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The map label for this gene is qor [C]

Identifier: 86748273

GI number: 86748273

Start: 1320460

End: 1321479

Strand: Direct

Name: qor [C]

Synonym: RPB_1148

Alternate gene names: 86748273

Gene position: 1320460-1321479 (Clockwise)

Preceding gene: 86748272

Following gene: 86748274

Centisome position: 24.77

GC content: 67.55

Gene sequence:

>1020_bases
ATGCGCGCGATGGTCCTGCGGGAACACGGGGGGCTCGACAAGCTCACCTTCGATCCGAATTTCCCCGATCCCGACATCGG
ACCCGGCGACGTGCTGTTGCGCGTGCGCGCGACCTCGCTGAACTATCACGACATCTTCACCCGTCGCGGCATGCCGGGCA
TCAAGATCCCGTTGCCGGTGATCATGGGGCTCGATGTCGCAGGCGAGATCGTCGTGGTCGGCGACGGCGTCGAGGGCTGG
AAGGCCGGCGACCGCGTGCTGGTCGATCCGCTCAACCGCGTCGAAGGCGGGCTGATGGGCGAGACCATGAATGGCGGCCT
CGCCGAATTGTGCAAGGCGCGCGCGCATCAGCTCGTGCGTATCCCCGATAATGTGAGCTTCGAACAGGCCGCGGCGCTGC
CGGTCGCCTACGGCACCGCGCACCGCATGATGACCACCAACGGGCAGGTCAAGGCGGGCGAGAAGGTGCTGATCCTCGGC
GCCTCCGGCGGCGTCGGCGTGTGCTGCGTGCAGCTCGCCAAGATCGCCGGCGCTTACGTGATCGCCTGCGCCGGCTCCGC
CGAGAAAGGCGAGCGCCTGAAGCAGCTCGGCGCCGACGAGGTCATCCTCTACACGCAGGAAGACTTCATGCAGGTGGTGC
GGCAACGCCATGGCCGGCCGGCGCGGGTCGGCGGCACAGGCTCGGAGAACGGCGGCGTCGACGTCGTGGTGAATTTCACG
GGCGGCGACACCTGGGTGAAGTCGCTGCGCACGCTCAAGCTCGGCGGTCGCATCCTGACCTGCGGCGCCACCGCGGGCTA
CGATCCGGCCGAGGATCTGCGCGTGATCTGGACGTTCGAGTTGCAGGTCCGCGGCTCCAACGGCTGGGAGCGCGACGACA
TCGAGAAGCTGTTCGGGCTGCTGTCGTCGGGACGGCTCACCGCCAAGGTCGACAAGGCGTTTCCGCTGCAGCAGGCCGCG
GATGCACTGGCGATGCTGGAAGACCGCACCGTGTTCGGAAAAGTCGTGGTGACGCCATGA

Upstream 100 bases:

>100_bases
TTACGACTCGACGCTGCTGCACGCCGATGCGGCGGTCGACTTCGCACTCGGCAGCGGCCCGCTCGGCCGCGCCGACGCAG
CCTAAGGAGAACAAGAAAAC

Downstream 100 bases:

>100_bases
GCGAGCCGCTGGCGCCCGCGCAGATCGAGGCGATGCTGCAGGCCTCGCCGTTCATTTCGTTTCTCGGCCTGACGGTGAGT
TCGCTCGACGCCGCCAATCA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRAMVLREHGGLDKLTFDPNFPDPDIGPGDVLLRVRATSLNYHDIFTRRGMPGIKIPLPVIMGLDVAGEIVVVGDGVEGW
KAGDRVLVDPLNRVEGGLMGETMNGGLAELCKARAHQLVRIPDNVSFEQAAALPVAYGTAHRMMTTNGQVKAGEKVLILG
ASGGVGVCCVQLAKIAGAYVIACAGSAEKGERLKQLGADEVILYTQEDFMQVVRQRHGRPARVGGTGSENGGVDVVVNFT
GGDTWVKSLRTLKLGGRILTCGATAGYDPAEDLRVIWTFELQVRGSNGWERDDIEKLFGLLSSGRLTAKVDKAFPLQQAA
DALAMLEDRTVFGKVVVTP

Sequences:

>Translated_339_residues
MRAMVLREHGGLDKLTFDPNFPDPDIGPGDVLLRVRATSLNYHDIFTRRGMPGIKIPLPVIMGLDVAGEIVVVGDGVEGW
KAGDRVLVDPLNRVEGGLMGETMNGGLAELCKARAHQLVRIPDNVSFEQAAALPVAYGTAHRMMTTNGQVKAGEKVLILG
ASGGVGVCCVQLAKIAGAYVIACAGSAEKGERLKQLGADEVILYTQEDFMQVVRQRHGRPARVGGTGSENGGVDVVVNFT
GGDTWVKSLRTLKLGGRILTCGATAGYDPAEDLRVIWTFELQVRGSNGWERDDIEKLFGLLSSGRLTAKVDKAFPLQQAA
DALAMLEDRTVFGKVVVTP
>Mature_339_residues
MRAMVLREHGGLDKLTFDPNFPDPDIGPGDVLLRVRATSLNYHDIFTRRGMPGIKIPLPVIMGLDVAGEIVVVGDGVEGW
KAGDRVLVDPLNRVEGGLMGETMNGGLAELCKARAHQLVRIPDNVSFEQAAALPVAYGTAHRMMTTNGQVKAGEKVLILG
ASGGVGVCCVQLAKIAGAYVIACAGSAEKGERLKQLGADEVILYTQEDFMQVVRQRHGRPARVGGTGSENGGVDVVVNFT
GGDTWVKSLRTLKLGGRILTCGATAGYDPAEDLRVIWTFELQVRGSNGWERDDIEKLFGLLSSGRLTAKVDKAFPLQQAA
DALAMLEDRTVFGKVVVTP

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI18379349, Length=364, Percent_Identity=30.2197802197802, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI194239674, Length=330, Percent_Identity=28.7878787878788, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI13236495, Length=330, Percent_Identity=28.7878787878788, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI22538446, Length=355, Percent_Identity=28.169014084507, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI22538444, Length=355, Percent_Identity=28.169014084507, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI194239676, Length=214, Percent_Identity=34.1121495327103, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI24308257, Length=367, Percent_Identity=28.6103542234332, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI47519420, Length=372, Percent_Identity=26.6129032258064, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI67078404, Length=352, Percent_Identity=26.4204545454545, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI67078406, Length=316, Percent_Identity=26.5822784810127, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI156627571, Length=337, Percent_Identity=25.8160237388724, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI28557745, Length=256, Percent_Identity=29.296875, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI41872631, Length=245, Percent_Identity=28.9795918367347, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790485, Length=356, Percent_Identity=27.247191011236, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788075, Length=354, Percent_Identity=25.7062146892655, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789651, Length=272, Percent_Identity=29.0441176470588, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790045, Length=332, Percent_Identity=26.5060240963855, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507255, Length=221, Percent_Identity=33.4841628959276, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17536829, Length=236, Percent_Identity=29.6610169491525, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319520, Length=351, Percent_Identity=27.9202279202279, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323961, Length=354, Percent_Identity=24.2937853107345, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=358, Percent_Identity=25.4189944134078, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=353, Percent_Identity=23.5127478753541, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=352, Percent_Identity=23.5795454545455, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221330659, Length=162, Percent_Identity=32.7160493827161, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920632, Length=162, Percent_Identity=32.7160493827161, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581345, Length=170, Percent_Identity=30.5882352941176, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550423, Length=313, Percent_Identity=25.8785942492013, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 36205; Mature: 36205

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMVLREHGGLDKLTFDPNFPDPDIGPGDVLLRVRATSLNYHDIFTRRGMPGIKIPLPV
CCEEEEECCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCHHH
IMGLDVAGEIVVVGDGVEGWKAGDRVLVDPLNRVEGGLMGETMNGGLAELCKARAHQLVR
EECCCCCCEEEEEECCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHEEEE
IPDNVSFEQAAALPVAYGTAHRMMTTNGQVKAGEKVLILGASGGVGVCCVQLAKIAGAYV
CCCCCCHHHHHCCEEEECCCEEEEECCCCEECCCEEEEEECCCCHHHHHHHHHHHCCEEE
IACAGSAEKGERLKQLGADEVILYTQEDFMQVVRQRHGRPARVGGTGSENGGVDVVVNFT
EEECCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEEC
GGDTWVKSLRTLKLGGRILTCGATAGYDPAEDLRVIWTFELQVRGSNGWERDDIEKLFGL
CCHHHHHHHHHHEECCEEEEECCCCCCCCHHCEEEEEEEEEEEECCCCCCHHHHHHHHHH
LSSGRLTAKVDKAFPLQQAADALAMLEDRTVFGKVVVTP
HHCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEEECC
>Mature Secondary Structure
MRAMVLREHGGLDKLTFDPNFPDPDIGPGDVLLRVRATSLNYHDIFTRRGMPGIKIPLPV
CCEEEEECCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCHHH
IMGLDVAGEIVVVGDGVEGWKAGDRVLVDPLNRVEGGLMGETMNGGLAELCKARAHQLVR
EECCCCCCEEEEEECCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHEEEE
IPDNVSFEQAAALPVAYGTAHRMMTTNGQVKAGEKVLILGASGGVGVCCVQLAKIAGAYV
CCCCCCHHHHHCCEEEECCCEEEEECCCCEECCCEEEEEECCCCHHHHHHHHHHHCCEEE
IACAGSAEKGERLKQLGADEVILYTQEDFMQVVRQRHGRPARVGGTGSENGGVDVVVNFT
EEECCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEEC
GGDTWVKSLRTLKLGGRILTCGATAGYDPAEDLRVIWTFELQVRGSNGWERDDIEKLFGL
CCHHHHHHHHHHEECCEEEEECCCCCCCCHHCEEEEEEEEEEEECCCCCCHHHHHHHHHH
LSSGRLTAKVDKAFPLQQAADALAMLEDRTVFGKVVVTP
HHCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]