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The map label for this gene is gcvT [H]

Identifier: 86608619

GI number: 86608619

Start: 1177669

End: 1178793

Strand: Direct

Name: gcvT [H]

Synonym: CYB_1141

Alternate gene names: 86608619

Gene position: 1177669-1178793 (Clockwise)

Preceding gene: 86608617

Following gene: 86608621

Centisome position: 38.65

GC content: 61.42

Gene sequence:

>1125_bases
ATGAGTTCAACCCCGCTGCAGCGCACCCCCTTGTTCCCCCTTCATCAAGCTTTGGGGGCGCGATTTGTCTCTTTTGCCGG
CTGGGAAATGCCGCTGCAGTATCGGGGAGTGATAGCAGAACATCGGGCAGTGCGGGAGAGGGTGGGGACATTCGACATTT
CCCACATGGGCAAGTTCACCCTCTGGGGGCCGGAGCTGGGATCCCACCTCAGCCGTCTGGTTCCCAGCGATCTGAGCGCT
GTTCCTGTGGGATCCGGTCGCTACACCGTCCTGCTCAATCCGCTGGGGGGCATTTTGGATGATGTCATCTTCTACCGGCA
TCCACCGGAGGGTGAGCTGGAGCACTGGAGCGTGATCGTCAATGCAGCTACCCGGCAGAAGGATTGGGATTGGCTCAACC
ACCACTTCCAAGGGATCCCCGGAGTCAACCTTCAGGATCACTCCGACACTCGGGTCTTGTTGGCGGTGCAGGGGCCGGCA
GCCGAGGAGGTTCTCCAGCCCTTTTTAGAGGGATCCCTGAAGGCTTTGCGCCGGTTTCAGCACGGTCGGTTTGCCACAGC
AGCGGGAACCTCGGGAGAGACTATCTTTGTGGCCCGCACCGGCTACACCGGAGAAGATGGCTTTGAAGTTATGCTCAGCC
CCGAAGACGGCATCCGCCTTTGGGAGCAACTGATCCAGGCCGGCGTGCAACCCTGTGGGCTGGGCTGCCGCGATACCCTA
CGTCTGGAGGCCGCGCTCCATCTCTACGGGCAGGACATGGACGAGAGCACCACTCCCTTAGAAGCCGGCTTGGGCTGGTT
GGTGAACAACCCAGGGGACTACATCGGCAAGCCCGCCATCGAAAGCCAACGGCAGCAAGGGATCCCTCGCCACCTGGTGG
GGTTTCGCATGCTGCATCCGGCCATCCCCCGCAGCGGCTATGCCATCTACGCTCCCAACTCCCCTGAGCCGATCGGACGG
GTAACCAGCGGCACCCATTCTCCCAGTTTGGGCTACGGCATCGGCTTGGGCTATGTCGCTCCGGCTTGGGCCAAGGTGGG
ATCCCGGCTGGAAATTGAAATTCGGGGGCAGCGCCAGCCTGCCGAAGTGGTGAAAAAACCTTTCTACAGTGCTGCGCACC
GCTGA

Upstream 100 bases:

>100_bases
CCAGGGTACCAGCTCCCACCGTCGTCGATGGACAGGATCCCCAAAATGCGCGACGGTGAGTTTATTCTGGTCGTTACGCT
GGACGCCAAAGGGATCCCTG

Downstream 100 bases:

>100_bases
CGCAAACGGTTACAGGTTCCCGTTAACCCAGGGTTTGGCAGCTTTGGGCGTGGAGTATTCCTGTTGCAGCCGCCGCAATT
TCCGCAAGGCCCGCCGCTCA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYRGVIAEHRAVRERVGTFDISHMGKFTLWGPELGSHLSRLVPSDLSA
VPVGSGRYTVLLNPLGGILDDVIFYRHPPEGELEHWSVIVNAATRQKDWDWLNHHFQGIPGVNLQDHSDTRVLLAVQGPA
AEEVLQPFLEGSLKALRRFQHGRFATAAGTSGETIFVARTGYTGEDGFEVMLSPEDGIRLWEQLIQAGVQPCGLGCRDTL
RLEAALHLYGQDMDESTTPLEAGLGWLVNNPGDYIGKPAIESQRQQGIPRHLVGFRMLHPAIPRSGYAIYAPNSPEPIGR
VTSGTHSPSLGYGIGLGYVAPAWAKVGSRLEIEIRGQRQPAEVVKKPFYSAAHR

Sequences:

>Translated_374_residues
MSSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYRGVIAEHRAVRERVGTFDISHMGKFTLWGPELGSHLSRLVPSDLSA
VPVGSGRYTVLLNPLGGILDDVIFYRHPPEGELEHWSVIVNAATRQKDWDWLNHHFQGIPGVNLQDHSDTRVLLAVQGPA
AEEVLQPFLEGSLKALRRFQHGRFATAAGTSGETIFVARTGYTGEDGFEVMLSPEDGIRLWEQLIQAGVQPCGLGCRDTL
RLEAALHLYGQDMDESTTPLEAGLGWLVNNPGDYIGKPAIESQRQQGIPRHLVGFRMLHPAIPRSGYAIYAPNSPEPIGR
VTSGTHSPSLGYGIGLGYVAPAWAKVGSRLEIEIRGQRQPAEVVKKPFYSAAHR
>Mature_373_residues
SSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYRGVIAEHRAVRERVGTFDISHMGKFTLWGPELGSHLSRLVPSDLSAV
PVGSGRYTVLLNPLGGILDDVIFYRHPPEGELEHWSVIVNAATRQKDWDWLNHHFQGIPGVNLQDHSDTRVLLAVQGPAA
EEVLQPFLEGSLKALRRFQHGRFATAAGTSGETIFVARTGYTGEDGFEVMLSPEDGIRLWEQLIQAGVQPCGLGCRDTLR
LEAALHLYGQDMDESTTPLEAGLGWLVNNPGDYIGKPAIESQRQQGIPRHLVGFRMLHPAIPRSGYAIYAPNSPEPIGRV
TSGTHSPSLGYGIGLGYVAPAWAKVGSRLEIEIRGQRQPAEVVKKPFYSAAHR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=375, Percent_Identity=34.1333333333333, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI257796258, Length=361, Percent_Identity=33.5180055401662, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI257796254, Length=369, Percent_Identity=31.1653116531165, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI257796256, Length=319, Percent_Identity=32.6018808777429, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI24797151, Length=371, Percent_Identity=27.7628032345013, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI197927446, Length=329, Percent_Identity=25.8358662613982, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI21361378, Length=329, Percent_Identity=25.8358662613982, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI194306651, Length=371, Percent_Identity=26.1455525606469, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=37.7717391304348, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17560118, Length=377, Percent_Identity=35.0132625994695, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI32563613, Length=348, Percent_Identity=25.2873563218391, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994045, Length=381, Percent_Identity=20.997375328084, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994052, Length=381, Percent_Identity=20.997375328084, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320222, Length=384, Percent_Identity=36.9791666666667, Blast_Score=235, Evalue=7e-63,
Organism=Drosophila melanogaster, GI20129441, Length=387, Percent_Identity=37.984496124031, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI28571104, Length=273, Percent_Identity=29.3040293040293, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI20130091, Length=366, Percent_Identity=26.2295081967213, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41112; Mature: 40981

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYRGVIAEHRAVRERVGTFDISHMGKFT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEE
LWGPELGSHLSRLVPSDLSAVPVGSGRYTVLLNPLGGILDDVIFYRHPPEGELEHWSVIV
EECHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEE
NAATRQKDWDWLNHHFQGIPGVNLQDHSDTRVLLAVQGPAAEEVLQPFLEGSLKALRRFQ
EHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
HGRFATAAGTSGETIFVARTGYTGEDGFEVMLSPEDGIRLWEQLIQAGVQPCGLGCRDTL
CCCEEEECCCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHH
RLEAALHLYGQDMDESTTPLEAGLGWLVNNPGDYIGKPAIESQRQQGIPRHLVGFRMLHP
HHHHHHHHHCCCCCCCCCCHHHCCCEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHC
AIPRSGYAIYAPNSPEPIGRVTSGTHSPSLGYGIGLGYVAPAWAKVGSRLEIEIRGQRQP
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCH
AEVVKKPFYSAAHR
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYRGVIAEHRAVRERVGTFDISHMGKFT
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEE
LWGPELGSHLSRLVPSDLSAVPVGSGRYTVLLNPLGGILDDVIFYRHPPEGELEHWSVIV
EECHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEE
NAATRQKDWDWLNHHFQGIPGVNLQDHSDTRVLLAVQGPAAEEVLQPFLEGSLKALRRFQ
EHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
HGRFATAAGTSGETIFVARTGYTGEDGFEVMLSPEDGIRLWEQLIQAGVQPCGLGCRDTL
CCCEEEECCCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHH
RLEAALHLYGQDMDESTTPLEAGLGWLVNNPGDYIGKPAIESQRQQGIPRHLVGFRMLHP
HHHHHHHHHCCCCCCCCCCHHHCCCEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHC
AIPRSGYAIYAPNSPEPIGRVTSGTHSPSLGYGIGLGYVAPAWAKVGSRLEIEIRGQRQP
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCH
AEVVKKPFYSAAHR
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA