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The map label for this gene is pncB [H]

Identifier: 86606186

GI number: 86606186

Start: 1531693

End: 1533054

Strand: Reverse

Name: pncB [H]

Synonym: CYA_1521

Alternate gene names: 86606186

Gene position: 1533054-1531693 (Counterclockwise)

Preceding gene: 86606189

Following gene: 86606185

Centisome position: 52.27

GC content: 65.2

Gene sequence:

>1362_bases
ATGGTGAATTCAGACTTCTCCTCCCTGCAGCCCCAGGACTACGGCCTGTTGACGGATCTCTACCAGTTCACAATGGCTGC
CTGCTATGTGGGGGAGGGGCTGGAGAATCAGCCGGCGGCCTTTGAGCTGTTTGTGCGGCGCTTGCCTAGCGACTATGGCT
ACCTCATCGCCATGGGGCTGGCCCAAGCGGTGGAATACCTGCAGCAGTTGCACTTTCCGCCGCAAGCCTTGCAGGCGCTG
CGGGAGACGGGCATTTTTGCCGAGGCACCGCAACGCTTCTGGGAGCTGCTGGCTAGCTGCCGCTTCGAGGGGGATGTGTG
GGCAGTGCCGGAAGGAACGGCCGTTTTCGCCAACGAGCCGCTGCTGCGGGTAGAGGCTCCTCTGTGGCAGGCGCAACTGG
TGGAAACCTACTTGCTGACCACCTTCAACTACCAAACCCTGATTGCCACCAAGGCGGCCCGCATGCGGGATGCTGCCGGG
GATGAGGCCATTTTGTTGGAGTTCGGCACGCGGCGAGCCTTTAGCCCCCAGGCGGGCCTGTGGGCAGCGCGGGCAGCGCT
GGCGGCGGGGTTCAACGCCACCTCCAACGTCTTGGCAGCTCTCAAGCTGGGGCGCAAGCCGGCAGGCACGATGGCCCATT
CTCTGGTGATGGCCATTGCCGCCCTCTCCGGCGATGAGACCCGCGCTTTTCAAGCCTTCCGGCGCTACTTTCCCCAGGCG
GTTCTGCTCATCGATACCTACGATCCCATCCAGGGAGCGCGCACAGCGGCCCAGCTCTTTGCAGCCACCCATCCGGATCA
ACTGGGATCCCAAGGCGAGATCGGCGGCGTGCGCATCGACTCCGGGGACCTGGAGGCCCTCTCCCACCAGGTCAAGGCCA
TCCTGCCCCAGGGGGCGCCGGTCTTTGTCAGCGGCGATTTGGACGAGTACGAGATCGAACGGCTGCACCGCTCCCAAGCC
CCTATCAGCGGCTATGGAGTGGGGACGCGGCTGGTGACCGGCGAGGGCGTGAACGGAGTGTACAAATTGGTGGAGATTAA
CGGGATCCCAGTGGCCAAGGCCTCCTTTGCCAAAGCCACCCTGCCGGGGCGCAAGCAGATCTTCCGCGGTCCCACAGGGG
ACTTGCTCGGCCAGGCCGACGAGAGCCCGCCCCCTGGCTACCAGCCGCTGCTGCGCCCGATCCTGCGCAAGGGTGTGCTG
TTGGAGCCCCTGCCGGATCTGGAGGCGATTGCCCGCACCAGCCGTGCCTCGGTCCTGCGCCTGCCCCAGGCAGTGCGGCA
ACTGCGCCAGCCGGCTCCCTGGCCTATGGCCCTGACCCCTGCCCTGCAGCAGGTTAAGGATCGTCACCTGGGCTCTTCCT
AA

Upstream 100 bases:

>100_bases
CCCTGGCAGGCCAAACCTGTTACCATAGTAGCTCCAACTTTGGCAAGGACTTCTTTGCCCGCTCCCCTAGCTTTTCAGCG
GCTTGTCCCTTGAGGTTTCC

Downstream 100 bases:

>100_bases
GCAAGCAGAACCCCAGAGAAGGGGTTCCCGCTGCTCTATAATATTCTGGCTTTGGGGTTTCAGCTTTGCGAGTTTGTGCT
TGGCAAGGCGCTGAAGTCCC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MVNSDFSSLQPQDYGLLTDLYQFTMAACYVGEGLENQPAAFELFVRRLPSDYGYLIAMGLAQAVEYLQQLHFPPQALQAL
RETGIFAEAPQRFWELLASCRFEGDVWAVPEGTAVFANEPLLRVEAPLWQAQLVETYLLTTFNYQTLIATKAARMRDAAG
DEAILLEFGTRRAFSPQAGLWAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQAFRRYFPQA
VLLIDTYDPIQGARTAAQLFAATHPDQLGSQGEIGGVRIDSGDLEALSHQVKAILPQGAPVFVSGDLDEYEIERLHRSQA
PISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKATLPGRKQIFRGPTGDLLGQADESPPPGYQPLLRPILRKGVL
LEPLPDLEAIARTSRASVLRLPQAVRQLRQPAPWPMALTPALQQVKDRHLGSS

Sequences:

>Translated_453_residues
MVNSDFSSLQPQDYGLLTDLYQFTMAACYVGEGLENQPAAFELFVRRLPSDYGYLIAMGLAQAVEYLQQLHFPPQALQAL
RETGIFAEAPQRFWELLASCRFEGDVWAVPEGTAVFANEPLLRVEAPLWQAQLVETYLLTTFNYQTLIATKAARMRDAAG
DEAILLEFGTRRAFSPQAGLWAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQAFRRYFPQA
VLLIDTYDPIQGARTAAQLFAATHPDQLGSQGEIGGVRIDSGDLEALSHQVKAILPQGAPVFVSGDLDEYEIERLHRSQA
PISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKATLPGRKQIFRGPTGDLLGQADESPPPGYQPLLRPILRKGVL
LEPLPDLEAIARTSRASVLRLPQAVRQLRQPAPWPMALTPALQQVKDRHLGSS
>Mature_453_residues
MVNSDFSSLQPQDYGLLTDLYQFTMAACYVGEGLENQPAAFELFVRRLPSDYGYLIAMGLAQAVEYLQQLHFPPQALQAL
RETGIFAEAPQRFWELLASCRFEGDVWAVPEGTAVFANEPLLRVEAPLWQAQLVETYLLTTFNYQTLIATKAARMRDAAG
DEAILLEFGTRRAFSPQAGLWAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQAFRRYFPQA
VLLIDTYDPIQGARTAAQLFAATHPDQLGSQGEIGGVRIDSGDLEALSHQVKAILPQGAPVFVSGDLDEYEIERLHRSQA
PISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKATLPGRKQIFRGPTGDLLGQADESPPPGYQPLLRPILRKGVL
LEPLPDLEAIARTSRASVLRLPQAVRQLRQPAPWPMALTPALQQVKDRHLGSS

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=525, Percent_Identity=33.3333333333333, Blast_Score=188, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71997952, Length=536, Percent_Identity=30.9701492537313, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71997947, Length=536, Percent_Identity=30.9701492537313, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71997955, Length=221, Percent_Identity=37.10407239819, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24581587, Length=519, Percent_Identity=30.2504816955684, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI161076680, Length=217, Percent_Identity=38.2488479262673, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24581595, Length=217, Percent_Identity=38.2488479262673, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI28574709, Length=217, Percent_Identity=38.2488479262673, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24581593, Length=217, Percent_Identity=38.2488479262673, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24581591, Length=217, Percent_Identity=38.2488479262673, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 49206; Mature: 49206

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNSDFSSLQPQDYGLLTDLYQFTMAACYVGEGLENQPAAFELFVRRLPSDYGYLIAMGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
AQAVEYLQQLHFPPQALQALRETGIFAEAPQRFWELLASCRFEGDVWAVPEGTAVFANEP
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCEEECCCC
LLRVEAPLWQAQLVETYLLTTFNYQTLIATKAARMRDAAGDEAILLEFGTRRAFSPQAGL
CEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHH
WAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQAFRRYFPQA
HHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
VLLIDTYDPIQGARTAAQLFAATHPDQLGSQGEIGGVRIDSGDLEALSHQVKAILPQGAP
EEEEECCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCC
VFVSGDLDEYEIERLHRSQAPISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKAT
EEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHCC
LPGRKQIFRGPTGDLLGQADESPPPGYQPLLRPILRKGVLLEPLPDLEAIARTSRASVLR
CCCHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LPQAVRQLRQPAPWPMALTPALQQVKDRHLGSS
HHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVNSDFSSLQPQDYGLLTDLYQFTMAACYVGEGLENQPAAFELFVRRLPSDYGYLIAMGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
AQAVEYLQQLHFPPQALQALRETGIFAEAPQRFWELLASCRFEGDVWAVPEGTAVFANEP
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCEEECCCC
LLRVEAPLWQAQLVETYLLTTFNYQTLIATKAARMRDAAGDEAILLEFGTRRAFSPQAGL
CEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHH
WAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQAFRRYFPQA
HHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
VLLIDTYDPIQGARTAAQLFAATHPDQLGSQGEIGGVRIDSGDLEALSHQVKAILPQGAP
EEEEECCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCC
VFVSGDLDEYEIERLHRSQAPISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKAT
EEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHCC
LPGRKQIFRGPTGDLLGQADESPPPGYQPLLRPILRKGVLLEPLPDLEAIARTSRASVLR
CCCHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LPQAVRQLRQPAPWPMALTPALQQVKDRHLGSS
HHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]