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The map label for this gene is ndhD1 [H]

Identifier: 86610297

GI number: 86610297

Start: 2973826

End: 2975361

Strand: Direct

Name: ndhD1 [H]

Synonym: CYB_2876

Alternate gene names: 86610297

Gene position: 2973826-2975361 (Clockwise)

Preceding gene: 86610296

Following gene: 86610298

Centisome position: 97.61

GC content: 58.92

Gene sequence:

>1536_bases
ATGCTGAGTGCCTTGATTGTGTTGCCGATCTTGGGATCCCTGCTCCTGTTCTTAGGCTTGGGGGGGCGAAAGCTGGCGGT
GGCCTTGGCCGGGATCCTGCTGGGGATCTCGCTGCTGCTGTTTGCCAACTTTGACCTGCAAGCGGAAGGGCTGCAGTGGG
TGCAGCGGTGGGATTGGATCCCGGCAATTGGGCTGAGCTACTCCCTGGGCCTGGACGGGTTTTCCCTGCTGATGGTGGCT
TTGAATGGGCTGCTCACGCTGATTGCGGTGCTGACAGCTGAGCCAGAGGTGAAGCGGCCCAACCTCTTATACGGCTGCAT
TTTGTTCATGAGCGGGTCGGTCAACGGGGCTTTTGTTGCCCAGAACCTGCTTTTGTTCTTCTTGTTTTACGAGCTGGTGC
TGATCCCGATCTACCTGCTCATCTCCATTTGGGGCAGCCCCAAGCGGGATTATGCTGCCATCAAGTTTTTGATTTACACC
GCCGTTTCCGCCATCTTTCTGTTGGGGGCCTTTTTGGCCATCTACTGGCTGGGGGATCCCCATAGCTTTGAGCTGCTGGA
GATCCGCATCACCTCTCTCAGCCCTGTTGCCCAGACCTTGACGCTGTTGGCCTTGATCGTGGCTTTCGGCATTAAGATGC
CGCTGATCCCCTTCCACACCTGGTTGCCTGATGCATACGGGGAGTCGTCGCCGCCAGTGGCCATCCTCCTGGGAGGGATC
CTCTCCAAGTTAGGCACGTACGGTCTGTTTCGCTTTGGGCTGCAGTTGTTTCCCCAAGCTTGGGCCGACCTGGGCGGGAT
CCTAGCCTGGTGGGGAGCCATTGCCGTGTTGTCCGGGGCTTTGGCAGCCATCGCCCAAAAAGACATCAAGCGCATGGTGG
CCTACAGCTCCATTGGCCACATGGGCTACATCTTGCTGGGCATGGCGGCAGCCACCCCCATTAGCCTGACCGGGGCGATG
GTGCAGATGGTCTCCCATGGTCTCATCTTGGCGCTGCTGTTCGATTTGGTGGGCTTGGTGGAGCGCAAAGTGGGAACCCG
CGATCTGGATGTGCTCAACGGCCTGCTCAACCCCTTGCGGGGCTTGCCCACGGTGAGTGCTCTGCTCATCTTGGGGGGGA
TGGCCAGCGCCGGGATCCCTGGCCTGGTGGGCTTTGTGGCGGAGTTTTTGATCTTCCAGGGCAGCTACCAAGATTTTCCT
CTGCCCACTTTGATCAGCATCTGTGGCACCGGCTTGACGGCGGTGTACTTTGTGATTTTGCTGAACCGCACCTGCTTTGG
CAGGTTGGACAACCGCACCGCCTACTACCCGCGCGTGCATGGCTGGGAGCGGATCCCGGGGCTTATTTTGACGGCCTTGA
TCGTTTGGTTTGGGATCCAGCCCATGAGCCTGGTGAAATGGCCACAACCCTTGGCGTTTACCCTATCCACCCAGGTGGCT
CAAGCGCAAACGCTTATCCTGGCATCAGCCGGTGACCTTGCCCCCATCACCCTCTCTGGAGCCGATCCAGGCAAGCGGGA
AACTCCCAGGAATTGA

Upstream 100 bases:

>100_bases
TGCTGACGATTGTGGTGGGGGTGGCCCTGCTGGGCTGGCTGATTCTCTAGGCTTGGGCAAGGTAGCGGGACGGAGTCCTT
AGATAAAGAGGGAAAAGACC

Downstream 100 bases:

>100_bases
GATCCCAGCAGATGCCCCCTATGGAGCCAGGACTTTTGAAGAGTTGGAGACTTCTTCCATGACGACAACCCTTACAACCC
GCAAGCTTCCCCCTTCTACC

Product: NADH-ubiquinone/plastoquinone oxidoreductase subunit 4 family protein

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MLSALIVLPILGSLLLFLGLGGRKLAVALAGILLGISLLLFANFDLQAEGLQWVQRWDWIPAIGLSYSLGLDGFSLLMVA
LNGLLTLIAVLTAEPEVKRPNLLYGCILFMSGSVNGAFVAQNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYT
AVSAIFLLGAFLAIYWLGDPHSFELLEIRITSLSPVAQTLTLLALIVAFGIKMPLIPFHTWLPDAYGESSPPVAILLGGI
LSKLGTYGLFRFGLQLFPQAWADLGGILAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGHMGYILLGMAAATPISLTGAM
VQMVSHGLILALLFDLVGLVERKVGTRDLDVLNGLLNPLRGLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFP
LPTLISICGTGLTAVYFVILLNRTCFGRLDNRTAYYPRVHGWERIPGLILTALIVWFGIQPMSLVKWPQPLAFTLSTQVA
QAQTLILASAGDLAPITLSGADPGKRETPRN

Sequences:

>Translated_511_residues
MLSALIVLPILGSLLLFLGLGGRKLAVALAGILLGISLLLFANFDLQAEGLQWVQRWDWIPAIGLSYSLGLDGFSLLMVA
LNGLLTLIAVLTAEPEVKRPNLLYGCILFMSGSVNGAFVAQNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYT
AVSAIFLLGAFLAIYWLGDPHSFELLEIRITSLSPVAQTLTLLALIVAFGIKMPLIPFHTWLPDAYGESSPPVAILLGGI
LSKLGTYGLFRFGLQLFPQAWADLGGILAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGHMGYILLGMAAATPISLTGAM
VQMVSHGLILALLFDLVGLVERKVGTRDLDVLNGLLNPLRGLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFP
LPTLISICGTGLTAVYFVILLNRTCFGRLDNRTAYYPRVHGWERIPGLILTALIVWFGIQPMSLVKWPQPLAFTLSTQVA
QAQTLILASAGDLAPITLSGADPGKRETPRN
>Mature_511_residues
MLSALIVLPILGSLLLFLGLGGRKLAVALAGILLGISLLLFANFDLQAEGLQWVQRWDWIPAIGLSYSLGLDGFSLLMVA
LNGLLTLIAVLTAEPEVKRPNLLYGCILFMSGSVNGAFVAQNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYT
AVSAIFLLGAFLAIYWLGDPHSFELLEIRITSLSPVAQTLTLLALIVAFGIKMPLIPFHTWLPDAYGESSPPVAILLGGI
LSKLGTYGLFRFGLQLFPQAWADLGGILAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGHMGYILLGMAAATPISLTGAM
VQMVSHGLILALLFDLVGLVERKVGTRDLDVLNGLLNPLRGLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFP
LPTLISICGTGLTAVYFVILLNRTCFGRLDNRTAYYPRVHGWERIPGLILTALIVWFGIQPMSLVKWPQPLAFTLSTQVA
QAQTLILASAGDLAPITLSGADPGKRETPRN

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=271, Percent_Identity=35.0553505535055, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI251831117, Length=383, Percent_Identity=26.3707571801567, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788613, Length=518, Percent_Identity=34.9420849420849, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1788827, Length=297, Percent_Identity=26.2626262626263, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788831, Length=287, Percent_Identity=30.3135888501742, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788614, Length=437, Percent_Identity=28.3752860411899, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693160, Length=337, Percent_Identity=28.1899109792285, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788829, Length=307, Percent_Identity=27.6872964169381, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI2367154, Length=229, Percent_Identity=29.6943231441048, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 54991; Mature: 54991

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSALIVLPILGSLLLFLGLGGRKLAVALAGILLGISLLLFANFDLQAEGLQWVQRWDWI
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
PAIGLSYSLGLDGFSLLMVALNGLLTLIAVLTAEPEVKRPNLLYGCILFMSGSVNGAFVA
CCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHH
QNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYTAVSAIFLLGAFLAIYWLGDP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HSFELLEIRITSLSPVAQTLTLLALIVAFGIKMPLIPFHTWLPDAYGESSPPVAILLGGI
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHH
LSKLGTYGLFRFGLQLFPQAWADLGGILAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGYILLGMAAATPISLTGAMVQMVSHGLILALLFDLVGLVERKVGTRDLDVLNGLLNPLR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFPLPTLISICGTGLTAVYFVIL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LNRTCFGRLDNRTAYYPRVHGWERIPGLILTALIVWFGIQPMSLVKWPQPLAFTLSTQVA
HHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEHHHHHHH
QAQTLILASAGDLAPITLSGADPGKRETPRN
HHHHHEEECCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MLSALIVLPILGSLLLFLGLGGRKLAVALAGILLGISLLLFANFDLQAEGLQWVQRWDWI
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
PAIGLSYSLGLDGFSLLMVALNGLLTLIAVLTAEPEVKRPNLLYGCILFMSGSVNGAFVA
CCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHH
QNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYTAVSAIFLLGAFLAIYWLGDP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HSFELLEIRITSLSPVAQTLTLLALIVAFGIKMPLIPFHTWLPDAYGESSPPVAILLGGI
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHH
LSKLGTYGLFRFGLQLFPQAWADLGGILAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGYILLGMAAATPISLTGAMVQMVSHGLILALLFDLVGLVERKVGTRDLDVLNGLLNPLR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFPLPTLISICGTGLTAVYFVIL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LNRTCFGRLDNRTAYYPRVHGWERIPGLILTALIVWFGIQPMSLVKWPQPLAFTLSTQVA
HHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEHHHHHHH
QAQTLILASAGDLAPITLSGADPGKRETPRN
HHHHHEEECCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]