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The map label for this gene is panE [C]

Identifier: 86747344

GI number: 86747344

Start: 246331

End: 247233

Strand: Direct

Name: panE [C]

Synonym: RPB_0218

Alternate gene names: 86747344

Gene position: 246331-247233 (Clockwise)

Preceding gene: 86747341

Following gene: 86747352

Centisome position: 4.62

GC content: 70.21

Gene sequence:

>903_bases
ATGAAGGTTGCGGTGATGGGCGCCGGCGCGGTCGGCTGCTATTTCGGCGCGCTGCTGGCGCAGGCGGGCCACGACGTCAC
GCTGATCGGCCGCCCCGACCACGTCGCCGCCATCGACGCCCACGGGCTGCGGCTCGAAACCCGCGACGGCGAGAGCTTCA
TTGCGCTGAAGGCTGCGACCGACCCGGCCGCGCTCGATCCGCCGGATCTGGTGCTGTTCTGCGTCAAGTCGGCCGATACC
GAGACCGCGGGTCGCGCGCTGGCGCCGCGGCTGCGGCCGGACACCGCGATCCTCAGCCTGCAGAACGGCGTCGACAACGC
GCAGCGATTGTCGGCGGCGATCGGTCATCCGGTGATCGCGGCCGTCGTCTATGTCGGCACCGAGATGGCCGGCCCCGGCC
ATGTCCGGCATCACGGCCGCGGCGAATTGCTGATCGGCGCCTCGGCACAGAGCGGCGTTCTCGCCGCTGCGCTGTCGGAG
GCGAAGATCCCGACCACGGTGGCCGCCGATATCGATCAGGCGCTGTGGTCGAAGCTGATGATGAACAGCGCCTTCAACGC
GCTGTCGGCGGTCGCCGACATGGCCTATGGCCGGATGTTCGAGGTCGCGGGCGCGCGCGATGTGGTGACCAGCGTGATCG
CCGAATGCGCCGCGGTGGCGCGCGCCGGCGGCGTGTCGATTCCGGACGACATGCTGGAGAAGGCGCTGGCGCTGCCGGCG
TCGATGCCGAACCAGAAATCATCGACCGCGCAGGATCTCGCCCGCGGCAAGCCGAGCGAGATCGACTTCCTCAACGGCTA
CGTGGTGCGCCGCGGCGCCGCGCTCGGCATCCCGACCCCGACCAACCTGACGCTGCAGGTGGCGGTGAAACTGATCGAAG
CCAGCCGCGGCATCGGCCGCTGA

Upstream 100 bases:

>100_bases
CGCAATGCGCAAATCGTCGCCTGCGCCGAGACCGCGGGCGGTTGCCGCGCCAGCCGAACCGCTGCAGAACTGGCGCAGGA
CGCTTGCAAGGGAGAACAGA

Downstream 100 bases:

>100_bases
GGCGAGCTACGCAGACGTCCGACAAATGCCGTGCTCTCAACATTCTCGGCGTCATCCTGAGGTGCCCGGTGGACCGCGCG
CATGCGCGGTGCACCGGGCC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKVAVMGAGAVGCYFGALLAQAGHDVTLIGRPDHVAAIDAHGLRLETRDGESFIALKAATDPAALDPPDLVLFCVKSADT
ETAGRALAPRLRPDTAILSLQNGVDNAQRLSAAIGHPVIAAVVYVGTEMAGPGHVRHHGRGELLIGASAQSGVLAAALSE
AKIPTTVAADIDQALWSKLMMNSAFNALSAVADMAYGRMFEVAGARDVVTSVIAECAAVARAGGVSIPDDMLEKALALPA
SMPNQKSSTAQDLARGKPSEIDFLNGYVVRRGAALGIPTPTNLTLQVAVKLIEASRGIGR

Sequences:

>Translated_300_residues
MKVAVMGAGAVGCYFGALLAQAGHDVTLIGRPDHVAAIDAHGLRLETRDGESFIALKAATDPAALDPPDLVLFCVKSADT
ETAGRALAPRLRPDTAILSLQNGVDNAQRLSAAIGHPVIAAVVYVGTEMAGPGHVRHHGRGELLIGASAQSGVLAAALSE
AKIPTTVAADIDQALWSKLMMNSAFNALSAVADMAYGRMFEVAGARDVVTSVIAECAAVARAGGVSIPDDMLEKALALPA
SMPNQKSSTAQDLARGKPSEIDFLNGYVVRRGAALGIPTPTNLTLQVAVKLIEASRGIGR
>Mature_300_residues
MKVAVMGAGAVGCYFGALLAQAGHDVTLIGRPDHVAAIDAHGLRLETRDGESFIALKAATDPAALDPPDLVLFCVKSADT
ETAGRALAPRLRPDTAILSLQNGVDNAQRLSAAIGHPVIAAVVYVGTEMAGPGHVRHHGRGELLIGASAQSGVLAAALSE
AKIPTTVAADIDQALWSKLMMNSAFNALSAVADMAYGRMFEVAGARDVVTSVIAECAAVARAGGVSIPDDMLEKALALPA
SMPNQKSSTAQDLARGKPSEIDFLNGYVVRRGAALGIPTPTNLTLQVAVKLIEASRGIGR

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=301, Percent_Identity=27.5747508305648, Blast_Score=89, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 30844; Mature: 30844

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAVMGAGAVGCYFGALLAQAGHDVTLIGRPDHVAAIDAHGLRLETRDGESFIALKAAT
CEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCEEEEECCCCEEEEEEECC
DPAALDPPDLVLFCVKSADTETAGRALAPRLRPDTAILSLQNGVDNAQRLSAAIGHPVIA
CCCCCCCCCEEEEEECCCCCCHHCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCHHHH
AVVYVGTEMAGPGHVRHHGRGELLIGASAQSGVLAAALSEAKIPTTVAADIDQALWSKLM
HHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
MNSAFNALSAVADMAYGRMFEVAGARDVVTSVIAECAAVARAGGVSIPDDMLEKALALPA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
SMPNQKSSTAQDLARGKPSEIDFLNGYVVRRGAALGIPTPTNLTLQVAVKLIEASRGIGR
CCCCCCCHHHHHHHCCCCCCEEHHCCEEEECCCEECCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKVAVMGAGAVGCYFGALLAQAGHDVTLIGRPDHVAAIDAHGLRLETRDGESFIALKAAT
CEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCEEEEECCCCEEEEEEECC
DPAALDPPDLVLFCVKSADTETAGRALAPRLRPDTAILSLQNGVDNAQRLSAAIGHPVIA
CCCCCCCCCEEEEEECCCCCCHHCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCHHHH
AVVYVGTEMAGPGHVRHHGRGELLIGASAQSGVLAAALSEAKIPTTVAADIDQALWSKLM
HHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
MNSAFNALSAVADMAYGRMFEVAGARDVVTSVIAECAAVARAGGVSIPDDMLEKALALPA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
SMPNQKSSTAQDLARGKPSEIDFLNGYVVRRGAALGIPTPTNLTLQVAVKLIEASRGIGR
CCCCCCCHHHHHHHCCCCCCEEHHCCEEEECCCEECCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]