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The map label for this gene is upp-1 [H]

Identifier: 86609389

GI number: 86609389

Start: 2019866

End: 2020501

Strand: Direct

Name: upp-1 [H]

Synonym: CYB_1933

Alternate gene names: 86609389

Gene position: 2019866-2020501 (Clockwise)

Preceding gene: 86609387

Following gene: 86609396

Centisome position: 66.3

GC content: 60.22

Gene sequence:

>636_bases
ATGGTGGCCCAGGTGATTACCATCGATCACCCTCTGGTGCAGCACAAGCTCAGCCTCATGCGCCGTGTTGAAACTACAAC
CGCCGACTTCCGAGCGCTGATGCGGGAGATCAGCCTCTTGATGGCCTACGAGGTGACCCGCGATCTGCCCCTCAAGCTAC
AGCCCATTCAAACCCCGATGGCCCCAATGTTGGCGCCGATGTTGGCGGCAGAGAAAAAGTTGGTGCTTGTCTCCATCCTG
CGGGCCGGCCAAGGGCTCCTCGACGGCATGCTGGAGCTGATCCCATCAGCACGGGTGGGGCATATCGGCCTATATCGGGA
TCCCCATACCCTGATCCCCATCGAGTACTACTTCAAGGTGCCCACCGATATCGAAGATCGTGAGGTGCTGGTGGTGGATC
CAATGTTGGCCACCGGCCATTCGGCAGCAGCGGCTGTAGCGCGCCTACGCCAAACCCGACCCCAGTCGATCCGCTTCATC
TGCCTGGTGGCCGCCCCAGAAGGGATCCGATATTTCCACAAACAGAACCCGGATGTGCCGATTTATACCGCTGCTGTAGA
CGATGGCCTAGACGAGCACGGCTACATCCTCCCCGGCCTAGGAGATGCAGGGGATCGCCTGTTCGGCACCCGCTGA

Upstream 100 bases:

>100_bases
GACAACAGCAAGCAGACAAAGCCTTCGGCCCACCGGGGGGGCAAGCGCTTCTGCTATTCTGACATCCATCACGGGATCCC
GATTATCTCAGGAGCACAGC

Downstream 100 bases:

>100_bases
TACAAGAGTGCCATGCCTACAGCACCCTATGTTGCTGCGCCACACTGAACGGGAACCGCACCGCTGTCGCGATTAGGAAG
TTGGGTTGGGCGCCAACAAC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MVAQVITIDHPLVQHKLSLMRRVETTTADFRALMREISLLMAYEVTRDLPLKLQPIQTPMAPMLAPMLAAEKKLVLVSIL
RAGQGLLDGMLELIPSARVGHIGLYRDPHTLIPIEYYFKVPTDIEDREVLVVDPMLATGHSAAAAVARLRQTRPQSIRFI
CLVAAPEGIRYFHKQNPDVPIYTAAVDDGLDEHGYILPGLGDAGDRLFGTR

Sequences:

>Translated_211_residues
MVAQVITIDHPLVQHKLSLMRRVETTTADFRALMREISLLMAYEVTRDLPLKLQPIQTPMAPMLAPMLAAEKKLVLVSIL
RAGQGLLDGMLELIPSARVGHIGLYRDPHTLIPIEYYFKVPTDIEDREVLVVDPMLATGHSAAAAVARLRQTRPQSIRFI
CLVAAPEGIRYFHKQNPDVPIYTAAVDDGLDEHGYILPGLGDAGDRLFGTR
>Mature_211_residues
MVAQVITIDHPLVQHKLSLMRRVETTTADFRALMREISLLMAYEVTRDLPLKLQPIQTPMAPMLAPMLAAEKKLVLVSIL
RAGQGLLDGMLELIPSARVGHIGLYRDPHTLIPIEYYFKVPTDIEDREVLVVDPMLATGHSAAAAVARLRQTRPQSIRFI
CLVAAPEGIRYFHKQNPDVPIYTAAVDDGLDEHGYILPGLGDAGDRLFGTR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.1980198019802, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.1980198019802, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI21450816, Length=171, Percent_Identity=28.6549707602339, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=47.1153846153846, Blast_Score=206, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321920, Length=193, Percent_Identity=38.3419689119171, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=30.5825242718447, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=30.5825242718447, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=30.5825242718447, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=30.5825242718447, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23426; Mature: 23426

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAQVITIDHPLVQHKLSLMRRVETTTADFRALMREISLLMAYEVTRDLPLKLQPIQTPM
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCH
APMLAPMLAAEKKLVLVSILRAGQGLLDGMLELIPSARVGHIGLYRDPHTLIPIEYYFKV
HHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEEEEEC
PTDIEDREVLVVDPMLATGHSAAAAVARLRQTRPQSIRFICLVAAPEGIRYFHKQNPDVP
CCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCC
IYTAAVDDGLDEHGYILPGLGDAGDRLFGTR
EEEEEECCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MVAQVITIDHPLVQHKLSLMRRVETTTADFRALMREISLLMAYEVTRDLPLKLQPIQTPM
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCH
APMLAPMLAAEKKLVLVSILRAGQGLLDGMLELIPSARVGHIGLYRDPHTLIPIEYYFKV
HHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEEEEEC
PTDIEDREVLVVDPMLATGHSAAAAVARLRQTRPQSIRFICLVAAPEGIRYFHKQNPDVP
CCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCC
IYTAAVDDGLDEHGYILPGLGDAGDRLFGTR
EEEEEECCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA