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The map label for this gene is pepA

Identifier: 86609275

GI number: 86609275

Start: 1904034

End: 1905566

Strand: Reverse

Name: pepA

Synonym: CYB_1818

Alternate gene names: 86609275

Gene position: 1905566-1904034 (Counterclockwise)

Preceding gene: 86609276

Following gene: 86609274

Centisome position: 62.55

GC content: 59.82

Gene sequence:

>1533_bases
ATGCAGCTTCATCTTAGCGAGCCGCCACTCACTCAAGGGGAATGTGCCCTGGTCTATTGCTTTGCCGCTTCCGGCGGGAA
TGGCCGCTTTCCTCTGCCCCCTGAGATCGCCTCTTGGGATGAAAAGGCGTGGTCAGGGCTGGTGGCGGAAACCGTTCAGG
AGCAGGGGTTTCAGGGGAAGCCGAATAGCAGTGTTGCCCTGCGCCTGACAGGAGAGATCCGCAAACTGGTGTTGGTGGGG
CTAGGGGATCCCGCCGCCCTAACGCTAGAAGCCCTACGACGGGCCACAGCCAACGGCCTGCGCCAGGCTCACAGCCTAAA
AGCCAAGCAGGTGATGCTGTCTTTGCCGGAGACGGGGTTGGATCGGGTGCGTGGGGTTCAGGCGGTGGCCGAAGCCTGCC
TACTGGTGGCGCACCGGGACAATCGGTTTAAATCTTCAGCCAAAGGGGAAGAGGAAAACAGCTTTTCTGTGCAGGAAGTA
ACTCTCTTGGTGCCGGGGTTGGCCCAGGCTCGCCCCGATTACGAAGTCGCGCTGCAGCGGGCCATTGAGATGGCGGCAGG
AACCATCTTGGCTCGGGAATTGGTGGCTGCCCCCGCCAACATTGTTACTCCTCTTGCCCTGGCCGATACCGCCCGCCAAC
TGGCCCAGGAATATGGTCTAGAGGTGGAGATTTTGGGACAGGAAGAATGCGAAGCTCTGGGGATGGGGGCTTTTTTGGGT
GTGGCCAAAGCCTCTGACCTGCCGCCCCAGTTCATTCACCTCACCTACAAGCCGGCACAAGGGGATCCTGTTACCAAATT
GGCCCTGGTGGGCAAGGGGCTGACCTTTGATTCCGGTGGGCTGAACATCAAAACCGACTCCCGCAGCATCGCCATGATGA
AAACCGACATGGGGGGAGCAGCGGCAGTTTTGGGAGCTGCACGGGCCCTAGCCGCCCTCAAGCCGCAAGTGGAGCTGCAC
TTCATCGTCGCTGCCACGGAAAACATGATCAGCGGCCATGCCATCCACCCAGGGGATATCCTCACCGCCTCTAACCAAAA
GACCATCGAGGTCAACAACACCGACGCAGAAGGTCGCCTCACCTTGGCGGATGCACTGGTGTTTGCGGAAAAGCTGGGCG
TTGATGCCATCCTCGATCTGGCTACCCTGACCGGTGCCTGTGTGATTGCCCTGGGGGAAGAAATTGCCGGCTTGTTCACC
CCGGATGAGACGTTGGCCCAGGAGCTACAGCAAGCTGCCAACCTTTCCGGCGAAAAAATCTGGCGCCTGCCGCTGGAAGA
AGGCTACTTCGAGGGTCTCAGCTCCATTGTGGCCGACATGAAAAACACCGGCCCCCGCTCAGGGGGATCCATCACCGCTG
CCCTGTTCCTGAAGCAGTTTGTGGAGAAAACCCCTTGGGCCCACCTGGATATAGCAGGCCCCGTTTGGACAGAGAAGGAT
GCAGGCTACAACAACAAAGGGGCCACCGGTTATGGGGTGCGCACCCTGGTGGAGTGGGTCTTGGCGCGGCAAGCCGCAGC
AGCTTGCTCATAA

Upstream 100 bases:

>100_bases
CTTCCGGCCCGCCCACTAGAGGGGGGATCCCTTGCCCTAAGAGCCGGCAAAATTAGATAAACTGAGGATCTGCTGTCAAC
AGCTTGGTCAAGGGTTTCTC

Downstream 100 bases:

>100_bases
CCCCGCCTTTCTGGACGTTGGGCCTTGAAAAAGCATCTACTGAGGGAGGAGCCAAGGGCTGCTTGGCTGGAGCTGTCCGA
TCCCTAAAATAGGCTTAAAA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MQLHLSEPPLTQGECALVYCFAASGGNGRFPLPPEIASWDEKAWSGLVAETVQEQGFQGKPNSSVALRLTGEIRKLVLVG
LGDPAALTLEALRRATANGLRQAHSLKAKQVMLSLPETGLDRVRGVQAVAEACLLVAHRDNRFKSSAKGEEENSFSVQEV
TLLVPGLAQARPDYEVALQRAIEMAAGTILARELVAAPANIVTPLALADTARQLAQEYGLEVEILGQEECEALGMGAFLG
VAKASDLPPQFIHLTYKPAQGDPVTKLALVGKGLTFDSGGLNIKTDSRSIAMMKTDMGGAAAVLGAARALAALKPQVELH
FIVAATENMISGHAIHPGDILTASNQKTIEVNNTDAEGRLTLADALVFAEKLGVDAILDLATLTGACVIALGEEIAGLFT
PDETLAQELQQAANLSGEKIWRLPLEEGYFEGLSSIVADMKNTGPRSGGSITAALFLKQFVEKTPWAHLDIAGPVWTEKD
AGYNNKGATGYGVRTLVEWVLARQAAAACS

Sequences:

>Translated_510_residues
MQLHLSEPPLTQGECALVYCFAASGGNGRFPLPPEIASWDEKAWSGLVAETVQEQGFQGKPNSSVALRLTGEIRKLVLVG
LGDPAALTLEALRRATANGLRQAHSLKAKQVMLSLPETGLDRVRGVQAVAEACLLVAHRDNRFKSSAKGEEENSFSVQEV
TLLVPGLAQARPDYEVALQRAIEMAAGTILARELVAAPANIVTPLALADTARQLAQEYGLEVEILGQEECEALGMGAFLG
VAKASDLPPQFIHLTYKPAQGDPVTKLALVGKGLTFDSGGLNIKTDSRSIAMMKTDMGGAAAVLGAARALAALKPQVELH
FIVAATENMISGHAIHPGDILTASNQKTIEVNNTDAEGRLTLADALVFAEKLGVDAILDLATLTGACVIALGEEIAGLFT
PDETLAQELQQAANLSGEKIWRLPLEEGYFEGLSSIVADMKNTGPRSGGSITAALFLKQFVEKTPWAHLDIAGPVWTEKD
AGYNNKGATGYGVRTLVEWVLARQAAAACS
>Mature_510_residues
MQLHLSEPPLTQGECALVYCFAASGGNGRFPLPPEIASWDEKAWSGLVAETVQEQGFQGKPNSSVALRLTGEIRKLVLVG
LGDPAALTLEALRRATANGLRQAHSLKAKQVMLSLPETGLDRVRGVQAVAEACLLVAHRDNRFKSSAKGEEENSFSVQEV
TLLVPGLAQARPDYEVALQRAIEMAAGTILARELVAAPANIVTPLALADTARQLAQEYGLEVEILGQEECEALGMGAFLG
VAKASDLPPQFIHLTYKPAQGDPVTKLALVGKGLTFDSGGLNIKTDSRSIAMMKTDMGGAAAVLGAARALAALKPQVELH
FIVAATENMISGHAIHPGDILTASNQKTIEVNNTDAEGRLTLADALVFAEKLGVDAILDLATLTGACVIALGEEIAGLFT
PDETLAQELQQAANLSGEKIWRLPLEEGYFEGLSSIVADMKNTGPRSGGSITAALFLKQFVEKTPWAHLDIAGPVWTEKD
AGYNNKGATGYGVRTLVEWVLARQAAAACS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=446, Percent_Identity=38.3408071748879, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI47155554, Length=328, Percent_Identity=37.5, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1790710, Length=475, Percent_Identity=36.8421052631579, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=40.6940063091483, Blast_Score=170, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=312, Percent_Identity=39.1025641025641, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=249, Percent_Identity=29.718875502008, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24661038, Length=324, Percent_Identity=35.8024691358025, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21355725, Length=332, Percent_Identity=35.2409638554217, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20129969, Length=334, Percent_Identity=33.2335329341317, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI221379063, Length=355, Percent_Identity=33.2394366197183, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI221379062, Length=355, Percent_Identity=33.2394366197183, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI21357381, Length=355, Percent_Identity=33.2394366197183, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24662227, Length=408, Percent_Identity=29.656862745098, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI20129963, Length=435, Percent_Identity=31.9540229885057, Blast_Score=155, Evalue=9e-38,
Organism=Drosophila melanogaster, GI161077148, Length=447, Percent_Identity=28.1879194630872, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI20130057, Length=447, Percent_Identity=28.1879194630872, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21355645, Length=487, Percent_Identity=28.3367556468172, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24662223, Length=487, Percent_Identity=28.3367556468172, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI19922386, Length=459, Percent_Identity=27.6688453159041, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646701, Length=336, Percent_Identity=27.9761904761905, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646703, Length=336, Percent_Identity=27.9761904761905, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358201, Length=336, Percent_Identity=27.9761904761905, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_SYNJB (Q2JKL5)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_478037.1
- HSSP:   P00727
- ProteinModelPortal:   Q2JKL5
- SMR:   Q2JKL5
- STRING:   Q2JKL5
- GeneID:   3901201
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_1818
- TIGR:   CYB_1818
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   RSIAMMK
- PhylomeDB:   Q2JKL5
- ProtClustDB:   PRK00913
- BioCyc:   SSP321332:CYB_1818-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53873; Mature: 53873

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 284-284 ACT_SITE 359-359

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLHLSEPPLTQGECALVYCFAASGGNGRFPLPPEIASWDEKAWSGLVAETVQEQGFQGK
CEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
PNSSVALRLTGEIRKLVLVGLGDPAALTLEALRRATANGLRQAHSLKAKQVMLSLPETGL
CCCCEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
DRVRGVQAVAEACLLVAHRDNRFKSSAKGEEENSFSVQEVTLLVPGLAQARPDYEVALQR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCCHHHHHHH
AIEMAAGTILARELVAAPANIVTPLALADTARQLAQEYGLEVEILGQEECEALGMGAFLG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHCCHHHHH
VAKASDLPPQFIHLTYKPAQGDPVTKLALVGKGLTFDSGGLNIKTDSRSIAMMKTDMGGA
HHCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCEECCCCCEEEECCCEEEEEEECCCCH
AAVLGAARALAALKPQVELHFIVAATENMISGHAIHPGDILTASNQKTIEVNNTDAEGRL
HHHHHHHHHHHHCCCCEEEEEEEEECHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCEE
TLADALVFAEKLGVDAILDLATLTGACVIALGEEIAGLFTPDETLAQELQQAANLSGEKI
EHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECHHHHCCCCCCHHHHHHHHHHHCCCCCEE
WRLPLEEGYFEGLSSIVADMKNTGPRSGGSITAALFLKQFVEKTPWAHLDIAGPVWTEKD
EECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
AGYNNKGATGYGVRTLVEWVLARQAAAACS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLHLSEPPLTQGECALVYCFAASGGNGRFPLPPEIASWDEKAWSGLVAETVQEQGFQGK
CEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
PNSSVALRLTGEIRKLVLVGLGDPAALTLEALRRATANGLRQAHSLKAKQVMLSLPETGL
CCCCEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
DRVRGVQAVAEACLLVAHRDNRFKSSAKGEEENSFSVQEVTLLVPGLAQARPDYEVALQR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCCHHHHHHH
AIEMAAGTILARELVAAPANIVTPLALADTARQLAQEYGLEVEILGQEECEALGMGAFLG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHCCHHHHH
VAKASDLPPQFIHLTYKPAQGDPVTKLALVGKGLTFDSGGLNIKTDSRSIAMMKTDMGGA
HHCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCEECCCCCEEEECCCEEEEEEECCCCH
AAVLGAARALAALKPQVELHFIVAATENMISGHAIHPGDILTASNQKTIEVNNTDAEGRL
HHHHHHHHHHHHCCCCEEEEEEEEECHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCEE
TLADALVFAEKLGVDAILDLATLTGACVIALGEEIAGLFTPDETLAQELQQAANLSGEKI
EHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECHHHHCCCCCCHHHHHHHHHHHCCCCCEE
WRLPLEEGYFEGLSSIVADMKNTGPRSGGSITAALFLKQFVEKTPWAHLDIAGPVWTEKD
EECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
AGYNNKGATGYGVRTLVEWVLARQAAAACS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA