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The map label for this gene is fmt [H]

Identifier: 86609442

GI number: 86609442

Start: 2098812

End: 2099780

Strand: Direct

Name: fmt [H]

Synonym: CYB_1993

Alternate gene names: 86609442

Gene position: 2098812-2099780 (Clockwise)

Preceding gene: 86609441

Following gene: 86609447

Centisome position: 68.89

GC content: 60.99

Gene sequence:

>969_bases
ATGCGGGTTGTTTTTTTCGGCACGCCAGAGTTTGCCCTGCCTTCGCTGCAGATCCTGTTGCAGCCGCAGTCCCCCTTTGA
AGTGGTGGGATTGGTCTGCCAGCCGGATCGGCCCCAGGGACGGGGACAAAAGGTGCTTCCCCCCCCTACCAAGGTTCTCG
CCCAGGCCCACGGGATCCCGGTGTGGCAGCCTGTCCGCCTGCGGCGGGATCCCCAAGTGCTGGCGGCTCTGGAGGCGCTG
GCTGCCGATGTGTTTGTGGTGGTGGCCTACGGCCAGATCTTGCCCCTGACGGTGTTGCAGATGCCCAAGCTGGGCTGTGT
GAATGTGCATGGATCCCTCCTGCCCGCCTATCGTGGCGCTGCCCCCATCCAGTGGGCTATTGCCAACGGCGAAACCGAGA
CCGGCGTAACCACGATGCTCATGGATGAGGGAATGGATACGGGGGCCATCCTGCTCCAGGCCAAGCTACCCATTGGGCCA
GAGCAAACCAGCCTAGAATTGGCACCCCAACTGGCTCAACTGGGGGCAGAACTCTTGGTGGAAACGCTCTTGAAATTGGA
GAAAGGGGAACTCACCCCTATTCCTCAGGATGGATCCCGGGCAACCTACGCCCCTCTGCTCAAAAAACAAGACTTTCACC
TCGACTGGCAGCGCCCTGCCCAGGCCTTGCACAACCAAATCCGCGCCTTTTCCCCCAACTGTTTCACCGGTATAGAGGGA
CAGCGGATAAAGATTGTCCGCTCCGCCTCTCCCCAACTGCACTCGCCACCCCCTGAAATCCCCCAGGGCAGTCCCGGAGA
AGTGGTGGGGTTGGCCAGAGGAGAAGGGATCTACGTAGCCACAGGAGAGGGATCCCTGTTGATCCGGCGGGCGCAACTGC
CTGGCAAAAAAGAACAGTCCGCTTGGGACCTGGTCAATGGCGGCCAGCTCAAGGTGGGGATGCGCTTTGAGCCGCTGCCC
AATTCTTGA

Upstream 100 bases:

>100_bases
AATCTCCGGGTGTCAGTTGACGGAGGAGATAGTAAGTAGCCGAGCGTTTGCAGCCGCTGGCTGAGCGTATTCTGAAGGAC
AGTGCTCGTTGGGGTTGGCC

Downstream 100 bases:

>100_bases
GAGCCCACACACAGGGATCCCTTGGGCGTGGTCAACCCAAAGACGGCGAACCTGTCCGTTGCCTTGATTCTACTCTCTCT
CTCTGGGAGAAAGGCTGGGG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKVLAQAHGIPVWQPVRLRRDPQVLAALEAL
AADVFVVVAYGQILPLTVLQMPKLGCVNVHGSLLPAYRGAAPIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIGP
EQTSLELAPQLAQLGAELLVETLLKLEKGELTPIPQDGSRATYAPLLKKQDFHLDWQRPAQALHNQIRAFSPNCFTGIEG
QRIKIVRSASPQLHSPPPEIPQGSPGEVVGLARGEGIYVATGEGSLLIRRAQLPGKKEQSAWDLVNGGQLKVGMRFEPLP
NS

Sequences:

>Translated_322_residues
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKVLAQAHGIPVWQPVRLRRDPQVLAALEAL
AADVFVVVAYGQILPLTVLQMPKLGCVNVHGSLLPAYRGAAPIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIGP
EQTSLELAPQLAQLGAELLVETLLKLEKGELTPIPQDGSRATYAPLLKKQDFHLDWQRPAQALHNQIRAFSPNCFTGIEG
QRIKIVRSASPQLHSPPPEIPQGSPGEVVGLARGEGIYVATGEGSLLIRRAQLPGKKEQSAWDLVNGGQLKVGMRFEPLP
NS
>Mature_322_residues
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKVLAQAHGIPVWQPVRLRRDPQVLAALEAL
AADVFVVVAYGQILPLTVLQMPKLGCVNVHGSLLPAYRGAAPIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIGP
EQTSLELAPQLAQLGAELLVETLLKLEKGELTPIPQDGSRATYAPLLKKQDFHLDWQRPAQALHNQIRAFSPNCFTGIEG
QRIKIVRSASPQLHSPPPEIPQGSPGEVVGLARGEGIYVATGEGSLLIRRAQLPGKKEQSAWDLVNGGQLKVGMRFEPLP
NS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=207, Percent_Identity=32.3671497584541, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI238814322, Length=293, Percent_Identity=28.6689419795222, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI164663775, Length=318, Percent_Identity=27.9874213836478, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1789683, Length=310, Percent_Identity=46.7741935483871, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI1788589, Length=295, Percent_Identity=31.1864406779661, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI133930964, Length=263, Percent_Identity=26.9961977186312, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319458, Length=285, Percent_Identity=27.3684210526316, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550868, Length=312, Percent_Identity=30.7692307692308, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28571984, Length=230, Percent_Identity=33.0434782608696, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585660, Length=241, Percent_Identity=28.2157676348548, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34760; Mature: 34760

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKVLAQAHGIP
CEEEEECCCCCCCCCEEEEECCCCCHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCC
VWQPVRLRRDPQVLAALEALAADVFVVVAYGQILPLTVLQMPKLGCVNVHGSLLPAYRGA
CCCCHHCCCCHHHHHHHHHHHHHHEEEEHHCCHHHHHHHCCCCCCEEECCCCCCHHHCCC
APIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIGPEQTSLELAPQLAQLGAELLV
CCEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
ETLLKLEKGELTPIPQDGSRATYAPLLKKQDFHLDWQRPAQALHNQIRAFSPNCFTGIEG
HHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCC
QRIKIVRSASPQLHSPPPEIPQGSPGEVVGLARGEGIYVATGEGSLLIRRAQLPGKKEQS
CEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCCC
AWDLVNGGQLKVGMRFEPLPNS
HHCCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKVLAQAHGIP
CEEEEECCCCCCCCCEEEEECCCCCHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCC
VWQPVRLRRDPQVLAALEALAADVFVVVAYGQILPLTVLQMPKLGCVNVHGSLLPAYRGA
CCCCHHCCCCHHHHHHHHHHHHHHEEEEHHCCHHHHHHHCCCCCCEEECCCCCCHHHCCC
APIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIGPEQTSLELAPQLAQLGAELLV
CCEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
ETLLKLEKGELTPIPQDGSRATYAPLLKKQDFHLDWQRPAQALHNQIRAFSPNCFTGIEG
HHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCC
QRIKIVRSASPQLHSPPPEIPQGSPGEVVGLARGEGIYVATGEGSLLIRRAQLPGKKEQS
CEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCCC
AWDLVNGGQLKVGMRFEPLPNS
HHCCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA