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The map label for this gene is mprA [H]

Identifier: 86609198

GI number: 86609198

Start: 1822506

End: 1823747

Strand: Reverse

Name: mprA [H]

Synonym: CYB_1740

Alternate gene names: 86609198

Gene position: 1823747-1822506 (Counterclockwise)

Preceding gene: 86609199

Following gene: 86609197

Centisome position: 59.86

GC content: 57.81

Gene sequence:

>1242_bases
ATGTCCCGTTTTGTGTTCGGCTCGGAGGAACTTGCGCCACTGCTCAGGCAGCAAGGTTGGCGGTTTACCACTGGATATCT
GCACATTCACCTCAAGGGACTGGATCCCTCTGAGGGTGCGGAACCCTGGGTGTTGACCTACTACCACGGCAGGCTGCTTT
TTTCTGCCGATCAACCCCTCAACACGCAAATCCTGCTGAAACGCCTATCCCGCTTTATTCCTCGCCTCAACTTGGAATGG
CCACAGCGGGCCATCTCGGTGGTGCAAGAGCGCTTGATGAAAGACCATTCCTTACCTGAGCTGCTGGAGGCTATCACGCA
ATTGGGCCTGCTCAAGCCGGGGGAGCTGGAAGATGCCCTGTGGCTCAACCTGCTTACCGATTTCGACCGCTACCTATTCG
AACGGGCAGGCACCTGTTACTTTGAGGTGCAGGAGCAGGTCGCCCAAGAGGCCCCCATTGGCGGGTTTGAGTTGGAGCCG
CTGCTGCAAGAAGCCGCCCGGCGCCACGATCGCTGGGCAGATTTGAAGGTGGCGATCCCAACCCTGTTGGCGGTGCCGGT
GGTCAATTGGGAACGGGTCAACCGCTACCGCATCACCGATGAGCAACGACAGAAGCTCCACACCCTCACCAAAGATGGCC
AGTCGCTGGAAGCAATCGCCAAGAAGCTGTGCCGGGATCGGCTGGAGGTGGCCAATCTCTTTGCCTCCTGGGCGAAAAAA
GGTTTGGTCAGCCTACAAACACCCCAAGAGCTGCTGCAGACCAAGCGCCACAACCCGATAACCATCTTGGCGGTGGACGA
CAGCGTGGTGATGCAGGAAATCCTACGGCAGTATTTGCCCAACTATCAGGTGATTACAACGGGCAACCCCGCCGAGGTGC
TTCCTTTGTTGTTTCAGCATCGGCCCCACCTGTTGTTGATGGATATCGCCATGCCGGGGATCGATGGTCTAGAGCTTTGC
CGCATTGTGCGCAGCTTAGAAGAGTTTAAGTCCCTTCCCATCCTGATGGTTACCGCTCGCGATGGTCTGCTGGCCCGCAT
CCGCGGCAAATGGTCGGGGGCAACCGCCTACTTGACCAAGCCCTTCAACGAAAGTCAGCTTAATGCAGAGGTGAAGCGGC
TTCTGGCCCAACAGCCGCCTGCCCACAGACAAAATCCTCTGTCGGTTCAGGGAGGCAGAACAGGTCATCCTGCCCTGTTT
CAGGGATCCCCCCGTTCCCTCGAGGATCAAGCCAAGGCGTAG

Upstream 100 bases:

>100_bases
TAAGTGAGCTCTCTGAAGCTCTCCTTTCGACGGTTTGAGCGTGTGGCTGAGGTGAATCGCTGCTCATTTGGCCTGAAGAA
GTTGGCCCGGAGAACGCTGC

Downstream 100 bases:

>100_bases
TGTCCTTCTGAGTTGATCCCCGTCGCCATTGGCTTTCCTGTCAAAATCAACAAAGGTTTTATGTTAGATAAGAAGTCAAC
TCAAGAGACCATAACTTGTC

Product: response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSRFVFGSEELAPLLRQQGWRFTTGYLHIHLKGLDPSEGAEPWVLTYYHGRLLFSADQPLNTQILLKRLSRFIPRLNLEW
PQRAISVVQERLMKDHSLPELLEAITQLGLLKPGELEDALWLNLLTDFDRYLFERAGTCYFEVQEQVAQEAPIGGFELEP
LLQEAARRHDRWADLKVAIPTLLAVPVVNWERVNRYRITDEQRQKLHTLTKDGQSLEAIAKKLCRDRLEVANLFASWAKK
GLVSLQTPQELLQTKRHNPITILAVDDSVVMQEILRQYLPNYQVITTGNPAEVLPLLFQHRPHLLLMDIAMPGIDGLELC
RIVRSLEEFKSLPILMVTARDGLLARIRGKWSGATAYLTKPFNESQLNAEVKRLLAQQPPAHRQNPLSVQGGRTGHPALF
QGSPRSLEDQAKA

Sequences:

>Translated_413_residues
MSRFVFGSEELAPLLRQQGWRFTTGYLHIHLKGLDPSEGAEPWVLTYYHGRLLFSADQPLNTQILLKRLSRFIPRLNLEW
PQRAISVVQERLMKDHSLPELLEAITQLGLLKPGELEDALWLNLLTDFDRYLFERAGTCYFEVQEQVAQEAPIGGFELEP
LLQEAARRHDRWADLKVAIPTLLAVPVVNWERVNRYRITDEQRQKLHTLTKDGQSLEAIAKKLCRDRLEVANLFASWAKK
GLVSLQTPQELLQTKRHNPITILAVDDSVVMQEILRQYLPNYQVITTGNPAEVLPLLFQHRPHLLLMDIAMPGIDGLELC
RIVRSLEEFKSLPILMVTARDGLLARIRGKWSGATAYLTKPFNESQLNAEVKRLLAQQPPAHRQNPLSVQGGRTGHPALF
QGSPRSLEDQAKA
>Mature_412_residues
SRFVFGSEELAPLLRQQGWRFTTGYLHIHLKGLDPSEGAEPWVLTYYHGRLLFSADQPLNTQILLKRLSRFIPRLNLEWP
QRAISVVQERLMKDHSLPELLEAITQLGLLKPGELEDALWLNLLTDFDRYLFERAGTCYFEVQEQVAQEAPIGGFELEPL
LQEAARRHDRWADLKVAIPTLLAVPVVNWERVNRYRITDEQRQKLHTLTKDGQSLEAIAKKLCRDRLEVANLFASWAKKG
LVSLQTPQELLQTKRHNPITILAVDDSVVMQEILRQYLPNYQVITTGNPAEVLPLLFQHRPHLLLMDIAMPGIDGLELCR
IVRSLEEFKSLPILMVTARDGLLARIRGKWSGATAYLTKPFNESQLNAEVKRLLAQQPPAHRQNPLSVQGGRTGHPALFQ
GSPRSLEDQAKA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=37.8151260504202, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788394, Length=155, Percent_Identity=33.5483870967742, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082012, Length=119, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790863, Length=118, Percent_Identity=33.0508474576271, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790299, Length=131, Percent_Identity=33.587786259542, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 47107; Mature: 46976

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFVFGSEELAPLLRQQGWRFTTGYLHIHLKGLDPSEGAEPWVLTYYHGRLLFSADQPL
CCCCCCCCHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCCCEEEEEECCEEEEECCCCC
NTQILLKRLSRFIPRLNLEWPQRAISVVQERLMKDHSLPELLEAITQLGLLKPGELEDAL
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHH
WLNLLTDFDRYLFERAGTCYFEVQEQVAQEAPIGGFELEPLLQEAARRHDRWADLKVAIP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
TLLAVPVVNWERVNRYRITDEQRQKLHTLTKDGQSLEAIAKKLCRDRLEVANLFASWAKK
HHHHHCCCCHHHCCCEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GLVSLQTPQELLQTKRHNPITILAVDDSVVMQEILRQYLPNYQVITTGNPAEVLPLLFQH
CCEECCCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCC
RPHLLLMDIAMPGIDGLELCRIVRSLEEFKSLPILMVTARDGLLARIRGKWSGATAYLTK
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCEEEEEC
PFNESQLNAEVKRLLAQQPPAHRQNPLSVQGGRTGHPALFQGSPRSLEDQAKA
CCCHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCEECCCCCCCHHHCCC
>Mature Secondary Structure 
SRFVFGSEELAPLLRQQGWRFTTGYLHIHLKGLDPSEGAEPWVLTYYHGRLLFSADQPL
CCCCCCCHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCCCEEEEEECCEEEEECCCCC
NTQILLKRLSRFIPRLNLEWPQRAISVVQERLMKDHSLPELLEAITQLGLLKPGELEDAL
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHH
WLNLLTDFDRYLFERAGTCYFEVQEQVAQEAPIGGFELEPLLQEAARRHDRWADLKVAIP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
TLLAVPVVNWERVNRYRITDEQRQKLHTLTKDGQSLEAIAKKLCRDRLEVANLFASWAKK
HHHHHCCCCHHHCCCEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GLVSLQTPQELLQTKRHNPITILAVDDSVVMQEILRQYLPNYQVITTGNPAEVLPLLFQH
CCEECCCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCC
RPHLLLMDIAMPGIDGLELCRIVRSLEEFKSLPILMVTARDGLLARIRGKWSGATAYLTK
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCEEEEEC
PFNESQLNAEVKRLLAQQPPAHRQNPLSVQGGRTGHPALFQGSPRSLEDQAKA
CCCHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCEECCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA