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The map label for this gene is phoR [H]

Identifier: 86747901

GI number: 86747901

Start: 868280

End: 869629

Strand: Direct

Name: phoR [H]

Synonym: RPB_0775

Alternate gene names: 86747901

Gene position: 868280-869629 (Clockwise)

Preceding gene: 86747900

Following gene: 86747902

Centisome position: 16.29

GC content: 69.63

Gene sequence:

>1350_bases
ATGATCGCGCCGGCATCCGACGAACAAGCCCGCCATGGCGGACCGCCGGTCCCGGCCGCGGACAAGACCACCGTGGCCGC
GGCGACGCCCTGGGCGGACCGGCTGCGTCACGCCGCGATCATCCTGCTGGCGGCGGCGATCGCGCTGGTGACGCTGGCCG
TGCTCGGCGAAGTCACCGTCCTCGCCGCGGGGGCGGTGTTCGTCTGCGTCGCAGCGGCGGCGCTGGTGCCGTGGCGGCTG
CACGATGCGGCCAACAAGCGCGACGACGTCCCGGGCACCAGCCCGGTCGAGACGCCGGTGGTTCGCGCCATCGTCGCCGG
CATGCCCGACCCTGCGGCGCTGCTCGACCGCGCCGGCCGGGTGCTGCATCTCAACGCCGCCGCGGCGCAGCTCGCGCCGG
CCTTGCGGGTCCGCGAGCTGGCGCAATTCGCGCTGCGCAATCCGGAGATCGTCAATGCGCTGCGCGAGGCGATCGCCACC
GCCGAGCCGCGCCGCGTCAGCTATCTCGATCACGCGCCGATCGAGCGCTGGATGGAGCTGATCATCGCGCCGGTGCAGGT
GCCGACCACGTTCGGCGGCACCGACCAGTGCATGCTGATGACGTTTCACGATCTGACGCCGCTACGCCGGGTCGAGGAGA
TGCGCGCCGATTTCGTCGCCAATGCCAGCCACGAATTGCGCACGCCGCTGGCGGCGCTGTCCGGCTTCATCGAAACCCTG
CAGGGGCCCGCGCGCGACGACGCCAAGGCGCGCGAGCGCTTTCTCGGCATCATGCAGGCGCAGGCGACGCGGATGGCGCG
GCTGATCGACGATCTGCTGTCGCTGTCGCGGGTCGAACTCAGCGCCCATGTCCGGCCGGACGTGCAGATCGACCTCGCGC
CGCTGATCCGGCAGGTCGCCGACGGGCTCGAGCCGCTGGCGAAGGAGCGCCAGGTCGCGATCGAGATCGACATGCCCGAG
ACGCCGGCGGTGATCGCGGGCGACCGCGAGGAATTGCTGCGGGTGTTCGAGAACCTGATCGAGAACGCATTGAAATACGG
CGCCTCCGGCGGCCGCGTCGCGGTGTCGGTGGCGGCGCTGGCGTCCGGCGAGGGCGGCACCGAATATCGCGTCGCGGTGC
GCGACTTCGGCCCCGGCATCGCGCCCGAACATCTGCCGCGGCTGACCGAGCGATTTTACCGCGTCGACGTCGGCGACAGC
CGTTCACAAGGCGGTACTGGATTAGGATTATCGCTGGTGAAACATATTGTTAACCGCCACCGCGGCCGGCTTTTGATCGA
AAGCGTACCGAAAAAGGGCGCCACTTTCACCGTCTGTTTTCCTCCGGTAAAGCCCGAGGTTCGCGCTTAA

Upstream 100 bases:

>100_bases
TCCGCGAGATCGTCATCGGCACGCGCCTCAAACGGATGGATCGGCTCGCCGCCGCGCTCGATCCGAAGCCGATCCGACAG
GATCCCACCCCAGGCTGACC

Downstream 100 bases:

>100_bases
AATTTAAATGAATTCAGTGGGTTGCGATAGTCACAGGAGTGTCATCGAACTCTCATAAAAGGTCAATCGACCGCTCGTAA
AGCGAGCGGGGTAAGCGCAG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MIAPASDEQARHGGPPVPAADKTTVAAATPWADRLRHAAIILLAAAIALVTLAVLGEVTVLAAGAVFVCVAAAALVPWRL
HDAANKRDDVPGTSPVETPVVRAIVAGMPDPAALLDRAGRVLHLNAAAAQLAPALRVRELAQFALRNPEIVNALREAIAT
AEPRRVSYLDHAPIERWMELIIAPVQVPTTFGGTDQCMLMTFHDLTPLRRVEEMRADFVANASHELRTPLAALSGFIETL
QGPARDDAKARERFLGIMQAQATRMARLIDDLLSLSRVELSAHVRPDVQIDLAPLIRQVADGLEPLAKERQVAIEIDMPE
TPAVIAGDREELLRVFENLIENALKYGASGGRVAVSVAALASGEGGTEYRVAVRDFGPGIAPEHLPRLTERFYRVDVGDS
RSQGGTGLGLSLVKHIVNRHRGRLLIESVPKKGATFTVCFPPVKPEVRA

Sequences:

>Translated_449_residues
MIAPASDEQARHGGPPVPAADKTTVAAATPWADRLRHAAIILLAAAIALVTLAVLGEVTVLAAGAVFVCVAAAALVPWRL
HDAANKRDDVPGTSPVETPVVRAIVAGMPDPAALLDRAGRVLHLNAAAAQLAPALRVRELAQFALRNPEIVNALREAIAT
AEPRRVSYLDHAPIERWMELIIAPVQVPTTFGGTDQCMLMTFHDLTPLRRVEEMRADFVANASHELRTPLAALSGFIETL
QGPARDDAKARERFLGIMQAQATRMARLIDDLLSLSRVELSAHVRPDVQIDLAPLIRQVADGLEPLAKERQVAIEIDMPE
TPAVIAGDREELLRVFENLIENALKYGASGGRVAVSVAALASGEGGTEYRVAVRDFGPGIAPEHLPRLTERFYRVDVGDS
RSQGGTGLGLSLVKHIVNRHRGRLLIESVPKKGATFTVCFPPVKPEVRA
>Mature_449_residues
MIAPASDEQARHGGPPVPAADKTTVAAATPWADRLRHAAIILLAAAIALVTLAVLGEVTVLAAGAVFVCVAAAALVPWRL
HDAANKRDDVPGTSPVETPVVRAIVAGMPDPAALLDRAGRVLHLNAAAAQLAPALRVRELAQFALRNPEIVNALREAIAT
AEPRRVSYLDHAPIERWMELIIAPVQVPTTFGGTDQCMLMTFHDLTPLRRVEEMRADFVANASHELRTPLAALSGFIETL
QGPARDDAKARERFLGIMQAQATRMARLIDDLLSLSRVELSAHVRPDVQIDLAPLIRQVADGLEPLAKERQVAIEIDMPE
TPAVIAGDREELLRVFENLIENALKYGASGGRVAVSVAALASGEGGTEYRVAVRDFGPGIAPEHLPRLTERFYRVDVGDS
RSQGGTGLGLSLVKHIVNRHRGRLLIESVPKKGATFTVCFPPVKPEVRA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=353, Percent_Identity=33.4277620396601, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=34.3220338983051, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=31.9838056680162, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788713, Length=438, Percent_Identity=22.1461187214612, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=28.8793103448276, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=28.3898305084746, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=245, Percent_Identity=29.3877551020408, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789403, Length=203, Percent_Identity=32.0197044334975, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788549, Length=355, Percent_Identity=21.9718309859155, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.004329004329, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=29.045643153527, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI48994928, Length=250, Percent_Identity=27.6, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=244, Percent_Identity=26.6393442622951, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=29.6137339055794, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=229, Percent_Identity=27.0742358078603, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790551, Length=222, Percent_Identity=30.6306306306306, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87081816, Length=243, Percent_Identity=27.9835390946502, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=27.9816513761468, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=240, Percent_Identity=28.75, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48216; Mature: 48216

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAPASDEQARHGGPPVPAADKTTVAAATPWADRLRHAAIILLAAAIALVTLAVLGEVTV
CCCCCCCCCHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAGAVFVCVAAAALVPWRLHDAANKRDDVPGTSPVETPVVRAIVAGMPDPAALLDRAGR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCC
VLHLNAAAAQLAPALRVRELAQFALRNPEIVNALREAIATAEPRRVSYLDHAPIERWMEL
EEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
IIAPVQVPTTFGGTDQCMLMTFHDLTPLRRVEEMRADFVANASHELRTPLAALSGFIETL
HHCCCCCCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QGPARDDAKARERFLGIMQAQATRMARLIDDLLSLSRVELSAHVRPDVQIDLAPLIRQVA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHH
DGLEPLAKERQVAIEIDMPETPAVIAGDREELLRVFENLIENALKYGASGGRVAVSVAAL
HHHHHHHHCCEEEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEH
ASGEGGTEYRVAVRDFGPGIAPEHLPRLTERFYRVDVGDSRSQGGTGLGLSLVKHIVNRH
HCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
RGRLLIESVPKKGATFTVCFPPVKPEVRA
CCCEEEHHCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MIAPASDEQARHGGPPVPAADKTTVAAATPWADRLRHAAIILLAAAIALVTLAVLGEVTV
CCCCCCCCCHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAGAVFVCVAAAALVPWRLHDAANKRDDVPGTSPVETPVVRAIVAGMPDPAALLDRAGR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCC
VLHLNAAAAQLAPALRVRELAQFALRNPEIVNALREAIATAEPRRVSYLDHAPIERWMEL
EEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
IIAPVQVPTTFGGTDQCMLMTFHDLTPLRRVEEMRADFVANASHELRTPLAALSGFIETL
HHCCCCCCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QGPARDDAKARERFLGIMQAQATRMARLIDDLLSLSRVELSAHVRPDVQIDLAPLIRQVA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHH
DGLEPLAKERQVAIEIDMPETPAVIAGDREELLRVFENLIENALKYGASGGRVAVSVAAL
HHHHHHHHCCEEEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEH
ASGEGGTEYRVAVRDFGPGIAPEHLPRLTERFYRVDVGDSRSQGGTGLGLSLVKHIVNRH
HCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
RGRLLIESVPKKGATFTVCFPPVKPEVRA
CCCEEEHHCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]