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The map label for this gene is pdhA [H]

Identifier: 86607798

GI number: 86607798

Start: 310591

End: 311592

Strand: Reverse

Name: pdhA [H]

Synonym: CYB_0299

Alternate gene names: 86607798

Gene position: 311592-310591 (Counterclockwise)

Preceding gene: 86607802

Following gene: 86607797

Centisome position: 10.23

GC content: 58.88

Gene sequence:

>1002_bases
ATGGTTCAAGAACTTACTTCGCGCTCCACAACTGCTCGCATTTCTGCCGAAGAGGCTCGTCTTCTTTATGAAGACATGGT
GCTGGGCCGCCTGTTTGAAGACAAGTGCGCCGAAATGTACTACAAGGGCAAGATGTTCGGCTTTGTGCATCTGTACAACG
GCCAAGAGGCCGTCTCTACGGGGGTGATCAAGGCGCTCAAGCCCACCGACTACGTGTGCAGCACCTACCGCGATCATGTG
CATGCCCTCAGCACCGGGATCCCGCCGCGGGCGGTCATGGCAGAGTTGTTCGGCAAGGCCACCGGCTGCAGCAAGGGTCG
GGGTGGTTCCATGCACCTCTTCTCGGCGGAGCACAATTTCTTGGGGGGCTATGCCTTTGTGGCCGAAGGGATCCCAGTGG
CGACGGGGGCTGCTTTTTCTGCCAAATATCGGGGCACCGACCAGGTAACCGCCTGCTTCTTCGGGGATGGAGCCTGCAAC
AACGGCCAGTTTTACGAGTGCCTCAACATGGCTGCCCTCTGGAAGTTGCCCATCATCTATGTGGTGGAAAATAACTTCTG
GGCTATTGGCATGGCCCATGAACGCGCCACTTCCGACACCGATATTTACCGCAAAGGCCCGGCTTTTGGCATGCCCGGCT
ACCAGGTGGATGGGATGGATGTGCTAGCAGTGCGAGAGGCCGCCCAACAGGCCATCGCCCGCGCCCGTGCCGGAGAAGGC
CCCACCTTGCTGGAGTGCATCACCTATCGTTTCCGGGGCCATTCTCTGGCCGACCCTGACGAGCTGCGCAGTCCTGAGGA
AAAAGAGTTCTGGCGGCAGCGGGATCCCATCAAGCAACTGGAACGCTATGCCCTGGAGCACAACCTAATGACCGAGGCAG
ACTTCCAAGCCATCCACGCGGAGGTCAGCGCCGTGATTGAGGACGCGGTTCTTTTTGCTCTGGAAAGCCCAGAGCCAACC
CTGGACGAGCTGCACCGTTTTGTCTTTGCCGAAGACGAGTAG

Upstream 100 bases:

>100_bases
TCCAGGTAAGGTGGCAGACAGACTGGAGCATGAGATAATGGGCAAACCGCAAAGCTCACTGCTGACCGCCTAAGATACCT
CTGATTCGTTGCACCGCAGC

Downstream 100 bases:

>100_bases
ACCCCCCCAGGTACCGGGGGAGTTCAGGAGCCGAGATCTTGCTTGGCCGGAGGATCCCTGGCCAACTCGGGTGGCCCATC
CACCTGGCGGAGCGCTATCG

Product: dehydrogenase E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVQELTSRSTTARISAEEARLLYEDMVLGRLFEDKCAEMYYKGKMFGFVHLYNGQEAVSTGVIKALKPTDYVCSTYRDHV
HALSTGIPPRAVMAELFGKATGCSKGRGGSMHLFSAEHNFLGGYAFVAEGIPVATGAAFSAKYRGTDQVTACFFGDGACN
NGQFYECLNMAALWKLPIIYVVENNFWAIGMAHERATSDTDIYRKGPAFGMPGYQVDGMDVLAVREAAQQAIARARAGEG
PTLLECITYRFRGHSLADPDELRSPEEKEFWRQRDPIKQLERYALEHNLMTEADFQAIHAEVSAVIEDAVLFALESPEPT
LDELHRFVFAEDE

Sequences:

>Translated_333_residues
MVQELTSRSTTARISAEEARLLYEDMVLGRLFEDKCAEMYYKGKMFGFVHLYNGQEAVSTGVIKALKPTDYVCSTYRDHV
HALSTGIPPRAVMAELFGKATGCSKGRGGSMHLFSAEHNFLGGYAFVAEGIPVATGAAFSAKYRGTDQVTACFFGDGACN
NGQFYECLNMAALWKLPIIYVVENNFWAIGMAHERATSDTDIYRKGPAFGMPGYQVDGMDVLAVREAAQQAIARARAGEG
PTLLECITYRFRGHSLADPDELRSPEEKEFWRQRDPIKQLERYALEHNLMTEADFQAIHAEVSAVIEDAVLFALESPEPT
LDELHRFVFAEDE
>Mature_333_residues
MVQELTSRSTTARISAEEARLLYEDMVLGRLFEDKCAEMYYKGKMFGFVHLYNGQEAVSTGVIKALKPTDYVCSTYRDHV
HALSTGIPPRAVMAELFGKATGCSKGRGGSMHLFSAEHNFLGGYAFVAEGIPVATGAAFSAKYRGTDQVTACFFGDGACN
NGQFYECLNMAALWKLPIIYVVENNFWAIGMAHERATSDTDIYRKGPAFGMPGYQVDGMDVLAVREAAQQAIARARAGEG
PTLLECITYRFRGHSLADPDELRSPEEKEFWRQRDPIKQLERYALEHNLMTEADFQAIHAEVSAVIEDAVLFALESPEPT
LDELHRFVFAEDE

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=325, Percent_Identity=40.6153846153846, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4505685, Length=325, Percent_Identity=41.2307692307692, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI291084742, Length=325, Percent_Identity=41.2307692307692, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI291084744, Length=332, Percent_Identity=40.3614457831325, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI291084757, Length=325, Percent_Identity=37.8461538461538, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI11386135, Length=330, Percent_Identity=30, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI258645172, Length=335, Percent_Identity=30.1492537313433, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=307, Percent_Identity=38.7622149837134, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17536047, Length=307, Percent_Identity=38.7622149837134, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI86563357, Length=308, Percent_Identity=27.9220779220779, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI86563355, Length=308, Percent_Identity=27.9220779220779, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=300, Percent_Identity=37, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24639744, Length=326, Percent_Identity=38.0368098159509, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI28571106, Length=326, Percent_Identity=38.0368098159509, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24639740, Length=326, Percent_Identity=38.0368098159509, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=39.344262295082, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24639748, Length=321, Percent_Identity=39.5638629283489, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI21355903, Length=332, Percent_Identity=26.2048192771084, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37018; Mature: 37018

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQELTSRSTTARISAEEARLLYEDMVLGRLFEDKCAEMYYKGKMFGFVHLYNGQEAVST
CCCCHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHH
GVIKALKPTDYVCSTYRDHVHALSTGIPPRAVMAELFGKATGCSKGRGGSMHLFSAEHNF
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
LGGYAFVAEGIPVATGAAFSAKYRGTDQVTACFFGDGACNNGQFYECLNMAALWKLPIIY
CCCCHHHHCCCCEECCCCEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEE
VVENNFWAIGMAHERATSDTDIYRKGPAFGMPGYQVDGMDVLAVREAAQQAIARARAGEG
EEECCEEEEEECHHCCCCCCHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCC
PTLLECITYRFRGHSLADPDELRSPEEKEFWRQRDPIKQLERYALEHNLMTEADFQAIHA
CHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHH
EVSAVIEDAVLFALESPEPTLDELHRFVFAEDE
HHHHHHHHHHHEEECCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MVQELTSRSTTARISAEEARLLYEDMVLGRLFEDKCAEMYYKGKMFGFVHLYNGQEAVST
CCCCHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHH
GVIKALKPTDYVCSTYRDHVHALSTGIPPRAVMAELFGKATGCSKGRGGSMHLFSAEHNF
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
LGGYAFVAEGIPVATGAAFSAKYRGTDQVTACFFGDGACNNGQFYECLNMAALWKLPIIY
CCCCHHHHCCCCEECCCCEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEE
VVENNFWAIGMAHERATSDTDIYRKGPAFGMPGYQVDGMDVLAVREAAQQAIARARAGEG
EEECCEEEEEECHHCCCCCCHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCC
PTLLECITYRFRGHSLADPDELRSPEEKEFWRQRDPIKQLERYALEHNLMTEADFQAIHA
CHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHH
EVSAVIEDAVLFALESPEPTLDELHRFVFAEDE
HHHHHHHHHHHEEECCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA