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The map label for this gene is blh [H]

Identifier: 86609383

GI number: 86609383

Start: 2011395

End: 2012111

Strand: Reverse

Name: blh [H]

Synonym: CYB_1927

Alternate gene names: 86609383

Gene position: 2012111-2011395 (Counterclockwise)

Preceding gene: 86609385

Following gene: 86609382

Centisome position: 66.04

GC content: 59.69

Gene sequence:

>717_bases
ATGCTATTTCGCCAACTGTTCGACGCAGAAACAAGCACCTACACCTATTTAATCGCGGATCCGGCAACCCGCGAGGCCGC
CCTGGTGGATCCGGTACTGGAGCAGGTGGAGCGGGATTTGAAGTTGATTCGGGAATTGGGTCTAACCTTGAAGTACTGCC
TGGAAACCCACGTTCACGCGGATCACATCACGGGAACCGGGAAGCTGCGGGAACTGACCGGTTGCCAAGGGGTGGTGCCG
GTACAGGCTAAGGCTCAGTGTGCAGATCGTTTCATCGGTCATGGGGAAACGCTGCAAGTGGGATCCGTCGTCATTGAAGC
CATCGCTACCCTGGGCCACACCGACAGCCACATGACCTACCGCGTGAATGGGGATCGCGTCCTTACCGGAGATGCCCTGC
TGATCCGCGGCTGTGGGCGCACGGATTTCCAAAGCGGGGATCCCGGCCTGATGTACGACCATGTTACCCAGCACTTGTTT
ACGCTGCCCGATGAGACGCTGGTCTATCCTGGCCACGACTATCGCGGGCACACCGTCTCCACCATTGGCGAGGAGAAGCG
CTGGAACCCGCGCTTTGTGGATCCGGAAACGGGCAACCTGCGTTCCCGTGAGAGCTTCATTGCCCTCATGAACAGCCTCA
ACCTGCCCCAGCCGAAGAAGATCCAGGAAGCGGTGCCGGCCAACGAGCAGTGCGGCCAAGTGGCAGCCGCGGTTTAG

Upstream 100 bases:

>100_bases
GTTCGTCAACTTGATTTTAATTTTAACACTAGATAGTTATATAGTGTTCCTAGAAAGCCCAAGTTCACGTCGGGCTTTCG
ATACCAGACAGGAGGGCACT

Downstream 100 bases:

>100_bases
TGGGGCAAACCCTCTTGGGTGGGAGAGCCTGGCTGTAAAGCCTGCGGGGCTAGCTAGACTTCTCTGAGCTGGCGGGTCAG
AAGGGGGAGGGTTGAGAGTG

Product: metallo-beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MLFRQLFDAETSTYTYLIADPATREAALVDPVLEQVERDLKLIRELGLTLKYCLETHVHADHITGTGKLRELTGCQGVVP
VQAKAQCADRFIGHGETLQVGSVVIEAIATLGHTDSHMTYRVNGDRVLTGDALLIRGCGRTDFQSGDPGLMYDHVTQHLF
TLPDETLVYPGHDYRGHTVSTIGEEKRWNPRFVDPETGNLRSRESFIALMNSLNLPQPKKIQEAVPANEQCGQVAAAV

Sequences:

>Translated_238_residues
MLFRQLFDAETSTYTYLIADPATREAALVDPVLEQVERDLKLIRELGLTLKYCLETHVHADHITGTGKLRELTGCQGVVP
VQAKAQCADRFIGHGETLQVGSVVIEAIATLGHTDSHMTYRVNGDRVLTGDALLIRGCGRTDFQSGDPGLMYDHVTQHLF
TLPDETLVYPGHDYRGHTVSTIGEEKRWNPRFVDPETGNLRSRESFIALMNSLNLPQPKKIQEAVPANEQCGQVAAAV
>Mature_238_residues
MLFRQLFDAETSTYTYLIADPATREAALVDPVLEQVERDLKLIRELGLTLKYCLETHVHADHITGTGKLRELTGCQGVVP
VQAKAQCADRFIGHGETLQVGSVVIEAIATLGHTDSHMTYRVNGDRVLTGDALLIRGCGRTDFQSGDPGLMYDHVTQHLF
TLPDETLVYPGHDYRGHTVSTIGEEKRWNPRFVDPETGNLRSRESFIALMNSLNLPQPKKIQEAVPANEQCGQVAAAV

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=234, Percent_Identity=49.1452991452991, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI94538322, Length=231, Percent_Identity=32.9004329004329, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI94538320, Length=231, Percent_Identity=32.9004329004329, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI14150041, Length=210, Percent_Identity=30.4761904761905, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI46361987, Length=200, Percent_Identity=31.5, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI116642887, Length=219, Percent_Identity=28.7671232876712, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21703352, Length=219, Percent_Identity=28.7671232876712, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1787158, Length=216, Percent_Identity=29.6296296296296, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538952, Length=233, Percent_Identity=43.3476394849785, Blast_Score=200, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17536925, Length=183, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221330176, Length=233, Percent_Identity=50.6437768240343, Blast_Score=249, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24667703, Length=225, Percent_Identity=32, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21356335, Length=225, Percent_Identity=32, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24667711, Length=225, Percent_Identity=32, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 26309; Mature: 26309

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFRQLFDAETSTYTYLIADPATREAALVDPVLEQVERDLKLIRELGLTLKYCLETHVHA
CCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DHITGTGKLRELTGCQGVVPVQAKAQCADRFIGHGETLQVGSVVIEAIATLGHTDSHMTY
HCCCCCCCHHHHCCCCCEECCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCCEEE
RVNGDRVLTGDALLIRGCGRTDFQSGDPGLMYDHVTQHLFTLPDETLVYPGHDYRGHTVS
EECCCEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHH
TIGEEKRWNPRFVDPETGNLRSRESFIALMNSLNLPQPKKIQEAVPANEQCGQVAAAV
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MLFRQLFDAETSTYTYLIADPATREAALVDPVLEQVERDLKLIRELGLTLKYCLETHVHA
CCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DHITGTGKLRELTGCQGVVPVQAKAQCADRFIGHGETLQVGSVVIEAIATLGHTDSHMTY
HCCCCCCCHHHHCCCCCEECCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCCEEE
RVNGDRVLTGDALLIRGCGRTDFQSGDPGLMYDHVTQHLFTLPDETLVYPGHDYRGHTVS
EECCCEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHH
TIGEEKRWNPRFVDPETGNLRSRESFIALMNSLNLPQPKKIQEAVPANEQCGQVAAAV
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]