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The map label for this gene is crtE [C]

Identifier: 86609315

GI number: 86609315

Start: 1941223

End: 1942116

Strand: Reverse

Name: crtE [C]

Synonym: CYB_1859

Alternate gene names: 86609315

Gene position: 1942116-1941223 (Counterclockwise)

Preceding gene: 86609316

Following gene: 86609314

Centisome position: 63.75

GC content: 59.73

Gene sequence:

>894_bases
TTGGTTGCCCAAACCTTTAACCTGAAAGCCTACCTGAGCCAGCGTCAGCAACAGGTGGAAGAAGCTCTCTCTGCAGCTTT
GGTTCCCGCCTATCCGGAGCGCATTTACGAGGCGATGCGCTACAGCCTATTGGCAGGGGGGAAGCGCCTCAGGCCCATCC
TCTGTCTGGCTGCTTGCGAGTTGGCCGGCGGCACTGTGGAGCAGGCTCTGCCTACCGCCTGTGCCCTGGAAATGATCCAC
ACCATGTCGCTCATCCATGACGACTTGCCGGCCATGGACAATGACGACTTTCGCCGCGGCAAACCCACCAACCACAAGGT
GTTCGGCGAAGACATTGCCATCTTGGCAGGAGATGCCCTGCTGGCCTTTGCCTTTGAGCACATTGCCAGCCAAACTCAGG
GGGTACCGCCGCAGTTGGTGTTACAGGTGATCGCCCGCATTGGCCATGCTGTGGCTGCAACCGGTTTGGTGGGGGGACAG
GTGGTGGATCTGGAGTCGGAGGGCAAGGCCATTTCCCTGGAAACTCTGGAGTACATTCACAGCCACAAAACCGGCGCTCT
ATTGGAAGTCTCGGTGGTTTCGGGAGGGATCCTGGCGGGGGGAGATGAGGAGCTGCTGGCCCACCTGAGCCGCTACGCCC
GCGATATTGGCTTGGCCTTTCAGATTGTGGACGACATTTTGGACATCACCGCCACCAGCGAGCAACTGGGCAAAACGGCA
GGCAAGGATCAAGCTGCCGCCAAAGCCACCTATCCCAGCTTGTTGGGCCTAGAGGCCTCCCGGCAAAAAGCCGAGGAGCT
GATTCAATCGGCCAAGGAAACGTTGCGCCCCTACGGACCGCGGGCAGAACCGCTGCTGGCTCTGGCGGACTTCATCACTC
GCCGTCAGCATTAG

Upstream 100 bases:

>100_bases
TCCCCAATTAAAGTGGACATGAGATAATGACACCTGACAAGTCTGTTGAAGAACGGCTCGACAAGGATCCCCCCATTGCC
GAGTTGAGAGGAAACCCCGC

Downstream 100 bases:

>100_bases
GGCAGGACAAGAGGACAAGTTAGATGGGATCCCTGGAGACCCTGCTCGCATTCCTGTGCTGGAGAGCCGTATGCTGCAAC
AGTTGATGGCCAATCATGTC

Product: geranylgeranyl diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MVAQTFNLKAYLSQRQQQVEEALSAALVPAYPERIYEAMRYSLLAGGKRLRPILCLAACELAGGTVEQALPTACALEMIH
TMSLIHDDLPAMDNDDFRRGKPTNHKVFGEDIAILAGDALLAFAFEHIASQTQGVPPQLVLQVIARIGHAVAATGLVGGQ
VVDLESEGKAISLETLEYIHSHKTGALLEVSVVSGGILAGGDEELLAHLSRYARDIGLAFQIVDDILDITATSEQLGKTA
GKDQAAAKATYPSLLGLEASRQKAEELIQSAKETLRPYGPRAEPLLALADFITRRQH

Sequences:

>Translated_297_residues
MVAQTFNLKAYLSQRQQQVEEALSAALVPAYPERIYEAMRYSLLAGGKRLRPILCLAACELAGGTVEQALPTACALEMIH
TMSLIHDDLPAMDNDDFRRGKPTNHKVFGEDIAILAGDALLAFAFEHIASQTQGVPPQLVLQVIARIGHAVAATGLVGGQ
VVDLESEGKAISLETLEYIHSHKTGALLEVSVVSGGILAGGDEELLAHLSRYARDIGLAFQIVDDILDITATSEQLGKTA
GKDQAAAKATYPSLLGLEASRQKAEELIQSAKETLRPYGPRAEPLLALADFITRRQH
>Mature_297_residues
MVAQTFNLKAYLSQRQQQVEEALSAALVPAYPERIYEAMRYSLLAGGKRLRPILCLAACELAGGTVEQALPTACALEMIH
TMSLIHDDLPAMDNDDFRRGKPTNHKVFGEDIAILAGDALLAFAFEHIASQTQGVPPQLVLQVIARIGHAVAATGLVGGQ
VVDLESEGKAISLETLEYIHSHKTGALLEVSVVSGGILAGGDEELLAHLSRYARDIGLAFQIVDDILDITATSEQLGKTA
GKDQAAAKATYPSLLGLEASRQKAEELIQSAKETLRPYGPRAEPLLALADFITRRQH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=234, Percent_Identity=32.9059829059829, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786623, Length=287, Percent_Identity=44.5993031358885, Blast_Score=190, Evalue=8e-50,
Organism=Escherichia coli, GI1789578, Length=234, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17505681, Length=249, Percent_Identity=30.1204819277108, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24651612, Length=231, Percent_Identity=29.4372294372294, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31900; Mature: 31900

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAQTFNLKAYLSQRQQQVEEALSAALVPAYPERIYEAMRYSLLAGGKRLRPILCLAACE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAGGTVEQALPTACALEMIHTMSLIHDDLPAMDNDDFRRGKPTNHKVFGEDIAILAGDAL
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LAFAFEHIASQTQGVPPQLVLQVIARIGHAVAATGLVGGQVVDLESEGKAISLETLEYIH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHH
SHKTGALLEVSVVSGGILAGGDEELLAHLSRYARDIGLAFQIVDDILDITATSEQLGKTA
CCCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GKDQAAAKATYPSLLGLEASRQKAEELIQSAKETLRPYGPRAEPLLALADFITRRQH
CCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVAQTFNLKAYLSQRQQQVEEALSAALVPAYPERIYEAMRYSLLAGGKRLRPILCLAACE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAGGTVEQALPTACALEMIHTMSLIHDDLPAMDNDDFRRGKPTNHKVFGEDIAILAGDAL
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LAFAFEHIASQTQGVPPQLVLQVIARIGHAVAATGLVGGQVVDLESEGKAISLETLEYIH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHH
SHKTGALLEVSVVSGGILAGGDEELLAHLSRYARDIGLAFQIVDDILDITATSEQLGKTA
CCCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GKDQAAAKATYPSLLGLEASRQKAEELIQSAKETLRPYGPRAEPLLALADFITRRQH
CCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]