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The map label for this gene is serA

Identifier: 86606026

GI number: 86606026

Start: 1364668

End: 1366251

Strand: Reverse

Name: serA

Synonym: CYA_1354

Alternate gene names: 86606026

Gene position: 1366251-1364668 (Counterclockwise)

Preceding gene: 86606027

Following gene: 86606025

Centisome position: 46.59

GC content: 60.98

Gene sequence:

>1584_bases
ATGCCCAGAGTTATCGTCACGGATCCCATCGATCAGGCGGGGATCGACATCCTCTCCCAAGTGGCCCAGGTGGATGTGCA
AACCGACCTTACGCCGGAGCAGTTGATCGCGGTCATTCCCAACTACGACGCCATCATGGTGCGCTCCGGCACGCGGGTCA
CCCGCGAGGTGATCGAGGCGGGGACGAACTTGAAAATCATCGGTCGGGCGGGGGTGGGCGTGGACAACATCGACGTGGCT
GCCGCCACCAAAGCTGGGATCCTGGTGGTCAACTCCCCTGAGGGCAATACGATTGCTGCCGCCGAGCACGCCATCGCTCT
GATGATGGCCCTCTCCCGCCACATCGCCGATGCCAATGCCTCTCTGAAAGCGGGCCAATGGAAGCGGCAGGAGTTTGTCG
GGGTAGAAGTCTACAAAAAAACGCTGGGGATTGTGGGATTGGGTCGCATTGGATCCCATGTGGCCCAGATTGCCAAGGCG
ATGGGGATGCGGCTTTTGGCCTACGATCCCTACCTTTCGATGGAGCGGGCGGAGCAACTGGGGGTGCGCCTAGTGGATTT
CAAAACCTTGGTGCAGGAGTCAGACTACATCACCCTGCATGTCCCCAAGACCCCTGAGACCACTAACCTGTTCAACGCTG
AGACCTTCCGCATGATGAAGCCGACCGCCCGCCTGATCAACTGTGCCCGCGGCGGCTTGGTGGACGAGCAAGCCCTTTAT
GAAGCTCTCAAGTCCGGCCAAATTGCGGGGGCGGCCCTGGACGTCTTTGCCGACGAGCCCCTCAGCAAAGACTCACCTCT
CCTTTCCTTGGGCAAGGAGATCCTGCTGACACCTCACCTGGGGGCCTCTACCGAGGAGGCGCAGGTCAACGTAGCCATCG
ACGTAGCCGAGCAGATCCGCGATGTGTTGTTGGGGCTGCCTGCCCGTTCTGCCGTGAACATCCCTGGCCTGCAGGCGGAG
GTGCTGCAAAGCCTCAAGCCCTACCTGGACTTGGCGGAAACTTTGGGCAACTTAGTGGGCCAGTTGGCGGGGGATCGGGT
GAGCCAGTTGGAGATCCGCCTCCAGGGATCCCTTGCGGAAAAAGATGGCCAGCCGATCGTCATCGCCGCGCTCAAGGGGC
TTTTGACGCTGGCTCTGCGGGAGCGCGTCAACTACGTCAATGCTTCCATCGAGGCCAAGGAACGAGGCATTCGCGTGGTG
GAGACGCGAGATCCCTCTTTGAAGGATTACTCCGGATCCCTGACGTTGATTGCCCACGGCCCCAATGGGGTGCGTTCCGT
CTCGGGGGCGCTGATTGGGGAGCGGGAGGTGCGCATTACCCAGATCGACGAGTTCCCGGTCAATGTGCCGCCTTCGGCCA
ACATGCTGATGACCTTGCACCGGGATATGCCGGGGATCATCGGGCGGATTGGCACCCTGCTGGGGGCCTACAACGTCAAC
ATCGCCAGCATGCAGGTGGGGCGCAAGATCATCCGCGGCGATGCGGTGATGGTGCTCAGCCTGGATGATCCCCTGCCGGA
TGGAATCCTAGAAGAGGTGCTCAAGCAGCCGGGCATTCGCGACGCTTTTGTGGTGAACCTTTGA

Upstream 100 bases:

>100_bases
GGCTGAGGTTGGGTCAACAGGGTGGCTGGGATCCAGCCTAGCTTGCAGTATTGGCTCTTCTGCTTCTGTTGCCCTACATC
CGATTAGGCTATCGTCGCTT

Downstream 100 bases:

>100_bases
CAGCTTTTGGCGCCAGTGAGGAAGTGCCGAGTTGAGGTGAAGCTTGAGCCTGAATACCCTGTCGCCAATGGGTGGGATCT
CAACCTGGGATTGGCCTGGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MPRVIVTDPIDQAGIDILSQVAQVDVQTDLTPEQLIAVIPNYDAIMVRSGTRVTREVIEAGTNLKIIGRAGVGVDNIDVA
AATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIADANASLKAGQWKRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKA
MGMRLLAYDPYLSMERAEQLGVRLVDFKTLVQESDYITLHVPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALY
EALKSGQIAGAALDVFADEPLSKDSPLLSLGKEILLTPHLGASTEEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGLQAE
VLQSLKPYLDLAETLGNLVGQLAGDRVSQLEIRLQGSLAEKDGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVV
ETRDPSLKDYSGSLTLIAHGPNGVRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVN
IASMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL

Sequences:

>Translated_527_residues
MPRVIVTDPIDQAGIDILSQVAQVDVQTDLTPEQLIAVIPNYDAIMVRSGTRVTREVIEAGTNLKIIGRAGVGVDNIDVA
AATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIADANASLKAGQWKRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKA
MGMRLLAYDPYLSMERAEQLGVRLVDFKTLVQESDYITLHVPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALY
EALKSGQIAGAALDVFADEPLSKDSPLLSLGKEILLTPHLGASTEEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGLQAE
VLQSLKPYLDLAETLGNLVGQLAGDRVSQLEIRLQGSLAEKDGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVV
ETRDPSLKDYSGSLTLIAHGPNGVRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVN
IASMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL
>Mature_526_residues
PRVIVTDPIDQAGIDILSQVAQVDVQTDLTPEQLIAVIPNYDAIMVRSGTRVTREVIEAGTNLKIIGRAGVGVDNIDVAA
ATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIADANASLKAGQWKRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKAM
GMRLLAYDPYLSMERAEQLGVRLVDFKTLVQESDYITLHVPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALYE
ALKSGQIAGAALDVFADEPLSKDSPLLSLGKEILLTPHLGASTEEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGLQAEV
LQSLKPYLDLAETLGNLVGQLAGDRVSQLEIRLQGSLAEKDGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVVE
TRDPSLKDYSGSLTLIAHGPNGVRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVNI
ASMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=406, Percent_Identity=41.3793103448276, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=38.2352941176471, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI61743967, Length=272, Percent_Identity=38.2352941176471, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI145580578, Length=307, Percent_Identity=34.8534201954397, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI4557499, Length=307, Percent_Identity=34.8534201954397, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=35.9259259259259, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI6912396, Length=301, Percent_Identity=31.8936877076412, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1789279, Length=321, Percent_Identity=35.5140186915888, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87082289, Length=300, Percent_Identity=37.3333333333333, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1787645, Length=241, Percent_Identity=37.7593360995851, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788660, Length=229, Percent_Identity=32.7510917030568, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081824, Length=245, Percent_Identity=28.9795918367347, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=44.4099378881988, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI25147481, Length=298, Percent_Identity=30.2013422818792, Blast_Score=128, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=327, Percent_Identity=38.2262996941896, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=37.0030581039755, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324055, Length=329, Percent_Identity=30.3951367781155, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=264, Percent_Identity=28.4090909090909, Blast_Score=103, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=28.1081081081081, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=177, Percent_Identity=26.5536723163842, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=296, Percent_Identity=28.0405405405405, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=44, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI28571528, Length=319, Percent_Identity=36.0501567398119, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28574286, Length=252, Percent_Identity=34.9206349206349, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45551003, Length=315, Percent_Identity=31.1111111111111, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646446, Length=276, Percent_Identity=35.8695652173913, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646448, Length=276, Percent_Identity=35.8695652173913, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646452, Length=276, Percent_Identity=35.8695652173913, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646450, Length=276, Percent_Identity=35.8695652173913, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=35.8490566037736, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24585516, Length=279, Percent_Identity=29.7491039426523, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56534; Mature: 56403

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVIVTDPIDQAGIDILSQVAQVDVQTDLTPEQLIAVIPNYDAIMVRSGTRVTREVIEA
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCEEEEECCCHHHHHHHHC
GTNLKIIGRAGVGVDNIDVAAATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIADANA
CCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCC
SLKAGQWKRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKAMGMRLLAYDPYLSMERAEQL
CCCCCCCHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GVRLVDFKTLVQESDYITLHVPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALY
CCEEEHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
EALKSGQIAGAALDVFADEPLSKDSPLLSLGKEILLTPHLGASTEEAQVNVAIDVAEQIR
HHHHCCCCCCEEEEECCCCCCCCCCCHHHCCCCEEEECCCCCCCCCCEEEEEEEHHHHHH
DVLLGLPARSAVNIPGLQAEVLQSLKPYLDLAETLGNLVGQLAGDRVSQLEIRLQGSLAE
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHC
KDGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVVETRDPSLKDYSGSLTLIAHG
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEHHHCCEEEEECCCCCCCCCCCCEEEEEEC
PNGVRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVN
CCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHCCE
IASMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL
EHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
PRVIVTDPIDQAGIDILSQVAQVDVQTDLTPEQLIAVIPNYDAIMVRSGTRVTREVIEA
CCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCEEEEECCCHHHHHHHHC
GTNLKIIGRAGVGVDNIDVAAATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIADANA
CCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCC
SLKAGQWKRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKAMGMRLLAYDPYLSMERAEQL
CCCCCCCHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GVRLVDFKTLVQESDYITLHVPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALY
CCEEEHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
EALKSGQIAGAALDVFADEPLSKDSPLLSLGKEILLTPHLGASTEEAQVNVAIDVAEQIR
HHHHCCCCCCEEEEECCCCCCCCCCCHHHCCCCEEEECCCCCCCCCCEEEEEEEHHHHHH
DVLLGLPARSAVNIPGLQAEVLQSLKPYLDLAETLGNLVGQLAGDRVSQLEIRLQGSLAE
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHC
KDGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVVETRDPSLKDYSGSLTLIAHG
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEHHHCCEEEEECCCCCCCCCCCCEEEEEEC
PNGVRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVN
CCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHCCE
IASMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL
EHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]