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The map label for this gene is ubiB [C]

Identifier: 86607643

GI number: 86607643

Start: 154702

End: 156357

Strand: Direct

Name: ubiB [C]

Synonym: CYB_0141

Alternate gene names: 86607643

Gene position: 154702-156357 (Clockwise)

Preceding gene: 86607642

Following gene: 86607644

Centisome position: 5.08

GC content: 62.98

Gene sequence:

>1656_bases
ATGTTTGCCCGTCTGGCCCAGAGTGGGGCGCGTCAGGCCGAGATCCTGGAGGTGGTTTTGCGCCACGGTTGGGACTACAT
GCGCCGCTTGCTCTCTTTTGGCAAGGCTGGGGAACCCCAACTGCCCCCCCCAATGGTGCTGCGCAACATTTTGGTGGATC
TGGGGCCGGTCTATGTCAAGCTAGGCCAGCTGCTGAGCACCCGTCCGGACCTGTTGCCGCGAGAGTACATCGAGGCCCTC
AGCACTCTGCAGGCCGACGTACCTCCTGTTCCCTGGAATGCGGTGGAGATCCTGCTGCGGCAGCAGTTGCGGCAGCCGTT
GGAGCAGGTGTTCAGCAGCCTGGACACAGAGTCGGTTGCGGCGGGATCCATTGCCCAAGTCCATCGGGCTTGTCTGGTCA
GCGGCGAGTGGGTGGCCCTCAAGATCCAGCGGCCCGGGCTGGAGGCGGTGGTGGAGCGGGATACGCGGCTAATCCGGGGC
ATTGCCGAGCTGGTGGCGCAAACGGAGTTCGGCAGGTTGGCAGATGTGGTGGCCTTGGCGGATGAGTTCTGCCGGGCCAT
TCAAGCAGAGCTGGACTTTACCCAAGAGGCCCGCCACACCGAGCAGCTCCGCCAACAGTTGCAAAGGGGGCGTTGGTTTG
ATCCGGCCCAACTGGTGGTGCCGCGCATCCATTGGCCTCTCACTACGCCAAAGGTGTTGACGCTGGAGTGGATCGAGGGC
CGGCCCCTGTTGGAGGCGGATCGCAGCGACGCGGACCCGGAAAACATCGCCCGCCTCTTGACCCGCGCTTTTTTCCAGCA
GATCTGCATTGATGGCTATTTCCACGCCGATCCCCACCCCGGCAACCTCTTTTACTTGGGATCCGGTCGCGTAGCCCTGC
TGGATTGCGGCATGATTGGGCGGCTGGATCCGCGTACGCAGCAGATTCTGCTGGAGCTGATGCTGGCCATTGTCAGCCTC
GATGCCCAGCGCTGTGCCGAATTGACCCTGGAGTTGGCCCTGCCGGAAAGATCCGCGGCCCGCTCGCGGGATCAGACTGT
CAGCTTGGCCCAGCTCCAAAGCGACTACGAGCGTCTGCTGCGCCAGTACTACGCCCTGAGCATTGCGGAGCTCAACTTCA
GCCAGCTCTTTTCTGAGATCCTGCAGGCGGCCCGGCGCAACCAGATCCGCATTCCCGGCAATTTGGGCCTCTGTGCCAAG
GCGCTGGCCAATTTGGAAGGGATCGCCCGCCAGCTCACCCCCGACTACAACCTGCCGGAGCAGCTTCGCCCCCTGATGGC
GGATGTGTTTCGGGCGCAATTGCTGGGGGAGGCCCCTCTGCCTTCGCTGCTGCGCACGGCTTTGGATTTGAAAAATCTCT
CTCTGCAATCGCCGCGCCAGATGGAGCTGCTGCTCAGCCGCATCACCTCGGAAACCCAGCGCTGGAACTTGACCATCCAA
GAGCTGGACGGGATCCGCAGCAGCCTGGATCAGTCGGCCAACCGCCTTTCCTACAGCATTGTGGTCGGCTCTCTGATCGT
CGGAGCTGCCATCATCTCGGCTCAGACGCAGCGGTTTCAGGTCTTTTGGCTGAGCGAACTCCTGTTCGGGGCGGCCAGCC
TGTTGGGGCTGTGGCTCGTCATCAGCATCCTGCGCTCCGGTCGCCTGCGTGGCTAG

Upstream 100 bases:

>100_bases
GCTGCAAACCGGCTGGGATGGAACCCGTAGGGTGGCCCCTATCCCCTTTTTCTAGGGATCGGGCTTCTCTGCCATTGGAC
TTCCAGGGAGAGAGACTGCG

Downstream 100 bases:

>100_bases
ATCCCTCACTCGGATCCCAATGTTTCCAAAAGAACACCAAAACGGTATCAACGCCTCTGCGAGCGTCCCTGAAAATCCCG
GAAAAGCTCATTCTTTCGTC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MFARLAQSGARQAEILEVVLRHGWDYMRRLLSFGKAGEPQLPPPMVLRNILVDLGPVYVKLGQLLSTRPDLLPREYIEAL
STLQADVPPVPWNAVEILLRQQLRQPLEQVFSSLDTESVAAGSIAQVHRACLVSGEWVALKIQRPGLEAVVERDTRLIRG
IAELVAQTEFGRLADVVALADEFCRAIQAELDFTQEARHTEQLRQQLQRGRWFDPAQLVVPRIHWPLTTPKVLTLEWIEG
RPLLEADRSDADPENIARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMIGRLDPRTQQILLELMLAIVSL
DAQRCAELTLELALPERSAARSRDQTVSLAQLQSDYERLLRQYYALSIAELNFSQLFSEILQAARRNQIRIPGNLGLCAK
ALANLEGIARQLTPDYNLPEQLRPLMADVFRAQLLGEAPLPSLLRTALDLKNLSLQSPRQMELLLSRITSETQRWNLTIQ
ELDGIRSSLDQSANRLSYSIVVGSLIVGAAIISAQTQRFQVFWLSELLFGAASLLGLWLVISILRSGRLRG

Sequences:

>Translated_551_residues
MFARLAQSGARQAEILEVVLRHGWDYMRRLLSFGKAGEPQLPPPMVLRNILVDLGPVYVKLGQLLSTRPDLLPREYIEAL
STLQADVPPVPWNAVEILLRQQLRQPLEQVFSSLDTESVAAGSIAQVHRACLVSGEWVALKIQRPGLEAVVERDTRLIRG
IAELVAQTEFGRLADVVALADEFCRAIQAELDFTQEARHTEQLRQQLQRGRWFDPAQLVVPRIHWPLTTPKVLTLEWIEG
RPLLEADRSDADPENIARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMIGRLDPRTQQILLELMLAIVSL
DAQRCAELTLELALPERSAARSRDQTVSLAQLQSDYERLLRQYYALSIAELNFSQLFSEILQAARRNQIRIPGNLGLCAK
ALANLEGIARQLTPDYNLPEQLRPLMADVFRAQLLGEAPLPSLLRTALDLKNLSLQSPRQMELLLSRITSETQRWNLTIQ
ELDGIRSSLDQSANRLSYSIVVGSLIVGAAIISAQTQRFQVFWLSELLFGAASLLGLWLVISILRSGRLRG
>Mature_551_residues
MFARLAQSGARQAEILEVVLRHGWDYMRRLLSFGKAGEPQLPPPMVLRNILVDLGPVYVKLGQLLSTRPDLLPREYIEAL
STLQADVPPVPWNAVEILLRQQLRQPLEQVFSSLDTESVAAGSIAQVHRACLVSGEWVALKIQRPGLEAVVERDTRLIRG
IAELVAQTEFGRLADVVALADEFCRAIQAELDFTQEARHTEQLRQQLQRGRWFDPAQLVVPRIHWPLTTPKVLTLEWIEG
RPLLEADRSDADPENIARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMIGRLDPRTQQILLELMLAIVSL
DAQRCAELTLELALPERSAARSRDQTVSLAQLQSDYERLLRQYYALSIAELNFSQLFSEILQAARRNQIRIPGNLGLCAK
ALANLEGIARQLTPDYNLPEQLRPLMADVFRAQLLGEAPLPSLLRTALDLKNLSLQSPRQMELLLSRITSETQRWNLTIQ
ELDGIRSSLDQSANRLSYSIVVGSLIVGAAIISAQTQRFQVFWLSELLFGAASLLGLWLVISILRSGRLRG

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=331, Percent_Identity=30.8157099697885, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI217035081, Length=293, Percent_Identity=31.0580204778157, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI41393593, Length=276, Percent_Identity=31.8840579710145, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI34147522, Length=286, Percent_Identity=25.5244755244755, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI2367309, Length=413, Percent_Identity=28.5714285714286, Blast_Score=156, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17559152, Length=290, Percent_Identity=29.6551724137931, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32565180, Length=291, Percent_Identity=24.3986254295533, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325148, Length=446, Percent_Identity=20.8520179372197, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323282, Length=284, Percent_Identity=26.056338028169, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=257, Percent_Identity=28.7937743190661, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI22024280, Length=291, Percent_Identity=28.8659793814433, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24662575, Length=272, Percent_Identity=31.6176470588235, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI18859849, Length=247, Percent_Identity=31.5789473684211, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61838; Mature: 61838

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFARLAQSGARQAEILEVVLRHGWDYMRRLLSFGKAGEPQLPPPMVLRNILVDLGPVYVK
CCCHHHHCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGQLLSTRPDLLPREYIEALSTLQADVPPVPWNAVEILLRQQLRQPLEQVFSSLDTESVA
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AGSIAQVHRACLVSGEWVALKIQRPGLEAVVERDTRLIRGIAELVAQTEFGRLADVVALA
CCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEFCRAIQAELDFTQEARHTEQLRQQLQRGRWFDPAQLVVPRIHWPLTTPKVLTLEWIEG
HHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECC
RPLLEADRSDADPENIARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMIG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCCCC
RLDPRTQQILLELMLAIVSLDAQRCAELTLELALPERSAARSRDQTVSLAQLQSDYERLL
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHH
RQYYALSIAELNFSQLFSEILQAARRNQIRIPGNLGLCAKALANLEGIARQLTPDYNLPE
HHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
QLRPLMADVFRAQLLGEAPLPSLLRTALDLKNLSLQSPRQMELLLSRITSETQRWNLTIQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHH
ELDGIRSSLDQSANRLSYSIVVGSLIVGAAIISAQTQRFQVFWLSELLFGAASLLGLWLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISILRSGRLRG
HHHHHCCCCCC
>Mature Secondary Structure
MFARLAQSGARQAEILEVVLRHGWDYMRRLLSFGKAGEPQLPPPMVLRNILVDLGPVYVK
CCCHHHHCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGQLLSTRPDLLPREYIEALSTLQADVPPVPWNAVEILLRQQLRQPLEQVFSSLDTESVA
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AGSIAQVHRACLVSGEWVALKIQRPGLEAVVERDTRLIRGIAELVAQTEFGRLADVVALA
CCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEFCRAIQAELDFTQEARHTEQLRQQLQRGRWFDPAQLVVPRIHWPLTTPKVLTLEWIEG
HHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECC
RPLLEADRSDADPENIARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMIG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCCCC
RLDPRTQQILLELMLAIVSLDAQRCAELTLELALPERSAARSRDQTVSLAQLQSDYERLL
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHH
RQYYALSIAELNFSQLFSEILQAARRNQIRIPGNLGLCAKALANLEGIARQLTPDYNLPE
HHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
QLRPLMADVFRAQLLGEAPLPSLLRTALDLKNLSLQSPRQMELLLSRITSETQRWNLTIQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHH
ELDGIRSSLDQSANRLSYSIVVGSLIVGAAIISAQTQRFQVFWLSELLFGAASLLGLWLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISILRSGRLRG
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]