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The map label for this gene is hbdA [H]

Identifier: 86747947

GI number: 86747947

Start: 936813

End: 937694

Strand: Direct

Name: hbdA [H]

Synonym: RPB_0821

Alternate gene names: 86747947

Gene position: 936813-937694 (Clockwise)

Preceding gene: 86747946

Following gene: 86747949

Centisome position: 17.57

GC content: 63.38

Gene sequence:

>882_bases
ATGGCGGCAGCAATCAAGAAGGTCGGCGTAATCGGCTCGGGTCAGATGGGCAACGGCATCGCGCATGTCGCCGCTCTCGG
CGGCTTTGCGGTGGTGCTGAACGACGTCTCGGCCGAGCGGCTGAAATCGGCGATGGCCACCATCAACGGCAATCTGTCGC
GCCAGCTCGCCAAGAAGATCATCACCGAGGACGCCCGCAAATCGGCGCTCGCCAACATCACCGCCACCGAAAAGCTCGAC
GGCCTGTCCGATTGCGATCTGGTGATCGAGACCGCGGTCGAAAAGGAAGAGGTCAAGCGCAAGATCTTCCACGATCTGTG
CGCGACGCTGAAGCCGGAGGCGATCGTCGCCTCCAACACCTCGTCGATCTCGATCACTCGGCTCGCCGCCTCGACCGACC
GGCCGGAGCGCTTCATCGGCATTCATTTCATGAATCCGGTGCCGCTGATGGAGCTGGTCGAGCTGATCCGCGGCATCGCC
ACCGACGACGCCACCTTCGACGCCGCGAAAGCCTTCGTCACCCAGCTCGGCAAACAGATCGCGGTGTCGGAAGATTTCCC
GGCCTTCATCGTCAACCGCATCCTGCTGCCGATGATCAACGAGGCGATCTACACGCTGTATGAAGGCGTCGGCAATGTCG
AGGCGATCGACATGGCGATGAAGCTCGGCGCGCACCACCCGATGGGCCCGCTGGAGCTGGCGGATTTCATCGGCCTCGAC
ACCTGCCTGTCGATCATGCAGGTGCTGCACGAGGGCCTGGCGGACTCGAAGTATCGGCCGTGCCCGCTGCTGGTGAAATA
CGTCGAGGCCGGCTGGCTCGGCCGCAAGACCCAGCGTGGCTTCTACGATTATCGCGGCGACAAGCCGGTCCCGACGCGCT
GA

Upstream 100 bases:

>100_bases
GTGATACGATCGCCGCGCCGGTGCAACGGATGGCGGCGTAAAATATCCGATACTGACCGGCCGGCGGATCGCGCGGCCGG
ACTCCCAACGAGATGGCGAG

Downstream 100 bases:

>100_bases
GCGCCTTACGCGATTCCCGGCACGGTTCTGATCTGCTCCACCAGGAAGTCGATCAGTAGCCGGACACGTGCGATGCCGGC
GCGCTCCGGCACGATCAGCA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MAAAIKKVGVIGSGQMGNGIAHVAALGGFAVVLNDVSAERLKSAMATINGNLSRQLAKKIITEDARKSALANITATEKLD
GLSDCDLVIETAVEKEEVKRKIFHDLCATLKPEAIVASNTSSISITRLAASTDRPERFIGIHFMNPVPLMELVELIRGIA
TDDATFDAAKAFVTQLGKQIAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDMAMKLGAHHPMGPLELADFIGLD
TCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGDKPVPTR

Sequences:

>Translated_293_residues
MAAAIKKVGVIGSGQMGNGIAHVAALGGFAVVLNDVSAERLKSAMATINGNLSRQLAKKIITEDARKSALANITATEKLD
GLSDCDLVIETAVEKEEVKRKIFHDLCATLKPEAIVASNTSSISITRLAASTDRPERFIGIHFMNPVPLMELVELIRGIA
TDDATFDAAKAFVTQLGKQIAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDMAMKLGAHHPMGPLELADFIGLD
TCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGDKPVPTR
>Mature_292_residues
AAAIKKVGVIGSGQMGNGIAHVAALGGFAVVLNDVSAERLKSAMATINGNLSRQLAKKIITEDARKSALANITATEKLDG
LSDCDLVIETAVEKEEVKRKIFHDLCATLKPEAIVASNTSSISITRLAASTDRPERFIGIHFMNPVPLMELVELIRGIAT
DDATFDAAKAFVTQLGKQIAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDMAMKLGAHHPMGPLELADFIGLDT
CLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGDKPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=42.560553633218, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=41.042345276873, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=32.6241134751773, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI261878539, Length=299, Percent_Identity=30.4347826086957, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI68989263, Length=299, Percent_Identity=30.4347826086957, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI115430219, Length=239, Percent_Identity=27.6150627615063, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787661, Length=289, Percent_Identity=38.4083044982699, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1790281, Length=269, Percent_Identity=31.9702602230483, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1788682, Length=262, Percent_Identity=34.3511450381679, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=38.9655172413793, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=40.9722222222222, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=36.1111111111111, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=291, Percent_Identity=31.9587628865979, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17508951, Length=291, Percent_Identity=31.9587628865979, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17508953, Length=291, Percent_Identity=31.9587628865979, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17558304, Length=294, Percent_Identity=32.9931972789116, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=29.9295774647887, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71985930, Length=283, Percent_Identity=26.8551236749117, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=33.2191780821918, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=33.2191780821918, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=33.2191780821918, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=27.0833333333333, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI20129993, Length=237, Percent_Identity=24.4725738396624, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31711; Mature: 31580

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAIKKVGVIGSGQMGNGIAHVAALGGFAVVLNDVSAERLKSAMATINGNLSRQLAKKI
CCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ITEDARKSALANITATEKLDGLSDCDLVIETAVEKEEVKRKIFHDLCATLKPEAIVASNT
HHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SSISITRLAASTDRPERFIGIHFMNPVPLMELVELIRGIATDDATFDAAKAFVTQLGKQI
CCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDMAMKLGAHHPMGPLELADFIGLD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGDKPVPTR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAAIKKVGVIGSGQMGNGIAHVAALGGFAVVLNDVSAERLKSAMATINGNLSRQLAKKI
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ITEDARKSALANITATEKLDGLSDCDLVIETAVEKEEVKRKIFHDLCATLKPEAIVASNT
HHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SSISITRLAASTDRPERFIGIHFMNPVPLMELVELIRGIATDDATFDAAKAFVTQLGKQI
CCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDMAMKLGAHHPMGPLELADFIGLD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGDKPVPTR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]