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The map label for this gene is ubiB [C]

Identifier: 86606594

GI number: 86606594

Start: 1960584

End: 1962242

Strand: Reverse

Name: ubiB [C]

Synonym: CYA_1948

Alternate gene names: 86606594

Gene position: 1962242-1960584 (Counterclockwise)

Preceding gene: 86606595

Following gene: 86606591

Centisome position: 66.91

GC content: 63.47

Gene sequence:

>1659_bases
GTGGTCTTTGCGCGGCTGGCCCAGAATAGCGCCCGTCAGGCGGAGATCCTAGAAGTAGTCCTGCGCCACGGCTGGGACTA
CATGCGGCGCTTGCTCTCTTTGGGCAAGGCGGAAGAGCCGCAACTGCCACCACCCCTGGTGCTGCGCAACATCCTGGTGG
ATCTGGGGCCGGTCTATGTGAAGCTGGGCCAGTTGCTGAGCACCCGCCCCGACCTGCTGCCGCGGGAGTATATCGAGGCC
CTCAGCACCCTGCAGAGCAATGTGCCCCCCGTGCCCTGGAACGCGGTGGAGATCCTGCTGCGCCAGCAGTTGCGAAAGCC
GCTGGAACAGGTATTCAGCAGCCTCGACACGGAAGCGGTGGCGGCGGGATCCATTGCCCAGGTCCATCGCGCCCATCTCG
TCAGCGGCGAAGCGGTGGCCCTCAAGATCCAGCGGCCCGGCGTGGAGGCAATAGTAGAGCGGGATACAAGGCTCATCCGC
AGCATTGCTGAATTGGTGGCGCAAACAGAATTTGGCCGGCTGGCAGACGTGGTGGCCTTGGCGGATGAGTTTTGCCGGGC
CATTCAGGCGGAGCTGGACTTTACCCAGGAAGCCCGCCACACGGAGCAGCTGCGGCAACGCCTGCAGGCTGGCCGTTGGT
TTGATCCCAACCAACTGGTGGTGCCGCGCGTCTATTGGGCTCTTACCACCCCCAAGGTGCTGACCCTGGAGTGGATCGAA
GGAAAGCCACTCCTGGAGGCGGATCGCAGCGACGCCGAGCCGCAGCAGCTTGCCCGCCTGCTCACCCGCGCCTTTTTCCA
GCAGATCTGCATCGACGGCTACTTCCACGCCGATCCCCACCCCGGCAACTTGTTCTATTTGGGATCCGGTCGCGTAGCCC
TCTTGGACTGCGGCATGATTGGGCGGCTGGATCCGCGCACGCAGCAGATTGTGCTGGAGCTGATTTTGGCCATCGTCAGC
CTGGATGCCCAGCGCTGTGCCGAACTCACCCTGGAGCTGGCCCTGCCGGAAAGCCCCAGGGGCCGCTTGCGGGATCCCGC
CGTCAGCCTGGCCCAGTTGCAGCGGGAATACGAGCGTCTTTTGCGGCAGTACTACACCCTAACTGTGGCCGAGCTGGATT
TTAGCCAGCTTTTCTCCGAGATCCTGCAAGCAGCGCGGCGCAACCAGATCCGCATCCCCGGCAACCTGGGGCTGTGCGCC
AAGGCCCTGGCCAATCTGGAAGGGATCGCCCGCCAGCTCACCCCAGACTACAATCTGCCGGAGCAAATTCGCCCCCTGAT
GGCGGACGTGTTTCGGCAGCAGTTGCTGGGGGAAGCTCCCCTACCCTCGCTGCTGCGCACAGCCTTGGACCTGAAAAACC
TCTCGCTGCAGTCGCCGCGGCAATTGGAAGTGCTGCTTAGCCGCATCACCTCGGAAACCCAACGCTGGAACCTCACCATC
CAAGAGCTGGAAGACCTCCGCATCAGCCTGGATCAGTCGGCCAACCGCCTCTCCTACAGCATCCTGGTCGGATCCCTGAT
TATCGGCGCCGCCATCATCTCGGCGCAAACCCAGCGCTTCCAGGTCTTCTGGCTGAGCGAGCTGCTTTTTGGCGCCGCCA
GCCTCTTGGGACTGTGGCTCATCCTCAGCATCCTCCGCTCCGGTCGCCTGCGCAATTAG

Upstream 100 bases:

>100_bases
CGAGAAGGGCTAGCCAGCGGCTGGGATGGAACCCGCCGGGTGGCTCCCGTGCCCTTTTTCTAAGCCTTCCTAGGCAAGCC
CGGAAGAGGAGAGGAAAGAG

Downstream 100 bases:

>100_bases
CCCCTAGCTCGGACTTGCCAGGGATCCCGATCCTAGCCATGTTGCCAAAAGCACATAAAAACGGTATCAACGCTTCTGCG
AGCGCCTCGCCAAAACCCGC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MVFARLAQNSARQAEILEVVLRHGWDYMRRLLSLGKAEEPQLPPPLVLRNILVDLGPVYVKLGQLLSTRPDLLPREYIEA
LSTLQSNVPPVPWNAVEILLRQQLRKPLEQVFSSLDTEAVAAGSIAQVHRAHLVSGEAVALKIQRPGVEAIVERDTRLIR
SIAELVAQTEFGRLADVVALADEFCRAIQAELDFTQEARHTEQLRQRLQAGRWFDPNQLVVPRVYWALTTPKVLTLEWIE
GKPLLEADRSDAEPQQLARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMIGRLDPRTQQIVLELILAIVS
LDAQRCAELTLELALPESPRGRLRDPAVSLAQLQREYERLLRQYYTLTVAELDFSQLFSEILQAARRNQIRIPGNLGLCA
KALANLEGIARQLTPDYNLPEQIRPLMADVFRQQLLGEAPLPSLLRTALDLKNLSLQSPRQLEVLLSRITSETQRWNLTI
QELEDLRISLDQSANRLSYSILVGSLIIGAAIISAQTQRFQVFWLSELLFGAASLLGLWLILSILRSGRLRN

Sequences:

>Translated_552_residues
MVFARLAQNSARQAEILEVVLRHGWDYMRRLLSLGKAEEPQLPPPLVLRNILVDLGPVYVKLGQLLSTRPDLLPREYIEA
LSTLQSNVPPVPWNAVEILLRQQLRKPLEQVFSSLDTEAVAAGSIAQVHRAHLVSGEAVALKIQRPGVEAIVERDTRLIR
SIAELVAQTEFGRLADVVALADEFCRAIQAELDFTQEARHTEQLRQRLQAGRWFDPNQLVVPRVYWALTTPKVLTLEWIE
GKPLLEADRSDAEPQQLARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMIGRLDPRTQQIVLELILAIVS
LDAQRCAELTLELALPESPRGRLRDPAVSLAQLQREYERLLRQYYTLTVAELDFSQLFSEILQAARRNQIRIPGNLGLCA
KALANLEGIARQLTPDYNLPEQIRPLMADVFRQQLLGEAPLPSLLRTALDLKNLSLQSPRQLEVLLSRITSETQRWNLTI
QELEDLRISLDQSANRLSYSILVGSLIIGAAIISAQTQRFQVFWLSELLFGAASLLGLWLILSILRSGRLRN
>Mature_552_residues
MVFARLAQNSARQAEILEVVLRHGWDYMRRLLSLGKAEEPQLPPPLVLRNILVDLGPVYVKLGQLLSTRPDLLPREYIEA
LSTLQSNVPPVPWNAVEILLRQQLRKPLEQVFSSLDTEAVAAGSIAQVHRAHLVSGEAVALKIQRPGVEAIVERDTRLIR
SIAELVAQTEFGRLADVVALADEFCRAIQAELDFTQEARHTEQLRQRLQAGRWFDPNQLVVPRVYWALTTPKVLTLEWIE
GKPLLEADRSDAEPQQLARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMIGRLDPRTQQIVLELILAIVS
LDAQRCAELTLELALPESPRGRLRDPAVSLAQLQREYERLLRQYYTLTVAELDFSQLFSEILQAARRNQIRIPGNLGLCA
KALANLEGIARQLTPDYNLPEQIRPLMADVFRQQLLGEAPLPSLLRTALDLKNLSLQSPRQLEVLLSRITSETQRWNLTI
QELEDLRISLDQSANRLSYSILVGSLIIGAAIISAQTQRFQVFWLSELLFGAASLLGLWLILSILRSGRLRN

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=331, Percent_Identity=30.8157099697885, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI217035081, Length=293, Percent_Identity=30.0341296928328, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI41393593, Length=276, Percent_Identity=30.7971014492754, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI34147522, Length=290, Percent_Identity=24.1379310344828, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI32261307, Length=347, Percent_Identity=21.9020172910663, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI2367309, Length=415, Percent_Identity=27.9518072289157, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17559152, Length=290, Percent_Identity=30, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI32565180, Length=291, Percent_Identity=26.4604810996564, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323282, Length=237, Percent_Identity=28.2700421940928, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325148, Length=448, Percent_Identity=21.6517857142857, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=257, Percent_Identity=28.4046692607004, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI22024280, Length=307, Percent_Identity=28.0130293159609, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24662575, Length=252, Percent_Identity=31.3492063492063, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI18859849, Length=249, Percent_Identity=31.3253012048193, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62214; Mature: 62214

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFARLAQNSARQAEILEVVLRHGWDYMRRLLSLGKAEEPQLPPPLVLRNILVDLGPVYV
CCHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
KLGQLLSTRPDLLPREYIEALSTLQSNVPPVPWNAVEILLRQQLRKPLEQVFSSLDTEAV
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
AAGSIAQVHRAHLVSGEAVALKIQRPGVEAIVERDTRLIRSIAELVAQTEFGRLADVVAL
HCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEFCRAIQAELDFTQEARHTEQLRQRLQAGRWFDPNQLVVPRVYWALTTPKVLTLEWIE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCEEEEEEEC
GKPLLEADRSDAEPQQLARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCCC
GRLDPRTQQIVLELILAIVSLDAQRCAELTLELALPESPRGRLRDPAVSLAQLQREYERL
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
LRQYYTLTVAELDFSQLFSEILQAARRNQIRIPGNLGLCAKALANLEGIARQLTPDYNLP
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCH
EQIRPLMADVFRQQLLGEAPLPSLLRTALDLKNLSLQSPRQLEVLLSRITSETQRWNLTI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHH
QELEDLRISLDQSANRLSYSILVGSLIIGAAIISAQTQRFQVFWLSELLFGAASLLGLWL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSILRSGRLRN
HHHHHHCCCCCC
>Mature Secondary Structure
MVFARLAQNSARQAEILEVVLRHGWDYMRRLLSLGKAEEPQLPPPLVLRNILVDLGPVYV
CCHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
KLGQLLSTRPDLLPREYIEALSTLQSNVPPVPWNAVEILLRQQLRKPLEQVFSSLDTEAV
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
AAGSIAQVHRAHLVSGEAVALKIQRPGVEAIVERDTRLIRSIAELVAQTEFGRLADVVAL
HCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEFCRAIQAELDFTQEARHTEQLRQRLQAGRWFDPNQLVVPRVYWALTTPKVLTLEWIE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCEEEEEEEC
GKPLLEADRSDAEPQQLARLLTRAFFQQICIDGYFHADPHPGNLFYLGSGRVALLDCGMI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCCC
GRLDPRTQQIVLELILAIVSLDAQRCAELTLELALPESPRGRLRDPAVSLAQLQREYERL
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
LRQYYTLTVAELDFSQLFSEILQAARRNQIRIPGNLGLCAKALANLEGIARQLTPDYNLP
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCH
EQIRPLMADVFRQQLLGEAPLPSLLRTALDLKNLSLQSPRQLEVLLSRITSETQRWNLTI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHH
QELEDLRISLDQSANRLSYSILVGSLIIGAAIISAQTQRFQVFWLSELLFGAASLLGLWL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSILRSGRLRN
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]