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The map label for this gene is ispD

Identifier: 86606172

GI number: 86606172

Start: 1514374

End: 1515081

Strand: Reverse

Name: ispD

Synonym: CYA_1505

Alternate gene names: 86606172

Gene position: 1515081-1514374 (Counterclockwise)

Preceding gene: 86606173

Following gene: 86606171

Centisome position: 51.66

GC content: 61.3

Gene sequence:

>708_bases
ATGCACCTTCTGATCCCGGCGGCTGGCAGCGGCAAGCGAATGGGAGCTGCGGTCAATAAGCTGTTGCTGCCGCTCTTGGG
TCAGCCAATTTTGGCTTGGACGTTGCAGGCTGCGGATCGAGCCAGCTCCATCGAGTGGATCGGCATTCTCTCCCAACCCG
GCGATTGGCCGGCCATCGAGCAGATCCTGGCGGCAATGGATCTGTCCACGCCGGTGCAGCTTTTACAAGGGGGGGCGACG
CGGCAGGAGTCGGTTTACAGGGGGGTTGAGTATCTCTATAACCTGGGAACAGTAGAGCGGGTGTTGATCCACGATGGGGC
CCGCTGCCTGGCTACCCCTAAGTTATTCGATCGCTGTAGTGCTGCTTTGCAGCAGGTGGATGGTCTCATCGCGGGGATCC
CTGTCAAGGACACGATCAAGGTCACCGAGACCGGCCCCAAGGGGATCCAAATCCAATCGACACCGGAGCGCAGCCGGCTG
TGGGCAGCCCAAACGCCGCAGGGGTTTCGCCTGTCGCTGTTGTGGCAAGCCCATCGGGAGGCGCTGGCCCAGGGGTGGCA
GGTAACCGATGACGCAGCCCTATTCGAGAAGCTGGGTTGGCCGGTTTACATCGTGGAAGGGGAGGAGTCTAACCTGAAGT
TAACCACCCCCTGGGATCTGGTGCTGGCCGAGCAAATTCTCCAGCAGCGCCTTGAGCTGGCGCGCTAG

Upstream 100 bases:

>100_bases
ACTGAAAATCAAGAGAGGGGGTCAGGTCTGGCCCTCTCTTTTGTGGCTTGTTGACCTCAAGCAGTACACTGGGATCCGGT
TGAATGCGCTTTTGGATCCC

Downstream 100 bases:

>100_bases
CTCAACTCACTATGGCGATGGCCCTGACGCAGAGCCGCCTTTTGCCACACCCGACTGCGCCAGCGGCTGAGCAACAGGCC
GGCCAAGCCGGCGACATAGA

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MHLLIPAAGSGKRMGAAVNKLLLPLLGQPILAWTLQAADRASSIEWIGILSQPGDWPAIEQILAAMDLSTPVQLLQGGAT
RQESVYRGVEYLYNLGTVERVLIHDGARCLATPKLFDRCSAALQQVDGLIAGIPVKDTIKVTETGPKGIQIQSTPERSRL
WAAQTPQGFRLSLLWQAHREALAQGWQVTDDAALFEKLGWPVYIVEGEESNLKLTTPWDLVLAEQILQQRLELAR

Sequences:

>Translated_235_residues
MHLLIPAAGSGKRMGAAVNKLLLPLLGQPILAWTLQAADRASSIEWIGILSQPGDWPAIEQILAAMDLSTPVQLLQGGAT
RQESVYRGVEYLYNLGTVERVLIHDGARCLATPKLFDRCSAALQQVDGLIAGIPVKDTIKVTETGPKGIQIQSTPERSRL
WAAQTPQGFRLSLLWQAHREALAQGWQVTDDAALFEKLGWPVYIVEGEESNLKLTTPWDLVLAEQILQQRLELAR
>Mature_235_residues
MHLLIPAAGSGKRMGAAVNKLLLPLLGQPILAWTLQAADRASSIEWIGILSQPGDWPAIEQILAAMDLSTPVQLLQGGAT
RQESVYRGVEYLYNLGTVERVLIHDGARCLATPKLFDRCSAALQQVDGLIAGIPVKDTIKVTETGPKGIQIQSTPERSRL
WAAQTPQGFRLSLLWQAHREALAQGWQVTDDAALFEKLGWPVYIVEGEESNLKLTTPWDLVLAEQILQQRLELAR

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=236, Percent_Identity=24.5762711864407, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1789104, Length=230, Percent_Identity=33.9130434782609, Blast_Score=101, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD_SYNJA (Q2JUE5)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_474935.1
- ProteinModelPortal:   Q2JUE5
- STRING:   Q2JUE5
- GeneID:   3899205
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1505
- TIGR:   CYA_1505
- eggNOG:   COG1211
- HOGENOM:   HBG672839
- OMA:   PSNIKVT
- ProtClustDB:   PRK00155
- BioCyc:   SSP321327:CYA_1505-MONOMER
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294
- TIGRFAMs:   TIGR00453

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 25818; Mature: 25818

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLLIPAAGSGKRMGAAVNKLLLPLLGQPILAWTLQAADRASSIEWIGILSQPGDWPAIE
CEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHH
QILAAMDLSTPVQLLQGGATRQESVYRGVEYLYNLGTVERVLIHDGARCLATPKLFDRCS
HHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHCCHHHHHHHH
AALQQVDGLIAGIPVKDTIKVTETGPKGIQIQSTPERSRLWAAQTPQGFRLSLLWQAHRE
HHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCHHHHEEECCCCCCCEEHHHHHHHHH
ALAQGWQVTDDAALFEKLGWPVYIVEGEESNLKLTTPWDLVLAEQILQQRLELAR
HHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHLLIPAAGSGKRMGAAVNKLLLPLLGQPILAWTLQAADRASSIEWIGILSQPGDWPAIE
CEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHH
QILAAMDLSTPVQLLQGGATRQESVYRGVEYLYNLGTVERVLIHDGARCLATPKLFDRCS
HHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHCCHHHHHHHH
AALQQVDGLIAGIPVKDTIKVTETGPKGIQIQSTPERSRLWAAQTPQGFRLSLLWQAHRE
HHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCHHHHEEECCCCCCCEEHHHHHHHHH
ALAQGWQVTDDAALFEKLGWPVYIVEGEESNLKLTTPWDLVLAEQILQQRLELAR
HHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA