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The map label for this gene is murC

Identifier: 86609024

GI number: 86609024

Start: 1633312

End: 1634748

Strand: Direct

Name: murC

Synonym: CYB_1559

Alternate gene names: 86609024

Gene position: 1633312-1634748 (Clockwise)

Preceding gene: 86609020

Following gene: 86609025

Centisome position: 53.61

GC content: 60.4

Gene sequence:

>1437_bases
TTGCCGGTTCCGTCTCAGCCTCTGCCCCTGCATTTGGATCCCCTAGATCCCTTGCTTTCGACCTATCACTTTGTGGGCAT
TGGTGGAGTAGGGATGTCGGCCCTGGCCTATATCCTGGCTAAACAAGGGTTTCGCGTTTCCGGATCCGACATTGTCGCCA
ATGGCCGTACCCGCCGCCTGGAAGCTTTGGGGGTGCGCTTCTTTCAGGGCCACAGCTCGGAGGGATTGGTCGGGGATCCC
CAGGTGGTCTATTCCAGCGCCATTCGCCCCACCAATCCAGAATTGGCTGCTGCCCTGGGCAAGGGATTGACGGTTTGGCA
CCGGGCAGACTTGTTGGCGGCTCTGTTTAACCGTCGCTCTGGCATTGGGGTGGCCGGCACTCACGGCAAAACCACCACCA
GCAGCATGATCGGCTATGTGTTGCTCTCGGCGGGCTGGGATCCCACCTTGATTATCGGCGGGGAAGTGGATGCCTGGGAT
GGCAATGCCCGTCTGGGCAAGGGGGAGTATTGGGTGGCCGAGGTGGATGAGTCGGATGGATCTCTGGTGCGGCTCTATCC
CAAGATTGGGGTGATCACCAACATTGAGCTGGATCACCCCGATCACTACGCCGATTTGGGGCAGGTGATCCGGGCTTTTC
AACAGTATGGGCAGCAGAGCCAAACCCTGGTGGCCTGCCTGGACTGTCCCAACGTGGCGGCTCACCTGAGGGTGGATGTG
GGCTACAGCCTGACCGGTCATCCCCAAGCCCAGTACCAAGCTCGCCAAATCCTCTACACTGCCAGTTTCACCTGCGCTGA
GATCTGGGAAAAGGGATCCCTGCTCGGACAGCTTCGCCTACAGGTGTTGGGATCCCACAACCTCAGCAATGCCCTGGCGG
CGGTTGCCGTTGGGCGACAGTTGGGCTTGGAGTTTGCGGTGATTGCCTCAGCTTTGGCGCAATTTCGGGGGGCGCATCGC
CGCTTTGAGCACAAGGGGGAAGTGGGTGGAGTCACCTTTATCGACGACTATGCCCACCATCCCAGCGAGATTCGAGCCAC
CCTGCAGGCAGCACGGCTACAGCAGCGGCGGGTGGTGGCGGTATTTCAGCCCCATCGCCACAGCCGCTTGGCTGCCCTGT
TCCAAGATTTTGCCCGCTGCTTTGGGGAGGCGGACGTAGTGGTGATCGTGCCCACGTATGGGGCAGGAGAGCCGGCGCCT
GAGGGTTCCGACAGCTTGCGCTTGGCCGTGGCGGTGGCGGAGCACCATCCCCATGTGCGCTATGTGTCGTCTTTGCCGCA
ATTGCCGGAGGTGTTGCCGTCCGTCCTGCAGCCTGGAGATCTCGCCGTTTTTTTGGGCGCAGGGGACCTAAATCAGCAGA
TAATCGCTACGATGCGGGCATATGCGGCTCAGGTGAGGGAACAGCCTGGGCAAGCCAAAAATCCAAACTTCAGCTGA

Upstream 100 bases:

>100_bases
GTCAGCAGAACGCAGTCCTTTTTTTGGAGTGTGGCGGTTTTAGGAGTGGGGTGGAGTTGCGATGGTGGAGACACTTGGAG
GAAGGGATCCCATCCCGCCG

Downstream 100 bases:

>100_bases
AAAGGAAAGCCAAAAATCCAAACTTCAGCTGAAAAGATAGCTGCTTCTGAGGTATTGAATCATGACGACGGCTCCGGTGG
TGCCTCAGCGGGACGGTTCC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MPVPSQPLPLHLDPLDPLLSTYHFVGIGGVGMSALAYILAKQGFRVSGSDIVANGRTRRLEALGVRFFQGHSSEGLVGDP
QVVYSSAIRPTNPELAAALGKGLTVWHRADLLAALFNRRSGIGVAGTHGKTTTSSMIGYVLLSAGWDPTLIIGGEVDAWD
GNARLGKGEYWVAEVDESDGSLVRLYPKIGVITNIELDHPDHYADLGQVIRAFQQYGQQSQTLVACLDCPNVAAHLRVDV
GYSLTGHPQAQYQARQILYTASFTCAEIWEKGSLLGQLRLQVLGSHNLSNALAAVAVGRQLGLEFAVIASALAQFRGAHR
RFEHKGEVGGVTFIDDYAHHPSEIRATLQAARLQQRRVVAVFQPHRHSRLAALFQDFARCFGEADVVVIVPTYGAGEPAP
EGSDSLRLAVAVAEHHPHVRYVSSLPQLPEVLPSVLQPGDLAVFLGAGDLNQQIIATMRAYAAQVREQPGQAKNPNFS

Sequences:

>Translated_478_residues
MPVPSQPLPLHLDPLDPLLSTYHFVGIGGVGMSALAYILAKQGFRVSGSDIVANGRTRRLEALGVRFFQGHSSEGLVGDP
QVVYSSAIRPTNPELAAALGKGLTVWHRADLLAALFNRRSGIGVAGTHGKTTTSSMIGYVLLSAGWDPTLIIGGEVDAWD
GNARLGKGEYWVAEVDESDGSLVRLYPKIGVITNIELDHPDHYADLGQVIRAFQQYGQQSQTLVACLDCPNVAAHLRVDV
GYSLTGHPQAQYQARQILYTASFTCAEIWEKGSLLGQLRLQVLGSHNLSNALAAVAVGRQLGLEFAVIASALAQFRGAHR
RFEHKGEVGGVTFIDDYAHHPSEIRATLQAARLQQRRVVAVFQPHRHSRLAALFQDFARCFGEADVVVIVPTYGAGEPAP
EGSDSLRLAVAVAEHHPHVRYVSSLPQLPEVLPSVLQPGDLAVFLGAGDLNQQIIATMRAYAAQVREQPGQAKNPNFS
>Mature_477_residues
PVPSQPLPLHLDPLDPLLSTYHFVGIGGVGMSALAYILAKQGFRVSGSDIVANGRTRRLEALGVRFFQGHSSEGLVGDPQ
VVYSSAIRPTNPELAAALGKGLTVWHRADLLAALFNRRSGIGVAGTHGKTTTSSMIGYVLLSAGWDPTLIIGGEVDAWDG
NARLGKGEYWVAEVDESDGSLVRLYPKIGVITNIELDHPDHYADLGQVIRAFQQYGQQSQTLVACLDCPNVAAHLRVDVG
YSLTGHPQAQYQARQILYTASFTCAEIWEKGSLLGQLRLQVLGSHNLSNALAAVAVGRQLGLEFAVIASALAQFRGAHRR
FEHKGEVGGVTFIDDYAHHPSEIRATLQAARLQQRRVVAVFQPHRHSRLAALFQDFARCFGEADVVVIVPTYGAGEPAPE
GSDSLRLAVAVAEHHPHVRYVSSLPQLPEVLPSVLQPGDLAVFLGAGDLNQQIIATMRAYAAQVREQPGQAKNPNFS

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=453, Percent_Identity=36.644591611479, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1790680, Length=471, Percent_Identity=29.5116772823779, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SYNJB (Q2JL88)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_477786.1
- ProteinModelPortal:   Q2JL88
- SMR:   Q2JL88
- STRING:   Q2JL88
- GeneID:   3901679
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_1559
- TIGR:   CYB_1559
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q2JL88
- ProtClustDB:   PRK00421
- BioCyc:   SSP321332:CYB_1559-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51509; Mature: 51378

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVPSQPLPLHLDPLDPLLSTYHFVGIGGVGMSALAYILAKQGFRVSGSDIVANGRTRRL
CCCCCCCCCEECCCHHHHHHHHHHEEECCHHHHHHHHHHHHCCCEECCCCEEECCCHHHH
EALGVRFFQGHSSEGLVGDPQVVYSSAIRPTNPELAAALGKGLTVWHRADLLAALFNRRS
HHHHHHHEECCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHCCC
GIGVAGTHGKTTTSSMIGYVLLSAGWDPTLIIGGEVDAWDGNARLGKGEYWVAEVDESDG
CCCEECCCCCCHHHHHHHHHHEECCCCCEEEECCEEECCCCCCEECCCCEEEEEECCCCC
SLVRLYPKIGVITNIELDHPDHYADLGQVIRAFQQYGQQSQTLVACLDCPNVAAHLRVDV
CEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEE
GYSLTGHPQAQYQARQILYTASFTCAEIWEKGSLLGQLRLQVLGSHNLSNALAAVAVGRQ
CCCCCCCCHHHHHHHHEEEECCCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGLEFAVIASALAQFRGAHRRFEHKGEVGGVTFIDDYAHHPSEIRATLQAARLQQRRVVA
HCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHCCEEE
VFQPHRHSRLAALFQDFARCFGEADVVVIVPTYGAGEPAPEGSDSLRLAVAVAEHHPHVR
EECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCHH
YVSSLPQLPEVLPSVLQPGDLAVFLGAGDLNQQIIATMRAYAAQVREQPGQAKNPNFS
HHHHCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PVPSQPLPLHLDPLDPLLSTYHFVGIGGVGMSALAYILAKQGFRVSGSDIVANGRTRRL
CCCCCCCCEECCCHHHHHHHHHHEEECCHHHHHHHHHHHHCCCEECCCCEEECCCHHHH
EALGVRFFQGHSSEGLVGDPQVVYSSAIRPTNPELAAALGKGLTVWHRADLLAALFNRRS
HHHHHHHEECCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHCCC
GIGVAGTHGKTTTSSMIGYVLLSAGWDPTLIIGGEVDAWDGNARLGKGEYWVAEVDESDG
CCCEECCCCCCHHHHHHHHHHEECCCCCEEEECCEEECCCCCCEECCCCEEEEEECCCCC
SLVRLYPKIGVITNIELDHPDHYADLGQVIRAFQQYGQQSQTLVACLDCPNVAAHLRVDV
CEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEE
GYSLTGHPQAQYQARQILYTASFTCAEIWEKGSLLGQLRLQVLGSHNLSNALAAVAVGRQ
CCCCCCCCHHHHHHHHEEEECCCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGLEFAVIASALAQFRGAHRRFEHKGEVGGVTFIDDYAHHPSEIRATLQAARLQQRRVVA
HCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHCCEEE
VFQPHRHSRLAALFQDFARCFGEADVVVIVPTYGAGEPAPEGSDSLRLAVAVAEHHPHVR
EECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCHH
YVSSLPQLPEVLPSVLQPGDLAVFLGAGDLNQQIIATMRAYAAQVREQPGQAKNPNFS
HHHHCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA