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The map label for this gene is glmU

Identifier: 86605839

GI number: 86605839

Start: 1174189

End: 1176054

Strand: Reverse

Name: glmU

Synonym: CYA_1151

Alternate gene names: 86605839

Gene position: 1176054-1174189 (Counterclockwise)

Preceding gene: 86605844

Following gene: 86605838

Centisome position: 40.1

GC content: 64.58

Gene sequence:

>1866_bases
ATGGCAGAACGAGATCTGGCGGTGGCGATCCTGGCGGCGGGCAAGGGCACCCGCATGCGGTCGCAGTTGCCCAAGGTGCT
GCACAAGCTGGGATCCCTGTCTTTGATCGAGCGGCTGCTGCGCACGGTGCTGACGTTGAAACCCCAGCGCTGTCTGGTGA
TTGTGGGGTACGAGCAGGAGCAAGTGCGCCGAGCCCTGCAGGAGTACCCGGTCGAATTTGTGGAGCAGGCGCAGCAATTG
GGCACTGGACATGCGGTGCAGCAGCTTCTGCCCGTTCTGGAGAATTTTCAGGGGGATCTGCTGGTGGTCAACGGGGATGT
GCCTCTGTTGCGGGCGGAAACCCTGCAGGCGCTGCTGGAGCGCCACCGCCAAGTTCAACCGGATGTGACCTTGCTCTCGG
CCCAGGTGGCGGATCCCTACGGCTATGGGCGGGTGTTTTGCGATGCCCAGCAGCGGATCCTGGAGTTGGTGGAAGAGCGA
GACTGCACCCCGGCCCAACGGCAAAATCGCCGCATCAACAGCGGGGTGTACTGTTTCCACTGGCCGGCCCTAGCAAGGGT
GCTGCCCCGTCTGGGCCGGAACAACGCCCAGCAGGAGTACTACCTCACCGAGGCCGTTAAACTTCTGGACACCGCCATCG
CCCTGGACGCCGAGGATGCGCGGGAAATCGTCGGCATTAACGACCGCCGCCAACTGGCCCAAGCCTACCAGATTCTGCAG
GATCGCCTCAAGGAAGCCTGGATGGAAGCCGGGGTCACCTTTGTGGATCCCGACAGCGTCAGCCTGGAAGAGACGGTGGA
ATTGGCCCCCGATGTGGTGATCGAACCCCAAACCCACCTGCGGGGCGTCTGTCGCATTGGGCCGCGCACTCGTCTAGGGC
CGGGCAGTTGGATCGAGTCCAGCACCATCGGCTCCGATTGCCACATCCTCTACTCGGTGGTCAGCCACAGCCAGATCGGG
GATCGCGTCTGGGTAGGCCCCTACGCCCACGTGCGCCCTCACAGCCAGATCGGCGACGGCTGCCGCATCGGCAACTTTGT
GGAAATCAAAAACGCCCAGATCGGATCCCATACCAACGCCGCCCACCTGGCCTACCTGGGCGACGCCAAGCTGGGATCCC
AGGTCAACATTGGCGCCGGCACGATCATCGCCAACTACGACGGCCAGCAGAAGCACTTCACAGAAATCGGCGATCGCAGC
AAGACAGGGGCCAACTCGGTGCTGGTGGCTCCCCTCAAGATAGGATCCGATGTCACCATCGCCGCCGGTTCCACCATCCC
TGCCCGCTACCCTGTGCCCGACGACTGCCTGGTGATCGCCCGCGCCTACCCGGTGGTCAAGCCGGGCTGGCGACCGGGGA
GCGCTGCTGCTGGCCGCCCCCAGCCTCTACCCACGGGATCCCTGCGCGTCTACCCCTTGCGCCTGCTGCCCGGCCAAGAC
CTAAAGCAGGAATTGGAGCGCTTTGCCCGCCAGCAACCCCTGCAGGCGGGGTTTGTCCTCAGCGCCGTCGGCAGCCTCAG
CCAAGCCACCCTGCGCCTGGCCGATCAAACCGAGGATTACCTATTGTCGGAACGCCTGGAGATCCTGGCTTTGAGCGGAT
CCCTGTGCCCGGACGGAGTCCATCTTCACCTCGCCGTTGCCGATGCCCAGGGCCGAACTTGGGGAGGGCACCTGCGCCCC
GGCTGCCTCATCTACACCACCGCCGAGATCGTCCTCGCCGACAGCCTGGAGTACCGCTTCTCCCGCCAGCCGGATCCGGC
CACCGGCTACTTGGAGCTGCACATTGAAAAGGTGGCAGAAGCAACCCCGCCCTCTCCCCAGAGGGCAGATGGGACAGGGG
TGGGGATCCCTTCTTGCCCGCCGTGA

Upstream 100 bases:

>100_bases
GTGCCACTAGGCTAGCTCAAGTGGCACGCGGCTCTGTCAAGCTACAGTTTGAGCAGGATCCTGCCGCATATACTTTATGG
GGGCAGAGTCTGGGGGGAAC

Downstream 100 bases:

>100_bases
GCCGCAAGCGGCTGTAGATGGACGGTATAATGGCCAACATTTAGCATTGAGTCATTAGCACCTCGTTTGGCAATCAAGGG
TTGCTGAAATAAACTCGGCA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MAERDLAVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPQRCLVIVGYEQEQVRRALQEYPVEFVEQAQQL
GTGHAVQQLLPVLENFQGDLLVVNGDVPLLRAETLQALLERHRQVQPDVTLLSAQVADPYGYGRVFCDAQQRILELVEER
DCTPAQRQNRRINSGVYCFHWPALARVLPRLGRNNAQQEYYLTEAVKLLDTAIALDAEDAREIVGINDRRQLAQAYQILQ
DRLKEAWMEAGVTFVDPDSVSLEETVELAPDVVIEPQTHLRGVCRIGPRTRLGPGSWIESSTIGSDCHILYSVVSHSQIG
DRVWVGPYAHVRPHSQIGDGCRIGNFVEIKNAQIGSHTNAAHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRS
KTGANSVLVAPLKIGSDVTIAAGSTIPARYPVPDDCLVIARAYPVVKPGWRPGSAAAGRPQPLPTGSLRVYPLRLLPGQD
LKQELERFARQQPLQAGFVLSAVGSLSQATLRLADQTEDYLLSERLEILALSGSLCPDGVHLHLAVADAQGRTWGGHLRP
GCLIYTTAEIVLADSLEYRFSRQPDPATGYLELHIEKVAEATPPSPQRADGTGVGIPSCPP

Sequences:

>Translated_621_residues
MAERDLAVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPQRCLVIVGYEQEQVRRALQEYPVEFVEQAQQL
GTGHAVQQLLPVLENFQGDLLVVNGDVPLLRAETLQALLERHRQVQPDVTLLSAQVADPYGYGRVFCDAQQRILELVEER
DCTPAQRQNRRINSGVYCFHWPALARVLPRLGRNNAQQEYYLTEAVKLLDTAIALDAEDAREIVGINDRRQLAQAYQILQ
DRLKEAWMEAGVTFVDPDSVSLEETVELAPDVVIEPQTHLRGVCRIGPRTRLGPGSWIESSTIGSDCHILYSVVSHSQIG
DRVWVGPYAHVRPHSQIGDGCRIGNFVEIKNAQIGSHTNAAHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRS
KTGANSVLVAPLKIGSDVTIAAGSTIPARYPVPDDCLVIARAYPVVKPGWRPGSAAAGRPQPLPTGSLRVYPLRLLPGQD
LKQELERFARQQPLQAGFVLSAVGSLSQATLRLADQTEDYLLSERLEILALSGSLCPDGVHLHLAVADAQGRTWGGHLRP
GCLIYTTAEIVLADSLEYRFSRQPDPATGYLELHIEKVAEATPPSPQRADGTGVGIPSCPP
>Mature_620_residues
AERDLAVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPQRCLVIVGYEQEQVRRALQEYPVEFVEQAQQLG
TGHAVQQLLPVLENFQGDLLVVNGDVPLLRAETLQALLERHRQVQPDVTLLSAQVADPYGYGRVFCDAQQRILELVEERD
CTPAQRQNRRINSGVYCFHWPALARVLPRLGRNNAQQEYYLTEAVKLLDTAIALDAEDAREIVGINDRRQLAQAYQILQD
RLKEAWMEAGVTFVDPDSVSLEETVELAPDVVIEPQTHLRGVCRIGPRTRLGPGSWIESSTIGSDCHILYSVVSHSQIGD
RVWVGPYAHVRPHSQIGDGCRIGNFVEIKNAQIGSHTNAAHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRSK
TGANSVLVAPLKIGSDVTIAAGSTIPARYPVPDDCLVIARAYPVVKPGWRPGSAAAGRPQPLPTGSLRVYPLRLLPGQDL
KQELERFARQQPLQAGFVLSAVGSLSQATLRLADQTEDYLLSERLEILALSGSLCPDGVHLHLAVADAQGRTWGGHLRPG
CLIYTTAEIVLADSLEYRFSRQPDPATGYLELHIEKVAEATPPSPQRADGTGVGIPSCPP

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=463, Percent_Identity=38.6609071274298, Blast_Score=311, Evalue=9e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_SYNJA (Q2JVA4)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_474602.1
- ProteinModelPortal:   Q2JVA4
- STRING:   Q2JVA4
- GeneID:   3898860
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1151
- TIGR:   CYA_1151
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK14360
- BioCyc:   SSP321327:CYA_1151-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005175
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF03479 DUF296; PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 67918; Mature: 67787

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 362-362 BINDING 76-76 BINDING 143-143 BINDING 158-158 BINDING 173-173 BINDING 386-386 BINDING 422-422 BINDING 441-441

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERDLAVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPQRCLVIVGYEQE
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCHH
QVRRALQEYPVEFVEQAQQLGTGHAVQQLLPVLENFQGDLLVVNGDVPLLRAETLQALLE
HHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHH
RHRQVQPDVTLLSAQVADPYGYGRVFCDAQQRILELVEERDCTPAQRQNRRINSGVYCFH
HHHCCCCCCEEEEEHHCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEE
WPALARVLPRLGRNNAQQEYYLTEAVKLLDTAIALDAEDAREIVGINDRRQLAQAYQILQ
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHH
DRLKEAWMEAGVTFVDPDSVSLEETVELAPDVVIEPQTHLRGVCRIGPRTRLGPGSWIES
HHHHHHHHHCCCEEECCCCCCHHHHHHHCCCEEECCCHHHHHHHCCCCCCCCCCCCCCCC
STIGSDCHILYSVVSHSQIGDRVWVGPYAHVRPHSQIGDGCRIGNFVEIKNAQIGSHTNA
CCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
AHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRSKTGANSVLVAPLKIGSDVTI
EEEEEECCCCCCCEEECCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCEEE
AAGSTIPARYPVPDDCLVIARAYPVVKPGWRPGSAAAGRPQPLPTGSLRVYPLRLLPGQD
ECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHH
LKQELERFARQQPLQAGFVLSAVGSLSQATLRLADQTEDYLLSERLEILALSGSLCPDGV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEEECCCCCCCCE
HLHLAVADAQGRTWGGHLRPGCLIYTTAEIVLADSLEYRFSRQPDPATGYLELHIEKVAE
EEEEEEEECCCCCCCCCCCCCEEEEEEEEEEEECCHHHHHCCCCCCCCCEEEEEEHHHHC
ATPPSPQRADGTGVGIPSCPP
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AERDLAVAILAAGKGTRMRSQLPKVLHKLGSLSLIERLLRTVLTLKPQRCLVIVGYEQE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCHH
QVRRALQEYPVEFVEQAQQLGTGHAVQQLLPVLENFQGDLLVVNGDVPLLRAETLQALLE
HHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHH
RHRQVQPDVTLLSAQVADPYGYGRVFCDAQQRILELVEERDCTPAQRQNRRINSGVYCFH
HHHCCCCCCEEEEEHHCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEE
WPALARVLPRLGRNNAQQEYYLTEAVKLLDTAIALDAEDAREIVGINDRRQLAQAYQILQ
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHH
DRLKEAWMEAGVTFVDPDSVSLEETVELAPDVVIEPQTHLRGVCRIGPRTRLGPGSWIES
HHHHHHHHHCCCEEECCCCCCHHHHHHHCCCEEECCCHHHHHHHCCCCCCCCCCCCCCCC
STIGSDCHILYSVVSHSQIGDRVWVGPYAHVRPHSQIGDGCRIGNFVEIKNAQIGSHTNA
CCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
AHLAYLGDAKLGSQVNIGAGTIIANYDGQQKHFTEIGDRSKTGANSVLVAPLKIGSDVTI
EEEEEECCCCCCCEEECCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCEEE
AAGSTIPARYPVPDDCLVIARAYPVVKPGWRPGSAAAGRPQPLPTGSLRVYPLRLLPGQD
ECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHH
LKQELERFARQQPLQAGFVLSAVGSLSQATLRLADQTEDYLLSERLEILALSGSLCPDGV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEEECCCCCCCCE
HLHLAVADAQGRTWGGHLRPGCLIYTTAEIVLADSLEYRFSRQPDPATGYLELHIEKVAE
EEEEEEEECCCCCCCCCCCCCEEEEEEEEEEEECCHHHHHCCCCCCCCCEEEEEEHHHHC
ATPPSPQRADGTGVGIPSCPP
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA