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The map label for this gene is glmU

Identifier: 86610066

GI number: 86610066

Start: 2725444

End: 2727342

Strand: Direct

Name: glmU

Synonym: CYB_2635

Alternate gene names: 86610066

Gene position: 2725444-2727342 (Clockwise)

Preceding gene: 86610060

Following gene: 86610067

Centisome position: 89.46

GC content: 62.14

Gene sequence:

>1899_bases
ATGGCAGAGCGGGAACTATCGGTAGCGATCTTGGCAGCGGGCAAAGGTACCCGGATGCGGTCGCAGTTGCCCAAGGTGCT
GCACAAACTGGGATCCCTGTCTTTGATCGAGCGGCTGCTGCGCACGGTGCTGACGTTAAAGCCCCACCGCTGTCTGGTGG
TCGTGGGTTATGAACAAGAGCAGGTGCGCCAAGCCCTGCGGGAGTACCCGGTTGAATTTGTGGAGCAGGCCCAGCAATTG
GGCACCGGACACGCCGTTCAACAGCTGTTGCCCGTCCTGGGCGGTTTTCAGGGGGATCTGCTGGTGATCAACGGGGATGT
GCCCCTGCTGCGGGCAGAAACCCTGCAAGCTCTGGTGGAGCGCCACCGCCAGGTGAACCCAGAGGTAACCTTGCTCTCGG
CTCAGGTGGCGGATCCCTATGGCTATGGACGGGTGTTCTGCGATGCCCAACAGCGAGTGCTGGAACTGGTGGAAGAGCGA
GACTGCACCCCAGCCCAACGGCAAAATCGCCGCATCAACAGTGGGGTGTATTGTTTTCACTGGCCGGCTCTGGCTCAGGT
TTTGCCCCATCTCAATCGCAACAACGCACAGCAGGAGTACTACCTAACAGATGCCGTCAAGCGGGTGGGCAAAGCCATCG
CTCTGGATGTTGCCGATCCGCAAGAAATTGTGGGCGTCAACGACCGCCGCCAACTGGCCCAGGCGTACCAGATTTTGCAG
GATCGCCTCAAAGAAGCCTGGATGGAAGCCGGGGTCACCTTTGTGGATCCCGACAGCAGCAGCCTCGAGGAAACGGTGGA
ATTGGCCCCCGATGTGGTGATCGAGCCCCAAACCCATCTGCGAGGGGTGTGCCGCATTGGGCCGGGAACCCGCCTGGGGC
CGGGCAGTTGGATCGAGTCCAGCGAGATTGGATCTGGGTGTCACATTCTCTACTCGGTGGTCAGCCACAGCCGCATCGGC
AACCACGTCTGGATAGGCCCCTACGCCCACGTGCGCCCCCACAGCCAGATCGGGGATCACTGCCGCATCGGCAACTTTGT
GGAAACCAAAAATGCCCAGATCGGATCCCACAGCAACGCCGCCCACTTGGCCTACCTGGGCGATGCCAAGCTGGGATCCC
AGGTCAACATCGGGGCGGGCACCATCATCGCCAACTACGACGGCCAGCAAAAGCACTTTACCGAAATTGGGGATCGCAGC
AAAACAGGCGCCAACTCGGTTCTGGTGGCTCCTTTGCAGGTGGGATCCGATGTCACCATTGCTGCCGGCTCCACCATCCC
TGCCCGCTACCCCCTGCCGGATGACTGCTTGGTGATCGCTCGCTCCCGCCCGGTGGTCAAGCCCGGTTGGCGACTTGGGA
TCCGCTCTTCCCGCCCCCAGGAGCCCCAGCCCATGCCGCCGGGATCCCTCAAGATTTATCCCTTGCGCCTTTTCCCCGGC
CAAGATCTCAAGCAGGAACTAGAGCGATTGGCCCGGCAGCAGCCCTTGCAAGCGGGGTTTGTCCTCAGCGCTGTCGGCAG
CCTCAGCCAAGCCACCCTGCGCCTGGCCGACCAAACGGGGGATCACCTGTTGTCGGAACGCCTGGAGATCCTGGCCCTGA
GTGGATCCCTGTGCCCTGACGGAGTCCATCTCCATCTCACCGTTGCCGATGCCCGAGGCCAAACCTGGGGGGGACACCTG
CGCCCCGGCTGCCTCATCTACACCACCGCCGAAATTGTCCTCGCCGACAGCCCGGAGTATCGCTTCTCCCGTCAACCGGA
TCCGGCCACCGGCTACCTGGAGTTGCACATCCAACCCGTGGCAGGGGATCCCTGCTGGCCGTCCCCACCCCCCCAACCCC
AGCAAAACCAGCAGACAAAACCAGAGGCTGACAACAGCAGGCCGAAAAGCCTACAGTAG

Upstream 100 bases:

>100_bases
TTTTGGCCGCACAGGGCTCAGGAACTTGGATCCAACCTTAGAAGATTTTTGAGCAGCATCCCGCCGCCTATACTTGATGG
GGGCGGTTCGGGGAAGGAAC

Downstream 100 bases:

>100_bases
TCAACACGAGTTACCTAAAGCTAAAGGGGGCTTGTGAGCGCCAAGCCGAAAGCTTCACGGAACTCATGGACGCTTTGCGG
TGTGGCGGGCATGTTACTGG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MAERELSVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPHRCLVVVGYEQEQVRQALREYPVEFVEQAQQL
GTGHAVQQLLPVLGGFQGDLLVINGDVPLLRAETLQALVERHRQVNPEVTLLSAQVADPYGYGRVFCDAQQRVLELVEER
DCTPAQRQNRRINSGVYCFHWPALAQVLPHLNRNNAQQEYYLTDAVKRVGKAIALDVADPQEIVGVNDRRQLAQAYQILQ
DRLKEAWMEAGVTFVDPDSSSLEETVELAPDVVIEPQTHLRGVCRIGPGTRLGPGSWIESSEIGSGCHILYSVVSHSRIG
NHVWIGPYAHVRPHSQIGDHCRIGNFVETKNAQIGSHSNAAHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRS
KTGANSVLVAPLQVGSDVTIAAGSTIPARYPLPDDCLVIARSRPVVKPGWRLGIRSSRPQEPQPMPPGSLKIYPLRLFPG
QDLKQELERLARQQPLQAGFVLSAVGSLSQATLRLADQTGDHLLSERLEILALSGSLCPDGVHLHLTVADARGQTWGGHL
RPGCLIYTTAEIVLADSPEYRFSRQPDPATGYLELHIQPVAGDPCWPSPPPQPQQNQQTKPEADNSRPKSLQ

Sequences:

>Translated_632_residues
MAERELSVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPHRCLVVVGYEQEQVRQALREYPVEFVEQAQQL
GTGHAVQQLLPVLGGFQGDLLVINGDVPLLRAETLQALVERHRQVNPEVTLLSAQVADPYGYGRVFCDAQQRVLELVEER
DCTPAQRQNRRINSGVYCFHWPALAQVLPHLNRNNAQQEYYLTDAVKRVGKAIALDVADPQEIVGVNDRRQLAQAYQILQ
DRLKEAWMEAGVTFVDPDSSSLEETVELAPDVVIEPQTHLRGVCRIGPGTRLGPGSWIESSEIGSGCHILYSVVSHSRIG
NHVWIGPYAHVRPHSQIGDHCRIGNFVETKNAQIGSHSNAAHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRS
KTGANSVLVAPLQVGSDVTIAAGSTIPARYPLPDDCLVIARSRPVVKPGWRLGIRSSRPQEPQPMPPGSLKIYPLRLFPG
QDLKQELERLARQQPLQAGFVLSAVGSLSQATLRLADQTGDHLLSERLEILALSGSLCPDGVHLHLTVADARGQTWGGHL
RPGCLIYTTAEIVLADSPEYRFSRQPDPATGYLELHIQPVAGDPCWPSPPPQPQQNQQTKPEADNSRPKSLQ
>Mature_631_residues
AERELSVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPHRCLVVVGYEQEQVRQALREYPVEFVEQAQQLG
TGHAVQQLLPVLGGFQGDLLVINGDVPLLRAETLQALVERHRQVNPEVTLLSAQVADPYGYGRVFCDAQQRVLELVEERD
CTPAQRQNRRINSGVYCFHWPALAQVLPHLNRNNAQQEYYLTDAVKRVGKAIALDVADPQEIVGVNDRRQLAQAYQILQD
RLKEAWMEAGVTFVDPDSSSLEETVELAPDVVIEPQTHLRGVCRIGPGTRLGPGSWIESSEIGSGCHILYSVVSHSRIGN
HVWIGPYAHVRPHSQIGDHCRIGNFVETKNAQIGSHSNAAHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRSK
TGANSVLVAPLQVGSDVTIAAGSTIPARYPLPDDCLVIARSRPVVKPGWRLGIRSSRPQEPQPMPPGSLKIYPLRLFPGQ
DLKQELERLARQQPLQAGFVLSAVGSLSQATLRLADQTGDHLLSERLEILALSGSLCPDGVHLHLTVADARGQTWGGHLR
PGCLIYTTAEIVLADSPEYRFSRQPDPATGYLELHIQPVAGDPCWPSPPPQPQQNQQTKPEADNSRPKSLQ

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=460, Percent_Identity=39.3478260869565, Blast_Score=300, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_SYNJB (Q2JII9)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_478828.1
- ProteinModelPortal:   Q2JII9
- STRING:   Q2JII9
- GeneID:   3900314
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_2635
- TIGR:   CYB_2635
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q2JII9
- ProtClustDB:   PRK14360
- BioCyc:   SSP321332:CYB_2635-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005175
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF03479 DUF296; PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 69355; Mature: 69224

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 362-362 BINDING 76-76 BINDING 143-143 BINDING 158-158 BINDING 173-173 BINDING 386-386 BINDING 422-422 BINDING 441-441

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERELSVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPHRCLVVVGYEQE
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCHH
QVRQALREYPVEFVEQAQQLGTGHAVQQLLPVLGGFQGDLLVINGDVPLLRAETLQALVE
HHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
RHRQVNPEVTLLSAQVADPYGYGRVFCDAQQRVLELVEERDCTPAQRQNRRINSGVYCFH
HHHCCCCCEEEEEEECCCCCCCCEEEECHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEE
WPALAQVLPHLNRNNAQQEYYLTDAVKRVGKAIALDVADPQEIVGVNDRRQLAQAYQILQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHCCCCHHHHHHHHHHHHH
DRLKEAWMEAGVTFVDPDSSSLEETVELAPDVVIEPQTHLRGVCRIGPGTRLGPGSWIES
HHHHHHHHHCCCEEECCCCHHHHHHHHHCCCEEECCCHHHCEEEEECCCCCCCCCCCCCC
SEIGSGCHILYSVVSHSRIGNHVWIGPYAHVRPHSQIGDHCRIGNFVETKNAQIGSHSNA
CCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHCCCCCCCCCEEECCCCCCCCCCCC
AHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRSKTGANSVLVAPLQVGSDVTI
EEEEEECCCCCCCEEECCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCEEE
AAGSTIPARYPLPDDCLVIARSRPVVKPGWRLGIRSSRPQEPQPMPPGSLKIYPLRLFPG
EECCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEEECCC
QDLKQELERLARQQPLQAGFVLSAVGSLSQATLRLADQTGDHLLSERLEILALSGSLCPD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCC
GVHLHLTVADARGQTWGGHLRPGCLIYTTAEIVLADSPEYRFSRQPDPATGYLELHIQPV
CEEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEC
AGDPCWPSPPPQPQQNQQTKPEADNSRPKSLQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AERELSVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPHRCLVVVGYEQE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCHH
QVRQALREYPVEFVEQAQQLGTGHAVQQLLPVLGGFQGDLLVINGDVPLLRAETLQALVE
HHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
RHRQVNPEVTLLSAQVADPYGYGRVFCDAQQRVLELVEERDCTPAQRQNRRINSGVYCFH
HHHCCCCCEEEEEEECCCCCCCCEEEECHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEE
WPALAQVLPHLNRNNAQQEYYLTDAVKRVGKAIALDVADPQEIVGVNDRRQLAQAYQILQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHCCCCHHHHHHHHHHHHH
DRLKEAWMEAGVTFVDPDSSSLEETVELAPDVVIEPQTHLRGVCRIGPGTRLGPGSWIES
HHHHHHHHHCCCEEECCCCHHHHHHHHHCCCEEECCCHHHCEEEEECCCCCCCCCCCCCC
SEIGSGCHILYSVVSHSRIGNHVWIGPYAHVRPHSQIGDHCRIGNFVETKNAQIGSHSNA
CCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHCCCCCCCCCEEECCCCCCCCCCCC
AHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRSKTGANSVLVAPLQVGSDVTI
EEEEEECCCCCCCEEECCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCEEE
AAGSTIPARYPLPDDCLVIARSRPVVKPGWRLGIRSSRPQEPQPMPPGSLKIYPLRLFPG
EECCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEEECCC
QDLKQELERLARQQPLQAGFVLSAVGSLSQATLRLADQTGDHLLSERLEILALSGSLCPD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCC
GVHLHLTVADARGQTWGGHLRPGCLIYTTAEIVLADSPEYRFSRQPDPATGYLELHIQPV
CEEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEC
AGDPCWPSPPPQPQQNQQTKPEADNSRPKSLQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA