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The map label for this gene is ndhD1

Identifier: 86607797

GI number: 86607797

Start: 308751

End: 310337

Strand: Reverse

Name: ndhD1

Synonym: CYB_0298

Alternate gene names: 86607797

Gene position: 310337-308751 (Counterclockwise)

Preceding gene: 86607798

Following gene: 86607795

Centisome position: 10.19

GC content: 59.04

Gene sequence:

>1587_bases
ATGAGCAATCCTCTTGAGTTTCCCTGGCTGTCGGTGCTGGTGCTCTTGCCTCTGCTGGCAGCCTTTGGGATCCCCTTGAT
CCCCCAGAGCCGTTGGGTGCGTTGGTATGCCCTCGCTGTGGGGGCTTTTGATTTGGGCCTGATGGCCTATGTCTTTGCGC
GGCACTATGACCTGCAGGACTTTTCTCTGCAACTGGCGGAGCGCTACGCCTGGGTGCCCCAAATTGGATTCCACTGGTCG
CTGGCGGTGGACGGCCTGTCCTTGCCGCTGGTATTGCTGTCCGGTTTGATCACAACCCTGTCGATTGTGGCGGCTTGGAA
TCTCTCCCACAAGCCGCGTTTGTTTTTCTTCCTGCTGCTGCTGATGTACGGCGCCCAGGTGGGCGTATTTCTGGCGCAGG
ACATGCTTCTATTCTTCCTGATGTGGGAGATTGAGCTGGTGCCGGTCTATCTGCTCATCTCCATTTGGGGTGGGCCGAAG
CGCCAGTACGCCGCCACCAAGTTCATCCTCTACACCGCCGCCGCCTCCATTTTTATCTTGGTGGGATCCCTGGCGATGGC
CTTCTACGGCGAGGGCTTCAGCCTGGAGATGGCAGAGCTGAGCGCTAAGTCTTACCCACTGGCCTTGGAGCTGTTGGCCT
ATGCGGCTTTGCTGATTGCCTTTGGGGTGAAGCTGCCGATTTTCCCGCTGCACACCTGGCTGCCGGATGCCCACAGCGAA
GCCTCTGCTCCCATTTCCATGATCTTGGCGGGAGTTCTGCTCAAGATGGGGGGCTATGGCCTGATCCGCATGAATGTGGG
CATGTTGTCGGAAGCCCACGTGTACTTCGCCCCTGTGCTGGCGGTGTTGGGTGTGGTGAACATCATTTACGGGGCGTTGG
CGGCCTTTGGTCAGAACCATCTCAAGCGGCGCTTGGCCTATTCGTCCATTGCCCACATGGGCTTTGTGTTGATCGGGATC
TCCGCCTTCACGGAGCTGGGCATCAATGGGGCAGTGCTGCAGATGATCTCCCACGGTCTGATTGCCGCGGTTCTGTTCTT
CCTGACGGGGATCACCTACGAGCGCACCCACACCCTTGCCCTCGACAAGTTGGGAGGGTTGGCCAAGCAGATGCCGAAGG
CTTTTGCCCTGTTTACAGCGGGATCCCTGGCCTCTCTGGCGCTGCCGGGGATGAGCGGATTTGTGGGTGAGCTGACGGTG
TTCTTGGGCTTGACCACCAGCGATGCCTATGCGCCGACCTTCAAAGCTGGAATTGCCCTGCTGGCGGCAGTGGGTATCAT
TTTGACGCCCATTTACTTGCTCTCCATGCTGCGTCAGGTGTTCTACGGGGCTCAGGATCCCGGCTTGGTTTTGGAAGACT
ACCTGGGGGATGTGCGTCCGCGGGAAATGGCGGTGGCCCTCTGTCTGCTGTTGCCGATTCTCGGCATTGGCTTCTACCCG
CGCCTGGCTACCCAAACCTACGATGTCACGACGGTGGCGGTAGCTGCCCAGTTGCGCAGTGTGTTGGCAACTGAAATCGT
GCAGCGGCCTTTCTTCCCCTCGCCAGTGCAATCGGCTCAGGTGGCGGCTTTGCCTCTGGAGGATTAA

Upstream 100 bases:

>100_bases
ATCTGCGCTATTGCGCAGATTTTTTTGTAAATATCGCTTCCCATTTGTTTACACAGCTTCATATCATTGAGGTATCGAGC
ATGAGTATTTATTCCCGGTC

Downstream 100 bases:

>100_bases
AGGGGGGTCGAGACTCGGTTCTTCTTTATCTCTATTCCTTACTCTGTCCAGAAGAGCTGGTGTTCGAGGTGCAACCCGAC
TCAACTTTCAGCTCTTCTTT

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSNPLEFPWLSVLVLLPLLAAFGIPLIPQSRWVRWYALAVGAFDLGLMAYVFARHYDLQDFSLQLAERYAWVPQIGFHWS
LAVDGLSLPLVLLSGLITTLSIVAAWNLSHKPRLFFFLLLLMYGAQVGVFLAQDMLLFFLMWEIELVPVYLLISIWGGPK
RQYAATKFILYTAAASIFILVGSLAMAFYGEGFSLEMAELSAKSYPLALELLAYAALLIAFGVKLPIFPLHTWLPDAHSE
ASAPISMILAGVLLKMGGYGLIRMNVGMLSEAHVYFAPVLAVLGVVNIIYGALAAFGQNHLKRRLAYSSIAHMGFVLIGI
SAFTELGINGAVLQMISHGLIAAVLFFLTGITYERTHTLALDKLGGLAKQMPKAFALFTAGSLASLALPGMSGFVGELTV
FLGLTTSDAYAPTFKAGIALLAAVGIILTPIYLLSMLRQVFYGAQDPGLVLEDYLGDVRPREMAVALCLLLPILGIGFYP
RLATQTYDVTTVAVAAQLRSVLATEIVQRPFFPSPVQSAQVAALPLED

Sequences:

>Translated_528_residues
MSNPLEFPWLSVLVLLPLLAAFGIPLIPQSRWVRWYALAVGAFDLGLMAYVFARHYDLQDFSLQLAERYAWVPQIGFHWS
LAVDGLSLPLVLLSGLITTLSIVAAWNLSHKPRLFFFLLLLMYGAQVGVFLAQDMLLFFLMWEIELVPVYLLISIWGGPK
RQYAATKFILYTAAASIFILVGSLAMAFYGEGFSLEMAELSAKSYPLALELLAYAALLIAFGVKLPIFPLHTWLPDAHSE
ASAPISMILAGVLLKMGGYGLIRMNVGMLSEAHVYFAPVLAVLGVVNIIYGALAAFGQNHLKRRLAYSSIAHMGFVLIGI
SAFTELGINGAVLQMISHGLIAAVLFFLTGITYERTHTLALDKLGGLAKQMPKAFALFTAGSLASLALPGMSGFVGELTV
FLGLTTSDAYAPTFKAGIALLAAVGIILTPIYLLSMLRQVFYGAQDPGLVLEDYLGDVRPREMAVALCLLLPILGIGFYP
RLATQTYDVTTVAVAAQLRSVLATEIVQRPFFPSPVQSAQVAALPLED
>Mature_527_residues
SNPLEFPWLSVLVLLPLLAAFGIPLIPQSRWVRWYALAVGAFDLGLMAYVFARHYDLQDFSLQLAERYAWVPQIGFHWSL
AVDGLSLPLVLLSGLITTLSIVAAWNLSHKPRLFFFLLLLMYGAQVGVFLAQDMLLFFLMWEIELVPVYLLISIWGGPKR
QYAATKFILYTAAASIFILVGSLAMAFYGEGFSLEMAELSAKSYPLALELLAYAALLIAFGVKLPIFPLHTWLPDAHSEA
SAPISMILAGVLLKMGGYGLIRMNVGMLSEAHVYFAPVLAVLGVVNIIYGALAAFGQNHLKRRLAYSSIAHMGFVLIGIS
AFTELGINGAVLQMISHGLIAAVLFFLTGITYERTHTLALDKLGGLAKQMPKAFALFTAGSLASLALPGMSGFVGELTVF
LGLTTSDAYAPTFKAGIALLAAVGIILTPIYLLSMLRQVFYGAQDPGLVLEDYLGDVRPREMAVALCLLLPILGIGFYPR
LATQTYDVTTVAVAAQLRSVLATEIVQRPFFPSPVQSAQVAALPLED

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family

Homologues:

Organism=Homo sapiens, GI251831116, Length=387, Percent_Identity=32.5581395348837, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI251831117, Length=301, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788613, Length=423, Percent_Identity=40.4255319148936, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1788827, Length=294, Percent_Identity=25.5102040816327, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI1788831, Length=307, Percent_Identity=31.9218241042345, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788614, Length=466, Percent_Identity=27.6824034334764, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788829, Length=452, Percent_Identity=27.4336283185841, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI2367154, Length=390, Percent_Identity=26.4102564102564, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI145693160, Length=263, Percent_Identity=31.5589353612167, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU4C1_SYNJB (Q2JPJ1)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_476559.1
- STRING:   Q2JPJ1
- GeneID:   3902145
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_0298
- TIGR:   CYB_0298
- eggNOG:   COG1008
- HOGENOM:   HBG643593
- OMA:   LYEASTN
- PhylomeDB:   Q2JPJ1
- ProtClustDB:   PRK12561
- BioCyc:   SSP321332:CYB_0298-MONOMER
- HAMAP:   MF_00491
- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- PRINTS:   PR01437
- TIGRFAMs:   TIGR01972

Pfam domain/function: PF00361 Oxidored_q1

EC number: 1.6.5.3

Molecular weight: Translated: 57318; Mature: 57187

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x119f7bec)-; HASH(0x112e8c44)-; HASH(0xdd6e2a8)-; HASH(0x11d9ff60)-; HASH(0xc8b9b18)-; HASH(0x11d9c7b0)-; HASH(0x11d9c6fc)-; HASH(0x11d9c564)-; HASH(0x1101a90c)-; HASH(0x1115cdd8)-; HASH(0x11892e58)-; HASH(0xf3f36b4)-; HASH(0x11dee88c)-; HASH(0x94cdd60)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLEFPWLSVLVLLPLLAAFGIPLIPQSRWVRWYALAVGAFDLGLMAYVFARHYDLQD
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FSLQLAERYAWVPQIGFHWSLAVDGLSLPLVLLSGLITTLSIVAAWNLSHKPRLFFFLLL
HHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LMYGAQVGVFLAQDMLLFFLMWEIELVPVYLLISIWGGPKRQYAATKFILYTAAASIFIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VGSLAMAFYGEGFSLEMAELSAKSYPLALELLAYAALLIAFGVKLPIFPLHTWLPDAHSE
HHHHHHHHHCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCC
ASAPISMILAGVLLKMGGYGLIRMNVGMLSEAHVYFAPVLAVLGVVNIIYGALAAFGQNH
CCCCHHHHHHHHHHHHCCCEEEEEECCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKRRLAYSSIAHMGFVLIGISAFTELGINGAVLQMISHGLIAAVLFFLTGITYERTHTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LDKLGGLAKQMPKAFALFTAGSLASLALPGMSGFVGELTVFLGLTTSDAYAPTFKAGIAL
HHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHH
LAAVGIILTPIYLLSMLRQVFYGAQDPGLVLEDYLGDVRPREMAVALCLLLPILGIGFYP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
RLATQTYDVTTVAVAAQLRSVLATEIVQRPFFPSPVQSAQVAALPLED
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCH
>Mature Secondary Structure 
SNPLEFPWLSVLVLLPLLAAFGIPLIPQSRWVRWYALAVGAFDLGLMAYVFARHYDLQD
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FSLQLAERYAWVPQIGFHWSLAVDGLSLPLVLLSGLITTLSIVAAWNLSHKPRLFFFLLL
HHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LMYGAQVGVFLAQDMLLFFLMWEIELVPVYLLISIWGGPKRQYAATKFILYTAAASIFIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VGSLAMAFYGEGFSLEMAELSAKSYPLALELLAYAALLIAFGVKLPIFPLHTWLPDAHSE
HHHHHHHHHCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCC
ASAPISMILAGVLLKMGGYGLIRMNVGMLSEAHVYFAPVLAVLGVVNIIYGALAAFGQNH
CCCCHHHHHHHHHHHHCCCEEEEEECCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKRRLAYSSIAHMGFVLIGISAFTELGINGAVLQMISHGLIAAVLFFLTGITYERTHTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LDKLGGLAKQMPKAFALFTAGSLASLALPGMSGFVGELTVFLGLTTSDAYAPTFKAGIAL
HHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHH
LAAVGIILTPIYLLSMLRQVFYGAQDPGLVLEDYLGDVRPREMAVALCLLLPILGIGFYP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
RLATQTYDVTTVAVAAQLRSVLATEIVQRPFFPSPVQSAQVAALPLED
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA