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The map label for this gene is ndhD1 [H]

Identifier: 86605353

GI number: 86605353

Start: 649763

End: 651292

Strand: Reverse

Name: ndhD1 [H]

Synonym: CYA_0639

Alternate gene names: 86605353

Gene position: 651292-649763 (Counterclockwise)

Preceding gene: 86605354

Following gene: 86605352

Centisome position: 22.21

GC content: 59.93

Gene sequence:

>1530_bases
ATGCTGAGTGCCTTGATTGTGTTGCCGATTTTGGGATCCCTGCTGCTGTTCCTGGGCTTGGGAGGGCGCAAGCTGGCGGT
GGTCTTGGCCGGGATCCCGTTGGCCATCTCGCTATTTCTGTTTACCCGCTTCGACGTGCAGGCGACCGGCTTTCAGTGGG
AGCAGCGGTGGGATTGGATCCCGCAAATCGGGCTGAGCTACTCCCTGGGCTTGGACGGGCTGGCTTTGTTGATGGTGGCC
CTGAACGGGCTGCTCACTCTCATCGCCATTTTGACGGCTGAGCCGGAGACCAAGCGGCCCAATCTCTTTTACGGCTGCAT
TCTGCTGATGAGTGGGTCGGTCAACGGGGCTTTTGCCGCCCAGAACCTGCTGTTGTTTTTCCTCTTTTACGAGCTGGTGC
TGATCCCGATCTACTTGCTCATTTCCATCTGGGGCAGCCCCAAGCGGGATTATGCCGCCATCAAGTTTTTGATCTACACC
GCTGTTTCCGCCGTCTTCCTGTTGGGGGCGTTTCTGGCCGTCTACTGGCTGGGGGATCCCCATACTTTTGAGCTGGCCGA
GATTCGCATCAGCTCCCTGGGCCCCGCTGCCCAAACCCTGGCCCTGTTGGCTTTGATTGTGGCCTTTGGCATCAAGATGC
CGCTGGTGCCCTTCCACACCTGGCTGCCCGACGCCTACGGCGAGTCTTCCCCGCCGGTGGCGGTGCTGCTGGGAGGGGTG
CTCTCCAAGTTGGGCACCTATGGTCTGTTTCGCTTTGGGCTGCAGTTGTTTCCCCAGGTTTGGGCCGATCTGAGTGGGCT
GCTGGCCTGGTGGGGGGCTATTGCTGTGCTGTCGGGGGCTTTGGCGGCCATCGCCCAAAAAGACATCAAGCGCATGGTGG
CCTACAGCTCCATCGGCCATATGGGCTACATCCTGCTGGGTATGGCGGCGGCCACGCCGATTAGCCTGACGGGGGCGATG
GTGCAGATGGTCTCCCACGGCCTGATTCTGGCGCTGCTGTTTGATCTGGTGGGCCTGGTGGAGCGCAAGGTGGGAACGCG
GGATCTCAACGTGATCAACGGCCTGCTCAATCCCCTGCGCGGCCTGCCCACGGTGAGTGCCCTGTTGATCTTGGGCGGCA
TGGCCAGCGCCGGGATCCCGGGCTTGGTGGGCTTTGTGGCCGAGTTTTTGATCTTCCAGGGCAGCTACCAAGATTTTCCG
TTGCCCACGTTGCTCAGCATCTGCGGCACCGGCTTGACGGCGGTGTATTTTGTGATTTTGCTCAACCGCACCTGCTTCGG
CAAATTGGACAACCGCACCGCCTACTACCCCCGGGTGCAAGGTTGGGAGCGGATCCCGGGCTTTCTTTTAACTGCCTTGA
TCGTCTGGTTTGGGATCCAGCCCATGAACCTGGTGAAATGGCCCCAAACCTTGGCCTTTACTCTATCCACCCAGGTGGCT
CAAGCCCAGACGCTTGTCATCGCGGAAGCCGAACATTCTTCTCCCTCCAGTTTGCTGCAGGGATCCCTGATGGACAACGC
AAGCTCATGA

Upstream 100 bases:

>100_bases
CAGGCCTATGTGCTGACGATTGTGGTGGGGGTGGCCCTGCTGGGCTGGCTAATTCTCTAGGCAGAGGGGGACGGAGTCCT
TAAGAAAGAGGGAAAAGACC

Downstream 100 bases:

>100_bases
CTTTCTCCCCTAGCCGAAGGCAGTGAAGAGTTGGAGACTTTTTCCATGACGACGACCCTGGTTACGCCCAAGCTCCCCCC
TTCCACCCATCCCTTTGCCG

Product: NADH-ubiquinone/plastoquinone oxidoreductase subunit 4 family protein

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MLSALIVLPILGSLLLFLGLGGRKLAVVLAGIPLAISLFLFTRFDVQATGFQWEQRWDWIPQIGLSYSLGLDGLALLMVA
LNGLLTLIAILTAEPETKRPNLFYGCILLMSGSVNGAFAAQNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYT
AVSAVFLLGAFLAVYWLGDPHTFELAEIRISSLGPAAQTLALLALIVAFGIKMPLVPFHTWLPDAYGESSPPVAVLLGGV
LSKLGTYGLFRFGLQLFPQVWADLSGLLAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGHMGYILLGMAAATPISLTGAM
VQMVSHGLILALLFDLVGLVERKVGTRDLNVINGLLNPLRGLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFP
LPTLLSICGTGLTAVYFVILLNRTCFGKLDNRTAYYPRVQGWERIPGFLLTALIVWFGIQPMNLVKWPQTLAFTLSTQVA
QAQTLVIAEAEHSSPSSLLQGSLMDNASS

Sequences:

>Translated_509_residues
MLSALIVLPILGSLLLFLGLGGRKLAVVLAGIPLAISLFLFTRFDVQATGFQWEQRWDWIPQIGLSYSLGLDGLALLMVA
LNGLLTLIAILTAEPETKRPNLFYGCILLMSGSVNGAFAAQNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYT
AVSAVFLLGAFLAVYWLGDPHTFELAEIRISSLGPAAQTLALLALIVAFGIKMPLVPFHTWLPDAYGESSPPVAVLLGGV
LSKLGTYGLFRFGLQLFPQVWADLSGLLAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGHMGYILLGMAAATPISLTGAM
VQMVSHGLILALLFDLVGLVERKVGTRDLNVINGLLNPLRGLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFP
LPTLLSICGTGLTAVYFVILLNRTCFGKLDNRTAYYPRVQGWERIPGFLLTALIVWFGIQPMNLVKWPQTLAFTLSTQVA
QAQTLVIAEAEHSSPSSLLQGSLMDNASS
>Mature_509_residues
MLSALIVLPILGSLLLFLGLGGRKLAVVLAGIPLAISLFLFTRFDVQATGFQWEQRWDWIPQIGLSYSLGLDGLALLMVA
LNGLLTLIAILTAEPETKRPNLFYGCILLMSGSVNGAFAAQNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYT
AVSAVFLLGAFLAVYWLGDPHTFELAEIRISSLGPAAQTLALLALIVAFGIKMPLVPFHTWLPDAYGESSPPVAVLLGGV
LSKLGTYGLFRFGLQLFPQVWADLSGLLAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGHMGYILLGMAAATPISLTGAM
VQMVSHGLILALLFDLVGLVERKVGTRDLNVINGLLNPLRGLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFP
LPTLLSICGTGLTAVYFVILLNRTCFGKLDNRTAYYPRVQGWERIPGFLLTALIVWFGIQPMNLVKWPQTLAFTLSTQVA
QAQTLVIAEAEHSSPSSLLQGSLMDNASS

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=346, Percent_Identity=30.9248554913295, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI251831117, Length=398, Percent_Identity=26.1306532663317, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788613, Length=455, Percent_Identity=37.1428571428571, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1788831, Length=281, Percent_Identity=32.0284697508897, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788827, Length=295, Percent_Identity=26.7796610169492, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788614, Length=438, Percent_Identity=27.6255707762557, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788829, Length=309, Percent_Identity=27.831715210356, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI145693160, Length=340, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI2367154, Length=227, Percent_Identity=28.1938325991189, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 54835; Mature: 54835

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSALIVLPILGSLLLFLGLGGRKLAVVLAGIPLAISLFLFTRFDVQATGFQWEQRWDWI
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHCCCC
PQIGLSYSLGLDGLALLMVALNGLLTLIAILTAEPETKRPNLFYGCILLMSGSVNGAFAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHH
QNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYTAVSAVFLLGAFLAVYWLGDP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HTFELAEIRISSLGPAAQTLALLALIVAFGIKMPLVPFHTWLPDAYGESSPPVAVLLGGV
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHH
LSKLGTYGLFRFGLQLFPQVWADLSGLLAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGYILLGMAAATPISLTGAMVQMVSHGLILALLFDLVGLVERKVGTRDLNVINGLLNPLR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFPLPTLLSICGTGLTAVYFVIL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LNRTCFGKLDNRTAYYPRVQGWERIPGFLLTALIVWFGIQPMNLVKWPQTLAFTLSTQVA
HCCHHCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHH
QAQTLVIAEAEHSSPSSLLQGSLMDNASS
HHHEEEEEECCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLSALIVLPILGSLLLFLGLGGRKLAVVLAGIPLAISLFLFTRFDVQATGFQWEQRWDWI
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHCCCC
PQIGLSYSLGLDGLALLMVALNGLLTLIAILTAEPETKRPNLFYGCILLMSGSVNGAFAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHH
QNLLLFFLFYELVLIPIYLLISIWGSPKRDYAAIKFLIYTAVSAVFLLGAFLAVYWLGDP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HTFELAEIRISSLGPAAQTLALLALIVAFGIKMPLVPFHTWLPDAYGESSPPVAVLLGGV
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHH
LSKLGTYGLFRFGLQLFPQVWADLSGLLAWWGAIAVLSGALAAIAQKDIKRMVAYSSIGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGYILLGMAAATPISLTGAMVQMVSHGLILALLFDLVGLVERKVGTRDLNVINGLLNPLR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GLPTVSALLILGGMASAGIPGLVGFVAEFLIFQGSYQDFPLPTLLSICGTGLTAVYFVIL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LNRTCFGKLDNRTAYYPRVQGWERIPGFLLTALIVWFGIQPMNLVKWPQTLAFTLSTQVA
HCCHHCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHH
QAQTLVIAEAEHSSPSSLLQGSLMDNASS
HHHEEEEEECCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]