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The map label for this gene is mprA [H]

Identifier: 86605629

GI number: 86605629

Start: 937057

End: 937728

Strand: Reverse

Name: mprA [H]

Synonym: CYA_0927

Alternate gene names: 86605629

Gene position: 937728-937057 (Counterclockwise)

Preceding gene: 86605630

Following gene: 86605626

Centisome position: 31.97

GC content: 59.38

Gene sequence:

>672_bases
ATGAAGCGCGTATTGGTCGTAGATGACGATCCCCTCTCCTTAAAGGTGCTGAGCCGCCACCTCACCCAGCACGGCTATCG
GGTTTGTACAGGCGCTTCGGGTGTAGAAGGGTTGCGCCTGTTTGCCCAAGAGCAGCCGGATGTGGTGGTATCGGATGTGG
TGATGCCGGAAATGGATGGCTTCGAGTTTTGCCGCCAACTGCGCCAACAGCGGGGCGGCGAACTCGTTCCTTTCATCTTC
CTCTCCTCTCGCAGCGAGCTGGATGACCGCGTTCAGGGCTACGAGTGGGGAGCCGACGACTACATCATCAAGCCCTTCGA
GCCGCTGGAGCTGGTGGCCAAGATCGAGGCGCAAATCGAACGAGCCCGCCGCACCCAGTTGGAGATTCTGCGCCTAATCC
AGCAGCAGACCCAGGCCAAAGCTGAAGCTGCCCCCCGTCCCACCTTGGCAGATCTCCCCCTCACCCCTGCCGAAGAGCGG
GTGTTCCGGGAAGTGATCCGCGGCCTCACCAACAAGCAAATTGGCGAGAAGCTGTTCATCAGTCCGCGTACCGTGCAGAC
CCACTTGACCAACATTCTCAGCAAGCTCTCTCTGGAAAATCGCTCCCAACTGGTGCGCTTTGCCTACGAACGGGGCTACA
TCCCCCGGGAAGAGTCGAGCGACAAAAAATAG

Upstream 100 bases:

>100_bases
CCTGTCTAAACTTCAATCTTGCGGCAAGGGTTGAACACTGCCCTCAAGTCATCCCTCTGTTACGCCTCAACCATTCCTCA
ACAGCCTCTCCCCGGTCATC

Downstream 100 bases:

>100_bases
GTTGGGAGAGAGGGATCCCTTCTAGGCTAGGTGGAGTCTTAAGACGGCAGGCGTTGCCTTGCGCACCCGGCAAGGAATCC
GCTCCCTACCCAAGCGGACA

Product: LuxR family DNA-binding response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDGFEFCRQLRQQRGGELVPFIF
LSSRSELDDRVQGYEWGADDYIIKPFEPLELVAKIEAQIERARRTQLEILRLIQQQTQAKAEAAPRPTLADLPLTPAEER
VFREVIRGLTNKQIGEKLFISPRTVQTHLTNILSKLSLENRSQLVRFAYERGYIPREESSDKK

Sequences:

>Translated_223_residues
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDGFEFCRQLRQQRGGELVPFIF
LSSRSELDDRVQGYEWGADDYIIKPFEPLELVAKIEAQIERARRTQLEILRLIQQQTQAKAEAAPRPTLADLPLTPAEER
VFREVIRGLTNKQIGEKLFISPRTVQTHLTNILSKLSLENRSQLVRFAYERGYIPREESSDKK
>Mature_223_residues
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDGFEFCRQLRQQRGGELVPFIF
LSSRSELDDRVQGYEWGADDYIIKPFEPLELVAKIEAQIERARRTQLEILRLIQQQTQAKAEAAPRPTLADLPLTPAEER
VFREVIRGLTNKQIGEKLFISPRTVQTHLTNILSKLSLENRSQLVRFAYERGYIPREESSDKK

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=29.2576419213974, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=41.1764705882353, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=27.5555555555556, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790299, Length=164, Percent_Identity=35.3658536585366, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=30.1801801801802, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1786784, Length=126, Percent_Identity=30.1587301587302, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082012, Length=129, Percent_Identity=31.7829457364341, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790860, Length=210, Percent_Identity=30.4761904761905, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787229, Length=127, Percent_Identity=37.007874015748, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786911, Length=125, Percent_Identity=37.6, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=35.1351351351351, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1788905, Length=120, Percent_Identity=35.8333333333333, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790863, Length=120, Percent_Identity=30.8333333333333, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788521, Length=213, Percent_Identity=28.169014084507, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1786747, Length=162, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=123, Percent_Identity=30.0813008130081, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790552, Length=119, Percent_Identity=31.9327731092437, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367329, Length=159, Percent_Identity=32.0754716981132, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1787375, Length=119, Percent_Identity=30.2521008403361, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=31.858407079646, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI145693140, Length=108, Percent_Identity=29.6296296296296, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1788713, Length=146, Percent_Identity=30.1369863013699, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25561; Mature: 25561

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDG
CCEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCEEEHHHHCCCCCH
FEFCRQLRQQRGGELVPFIFLSSRSELDDRVQGYEWGADDYIIKPFEPLELVAKIEAQIE
HHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHH
RARRTQLEILRLIQQQTQAKAEAAPRPTLADLPLTPAEERVFREVIRGLTNKQIGEKLFI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCC
SPRTVQTHLTNILSKLSLENRSQLVRFAYERGYIPREESSDKK
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDG
CCEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCEEEHHHHCCCCCH
FEFCRQLRQQRGGELVPFIFLSSRSELDDRVQGYEWGADDYIIKPFEPLELVAKIEAQIE
HHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHH
RARRTQLEILRLIQQQTQAKAEAAPRPTLADLPLTPAEERVFREVIRGLTNKQIGEKLFI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCC
SPRTVQTHLTNILSKLSLENRSQLVRFAYERGYIPREESSDKK
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA