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The map label for this gene is cocE [H]

Identifier: 86605739

GI number: 86605739

Start: 1064207

End: 1065829

Strand: Reverse

Name: cocE [H]

Synonym: CYA_1044

Alternate gene names: 86605739

Gene position: 1065829-1064207 (Counterclockwise)

Preceding gene: 86605740

Following gene: 86605738

Centisome position: 36.34

GC content: 64.63

Gene sequence:

>1623_bases
GTGCGCCCCCGAGAAACCGTTTCCATGTTCACCCGCGACGGGATCCAACTGGACGCGGATGTCTATCGCCCCGAAGGGGA
GGGGAGCTACCCGGTCTTGCTGATGCGGCAACCCTACGGGCGGGCCATTGCCTCGACGGTAGTATACGCCCATCCGCGCT
GGTATGCGGCCCACGGGTACATCGTGGTCGTTCAGGATGTGCGGGGGCGGGGCACGTCCAAGGGATCCTTCTACCCTTTC
CGCCACGAAGCCGAGGACGGGTTCGACGCCGTCAACTGGGCGGCCGCTTTGCCGGGGAGCAACGGTGTGGTGGGTATGTA
CGGCTTTTCTTACCAAGGCATGACCCAACTGTATGCCGCCTCCACCCGTCCCAGCGCCCTGAAGGCCATCTGCCCAGCCA
TGCTGCCCTACGATCTCTACGCCGATGCCGCCTATCCGGGGGGAGCCTTCGCTTTCTACAACAACCTCAGTTGGGCCCTG
CAACTGGAAGCTGAGGGGGCGCGCCTGCGCGGCGATGCCAACGCTTACCAGGCCCTTTTCAAGGCCTCCCGCAACCTGCC
CCTTTACGATCCCATCCCCCTCAAGCCAGGCGTGCTGCAGCAATATGCGCCCCAGTCCTATTACTTTGACTGGCTGGAGC
ACAGCGAGCCCGACGACTACTGGCGCCAGCTCTCCCCCCGTCTGGAAGCGGTGGATCTGCCGATGTTGCACATTGGCGGC
TGGTTCGACAGCTACCTAACCGGCAGCCTGCGCCTTTACAAGGAAATAAGCGCCCGCAGCCAAAACCCTCAGTACCTGGT
TGTCGGGCCCTGGGCCCACCTGCCTTGGGGGCGCAAAGTGGGGGCGCTGGACTTTGGCCCCGAGGCCGTCAGCCCCATCG
ATCGGCTGCAGGTGCGCTGGTTCGACCAGTTCCTCAAAGGCAAAGACACAGGGATCCTCCAAGAGCCGCCGGTACGCCTG
TTCGAGATGGGATCCAACCGCTGGCGCAGCTTTGAGGCCTGGCCCACGCCGGAGCCGAAGGTTTTCTACCTGCACAGCAG
CGGCCTGGCCGCCCTTTCTGAAGCAGAGGGATCCCTTCGCCCAGAGCCCCCACCAAAGCAGCAGTCGGATACTTTTGTTC
ACGATCCCTGGCGACCCGTGCCGGCCCTAGGAGGCCACCTCATCCATCCCGCCGGGCCGCAGGAGCGCTCTGCCCTCGAC
TGCCGCGCCGATGTTCTCACCTACACCACCTCTCCCCTGGCAACCGACCTCGTCCTGGCAGGGGACATTCTCGTGGAAGT
GTATGTGGAAGCCGACAGCCCCAGTTTCGATCTCTGCGCCGTGCTCTCGGTGGTGAGGCCGGAGGGCCAGGTGTATAACT
TTTCCCAGGGCTACCGCCGGCTGCGGGATCCCCAGCCCAAGGCCCCCATTGGGATCCGTTGCCAGCCCACCTGCATCCGC
ATTCCCCGCGGCCACGCCCTGCGCCTCAGCCTTAGCGCGGCCTGTTTCCCGGCCTACCCCGTTAACACAGGCACGGGGAT
GCGAGAAGAGCGGCTCATCGAGGCCCGCATTCTCACCCTCGCTCTTCACAGCGGCAGCGACACCCCCTCGCGGCTGCATC
TGCCCATTGTCGAGGGGAGTTAG

Upstream 100 bases:

>100_bases
CAGGGAAGAGCTACAGGTCTTGAGCCTAAAATACGCCTATCCCCTGCTGTGGAGATCCTTGGCTTCTTCAATGGACCCCA
CTGACCCGACCATGCTGCCT

Downstream 100 bases:

>100_bases
GGGGAGTGACAGTTTAAGACAACACAGCTTCTCATCCCTTCGCAACTCCTCCTCACAAACAGACATCAAACGTTAGGATA
GAAGCAAGCAGGGCAAGGGA

Product: S15 family X-Pro dipeptidyl-peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MRPRETVSMFTRDGIQLDADVYRPEGEGSYPVLLMRQPYGRAIASTVVYAHPRWYAAHGYIVVVQDVRGRGTSKGSFYPF
RHEAEDGFDAVNWAAALPGSNGVVGMYGFSYQGMTQLYAASTRPSALKAICPAMLPYDLYADAAYPGGAFAFYNNLSWAL
QLEAEGARLRGDANAYQALFKASRNLPLYDPIPLKPGVLQQYAPQSYYFDWLEHSEPDDYWRQLSPRLEAVDLPMLHIGG
WFDSYLTGSLRLYKEISARSQNPQYLVVGPWAHLPWGRKVGALDFGPEAVSPIDRLQVRWFDQFLKGKDTGILQEPPVRL
FEMGSNRWRSFEAWPTPEPKVFYLHSSGLAALSEAEGSLRPEPPPKQQSDTFVHDPWRPVPALGGHLIHPAGPQERSALD
CRADVLTYTTSPLATDLVLAGDILVEVYVEADSPSFDLCAVLSVVRPEGQVYNFSQGYRRLRDPQPKAPIGIRCQPTCIR
IPRGHALRLSLSAACFPAYPVNTGTGMREERLIEARILTLALHSGSDTPSRLHLPIVEGS

Sequences:

>Translated_540_residues
MRPRETVSMFTRDGIQLDADVYRPEGEGSYPVLLMRQPYGRAIASTVVYAHPRWYAAHGYIVVVQDVRGRGTSKGSFYPF
RHEAEDGFDAVNWAAALPGSNGVVGMYGFSYQGMTQLYAASTRPSALKAICPAMLPYDLYADAAYPGGAFAFYNNLSWAL
QLEAEGARLRGDANAYQALFKASRNLPLYDPIPLKPGVLQQYAPQSYYFDWLEHSEPDDYWRQLSPRLEAVDLPMLHIGG
WFDSYLTGSLRLYKEISARSQNPQYLVVGPWAHLPWGRKVGALDFGPEAVSPIDRLQVRWFDQFLKGKDTGILQEPPVRL
FEMGSNRWRSFEAWPTPEPKVFYLHSSGLAALSEAEGSLRPEPPPKQQSDTFVHDPWRPVPALGGHLIHPAGPQERSALD
CRADVLTYTTSPLATDLVLAGDILVEVYVEADSPSFDLCAVLSVVRPEGQVYNFSQGYRRLRDPQPKAPIGIRCQPTCIR
IPRGHALRLSLSAACFPAYPVNTGTGMREERLIEARILTLALHSGSDTPSRLHLPIVEGS
>Mature_540_residues
MRPRETVSMFTRDGIQLDADVYRPEGEGSYPVLLMRQPYGRAIASTVVYAHPRWYAAHGYIVVVQDVRGRGTSKGSFYPF
RHEAEDGFDAVNWAAALPGSNGVVGMYGFSYQGMTQLYAASTRPSALKAICPAMLPYDLYADAAYPGGAFAFYNNLSWAL
QLEAEGARLRGDANAYQALFKASRNLPLYDPIPLKPGVLQQYAPQSYYFDWLEHSEPDDYWRQLSPRLEAVDLPMLHIGG
WFDSYLTGSLRLYKEISARSQNPQYLVVGPWAHLPWGRKVGALDFGPEAVSPIDRLQVRWFDQFLKGKDTGILQEPPVRL
FEMGSNRWRSFEAWPTPEPKVFYLHSSGLAALSEAEGSLRPEPPPKQQSDTFVHDPWRPVPALGGHLIHPAGPQERSALD
CRADVLTYTTSPLATDLVLAGDILVEVYVEADSPSFDLCAVLSVVRPEGQVYNFSQGYRRLRDPQPKAPIGIRCQPTCIR
IPRGHALRLSLSAACFPAYPVNTGTGMREERLIEARILTLALHSGSDTPSRLHLPIVEGS

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 60131; Mature: 60131

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPRETVSMFTRDGIQLDADVYRPEGEGSYPVLLMRQPYGRAIASTVVYAHPRWYAAHGY
CCCHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEECCCCHHHHHHEEEECCCEEEECCE
IVVVQDVRGRGTSKGSFYPFRHEAEDGFDAVNWAAALPGSNGVVGMYGFSYQGMTQLYAA
EEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCCCCEEEEECCCCCCHHHHHCC
STRPSALKAICPAMLPYDLYADAAYPGGAFAFYNNLSWALQLEAEGARLRGDANAYQALF
CCCCHHHHHHHHHHCCHHHHCCCCCCCCEEEEECCCEEEEEEECCCCEECCCHHHHHHHH
KASRNLPLYDPIPLKPGVLQQYAPQSYYFDWLEHSEPDDYWRQLSPRLEAVDLPMLHIGG
HHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCEEECCCEEEECC
WFDSYLTGSLRLYKEISARSQNPQYLVVGPWAHLPWGRKVGALDFGPEAVSPIDRLQVRW
HHHHHHHCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEECCCCCCCHHCCHHHHHHHHH
FDQFLKGKDTGILQEPPVRLFEMGSNRWRSFEAWPTPEPKVFYLHSSGLAALSEAEGSLR
HHHHHCCCCCCCCCCCCHHHEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCC
PEPPPKQQSDTFVHDPWRPVPALGGHLIHPAGPQERSALDCRADVLTYTTSPLATDLVLA
CCCCCCCCCCCEECCCCCCCHHCCCEEECCCCCCCCCCHHHHHEEEEEECCCHHHHHEEE
GDILVEVYVEADSPSFDLCAVLSVVRPEGQVYNFSQGYRRLRDPQPKAPIGIRCQPTCIR
CEEEEEEEEECCCCCHHHHHHHHHHCCCCCEEECHHHHHHHCCCCCCCCCCEEECCCEEE
IPRGHALRLSLSAACFPAYPVNTGTGMREERLIEARILTLALHSGSDTPSRLHLPIVEGS
CCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHEEEEEEEEECCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRPRETVSMFTRDGIQLDADVYRPEGEGSYPVLLMRQPYGRAIASTVVYAHPRWYAAHGY
CCCHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEECCCCHHHHHHEEEECCCEEEECCE
IVVVQDVRGRGTSKGSFYPFRHEAEDGFDAVNWAAALPGSNGVVGMYGFSYQGMTQLYAA
EEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCCCCEEEEECCCCCCHHHHHCC
STRPSALKAICPAMLPYDLYADAAYPGGAFAFYNNLSWALQLEAEGARLRGDANAYQALF
CCCCHHHHHHHHHHCCHHHHCCCCCCCCEEEEECCCEEEEEEECCCCEECCCHHHHHHHH
KASRNLPLYDPIPLKPGVLQQYAPQSYYFDWLEHSEPDDYWRQLSPRLEAVDLPMLHIGG
HHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCEEECCCEEEECC
WFDSYLTGSLRLYKEISARSQNPQYLVVGPWAHLPWGRKVGALDFGPEAVSPIDRLQVRW
HHHHHHHCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEECCCCCCCHHCCHHHHHHHHH
FDQFLKGKDTGILQEPPVRLFEMGSNRWRSFEAWPTPEPKVFYLHSSGLAALSEAEGSLR
HHHHHCCCCCCCCCCCCHHHEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCC
PEPPPKQQSDTFVHDPWRPVPALGGHLIHPAGPQERSALDCRADVLTYTTSPLATDLVLA
CCCCCCCCCCCEECCCCCCCHHCCCEEECCCCCCCCCCHHHHHEEEEEECCCHHHHHEEE
GDILVEVYVEADSPSFDLCAVLSVVRPEGQVYNFSQGYRRLRDPQPKAPIGIRCQPTCIR
CEEEEEEEEECCCCCHHHHHHHHHHCCCCCEEECHHHHHHHCCCCCCCCCCEEECCCEEE
IPRGHALRLSLSAACFPAYPVNTGTGMREERLIEARILTLALHSGSDTPSRLHLPIVEGS
CCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHEEEEEEEEECCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]