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The map label for this gene is tesB [H]

Identifier: 86747496

GI number: 86747496

Start: 411182

End: 412057

Strand: Direct

Name: tesB [H]

Synonym: RPB_0370

Alternate gene names: 86747496

Gene position: 411182-412057 (Clockwise)

Preceding gene: 86747489

Following gene: 86747497

Centisome position: 7.71

GC content: 66.21

Gene sequence:

>876_bases
GTGTCCAAAAGCCTGATCGACCTGATCTCGATCCTCGATCTCGAACCGCTCGAGGTGAACCTGTTCCGCGGCACCAGCCC
GCAGACCAGCTGGCAGCGGGTGTTCGGCGGCCAGGTGATCGGCCAGGCGATGGTCGCCGGCTGCCGCACCGTCGAAAACC
GGCTGCCGCATTCGCTGCACTGCTATTTCATCCTGCCGGGCGATCCGGCGGTGCCGATCATCTACGAGGTCGAGCGGCTG
CGCGACGGCAAGAGCTACACCACCCGCCGCGTCACCGCGATCCAGCACGGCCAGGCGATCTTCTCGCTGATGATGTCGTT
CCACGACGACGAGGAGACCGAGTTCGACCATCAGGACAAGATGCCCGACGTGCCGCCGCCGGAGGCGCTGTCGGCCGAAG
AGATCGTCAAGCAGCCGTTCTTCAAGGAGATGCCGGACTTCATCAAGCGCTACTACGAGAGCGACCGGCCGATCGAGTTG
CGCCCGGTCGAGCTGTCGCGCTATTTCGGCCAGAAGATCGAAGACGGCCGCATCCACGTCTGGATTCGCACCGCCGCCAA
GCTGCCGGACGACCCGGCGCTGCATATGTGCGCGCTGGCCTATGCGTCGGACTTCTCGCTACTCGACGCGGTGATGGCAC
GCTACGGCCGCACGCTGTTCGACAAGCGGATGATGCCGGCCAGCCTCGACCACGCGATGTGGTTCCACCGCCCGTTTCGC
GCCGACGAATGGCTGCTTTACGTTCAGGACTCCCCGTCCGCCCAGAGCGGCCGCGGCCTGACCCGCGGCATGATCTACAA
GGCCGACGGCACCCTGGTGGCCTCGGTCGCCCAGGAGGGCTCGGTGCGGCAGCGACGAGACCTGCCGCGGACGTAG

Upstream 100 bases:

>100_bases
GCTGGGAAATCACGCGCCACTGGCCGACTATTTCGACGCGTTGCCTTCACGCGAACCGGTGCCCACTTCGCTTGAAAACG
CCTTAAAGGAGCGCCTGTCG

Downstream 100 bases:

>100_bases
CTTCGATCGGCAGCTCCCTCGCCGACGTCAATCCGCTTATTTTCTGCGCGCATTGCCGCTAAACCCGGCATATACATGAC
GAAACGCCGCGTCGCGCGGT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSKSLIDLISILDLEPLEVNLFRGTSPQTSWQRVFGGQVIGQAMVAGCRTVENRLPHSLHCYFILPGDPAVPIIYEVERL
RDGKSYTTRRVTAIQHGQAIFSLMMSFHDDEETEFDHQDKMPDVPPPEALSAEEIVKQPFFKEMPDFIKRYYESDRPIEL
RPVELSRYFGQKIEDGRIHVWIRTAAKLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFHRPFR
ADEWLLYVQDSPSAQSGRGLTRGMIYKADGTLVASVAQEGSVRQRRDLPRT

Sequences:

>Translated_291_residues
MSKSLIDLISILDLEPLEVNLFRGTSPQTSWQRVFGGQVIGQAMVAGCRTVENRLPHSLHCYFILPGDPAVPIIYEVERL
RDGKSYTTRRVTAIQHGQAIFSLMMSFHDDEETEFDHQDKMPDVPPPEALSAEEIVKQPFFKEMPDFIKRYYESDRPIEL
RPVELSRYFGQKIEDGRIHVWIRTAAKLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFHRPFR
ADEWLLYVQDSPSAQSGRGLTRGMIYKADGTLVASVAQEGSVRQRRDLPRT
>Mature_290_residues
SKSLIDLISILDLEPLEVNLFRGTSPQTSWQRVFGGQVIGQAMVAGCRTVENRLPHSLHCYFILPGDPAVPIIYEVERLR
DGKSYTTRRVTAIQHGQAIFSLMMSFHDDEETEFDHQDKMPDVPPPEALSAEEIVKQPFFKEMPDFIKRYYESDRPIELR
PVELSRYFGQKIEDGRIHVWIRTAAKLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFHRPFRA
DEWLLYVQDSPSAQSGRGLTRGMIYKADGTLVASVAQEGSVRQRRDLPRT

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=285, Percent_Identity=39.2982456140351, Blast_Score=211, Evalue=7e-55,
Organism=Escherichia coli, GI1786657, Length=287, Percent_Identity=44.5993031358885, Blast_Score=241, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI71988741, Length=305, Percent_Identity=37.3770491803279, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17558508, Length=319, Percent_Identity=36.0501567398119, Blast_Score=180, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17531889, Length=276, Percent_Identity=36.5942028985507, Blast_Score=166, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI115532456, Length=277, Percent_Identity=36.4620938628159, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17531885, Length=276, Percent_Identity=36.5942028985507, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71982224, Length=297, Percent_Identity=32.3232323232323, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI212645202, Length=266, Percent_Identity=32.7067669172932, Blast_Score=121, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322480, Length=333, Percent_Identity=26.4264264264264, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33322; Mature: 33190

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSLIDLISILDLEPLEVNLFRGTSPQTSWQRVFGGQVIGQAMVAGCRTVENRLPHSLH
CCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
CYFILPGDPAVPIIYEVERLRDGKSYTTRRVTAIQHGQAIFSLMMSFHDDEETEFDHQDK
EEEEECCCCCCCHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MPDVPPPEALSAEEIVKQPFFKEMPDFIKRYYESDRPIELRPVELSRYFGQKIEDGRIHV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCCCEEEE
WIRTAAKLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFHRPFR
EEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
ADEWLLYVQDSPSAQSGRGLTRGMIYKADGTLVASVAQEGSVRQRRDLPRT
CCCEEEEEECCCCCCCCCCCCCCEEEECCCCEEEEHHHCCCHHHHHCCCCC
>Mature Secondary Structure 
SKSLIDLISILDLEPLEVNLFRGTSPQTSWQRVFGGQVIGQAMVAGCRTVENRLPHSLH
CHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
CYFILPGDPAVPIIYEVERLRDGKSYTTRRVTAIQHGQAIFSLMMSFHDDEETEFDHQDK
EEEEECCCCCCCHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MPDVPPPEALSAEEIVKQPFFKEMPDFIKRYYESDRPIELRPVELSRYFGQKIEDGRIHV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCCCEEEE
WIRTAAKLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFHRPFR
EEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
ADEWLLYVQDSPSAQSGRGLTRGMIYKADGTLVASVAQEGSVRQRRDLPRT
CCCEEEEEECCCCCCCCCCCCCCEEEECCCCEEEEHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]