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The map label for this gene is folD

Identifier: 86607592

GI number: 86607592

Start: 105603

End: 106484

Strand: Direct

Name: folD

Synonym: CYB_0090

Alternate gene names: 86607592

Gene position: 105603-106484 (Clockwise)

Preceding gene: 86607591

Following gene: 86607597

Centisome position: 3.47

GC content: 62.36

Gene sequence:

>882_bases
ATGCCCGCAAAGATCCTCGATGGCAAAGCCTTAGCCGCCCGCTTGCAAGCGGAGATGGCCGCCCAAGTGCAAGCTTGGAT
ACCCCAGGTGGGGCGGCCACCGGGATTGGCAGTGCTGCGGGTTGGAGAGGATCCCGCCAGTGCGGCTTACGTGCGTGGCA
AAGAGCGGGCCTGTGAGCGGTTGGGCATTGCTTCTTTTGGCCGACATTTTTCCGCCCAAGACTCCCCTGCCCATTTGCTC
GACACCATCGACCAACTCAATCAGGACGAGCGGGTGGATGGCATCCTCGTCCAACTGCCCCTGCCCCCCGGCTGGGATCC
CATCCCCCCCCTTCTGGCCATCAATCCCGACAAAGATGTGGATGGACTCCATCCCCTCAACCTGGGCCGGCTGTTGCGCG
GCGAGCCCGGCCTACGCAGTTGTACCCCCTTGGGCGTGATGCGCCTGTTGCAAGCAGAAGGGATCCCGATTGCAGGCCGA
AAGGCAGTGGTGGTTGGTCGCAGCATCTTGGTGGGCAAGCCCTTGAGCTTGATGTTGTTGGCCGCCGATGCGACGGTCAC
CCTAGCCCACTCCCGCACCCCCGACTTGGCAGAAGTGACCCGCGCCGCCGACATTGTGGTGATGGCCGTGGGCCGCCCCC
GCCTATTGAGGGCAGACATGGTGAAACCCGGCGCGGTGGTCATCGACGTTGGCATCAACCGCATCGAGACCCCCACCGGA
GCCGAGCAATTGGTGGGAGATGTGGACTATGAAGCGGTCAAAGAGTTGGCCGCTGCCATCACGCCCGTACCGGGAGGCGT
AGGGCCGATGACGGTAACGATGCTGCTGGCCAACACCCTACAGAGCTATAAACTGCGCAGCCACTTGTGTAGTCATTATT
AA

Upstream 100 bases:

>100_bases
AATCATAGGGATCCCACCTGATCATTCCCCCTGCACTGCTGTCGCCATTCTGCTTCACTATGGATGGTCGTTGGATGGTT
GTCTTTATCCTTGCGCCCCC

Downstream 100 bases:

>100_bases
ACAGGAATGAAACATTTCTGTTGCATTGTTCCCTAACTTCCCTCTCTCTCTGGGAGAAGAGCTGGGGTTGGTCGCGGCAG
CGGCACAGAGCGCTTGGGGA

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPAKILDGKALAARLQAEMAAQVQAWIPQVGRPPGLAVLRVGEDPASAAYVRGKERACERLGIASFGRHFSAQDSPAHLL
DTIDQLNQDERVDGILVQLPLPPGWDPIPPLLAINPDKDVDGLHPLNLGRLLRGEPGLRSCTPLGVMRLLQAEGIPIAGR
KAVVVGRSILVGKPLSLMLLAADATVTLAHSRTPDLAEVTRAADIVVMAVGRPRLLRADMVKPGAVVIDVGINRIETPTG
AEQLVGDVDYEAVKELAAAITPVPGGVGPMTVTMLLANTLQSYKLRSHLCSHY

Sequences:

>Translated_293_residues
MPAKILDGKALAARLQAEMAAQVQAWIPQVGRPPGLAVLRVGEDPASAAYVRGKERACERLGIASFGRHFSAQDSPAHLL
DTIDQLNQDERVDGILVQLPLPPGWDPIPPLLAINPDKDVDGLHPLNLGRLLRGEPGLRSCTPLGVMRLLQAEGIPIAGR
KAVVVGRSILVGKPLSLMLLAADATVTLAHSRTPDLAEVTRAADIVVMAVGRPRLLRADMVKPGAVVIDVGINRIETPTG
AEQLVGDVDYEAVKELAAAITPVPGGVGPMTVTMLLANTLQSYKLRSHLCSHY
>Mature_292_residues
PAKILDGKALAARLQAEMAAQVQAWIPQVGRPPGLAVLRVGEDPASAAYVRGKERACERLGIASFGRHFSAQDSPAHLLD
TIDQLNQDERVDGILVQLPLPPGWDPIPPLLAINPDKDVDGLHPLNLGRLLRGEPGLRSCTPLGVMRLLQAEGIPIAGRK
AVVVGRSILVGKPLSLMLLAADATVTLAHSRTPDLAEVTRAADIVVMAVGRPRLLRADMVKPGAVVIDVGINRIETPTGA
EQLVGDVDYEAVKELAAAITPVPGGVGPMTVTMLLANTLQSYKLRSHLCSHY

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=293, Percent_Identity=47.098976109215, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI94721354, Length=293, Percent_Identity=45.3924914675768, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI222136639, Length=291, Percent_Identity=43.9862542955326, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI36796743, Length=210, Percent_Identity=25.7142857142857, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI1786741, Length=282, Percent_Identity=49.645390070922, Blast_Score=261, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17568735, Length=267, Percent_Identity=41.5730337078652, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321643, Length=297, Percent_Identity=40.0673400673401, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319558, Length=285, Percent_Identity=41.7543859649123, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322933, Length=325, Percent_Identity=25.2307692307692, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136816, Length=294, Percent_Identity=47.6190476190476, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI17136818, Length=294, Percent_Identity=47.6190476190476, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24645718, Length=286, Percent_Identity=44.0559440559441, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17137370, Length=286, Percent_Identity=44.0559440559441, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI62472483, Length=286, Percent_Identity=44.0559440559441, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI45551871, Length=286, Percent_Identity=44.0559440559441, Blast_Score=215, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_SYNJB (Q2JQ25)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_476354.1
- ProteinModelPortal:   Q2JQ25
- SMR:   Q2JQ25
- STRING:   Q2JQ25
- GeneID:   3900072
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_0090
- TIGR:   CYB_0090
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   TYVRNKQ
- PhylomeDB:   Q2JQ25
- ProtClustDB:   PRK14186
- BioCyc:   SSP321332:CYB_0090-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 31082; Mature: 30951

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKILDGKALAARLQAEMAAQVQAWIPQVGRPPGLAVLRVGEDPASAAYVRGKERACER
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHCCHHHHHHH
LGIASFGRHFSAQDSPAHLLDTIDQLNQDERVDGILVQLPLPPGWDPIPPLLAINPDKDV
HCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCC
DGLHPLNLGRLLRGEPGLRSCTPLGVMRLLQAEGIPIAGRKAVVVGRSILVGKPLSLMLL
CCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCEEEECCCCEEEEE
AADATVTLAHSRTPDLAEVTRAADIVVMAVGRPRLLRADMVKPGAVVIDVGINRIETPTG
ECCCEEEEECCCCCCHHHHHHHHCEEEEECCCCCEEHHHCCCCCEEEEEECCCCCCCCCC
AEQLVGDVDYEAVKELAAAITPVPGGVGPMTVTMLLANTLQSYKLRSHLCSHY
HHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAKILDGKALAARLQAEMAAQVQAWIPQVGRPPGLAVLRVGEDPASAAYVRGKERACER
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHCCHHHHHHH
LGIASFGRHFSAQDSPAHLLDTIDQLNQDERVDGILVQLPLPPGWDPIPPLLAINPDKDV
HCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCC
DGLHPLNLGRLLRGEPGLRSCTPLGVMRLLQAEGIPIAGRKAVVVGRSILVGKPLSLMLL
CCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCEEEECCCCEEEEE
AADATVTLAHSRTPDLAEVTRAADIVVMAVGRPRLLRADMVKPGAVVIDVGINRIETPTG
ECCCEEEEECCCCCCHHHHHHHHCEEEEECCCCCEEHHHCCCCCEEEEEECCCCCCCCCC
AEQLVGDVDYEAVKELAAAITPVPGGVGPMTVTMLLANTLQSYKLRSHLCSHY
HHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA