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The map label for this gene is menB [H]

Identifier: 86608057

GI number: 86608057

Start: 575034

End: 575858

Strand: Reverse

Name: menB [H]

Synonym: CYB_0565

Alternate gene names: 86608057

Gene position: 575858-575034 (Counterclockwise)

Preceding gene: 86608058

Following gene: 86608052

Centisome position: 18.9

GC content: 59.15

Gene sequence:

>825_bases
ATGTGGCAGACGGCCAAGCTCTACGAAGACATTCTTTACGAAAAAACGGATGGCATTGCCAAGATCACCATCAACCGTCC
CCACAAGCGCAACGCCTTCCGCCCCAAGACCATTGCCGAGCTGATTGATGCGTTTGCCGATGTGCGAGAGGATCCCAGGA
TTGGAGTAGTGCTCTTAACAGGCGCCGGGCCCCATACCGATGGGAAGTATGCCTTCTGCGCCGGCGGGGATCAAAGCGTA
CGGGGCGAGGCCGGTTACCTGGATGAGGCCGGGATCCCTCGTCTCAATGTGCTGGATCTGCAGCGCATCATCCGCTCTTT
GCCCAAGGTGGTGATTGCCCTAGTGGCAGGCTACGCCATTGGGGGTGGCCATGTTTTGCATCTCATCTGCGACCTGACCA
TTGCCGCCGATAATGCCATCTTTGGGCAAACCGGCCCTAGGGTGGGCAGCTTCGATGGGGGCTTTGGGGCCGCCTACCTG
GCGCGAGTGGTGGGGCAAAAAAAAGCCCGCGAGATTTGGTTCCTCTGCCGCCAATACACCGCAGCCCAAGCCCTAGAGAT
GGGTCTGGTCAATGCCGTGGTGCCAGTGGAAGAGCTAGAAGCTGAAGGGATCCGCTGGGCGCAAGAAATTCTCCAGCACA
GCCCCTTAGCCATCCGCTGCCTCAAAGCCGCCTTCAACGCCGACTGCGATGGGCAGGTGGGGCTGCAGGAGCTGGCCGGA
GATGCGACGTTGCTGTTCTACATGACCGAAGAAGCTGCTGAGGGCAAACGCGCCTTTTTGGAAAAGCGCCCACCTAACTT
TCGCCAGTTTCCCTGGCTGCCATAG

Upstream 100 bases:

>100_bases
CGGTAGCGGTGCAGAGTACCCAGGTGCTCCTCTATAATGAACCCGCCCATGCCGCCCGCGTCAGCCAGCCGGGCATCCCA
AGCAGATACACCCAGACACC

Downstream 100 bases:

>100_bases
TTTGTTTGTTTTCATTAATTCCACTTCCCCGAAGGGAAGCGACCTGTAGGGCTGGGCTTTACCTCAAACTCAAGCAGCAG
CACCACCTGACGGAAATACC

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MWQTAKLYEDILYEKTDGIAKITINRPHKRNAFRPKTIAELIDAFADVREDPRIGVVLLTGAGPHTDGKYAFCAGGDQSV
RGEAGYLDEAGIPRLNVLDLQRIIRSLPKVVIALVAGYAIGGGHVLHLICDLTIAADNAIFGQTGPRVGSFDGGFGAAYL
ARVVGQKKAREIWFLCRQYTAAQALEMGLVNAVVPVEELEAEGIRWAQEILQHSPLAIRCLKAAFNADCDGQVGLQELAG
DATLLFYMTEEAAEGKRAFLEKRPPNFRQFPWLP

Sequences:

>Translated_274_residues
MWQTAKLYEDILYEKTDGIAKITINRPHKRNAFRPKTIAELIDAFADVREDPRIGVVLLTGAGPHTDGKYAFCAGGDQSV
RGEAGYLDEAGIPRLNVLDLQRIIRSLPKVVIALVAGYAIGGGHVLHLICDLTIAADNAIFGQTGPRVGSFDGGFGAAYL
ARVVGQKKAREIWFLCRQYTAAQALEMGLVNAVVPVEELEAEGIRWAQEILQHSPLAIRCLKAAFNADCDGQVGLQELAG
DATLLFYMTEEAAEGKRAFLEKRPPNFRQFPWLP
>Mature_274_residues
MWQTAKLYEDILYEKTDGIAKITINRPHKRNAFRPKTIAELIDAFADVREDPRIGVVLLTGAGPHTDGKYAFCAGGDQSV
RGEAGYLDEAGIPRLNVLDLQRIIRSLPKVVIALVAGYAIGGGHVLHLICDLTIAADNAIFGQTGPRVGSFDGGFGAAYL
ARVVGQKKAREIWFLCRQYTAAQALEMGLVNAVVPVEELEAEGIRWAQEILQHSPLAIRCLKAAFNADCDGQVGLQELAG
DATLLFYMTEEAAEGKRAFLEKRPPNFRQFPWLP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=267, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI31542718, Length=268, Percent_Identity=30.5970149253731, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4502327, Length=268, Percent_Identity=29.1044776119403, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI70995211, Length=225, Percent_Identity=30.6666666666667, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788597, Length=269, Percent_Identity=69.1449814126394, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1787659, Length=264, Percent_Identity=31.0606060606061, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI221142681, Length=267, Percent_Identity=32.2097378277154, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082183, Length=271, Percent_Identity=30.6273062730627, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787660, Length=265, Percent_Identity=31.6981132075472, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788682, Length=212, Percent_Identity=29.7169811320755, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=253, Percent_Identity=32.8063241106719, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=270, Percent_Identity=30.7407407407407, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=218, Percent_Identity=28.8990825688073, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=214, Percent_Identity=29.9065420560748, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=201, Percent_Identity=31.3432835820896, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=223, Percent_Identity=25.5605381165919, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=230, Percent_Identity=25.6521739130435, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=34.136546184739, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=34.136546184739, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653139, Length=272, Percent_Identity=30.5147058823529, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357171, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922422, Length=275, Percent_Identity=24.7272727272727, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650670, Length=194, Percent_Identity=30.4123711340206, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24654903, Length=216, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 29992; Mature: 29992

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWQTAKLYEDILYEKTDGIAKITINRPHKRNAFRPKTIAELIDAFADVREDPRIGVVLLT
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
GAGPHTDGKYAFCAGGDQSVRGEAGYLDEAGIPRLNVLDLQRIIRSLPKVVIALVAGYAI
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GGGHVLHLICDLTIAADNAIFGQTGPRVGSFDGGFGAAYLARVVGQKKAREIWFLCRQYT
CCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AAQALEMGLVNAVVPVEELEAEGIRWAQEILQHSPLAIRCLKAAFNADCDGQVGLQELAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHCC
DATLLFYMTEEAAEGKRAFLEKRPPNFRQFPWLP
CEEEEEEEECHHCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MWQTAKLYEDILYEKTDGIAKITINRPHKRNAFRPKTIAELIDAFADVREDPRIGVVLLT
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
GAGPHTDGKYAFCAGGDQSVRGEAGYLDEAGIPRLNVLDLQRIIRSLPKVVIALVAGYAI
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GGGHVLHLICDLTIAADNAIFGQTGPRVGSFDGGFGAAYLARVVGQKKAREIWFLCRQYT
CCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AAQALEMGLVNAVVPVEELEAEGIRWAQEILQHSPLAIRCLKAAFNADCDGQVGLQELAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHCC
DATLLFYMTEEAAEGKRAFLEKRPPNFRQFPWLP
CEEEEEEEECHHCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]