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The map label for this gene is cysK [H]

Identifier: 86609431

GI number: 86609431

Start: 2081795

End: 2082751

Strand: Reverse

Name: cysK [H]

Synonym: CYB_1982

Alternate gene names: 86609431

Gene position: 2082751-2081795 (Counterclockwise)

Preceding gene: 86609433

Following gene: 86609429

Centisome position: 68.36

GC content: 60.4

Gene sequence:

>957_bases
ATGAAAATCGCCGCCAACATCACCCAGCTCATCGGTCGCACCCCGCTAGTGCGGTTGAATCGGATCCCGCAATCGGAGGG
GTGCCTGGCCGAGATCGTGGTGAAATTGGAGAGCTTTAACCCTGCCGCTTCGGTGAAAGACCGCATTGCCGTCAGCATGA
TCGAGGCTGCCGAACAGGCCGGTTTGATCACCCCCGGCAAGACCATCTTGGTGGAGCCCACCTCTGGCAATACCGGCATT
GGCCTGGCCATGGCCGCTGCTGCCAAGGGTTACCGGCTCATCATCGTCATGCCTGAGAGCATGAGCCTGGAGCGGCGACT
GCTGTTGAAAGCCTACGGAGCAGAGGTGCACCTGGCCAGTAGCGCCGGCGGCATGGGGGAAGCCATCTGGAAGGCTGAAG
AGATCGTCCGCCGCACTCCCAACGCTTACATGTTGGGCCAGTTCACCAATCCCGCCAACCCCCGGATCCATGCCAGAACC
ACCGGCCCGGAAATTTGGGAAGATACCGATGGTCAAGTGGATATCCTGGTGGCAGGGGTAGGTACCGGCGGCACCATCAC
GGGGGCGGGCGAGTTTTTGAAGGGGAAAAACCCAGCCATTCGACTGGTGGCCGTTGAACCCAAGGCCAGTGCCGTCTTGA
GTGGTGGACGGCCCGGCTTTCATCGCATTGAAGGGATCGGAGCGGGATTCGTGCCTGATGTGCTGCGGCGCGACCTGCTG
GATGAGGTGATCCCAGTGGAAGATGAAGAGAGCATGGTCTACAGCCGGCGCCTGGCCAAAGAAGAAGGGATCCTCTCCGG
CATTTCCACTGGGGCTGCCTTGGCGGGAGCCATCCAGGTGGGGCGGCGACCGGAAAACGCTGGCAAGCGGATTGTAATGA
TCCAGCCTAGTTTTGGGGAACGCTACCTGAGCACACCTCTTTTTCGCGACTTGGAGCGGGATTCCGATTCGAGATGA

Upstream 100 bases:

>100_bases
AGGAGCTTATTCAAGGGTTAGCCTCGCGTAAGGCCCTCGGTTGCTCCGGAGTTAAGGGCTAGGGCCCACTGCCGCGATGG
TTTCTTCCTTTTTGTTAGCC

Downstream 100 bases:

>100_bases
CGATGATGCTGAGACTGCTGCCCTACAGGTCGCCCTGGCCCAGAGGGCGAGCTAGCATGGGTGAGAGTGACGTGGCGGAA
CGGCAGACGCGCTAGACTTA

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKIAANITQLIGRTPLVRLNRIPQSEGCLAEIVVKLESFNPAASVKDRIAVSMIEAAEQAGLITPGKTILVEPTSGNTGI
GLAMAAAAKGYRLIIVMPESMSLERRLLLKAYGAEVHLASSAGGMGEAIWKAEEIVRRTPNAYMLGQFTNPANPRIHART
TGPEIWEDTDGQVDILVAGVGTGGTITGAGEFLKGKNPAIRLVAVEPKASAVLSGGRPGFHRIEGIGAGFVPDVLRRDLL
DEVIPVEDEESMVYSRRLAKEEGILSGISTGAALAGAIQVGRRPENAGKRIVMIQPSFGERYLSTPLFRDLERDSDSR

Sequences:

>Translated_318_residues
MKIAANITQLIGRTPLVRLNRIPQSEGCLAEIVVKLESFNPAASVKDRIAVSMIEAAEQAGLITPGKTILVEPTSGNTGI
GLAMAAAAKGYRLIIVMPESMSLERRLLLKAYGAEVHLASSAGGMGEAIWKAEEIVRRTPNAYMLGQFTNPANPRIHART
TGPEIWEDTDGQVDILVAGVGTGGTITGAGEFLKGKNPAIRLVAVEPKASAVLSGGRPGFHRIEGIGAGFVPDVLRRDLL
DEVIPVEDEESMVYSRRLAKEEGILSGISTGAALAGAIQVGRRPENAGKRIVMIQPSFGERYLSTPLFRDLERDSDSR
>Mature_318_residues
MKIAANITQLIGRTPLVRLNRIPQSEGCLAEIVVKLESFNPAASVKDRIAVSMIEAAEQAGLITPGKTILVEPTSGNTGI
GLAMAAAAKGYRLIIVMPESMSLERRLLLKAYGAEVHLASSAGGMGEAIWKAEEIVRRTPNAYMLGQFTNPANPRIHART
TGPEIWEDTDGQVDILVAGVGTGGTITGAGEFLKGKNPAIRLVAVEPKASAVLSGGRPGFHRIEGIGAGFVPDVLRRDLL
DEVIPVEDEESMVYSRRLAKEEGILSGISTGAALAGAIQVGRRPENAGKRIVMIQPSFGERYLSTPLFRDLERDSDSR

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=42.5396825396825, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=42.5396825396825, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=42.5396825396825, Blast_Score=234, Evalue=7e-62,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=54.5454545454545, Blast_Score=288, Evalue=2e-79,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=42.4342105263158, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=54.071661237785, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=53.156146179402, Blast_Score=311, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=53.9249146757679, Blast_Score=304, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI115535073, Length=313, Percent_Identity=52.7156549520767, Blast_Score=301, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=51.8272425249169, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=51.1627906976744, Blast_Score=223, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17534315, Length=322, Percent_Identity=38.1987577639752, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=36.7924528301887, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17561716, Length=120, Percent_Identity=46.6666666666667, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=40.4458598726115, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321449, Length=340, Percent_Identity=34.4117647058824, Blast_Score=136, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=41.4790996784566, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=41.4790996784566, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33903; Mature: 33903

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAANITQLIGRTPLVRLNRIPQSEGCLAEIVVKLESFNPAASVKDRIAVSMIEAAEQA
CCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GLITPGKTILVEPTSGNTGIGLAMAAAAKGYRLIIVMPESMSLERRLLLKAYGAEVHLAS
CCCCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEC
SAGGMGEAIWKAEEIVRRTPNAYMLGQFTNPANPRIHARTTGPEIWEDTDGQVDILVAGV
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEC
GTGGTITGAGEFLKGKNPAIRLVAVEPKASAVLSGGRPGFHRIEGIGAGFVPDVLRRDLL
CCCCEECCCCHHHCCCCCEEEEEEECCCCHHEECCCCCCHHHHHCCCCCCHHHHHHHHHH
DEVIPVEDEESMVYSRRLAKEEGILSGISTGAALAGAIQVGRRPENAGKRIVMIQPSFGE
HHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
RYLSTPLFRDLERDSDSR
HHHCCHHHHHHHCCCCCC
>Mature Secondary Structure
MKIAANITQLIGRTPLVRLNRIPQSEGCLAEIVVKLESFNPAASVKDRIAVSMIEAAEQA
CCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GLITPGKTILVEPTSGNTGIGLAMAAAAKGYRLIIVMPESMSLERRLLLKAYGAEVHLAS
CCCCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEC
SAGGMGEAIWKAEEIVRRTPNAYMLGQFTNPANPRIHARTTGPEIWEDTDGQVDILVAGV
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEC
GTGGTITGAGEFLKGKNPAIRLVAVEPKASAVLSGGRPGFHRIEGIGAGFVPDVLRRDLL
CCCCEECCCCHHHCCCCCEEEEEEECCCCHHEECCCCCCHHHHHCCCCCCHHHHHHHHHH
DEVIPVEDEESMVYSRRLAKEEGILSGISTGAALAGAIQVGRRPENAGKRIVMIQPSFGE
HHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
RYLSTPLFRDLERDSDSR
HHHCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]