRDLNIAFMNELALIFQSLEIDTDDVLAAARTK
WNFLPFQPGLVGGHCIGVDPYYLTFRAEKAGYHPEVILAGRRINDAMGAEIARQCIRRMMRCRYRSETVTILGLTFKENV
PDIRNTKVVDIVRELESFGVAVQICDPWANPGDASREYGIEPVDLDKLQPADAVIVAVAHDDFLQLGWPRIQTLLHGGKG
IVFDVKAKLDRSAKPADIELLRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=357, Percent_Identity=32.2128851540616, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46381; Mature: 46381

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIAVVGLGYVGLPVAIGFARSYQVVGFDVDRVRISELNEGFDRTREVEPDALRGASIK
CCEEEEEECCHHHHHHHHHHHCCEEEEEEECCCEEHHHHHHHHHHHCCCCCHHHCCCCEE
FTSVVAELSGCDFYIVAVPTPLDDARRPDLGAMLSASRAVGSVLKKNDIVVYESTVYPGA
HHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
VEEECLPVLEQASGLLAGVDFKVGYSPERINPGDKNHRFETITKVVSAQDAESLDIVADV
CCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
YGSVVTAGIYRAPSIKVAEAAKVIENTQRDLNIAFMNELALIFQSLEIDTDDVLAAARTK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHCCCHHHHHHHHHCC
WNFLPFQPGLVGGHCIGVDPYYLTFRAEKAGYHPEVILAGRRINDAMGAEIARQCIRRMM
CCCCCCCCCCCCCEEEECCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
RCRYRSETVTILGLTFKENVPDIRNTKVVDIVRELESFGVAVQICDPWANPGDASREYGI
HHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHCCC
EPVDLDKLQPADAVIVAVAHDDFLQLGWPRIQTLLHGGKGIVFDVKAKLDRSAKPADIEL
CCCCCCCCCCCCEEEEEEECCCHHHCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEE
LRL
EEC
>Mature Secondary Structure
MRKIAVVGLGYVGLPVAIGFARSYQVVGFDVDRVRISELNEGFDRTREVEPDALRGASIK
CCEEEEEECCHHHHHHHHHHHCCEEEEEEECCCEEHHHHHHHHHHHCCCCCHHHCCCCEE
FTSVVAELSGCDFYIVAVPTPLDDARRPDLGAMLSASRAVGSVLKKNDIVVYESTVYPGA
HHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
VEEECLPVLEQASGLLAGVDFKVGYSPERINPGDKNHRFETITKVVSAQDAESLDIVADV
CCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
YGSVVTAGIYRAPSIKVAEAAKVIENTQRDLNIAFMNELALIFQSLEIDTDDVLAAARTK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHCCCHHHHHHHHHCC
WNFLPFQPGLVGGHCIGVDPYYLTFRAEKAGYHPEVILAGRRINDAMGAEIARQCIRRMM
CCCCCCCCCCCCCEEEECCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
RCRYRSETVTILGLTFKENVPDIRNTKVVDIVRELESFGVAVQICDPWANPGDASREYGI
HHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHCCC
EPVDLDKLQPADAVIVAVAHDDFLQLGWPRIQTLLHGGKGIVFDVKAKLDRSAKPADIEL
CCCCCCCCCCCCEEEEEEECCCHHHCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEE
LRL
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]