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The map label for this gene is fnr [H]

Identifier: 86748590

GI number: 86748590

Start: 1654011

End: 1654721

Strand: Reverse

Name: fnr [H]

Synonym: RPB_1465

Alternate gene names: 86748590

Gene position: 1654721-1654011 (Counterclockwise)

Preceding gene: 86748591

Following gene: 86748589

Centisome position: 31.04

GC content: 68.35

Gene sequence:

>711_bases
ATGGCGACCATCGACACCTCTCTCGTTGCGAAACTGCCACTGTTCGCGGGCTGCAGTGCCGACGAGCTCGACGCCATCCT
CAAGGAGGCCCGCTCGATCCGGGTTCCGAAGAACGGCAACGTGTTCGAGCAAGGCGAGGACGCGCATTCGTTCTTCGTGC
TGCTGCACGGCCATGTCCGCGCCAGCAAGCTGACGCCGGCCGGCGAGCAGGTGGTGGTGCGCTATGTGGCGCCCGGCGAG
ACGCTGGGCGTCGCGATGGCGATCGGGCTGCCAAGCTATCCGGCGACGGCGACCGCGGTCGACGACAGCGTGGTGCTGGC
ATGGCCGACCGCGGCGTGGCCGCGCCTCGTCGAGCGCCATCCGGCGCTCGCCACCAACACGCTGCGGACCGTCGGGGCCC
GGTTGCAGGAAACCCATTCGCGCGTCATTGAAATGTCGACCCAACAGGTCGAGCAGCGCGTCGCCCGGGCATTGCTGCGG
CTCGCCAAGCAATCCGGCCGCCCGGTCGAGACCGGCGTCGAGATCGATTTTCCGATCAGCCGGCAGGATATCGCACAAAT
GACGGGAACCACACTGCACACCGTCAGCAGATTGCTGTCCGGCTGGGAGAGCCGCGGCCTGATCGAGGGCGGCCGACGGC
GCATCGTGCTGCGCGCGCCGGATCAGCTCGTGGCGCTGGCGGAACAGACGCCCGACGACACCGCGTCGTGA

Upstream 100 bases:

>100_bases
GCCGCTCACAGGGGGCAGCGCGCTGGTCCGCCCACGCCCCCTTGCCCTCCGCCGCAATCGCGATCTAGCTGGCTGCGCGC
CCATCATCGAGAACCATCGC

Downstream 100 bases:

>100_bases
AGGGACAGCAAATACCTTCGCTGCAGGGCACCGCACCGAAACGCGAATCGCTTGCAGCTATCGCATTTGCGTTTCGCCGC
ACGCCATGTGCTAGACTGTC

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MATIDTSLVAKLPLFAGCSADELDAILKEARSIRVPKNGNVFEQGEDAHSFFVLLHGHVRASKLTPAGEQVVVRYVAPGE
TLGVAMAIGLPSYPATATAVDDSVVLAWPTAAWPRLVERHPALATNTLRTVGARLQETHSRVIEMSTQQVEQRVARALLR
LAKQSGRPVETGVEIDFPISRQDIAQMTGTTLHTVSRLLSGWESRGLIEGGRRRIVLRAPDQLVALAEQTPDDTAS

Sequences:

>Translated_236_residues
MATIDTSLVAKLPLFAGCSADELDAILKEARSIRVPKNGNVFEQGEDAHSFFVLLHGHVRASKLTPAGEQVVVRYVAPGE
TLGVAMAIGLPSYPATATAVDDSVVLAWPTAAWPRLVERHPALATNTLRTVGARLQETHSRVIEMSTQQVEQRVARALLR
LAKQSGRPVETGVEIDFPISRQDIAQMTGTTLHTVSRLLSGWESRGLIEGGRRRIVLRAPDQLVALAEQTPDDTAS
>Mature_235_residues
ATIDTSLVAKLPLFAGCSADELDAILKEARSIRVPKNGNVFEQGEDAHSFFVLLHGHVRASKLTPAGEQVVVRYVAPGET
LGVAMAIGLPSYPATATAVDDSVVLAWPTAAWPRLVERHPALATNTLRTVGARLQETHSRVIEMSTQQVEQRVARALLRL
AKQSGRPVETGVEIDFPISRQDIAQMTGTTLHTVSRLLSGWESRGLIEGGRRRIVLRAPDQLVALAEQTPDDTAS

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=210, Percent_Identity=23.8095238095238, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25513; Mature: 25382

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIDTSLVAKLPLFAGCSADELDAILKEARSIRVPKNGNVFEQGEDAHSFFVLLHGHVR
CCCCCHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCEE
ASKLTPAGEQVVVRYVAPGETLGVAMAIGLPSYPATATAVDDSVVLAWPTAAWPRLVERH
ECCCCCCCCEEEEEEECCCCHHEEEEEECCCCCCCCEEECCCCEEEEECCHHHHHHHHHC
PALATNTLRTVGARLQETHSRVIEMSTQQVEQRVARALLRLAKQSGRPVETGVEIDFPIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
RQDIAQMTGTTLHTVSRLLSGWESRGLIEGGRRRIVLRAPDQLVALAEQTPDDTAS
HHHHHHHCCHHHHHHHHHHHCHHCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ATIDTSLVAKLPLFAGCSADELDAILKEARSIRVPKNGNVFEQGEDAHSFFVLLHGHVR
CCCCHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCEE
ASKLTPAGEQVVVRYVAPGETLGVAMAIGLPSYPATATAVDDSVVLAWPTAAWPRLVERH
ECCCCCCCCEEEEEEECCCCHHEEEEEECCCCCCCCEEECCCCEEEEECCHHHHHHHHHC
PALATNTLRTVGARLQETHSRVIEMSTQQVEQRVARALLRLAKQSGRPVETGVEIDFPIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
RQDIAQMTGTTLHTVSRLLSGWESRGLIEGGRRRIVLRAPDQLVALAEQTPDDTAS
HHHHHHHCCHHHHHHHHHHHCHHCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]