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The map label for this gene is ilvA

Identifier: 86604872

GI number: 86604872

Start: 137266

End: 138777

Strand: Reverse

Name: ilvA

Synonym: CYA_0143

Alternate gene names: 86604872

Gene position: 138777-137266 (Counterclockwise)

Preceding gene: 86604874

Following gene: 86604871

Centisome position: 4.73

GC content: 63.16

Gene sequence:

>1512_bases
ATGTATTGTGACTATCTTGTTCAGATCCTCACGGCTCGCGTTTACGACGTCGCCCAAGAAACCCCCCTGGAGCCGGCTTT
TAACCTCTCCCGCCGCCTGAACAACCAGGTCTGGCTCAAGCGGGAAGATCTGCAGCCGGTTTTCTCCTTTAAGCTGCGGG
GGGCCTACAACAAGATGGCCCACCTGCCTCCGGAGCAACTGGCGCAAGGGGTGATCGCGGCCTCTGCGGGCAACCACGCC
CAAGGGGTAGCCCTGGCAGCGCAGCGGCTGGGCACCCACGCGGTCATCGTGATGCCCGTCACCACCCCCCAGGTGAAGAT
AGACGCGGTGCGGGCGCGGGGGGCCCAGGTGGTCTTGCACGGCGACACCTTTGACGATGCCTATGCTCACGCGCGGCAAC
TGGAAGCCGAGAAAGGTTTGACCTTCATCCATCCGTTCGACGATCCCCTGGTGATCGCTGGCCAGGGCACCATCGGCATG
GAGATCCTGCGCCAGTCTCAACAGCCCATCCACGCCATCTTCGTCGCCGTCGGCGGGGGCGGCCTGATCTCGGGCATCGC
CGCCTACGTCAAGCGCCTGCGCCCGGAGATCAAAATCATTGGGGTAGAACCGCTGGACGCCGACGCCATGTACCGCTCCC
TACGAGCTGGCCGAAGGGTGCGCCTCTCTCAGGTAGGCCTGTTTGCTGATGGGGTGGCGGTGCGAGAGGTGGGGGAAGAA
ACCTTCCGCCTCTGTCAGCAGTACGTGGACGAGATCCTCTTGGTGAGCACCGACGACACCTGTGCCGCCATCAAGGATGT
CTTTGAAGATACCCGCTCTATTTTGGAGCCCGCCGGCGCCTTGGCCATTGCCGGCCTCAAAGCCTACGTCAGCCGCACCG
GCATCCAGGGACAGACCCTGGTGGCGGTGGCCAGCGGGGCCAATATGAACTTCGACCGCCTGCGCTTTGTGGCCGAGCGA
GCCGAGATCGGCGAACAGCGGGAGGCCATTTTCGCCGTCACCATCCCCGAAGAGCGGGGCAGCCTGCGTCGGTTCTGCGC
CCACATCGGCCAGCGCAACCTCACCGAGTTCAACTACCGCATTGCCGATACCCACGAAGCTCACATCTTTGTCGGCCTAC
AGGTGCGGGATCGGGCCGATGCCCAGGCAGCGGCCCTGGATCTGGAGCGGGCTGGCTTTAAGACCTTGGATCTCACCGAC
GACGAGCTGGCCAAGCTGCATCTACGCCACATGGTGGGGGGGCGCTCCCCCCTGGCCGAGAACGAGCTGCTCTACCGCTT
CGAGTTCCCGGAGCGGCCCGGGGCCCTGATGCAGTTCTTGTCTTGCATGAGCCCCAACTGGAACATCAGCCTCTTTCACT
ACCGCAACAACGGCGCCGACTACGGTCGCGTCCTCATCGGCATGCAAGTGCCCACCTCGGAAATGCCCGCCTGGCAGCGC
TTTCTGGATACCCTGAACTATCGCTACTGGGACGAAAGCCACAATCCGGCCTACAAACTCTTCCTAGCCTAA

Upstream 100 bases:

>100_bases
GGATCCCTGGGATAATATCCATTGCCCGTTTGAGCAGCCCGCACCACCGGGAGCAACGTTTTTCGACATTTTTCAACCCT
ATCGACGTCGATACATCCCG

Downstream 100 bases:

>100_bases
TCAGTGTCGGCTTGTTGCGGGGGTGAACAAAGTTGTAAACAAAACTTTACAGTCCTATGTAGAGCGCGCTACGCTAGTAG
AGAAAAAGCAAGGAGAATCC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MYCDYLVQILTARVYDVAQETPLEPAFNLSRRLNNQVWLKREDLQPVFSFKLRGAYNKMAHLPPEQLAQGVIAASAGNHA
QGVALAAQRLGTHAVIVMPVTTPQVKIDAVRARGAQVVLHGDTFDDAYAHARQLEAEKGLTFIHPFDDPLVIAGQGTIGM
EILRQSQQPIHAIFVAVGGGGLISGIAAYVKRLRPEIKIIGVEPLDADAMYRSLRAGRRVRLSQVGLFADGVAVREVGEE
TFRLCQQYVDEILLVSTDDTCAAIKDVFEDTRSILEPAGALAIAGLKAYVSRTGIQGQTLVAVASGANMNFDRLRFVAER
AEIGEQREAIFAVTIPEERGSLRRFCAHIGQRNLTEFNYRIADTHEAHIFVGLQVRDRADAQAAALDLERAGFKTLDLTD
DELAKLHLRHMVGGRSPLAENELLYRFEFPERPGALMQFLSCMSPNWNISLFHYRNNGADYGRVLIGMQVPTSEMPAWQR
FLDTLNYRYWDESHNPAYKLFLA

Sequences:

>Translated_503_residues
MYCDYLVQILTARVYDVAQETPLEPAFNLSRRLNNQVWLKREDLQPVFSFKLRGAYNKMAHLPPEQLAQGVIAASAGNHA
QGVALAAQRLGTHAVIVMPVTTPQVKIDAVRARGAQVVLHGDTFDDAYAHARQLEAEKGLTFIHPFDDPLVIAGQGTIGM
EILRQSQQPIHAIFVAVGGGGLISGIAAYVKRLRPEIKIIGVEPLDADAMYRSLRAGRRVRLSQVGLFADGVAVREVGEE
TFRLCQQYVDEILLVSTDDTCAAIKDVFEDTRSILEPAGALAIAGLKAYVSRTGIQGQTLVAVASGANMNFDRLRFVAER
AEIGEQREAIFAVTIPEERGSLRRFCAHIGQRNLTEFNYRIADTHEAHIFVGLQVRDRADAQAAALDLERAGFKTLDLTD
DELAKLHLRHMVGGRSPLAENELLYRFEFPERPGALMQFLSCMSPNWNISLFHYRNNGADYGRVLIGMQVPTSEMPAWQR
FLDTLNYRYWDESHNPAYKLFLA
>Mature_503_residues
MYCDYLVQILTARVYDVAQETPLEPAFNLSRRLNNQVWLKREDLQPVFSFKLRGAYNKMAHLPPEQLAQGVIAASAGNHA
QGVALAAQRLGTHAVIVMPVTTPQVKIDAVRARGAQVVLHGDTFDDAYAHARQLEAEKGLTFIHPFDDPLVIAGQGTIGM
EILRQSQQPIHAIFVAVGGGGLISGIAAYVKRLRPEIKIIGVEPLDADAMYRSLRAGRRVRLSQVGLFADGVAVREVGEE
TFRLCQQYVDEILLVSTDDTCAAIKDVFEDTRSILEPAGALAIAGLKAYVSRTGIQGQTLVAVASGANMNFDRLRFVAER
AEIGEQREAIFAVTIPEERGSLRRFCAHIGQRNLTEFNYRIADTHEAHIFVGLQVRDRADAQAAALDLERAGFKTLDLTD
DELAKLHLRHMVGGRSPLAENELLYRFEFPERPGALMQFLSCMSPNWNISLFHYRNNGADYGRVLIGMQVPTSEMPAWQR
FLDTLNYRYWDESHNPAYKLFLA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=328, Percent_Identity=31.7073170731707, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=29.9363057324841, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI19923959, Length=312, Percent_Identity=27.5641025641026, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1790207, Length=501, Percent_Identity=52.8942115768463, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1789505, Length=307, Percent_Identity=38.1107491856677, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1789235, Length=239, Percent_Identity=30.1255230125523, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=336, Percent_Identity=33.0357142857143, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17537387, Length=324, Percent_Identity=33.641975308642, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17508781, Length=262, Percent_Identity=33.206106870229, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320930, Length=514, Percent_Identity=52.5291828793774, Blast_Score=499, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=36.963696369637, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=286, Percent_Identity=27.972027972028, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322024, Length=145, Percent_Identity=29.6551724137931, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355833, Length=329, Percent_Identity=32.2188449848024, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=30.8, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55988; Mature: 55988

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYCDYLVQILTARVYDVAQETPLEPAFNLSRRLNNQVWLKREDLQPVFSFKLRGAYNKMA
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHCCHHHHHH
HLPPEQLAQGVIAASAGNHAQGVALAAQRLGTHAVIVMPVTTPQVKIDAVRARGAQVVLH
CCCHHHHHCCEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCEEEEE
GDTFDDAYAHARQLEAEKGLTFIHPFDDPLVIAGQGTIGMEILRQSQQPIHAIFVAVGGG
CCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCHHHHHHHCCCCCEEEEEEEECCC
GLISGIAAYVKRLRPEIKIIGVEPLDADAMYRSLRAGRRVRLSQVGLFADGVAVREVGEE
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEHHHCCEEECCHHHHHHHHH
TFRLCQQYVDEILLVSTDDTCAAIKDVFEDTRSILEPAGALAIAGLKAYVSRTGIQGQTL
HHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEE
VAVASGANMNFDRLRFVAERAEIGEQREAIFAVTIPEERGSLRRFCAHIGQRNLTEFNYR
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHCCHHHHHHHHHCCCCCCCEEEE
IADTHEAHIFVGLQVRDRADAQAAALDLERAGFKTLDLTDDELAKLHLRHMVGGRSPLAE
EECCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCCCCCC
NELLYRFEFPERPGALMQFLSCMSPNWNISLFHYRNNGADYGRVLIGMQVPTSEMPAWQR
CCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHH
FLDTLNYRYWDESHNPAYKLFLA
HHHHHCCEECCCCCCCEEEEEEC
>Mature Secondary Structure
MYCDYLVQILTARVYDVAQETPLEPAFNLSRRLNNQVWLKREDLQPVFSFKLRGAYNKMA
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHCCHHHHHH
HLPPEQLAQGVIAASAGNHAQGVALAAQRLGTHAVIVMPVTTPQVKIDAVRARGAQVVLH
CCCHHHHHCCEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCEEEEE
GDTFDDAYAHARQLEAEKGLTFIHPFDDPLVIAGQGTIGMEILRQSQQPIHAIFVAVGGG
CCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCHHHHHHHCCCCCEEEEEEEECCC
GLISGIAAYVKRLRPEIKIIGVEPLDADAMYRSLRAGRRVRLSQVGLFADGVAVREVGEE
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEHHHCCEEECCHHHHHHHHH
TFRLCQQYVDEILLVSTDDTCAAIKDVFEDTRSILEPAGALAIAGLKAYVSRTGIQGQTL
HHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEE
VAVASGANMNFDRLRFVAERAEIGEQREAIFAVTIPEERGSLRRFCAHIGQRNLTEFNYR
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHCCHHHHHHHHHCCCCCCCEEEE
IADTHEAHIFVGLQVRDRADAQAAALDLERAGFKTLDLTDDELAKLHLRHMVGGRSPLAE
EECCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCCCCCC
NELLYRFEFPERPGALMQFLSCMSPNWNISLFHYRNNGADYGRVLIGMQVPTSEMPAWQR
CCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHH
FLDTLNYRYWDESHNPAYKLFLA
HHHHHCCEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA