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The map label for this gene is cobA/hemD [H]

Identifier: 86608058

GI number: 86608058

Start: 575976

End: 577478

Strand: Reverse

Name: cobA/hemD [H]

Synonym: CYB_0566

Alternate gene names: 86608058

Gene position: 577478-575976 (Counterclockwise)

Preceding gene: 86608059

Following gene: 86608057

Centisome position: 18.95

GC content: 63.27

Gene sequence:

>1503_bases
ATGGGCAAGGTGTATCTAGTGGGGGCAGGGCTGGGCGGGCGGGCGGGCCTGACGCAGGGAGCACTGGAGATCCTACGGCA
GGCTGAGGCTATCTGGATCGACGAGCTGGTGGATGAGCGCTTGTTGGCAGAGTTGCCGCCGCAGGCGCAGGTGTGGCGAC
GCTCTGGGCCAGGAAGCCTCCAGGAGGGCATCCACTGGCTCATCCAGCGCTGCCGAGAAGGCAAACAGGTGGTTCACCTC
AAGTCAGGGGATCCCTTGATCTTTGGCCGCGCTCGCGAAGAGATCCAAGCCCTTAGGGAGGCGGGCTGTCCCTTTGAGAT
TTGGCCGGGGTTGTCGTCGGCCCTGGCTGGCCCCCTCTGGGCAGGGATCCCCCTGACCGATAAGCACTTAAGCCGCGTTT
TTGCCGTGCTGACTGCCCACGATCTAGAGGCCTTGCCCTGGAGCGCCCTGGCCCAGTTGGATACTTTGGTGATTTTGATG
GGATCCCGGCAGCGACAGCACATTGGCGCACGGCTGATGGAGTCTGGGATCCCGGCAGACCGACCGGTGGCCTTGATCTG
GGGGGCGGGGCAAGCAGAGCAGCAGGTGTGGGTGGGCACCTTGGCCGAGCTGCAGCAGGGGGAGAGTCAGGCAAAGTTGC
CGGGCCTACTGGTGGTTGGGGAGGTGATCCGGTTGCGGCAGGACTTTTTGCCGGGGATCCCTCCTTTGCCTCCGCCGGCT
CCCCTGGCAGGCAAGACGGTGCTGGTTACCCGTTCTGAGGGGCAATCGCCAGCTTTTCGGGAGCTGCTACAGGCCCAGGG
AGCGCGGGTGCTGGAAATGCCCACCCTGGTGATCCAGCCGCCCACCTGTTGGGATCCCTTGGATGCCGCCATTGCCCGCC
TGGGCCAATTCAACTGGCTGTTGCTGACTTCGGCCAACGGGGTGCAGGCTTTCTTTGAGCGGTTGCACCGGCAAGGTCGG
GACAGTCGGGCTCTCCACCCCGTACAAGTGGCGGTGGTGGGATCCAAGACCGCTTCCGTGCTCGCCCAGTACGGCATCCA
TCCCGATCTCATGCCCCAAGAGTTTGTGGCCGAGGCCCTGCTTCAAGTTTGGCCGGAGCCGATCTCAGGGCAGCGGATTC
TCTTTCCCAGAGTGGAGTCGGGAGGCCGGGAGGAGGTGGTACAGGGTTTGCGGCAGCGAGGGGCAGAGGTGGTGGAGGTG
GCCGCCTATCAGTCTGCCTGTCCAGCAGCAGCGGATCCCCAGGTCCTGGAAGCTCTTAAAGCCCACCAGGTGGACATCCT
CACCTTTGCCAGCTCCAAGACAGTACAGCATTTTGCCCACTTGATCCGGCAGGCAGGGCTAGGCCCTGAGATCTGGGATC
CACCCGTGCAGATTGCCGCCATTGGCCCCAAGACGGCCGCAACCTGCAAGGCTGCATTTGGTCGAGTGGACATCGCAGCC
CAGGAGTATACTTTGGAAGGATTGGTGGAAGCCCTCATCCAAGCGACCAACCGTTCTACCTAG

Upstream 100 bases:

>100_bases
AGGAGCTGTTGGGAGGCGTCTTCGATTTATATTTATATTTGCAAAGCAAGCGGGATCCCCTTCTTACAAGGGGCAAGATC
GACATTCCAAGGGGTAGGGC

Downstream 100 bases:

>100_bases
CCTTTTCAGGCCGTTCGCGGTAGCGGTGCAGAGTACCCAGGTGCTCCTCTATAATGAACCCGCCCATGCCGCCCGCGTCA
GCCAGCCGGGCATCCCAAGC

Product: uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MGKVYLVGAGLGGRAGLTQGALEILRQAEAIWIDELVDERLLAELPPQAQVWRRSGPGSLQEGIHWLIQRCREGKQVVHL
KSGDPLIFGRAREEIQALREAGCPFEIWPGLSSALAGPLWAGIPLTDKHLSRVFAVLTAHDLEALPWSALAQLDTLVILM
GSRQRQHIGARLMESGIPADRPVALIWGAGQAEQQVWVGTLAELQQGESQAKLPGLLVVGEVIRLRQDFLPGIPPLPPPA
PLAGKTVLVTRSEGQSPAFRELLQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWLLLTSANGVQAFFERLHRQGR
DSRALHPVQVAVVGSKTASVLAQYGIHPDLMPQEFVAEALLQVWPEPISGQRILFPRVESGGREEVVQGLRQRGAEVVEV
AAYQSACPAAADPQVLEALKAHQVDILTFASSKTVQHFAHLIRQAGLGPEIWDPPVQIAAIGPKTAATCKAAFGRVDIAA
QEYTLEGLVEALIQATNRST

Sequences:

>Translated_500_residues
MGKVYLVGAGLGGRAGLTQGALEILRQAEAIWIDELVDERLLAELPPQAQVWRRSGPGSLQEGIHWLIQRCREGKQVVHL
KSGDPLIFGRAREEIQALREAGCPFEIWPGLSSALAGPLWAGIPLTDKHLSRVFAVLTAHDLEALPWSALAQLDTLVILM
GSRQRQHIGARLMESGIPADRPVALIWGAGQAEQQVWVGTLAELQQGESQAKLPGLLVVGEVIRLRQDFLPGIPPLPPPA
PLAGKTVLVTRSEGQSPAFRELLQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWLLLTSANGVQAFFERLHRQGR
DSRALHPVQVAVVGSKTASVLAQYGIHPDLMPQEFVAEALLQVWPEPISGQRILFPRVESGGREEVVQGLRQRGAEVVEV
AAYQSACPAAADPQVLEALKAHQVDILTFASSKTVQHFAHLIRQAGLGPEIWDPPVQIAAIGPKTAATCKAAFGRVDIAA
QEYTLEGLVEALIQATNRST
>Mature_499_residues
GKVYLVGAGLGGRAGLTQGALEILRQAEAIWIDELVDERLLAELPPQAQVWRRSGPGSLQEGIHWLIQRCREGKQVVHLK
SGDPLIFGRAREEIQALREAGCPFEIWPGLSSALAGPLWAGIPLTDKHLSRVFAVLTAHDLEALPWSALAQLDTLVILMG
SRQRQHIGARLMESGIPADRPVALIWGAGQAEQQVWVGTLAELQQGESQAKLPGLLVVGEVIRLRQDFLPGIPPLPPPAP
LAGKTVLVTRSEGQSPAFRELLQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWLLLTSANGVQAFFERLHRQGRD
SRALHPVQVAVVGSKTASVLAQYGIHPDLMPQEFVAEALLQVWPEPISGQRILFPRVESGGREEVVQGLRQRGAEVVEVA
AYQSACPAAADPQVLEALKAHQVDILTFASSKTVQHFAHLIRQAGLGPEIWDPPVQIAAIGPKTAATCKAAFGRVDIAAQ
EYTLEGLVEALIQATNRST

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=234, Percent_Identity=36.3247863247863, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322922, Length=237, Percent_Identity=31.2236286919831, Blast_Score=94, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 54090; Mature: 53959

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYLVGAGLGGRAGLTQGALEILRQAEAIWIDELVDERLLAELPPQAQVWRRSGPGSL
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHH
QEGIHWLIQRCREGKQVVHLKSGDPLIFGRAREEIQALREAGCPFEIWPGLSSALAGPLW
HHHHHHHHHHHHCCCEEEEEECCCCEEECCHHHHHHHHHHCCCCEEECCCCHHHHCCHHH
AGIPLTDKHLSRVFAVLTAHDLEALPWSALAQLDTLVILMGSRQRQHIGARLMESGIPAD
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCC
RPVALIWGAGQAEQQVWVGTLAELQQGESQAKLPGLLVVGEVIRLRQDFLPGIPPLPPPA
CCEEEEECCCCCCHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PLAGKTVLVTRSEGQSPAFRELLQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWL
CCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCEEEECCCCCCCHHHHHHHHHCCCCEE
LLTSANGVQAFFERLHRQGRDSRALHPVQVAVVGSKTASVLAQYGIHPDLMPQEFVAEAL
EEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHH
LQVWPEPISGQRILFPRVESGGREEVVQGLRQRGAEVVEVAAYQSACPAAADPQVLEALK
HHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHH
AHQVDILTFASSKTVQHFAHLIRQAGLGPEIWDPPVQIAAIGPKTAATCKAAFGRVDIAA
HCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCEEEHH
QEYTLEGLVEALIQATNRST
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GKVYLVGAGLGGRAGLTQGALEILRQAEAIWIDELVDERLLAELPPQAQVWRRSGPGSL
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHH
QEGIHWLIQRCREGKQVVHLKSGDPLIFGRAREEIQALREAGCPFEIWPGLSSALAGPLW
HHHHHHHHHHHHCCCEEEEEECCCCEEECCHHHHHHHHHHCCCCEEECCCCHHHHCCHHH
AGIPLTDKHLSRVFAVLTAHDLEALPWSALAQLDTLVILMGSRQRQHIGARLMESGIPAD
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCC
RPVALIWGAGQAEQQVWVGTLAELQQGESQAKLPGLLVVGEVIRLRQDFLPGIPPLPPPA
CCEEEEECCCCCCHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PLAGKTVLVTRSEGQSPAFRELLQAQGARVLEMPTLVIQPPTCWDPLDAAIARLGQFNWL
CCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCEEEECCCCCCCHHHHHHHHHCCCCEE
LLTSANGVQAFFERLHRQGRDSRALHPVQVAVVGSKTASVLAQYGIHPDLMPQEFVAEAL
EEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHH
LQVWPEPISGQRILFPRVESGGREEVVQGLRQRGAEVVEVAAYQSACPAAADPQVLEALK
HHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHH
AHQVDILTFASSKTVQHFAHLIRQAGLGPEIWDPPVQIAAIGPKTAATCKAAFGRVDIAA
HCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCEEEHH
QEYTLEGLVEALIQATNRST
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]