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The map label for this gene is dnaA

Identifier: 86747128

GI number: 86747128

Start: 676

End: 2094

Strand: Direct

Name: dnaA

Synonym: RPB_0001

Alternate gene names: 86747128

Gene position: 676-2094 (Clockwise)

Preceding gene: NA

Following gene: 86747129

Centisome position: 0.01

GC content: 66.81

Gene sequence:

>1419_bases
ATGTCGAACATGGAACATGATCGCTGGTCTCGCGTAAAAGGCCGTCTGCGCTCGAGCGTCGGCGAGGACGTGTATTCGAG
CTGGTTCGCGCGCATGGACCTCGAAGCCGTTCAGCCGGAGAGCGTGCATCTGTCGGTGCCGACGCGGTTTCTGAAGAGCT
GGATCCAGACGCACTATTCCGACAAGGTGCTGACCTGCTGGCAGGCCGAACTGCCGGAAGTCTGCCGCATCGATCTCACC
GTTCGCTCGCCGATGCGCGCGGCGGTGGCCAAGGAAGCGGCGGCGCCGGTCGAGCATCGTCGCGCCGAGCACCGTCCCGC
CACCGAGACGCGCAGCCACGCCACGGTGCCGGCCTCGTCCAATCACGATGCGCTCGGCGGCTCGCCGCTCGATCCGCGGC
TGACCTTCGCGAGCTTCGTCGTCGGCCGCTCCAACACGCTGGCGCATGCCGCCGCCAAGCAGGTGGCGGAAGGCCGCCGC
GGCGATCCGGTGATGTTCAACCCGCTCTACATCCATTCCGGCGTCGGCCTCGGCAAGACGCATCTGCTGCAGGCCGTCAC
CTGGGCCGGCAATACCGGCATCGAGCGCAAGGTGCTGTATCTCACCGCCGAGAAATTCATGTACGGCTTCGTCGCCGCGC
TGAAGACGCAGACCTCGCTCGCCTTCAAGGAAGCGCTGCGCGGCATCGACGTGCTGGTAATCGACGATCTGCAATTCCTG
CAGGGCAAGACCACCCAGGCCGAATTCTGCCACACGCTGAACGCGCTGATCGACGCCGGCCGCCAGGTCGTGGTCGCGGC
CGATCGTCCGCCGTCGGATCTCGAAAGCCTCGACGAGCGGGTGCGCTCGCGGCTCGCCGGCGGCCTCGTCGTCGAGATGG
CGCCGCTCGGCGAGGATCTGCGGCTCGGCATTCTGAAGTCGCGCGTGGTCGCGGCGCGCGCGCATCATGCGAGCTTCGAC
GTGCCGGCGCCGGTGCTGGAATATCTCGCCCGCGCCATCACGCATAACGGCCGCGATCTCGAAGGCGCGATCAACCGCCT
GCTGGCGCATTCCAAGCTCAACGCCCAGCCGGTGACGCTGGAGATGGCCGAGCACGAGGTGCGCGATCTGATCCGGCCGC
AGGAGCCGAAGCGGATCAAGATCGAAGACATTCAGCGCATCGTCGCGCGGCAGTACAATGTCAGCCGCTCGGATCTCTTG
TCGTCGCGCCGCACCGCCAATGTGGTACGCCCGCGCCAGGTGGCGATGTATCTGGCCAAGACGCTGACGCTGCGCTCGCT
GCCGGAGATCGGCCGCCGTTTCGGCGGGCGCGACCACACCACGGTGCTGCACGCCGTCCGCAAGATCGAGGGGCTGGTGT
CCAAGGACACCACGCTGTCCGACGAGGTGGATTCGCTCAAGCGCCAGCTTCAGGAATAG

Upstream 100 bases:

>100_bases
AGCTGTGTCCGGAGTTTGCTTCGCGACGTCGCGGCGCGGCGCGAGCCGTCATGGTTTCGCCCGCTGCGTTGAACATCACT
CCATCTGAAAAGCTGCTGAA

Downstream 100 bases:

>100_bases
CCCCGGCGGCGTGACGGACGAAACGACCGGGGAAGCGCCCGGCCGCGGCGGCCCTCGGCAAAACTCGGGGACATTCGGGG
CCATACCGGCCACGCACCCT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSNMEHDRWSRVKGRLRSSVGEDVYSSWFARMDLEAVQPESVHLSVPTRFLKSWIQTHYSDKVLTCWQAELPEVCRIDLT
VRSPMRAAVAKEAAAPVEHRRAEHRPATETRSHATVPASSNHDALGGSPLDPRLTFASFVVGRSNTLAHAAAKQVAEGRR
GDPVMFNPLYIHSGVGLGKTHLLQAVTWAGNTGIERKVLYLTAEKFMYGFVAALKTQTSLAFKEALRGIDVLVIDDLQFL
QGKTTQAEFCHTLNALIDAGRQVVVAADRPPSDLESLDERVRSRLAGGLVVEMAPLGEDLRLGILKSRVVAARAHHASFD
VPAPVLEYLARAITHNGRDLEGAINRLLAHSKLNAQPVTLEMAEHEVRDLIRPQEPKRIKIEDIQRIVARQYNVSRSDLL
SSRRTANVVRPRQVAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIEGLVSKDTTLSDEVDSLKRQLQE

Sequences:

>Translated_472_residues
MSNMEHDRWSRVKGRLRSSVGEDVYSSWFARMDLEAVQPESVHLSVPTRFLKSWIQTHYSDKVLTCWQAELPEVCRIDLT
VRSPMRAAVAKEAAAPVEHRRAEHRPATETRSHATVPASSNHDALGGSPLDPRLTFASFVVGRSNTLAHAAAKQVAEGRR
GDPVMFNPLYIHSGVGLGKTHLLQAVTWAGNTGIERKVLYLTAEKFMYGFVAALKTQTSLAFKEALRGIDVLVIDDLQFL
QGKTTQAEFCHTLNALIDAGRQVVVAADRPPSDLESLDERVRSRLAGGLVVEMAPLGEDLRLGILKSRVVAARAHHASFD
VPAPVLEYLARAITHNGRDLEGAINRLLAHSKLNAQPVTLEMAEHEVRDLIRPQEPKRIKIEDIQRIVARQYNVSRSDLL
SSRRTANVVRPRQVAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIEGLVSKDTTLSDEVDSLKRQLQE
>Mature_471_residues
SNMEHDRWSRVKGRLRSSVGEDVYSSWFARMDLEAVQPESVHLSVPTRFLKSWIQTHYSDKVLTCWQAELPEVCRIDLTV
RSPMRAAVAKEAAAPVEHRRAEHRPATETRSHATVPASSNHDALGGSPLDPRLTFASFVVGRSNTLAHAAAKQVAEGRRG
DPVMFNPLYIHSGVGLGKTHLLQAVTWAGNTGIERKVLYLTAEKFMYGFVAALKTQTSLAFKEALRGIDVLVIDDLQFLQ
GKTTQAEFCHTLNALIDAGRQVVVAADRPPSDLESLDERVRSRLAGGLVVEMAPLGEDLRLGILKSRVVAARAHHASFDV
PAPVLEYLARAITHNGRDLEGAINRLLAHSKLNAQPVTLEMAEHEVRDLIRPQEPKRIKIEDIQRIVARQYNVSRSDLLS
SRRTANVVRPRQVAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIEGLVSKDTTLSDEVDSLKRQLQE

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=476, Percent_Identity=37.1848739495798, Blast_Score=283, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_RHOP2 (Q2J497)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_483624.1
- ProteinModelPortal:   Q2J497
- SMR:   Q2J497
- STRING:   Q2J497
- GeneID:   3910206
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_0001
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- BioCyc:   RPAL316058:RPB_0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 52535; Mature: 52404

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNMEHDRWSRVKGRLRSSVGEDVYSSWFARMDLEAVQPESVHLSVPTRFLKSWIQTHYS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEECCHHHHHHHHHHHCC
DKVLTCWQAELPEVCRIDLTVRSPMRAAVAKEAAAPVEHRRAEHRPATETRSHATVPASS
CCEEEEHHHCCCHHHEEEEEECCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCC
NHDALGGSPLDPRLTFASFVVGRSNTLAHAAAKQVAEGRRGDPVMFNPLYIHSGVGLGKT
CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCEEEECCCCCCHH
HLLQAVTWAGNTGIERKVLYLTAEKFMYGFVAALKTQTSLAFKEALRGIDVLVIDDLQFL
HHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHH
QGKTTQAEFCHTLNALIDAGRQVVVAADRPPSDLESLDERVRSRLAGGLVVEMAPLGEDL
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHH
RLGILKSRVVAARAHHASFDVPAPVLEYLARAITHNGRDLEGAINRLLAHSKLNAQPVTL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEH
EMAEHEVRDLIRPQEPKRIKIEDIQRIVARQYNVSRSDLLSSRRTANVVRPRQVAMYLAK
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
TLTLRSLPEIGRRFGGRDHTTVLHAVRKIEGLVSKDTTLSDEVDSLKRQLQE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SNMEHDRWSRVKGRLRSSVGEDVYSSWFARMDLEAVQPESVHLSVPTRFLKSWIQTHYS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEECCHHHHHHHHHHHCC
DKVLTCWQAELPEVCRIDLTVRSPMRAAVAKEAAAPVEHRRAEHRPATETRSHATVPASS
CCEEEEHHHCCCHHHEEEEEECCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCC
NHDALGGSPLDPRLTFASFVVGRSNTLAHAAAKQVAEGRRGDPVMFNPLYIHSGVGLGKT
CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCEEEECCCCCCHH
HLLQAVTWAGNTGIERKVLYLTAEKFMYGFVAALKTQTSLAFKEALRGIDVLVIDDLQFL
HHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHH
QGKTTQAEFCHTLNALIDAGRQVVVAADRPPSDLESLDERVRSRLAGGLVVEMAPLGEDL
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHH
RLGILKSRVVAARAHHASFDVPAPVLEYLARAITHNGRDLEGAINRLLAHSKLNAQPVTL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEH
EMAEHEVRDLIRPQEPKRIKIEDIQRIVARQYNVSRSDLLSSRRTANVVRPRQVAMYLAK
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
TLTLRSLPEIGRRFGGRDHTTVLHAVRKIEGLVSKDTTLSDEVDSLKRQLQE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA