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The map label for this gene is cycW [H]

Identifier: 86747419

GI number: 86747419

Start: 332608

End: 333276

Strand: Direct

Name: cycW [H]

Synonym: RPB_0293

Alternate gene names: 86747419

Gene position: 332608-333276 (Clockwise)

Preceding gene: 86747418

Following gene: 86747424

Centisome position: 6.24

GC content: 72.2

Gene sequence:

>669_bases
ATGACCGCCCTCGGCGCCATTATCCGCCGCGACGTCGCGATCGCGCTGCGGGTCGGCGGCGGGGCGCTGATCGGGGTGCT
GTTCTTCCTCACCGTGGTGGTGCTGATGCCGTTCGCGGTCGGCCCCGACCTCAAGCTGCTGCAGCGGCTCGGCCCGGCGA
TCCTGTGGCTCGGCGCGCTGCTGGCGAGCCTGCTGACGCTCGACCGACTGTTCACCGCCGATGCCGAGGACGGCTCGCTC
GATCTGATCGTGATGAGCCGCACGCCGCTGGAACTGACCTGCGCCGCCAAGGCCTTCGCGCATTGGCTCGCCGCCGGCCT
GCCGCTGATCGTCGCGACCCCGGTGCTCGGGCTGTTGCTCAATCTCGACGGCACCGCCTCGCTCGCGGTGATGGCGACGC
TGCTCGCCGGTACGCCGGCGCTGACCTTCACCGGCATGATCGGCGCGGCGCTGGCGGTGGCGCTGCGCCGCGGCGGGCTG
CTGATGGCGGTGCTGGTGCTGCCGCTGTCGATCCCGGTGCTGATCTTCGGCGTCGCCGCCTCGCAGGCGGCGATCACAGG
GCCGGTGCCGTTCGGCACCCCGTTCTCGATCCTGTGCGCGCTGTCGCTGGCGAGCCTGGTGATCGGACCACTCGCCGCCG
CGGCGAGCCTGCGCCACGGGCTGGATTGA

Upstream 100 bases:

>100_bases
CTCGCTGCGCGAGCGACCCTCCCCCTCCAGGGGAGGGTATTCCTCGTGGCAGCCGCAAACCCTCAGATGCGATCGCCGCG
CGCAGCGCAGGAGGCCCGCG

Downstream 100 bases:

>100_bases
GCAGTTCCATCTCGGCCTTGATTGAATTTCGCCGCTCTTGATAGAATCAGGCCGCCAAGTAACCCGATCAATCAGGAACG
AACTCGACATGCTTGCAAGA

Product: heme exporter protein CcmB

Products: NA

Alternate protein names: Cytochrome c-type biogenesis protein CycW [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTALGAIIRRDVAIALRVGGGALIGVLFFLTVVVLMPFAVGPDLKLLQRLGPAILWLGALLASLLTLDRLFTADAEDGSL
DLIVMSRTPLELTCAAKAFAHWLAAGLPLIVATPVLGLLLNLDGTASLAVMATLLAGTPALTFTGMIGAALAVALRRGGL
LMAVLVLPLSIPVLIFGVAASQAAITGPVPFGTPFSILCALSLASLVIGPLAAAASLRHGLD

Sequences:

>Translated_222_residues
MTALGAIIRRDVAIALRVGGGALIGVLFFLTVVVLMPFAVGPDLKLLQRLGPAILWLGALLASLLTLDRLFTADAEDGSL
DLIVMSRTPLELTCAAKAFAHWLAAGLPLIVATPVLGLLLNLDGTASLAVMATLLAGTPALTFTGMIGAALAVALRRGGL
LMAVLVLPLSIPVLIFGVAASQAAITGPVPFGTPFSILCALSLASLVIGPLAAAASLRHGLD
>Mature_221_residues
TALGAIIRRDVAIALRVGGGALIGVLFFLTVVVLMPFAVGPDLKLLQRLGPAILWLGALLASLLTLDRLFTADAEDGSLD
LIVMSRTPLELTCAAKAFAHWLAAGLPLIVATPVLGLLLNLDGTASLAVMATLLAGTPALTFTGMIGAALAVALRRGGLL
MAVLVLPLSIPVLIFGVAASQAAITGPVPFGTPFSILCALSLASLVIGPLAAAASLRHGLD

Specific function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes [H]

COG id: COG2386

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmB/CycW/HelB family [H]

Homologues:

Organism=Escherichia coli, GI1788528, Length=212, Percent_Identity=42.9245283018868, Blast_Score=121, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003544 [H]

Pfam domain/function: PF03379 CcmB [H]

EC number: NA

Molecular weight: Translated: 22500; Mature: 22368

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALGAIIRRDVAIALRVGGGALIGVLFFLTVVVLMPFAVGPDLKLLQRLGPAILWLGAL
CCHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LASLLTLDRLFTADAEDGSLDLIVMSRTPLELTCAAKAFAHWLAAGLPLIVATPVLGLLL
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
NLDGTASLAVMATLLAGTPALTFTGMIGAALAVALRRGGLLMAVLVLPLSIPVLIFGVAA
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SQAAITGPVPFGTPFSILCALSLASLVIGPLAAAASLRHGLD
CCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TALGAIIRRDVAIALRVGGGALIGVLFFLTVVVLMPFAVGPDLKLLQRLGPAILWLGAL
CHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LASLLTLDRLFTADAEDGSLDLIVMSRTPLELTCAAKAFAHWLAAGLPLIVATPVLGLLL
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
NLDGTASLAVMATLLAGTPALTFTGMIGAALAVALRRGGLLMAVLVLPLSIPVLIFGVAA
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SQAAITGPVPFGTPFSILCALSLASLVIGPLAAAASLRHGLD
CCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1850420; 12597275 [H]