Click here to switch to the map view.

The map label for this gene is ndhD1 [H]

Identifier: 86609268

GI number: 86609268

Start: 1894838

End: 1896346

Strand: Reverse

Name: ndhD1 [H]

Synonym: CYB_1811

Alternate gene names: 86609268

Gene position: 1896346-1894838 (Counterclockwise)

Preceding gene: 86609269

Following gene: 86609267

Centisome position: 62.24

GC content: 58.91

Gene sequence:

>1509_bases
ATGTTGAGCCTTTTGATTGGGATCCCGTTGTTGGGGAGCATCTTGATTGGGTTGATTCCCGAGCAGGCGGGGAAGGGCTT
GCACCGGGCTTTGGCCTTGGGGTTTGGGTGGGTTTTGTTTGGCCTGAGCGCGGGGCTGTTGCTGATCTTTGACCCCCACC
TTGGATCCCTGCAATTGGCGGAAAGGATGGCCTGGATCCCCCAGTTGGGCTTGGTTTATGAGGTGGGAGTGGATGGGATC
TCTCTGCCTTTGGTGGTGATGACCGGGCTGCTGGTGCTGATGGCCATTTGGGCCAGTGGCCAGGTGGAGCGGCCCCGCCT
CTACTACAGCTTGGTGCTTATGCTGGCGGCAGCGGTGGCCGGAGCTTTTTTGGCTCAGAATTTGCTGCTGTTTTTCCTGT
TCTATGAAGTGGAGCTGATCCCCCTGTATTTGCTCATCGCCATCTGGGGAGGGCCGCGCCGCACCTATGCCGCCACCAAG
TTTTTGGTTTACACCGCTCTGTCGGGGATCCTCCTCTTGATTGGCTTTTTCGGCCTCAGTTGGCTGAGCGATGCCCACAG
CTTTACCTACACCGTCCTGCAGGCCCACCCTTTACCTCGGCTGTCGCAGATCCTTTTGCTCATTCCCATTCTGCTGGGCC
TGGCCATCAAGATCCCCTTGGTGCCCTTCCACACCTGGTTGCCGGATGCCCATGTGGAGGCTTCCACCCCCATTTCCGTG
TTGCTGGCGGGTTTGCTTTTGAAGTTGGGCACCTACGGCCTGGTGCGCTTTGGCCTGCAGCTCTTGCCGGATGCCTGGGA
TCAAGCCGGGCCTTGGCTGGCCGGTTGGGCGGTGGTTAACGTGCTCTATGGATCCCTGAACGCCTTGGTGCAGCAGGATA
TGAAAAAGCTGGTGGCCTACAGCTCCATTGCCCACATGGGCTACATCCTCTTGGCTGTAGCAGCAGCCACTCCCCTCTCC
CTGGTGGGATCCGTCTTCCAGATGGTCAGCCATGGCCTCATCTCCTCGCTGCTGTTTCTTCTGGTGGGAGCCGTCTATGC
CAACACCGGCACACGGGATCTCAAGCTGCTGCGGGGATTGCTCAACCCGGAGCGGGGCTTACCGCTTATTGGCAGCTTGA
TGGTGCTAGGGGTGATGGCCAGTGGCGGCACACCGGGCATGGTGGGCTTTATAGCTGAGTTCACCCTCTTTCGGGGCAGC
TTTGCCGTCTTTCCCCTGCAAACGCTCCTGTGCATGGTGGGGACGGGATTGACGGCGGCCTATTTTCTGCTGATGGTGAA
CCGTGTCTTTTTTGGGCGCCTCTCGCAAGTGGCCATAGCCATGCAACGCCACGCCACTGAAGAGCGCCTGCCTGCTGTTG
TTTTGGCAACGCTGGTGGTGTTACTGGGCCTGCAGCCTAGCTGGGCAACCCGCTGGGTGGAGTCCACCACCTTGGCCTTG
GCCAAGGCTAACCTAGCTGGTGTTGCAGGACTGGTCACTGCCTTTCAGTTTGGGTTGTCTTCCTTTTGA

Upstream 100 bases:

>100_bases
GCAACTCTATGTGCTGGTGATTGTCATCGGGATGGTGTTGGTTACAGCTTGGCTACTGCGTTCGCCCCATTTGGGGTTGG
CCTATTGATGGGAGAGAGCC

Downstream 100 bases:

>100_bases
TGATTTGATGAGATCGACGGAGTTTCTTTTGCTCCCATGACTGCCACTCTTGCTCCTGCTCCTTCCTGCTTCTTTCTGGC
CGGCTTATCTCCTCTGGAGC

Product: NADH-ubiquinone/plastoquinone oxidoreductase subunit 4 family protein

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MLSLLIGIPLLGSILIGLIPEQAGKGLHRALALGFGWVLFGLSAGLLLIFDPHLGSLQLAERMAWIPQLGLVYEVGVDGI
SLPLVVMTGLLVLMAIWASGQVERPRLYYSLVLMLAAAVAGAFLAQNLLLFFLFYEVELIPLYLLIAIWGGPRRTYAATK
FLVYTALSGILLLIGFFGLSWLSDAHSFTYTVLQAHPLPRLSQILLLIPILLGLAIKIPLVPFHTWLPDAHVEASTPISV
LLAGLLLKLGTYGLVRFGLQLLPDAWDQAGPWLAGWAVVNVLYGSLNALVQQDMKKLVAYSSIAHMGYILLAVAAATPLS
LVGSVFQMVSHGLISSLLFLLVGAVYANTGTRDLKLLRGLLNPERGLPLIGSLMVLGVMASGGTPGMVGFIAEFTLFRGS
FAVFPLQTLLCMVGTGLTAAYFLLMVNRVFFGRLSQVAIAMQRHATEERLPAVVLATLVVLLGLQPSWATRWVESTTLAL
AKANLAGVAGLVTAFQFGLSSF

Sequences:

>Translated_502_residues
MLSLLIGIPLLGSILIGLIPEQAGKGLHRALALGFGWVLFGLSAGLLLIFDPHLGSLQLAERMAWIPQLGLVYEVGVDGI
SLPLVVMTGLLVLMAIWASGQVERPRLYYSLVLMLAAAVAGAFLAQNLLLFFLFYEVELIPLYLLIAIWGGPRRTYAATK
FLVYTALSGILLLIGFFGLSWLSDAHSFTYTVLQAHPLPRLSQILLLIPILLGLAIKIPLVPFHTWLPDAHVEASTPISV
LLAGLLLKLGTYGLVRFGLQLLPDAWDQAGPWLAGWAVVNVLYGSLNALVQQDMKKLVAYSSIAHMGYILLAVAAATPLS
LVGSVFQMVSHGLISSLLFLLVGAVYANTGTRDLKLLRGLLNPERGLPLIGSLMVLGVMASGGTPGMVGFIAEFTLFRGS
FAVFPLQTLLCMVGTGLTAAYFLLMVNRVFFGRLSQVAIAMQRHATEERLPAVVLATLVVLLGLQPSWATRWVESTTLAL
AKANLAGVAGLVTAFQFGLSSF
>Mature_502_residues
MLSLLIGIPLLGSILIGLIPEQAGKGLHRALALGFGWVLFGLSAGLLLIFDPHLGSLQLAERMAWIPQLGLVYEVGVDGI
SLPLVVMTGLLVLMAIWASGQVERPRLYYSLVLMLAAAVAGAFLAQNLLLFFLFYEVELIPLYLLIAIWGGPRRTYAATK
FLVYTALSGILLLIGFFGLSWLSDAHSFTYTVLQAHPLPRLSQILLLIPILLGLAIKIPLVPFHTWLPDAHVEASTPISV
LLAGLLLKLGTYGLVRFGLQLLPDAWDQAGPWLAGWAVVNVLYGSLNALVQQDMKKLVAYSSIAHMGYILLAVAAATPLS
LVGSVFQMVSHGLISSLLFLLVGAVYANTGTRDLKLLRGLLNPERGLPLIGSLMVLGVMASGGTPGMVGFIAEFTLFRGS
FAVFPLQTLLCMVGTGLTAAYFLLMVNRVFFGRLSQVAIAMQRHATEERLPAVVLATLVVLLGLQPSWATRWVESTTLAL
AKANLAGVAGLVTAFQFGLSSF

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=374, Percent_Identity=32.620320855615, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI251831117, Length=211, Percent_Identity=25.5924170616114, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788613, Length=417, Percent_Identity=37.8896882494005, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1788829, Length=394, Percent_Identity=31.4720812182741, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1788827, Length=284, Percent_Identity=28.8732394366197, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788831, Length=283, Percent_Identity=29.3286219081272, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788614, Length=406, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI145693160, Length=349, Percent_Identity=29.2263610315186, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI2367154, Length=338, Percent_Identity=28.1065088757396, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 53866; Mature: 53866

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLLIGIPLLGSILIGLIPEQAGKGLHRALALGFGWVLFGLSAGLLLIFDPHLGSLQLA
CCHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHH
ERMAWIPQLGLVYEVGVDGISLPLVVMTGLLVLMAIWASGQVERPRLYYSLVLMLAAAVA
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
GAFLAQNLLLFFLFYEVELIPLYLLIAIWGGPRRTYAATKFLVYTALSGILLLIGFFGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLSDAHSFTYTVLQAHPLPRLSQILLLIPILLGLAIKIPLVPFHTWLPDAHVEASTPISV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCCCCCCHHH
LLAGLLLKLGTYGLVRFGLQLLPDAWDQAGPWLAGWAVVNVLYGSLNALVQQDMKKLVAY
HHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIAHMGYILLAVAAATPLSLVGSVFQMVSHGLISSLLFLLVGAVYANTGTRDLKLLRGL
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LNPERGLPLIGSLMVLGVMASGGTPGMVGFIAEFTLFRGSFAVFPLQTLLCMVGTGLTAA
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHH
YFLLMVNRVFFGRLSQVAIAMQRHATEERLPAVVLATLVVLLGLQPSWATRWVESTTLAL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AKANLAGVAGLVTAFQFGLSSF
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSLLIGIPLLGSILIGLIPEQAGKGLHRALALGFGWVLFGLSAGLLLIFDPHLGSLQLA
CCHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHH
ERMAWIPQLGLVYEVGVDGISLPLVVMTGLLVLMAIWASGQVERPRLYYSLVLMLAAAVA
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
GAFLAQNLLLFFLFYEVELIPLYLLIAIWGGPRRTYAATKFLVYTALSGILLLIGFFGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLSDAHSFTYTVLQAHPLPRLSQILLLIPILLGLAIKIPLVPFHTWLPDAHVEASTPISV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCCCCCCHHH
LLAGLLLKLGTYGLVRFGLQLLPDAWDQAGPWLAGWAVVNVLYGSLNALVQQDMKKLVAY
HHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIAHMGYILLAVAAATPLSLVGSVFQMVSHGLISSLLFLLVGAVYANTGTRDLKLLRGL
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LNPERGLPLIGSLMVLGVMASGGTPGMVGFIAEFTLFRGSFAVFPLQTLLCMVGTGLTAA
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHH
YFLLMVNRVFFGRLSQVAIAMQRHATEERLPAVVLATLVVLLGLQPSWATRWVESTTLAL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AKANLAGVAGLVTAFQFGLSSF
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]