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The map label for this gene is soxR [H]

Identifier: 86361288

GI number: 86361288

Start: 625887

End: 626321

Strand: Direct

Name: soxR [H]

Synonym: RHE_PF00560

Alternate gene names: 86361288

Gene position: 625887-626321 (Clockwise)

Preceding gene: 86361281

Following gene: 86361291

Centisome position: 97.41

GC content: 64.14

Gene sequence:

>435_bases
ATGGATCCGATGCTGACCATCACCGACGTGTCGCGGCGCAGCGGCGTTGCCTCATCGGCTCTGCGCTTCTATGAGGAGCG
TGGGTTGATCGCATCCGAGCGCGCCGGCTCGGGACATCGACGCTACCACCGGTCTGCATTGCGGCGGATCGCTTTCATCG
TCTTTGCACAGCGGATCGGGTTGACGCTTGAGGAGATCGGCGCCGAGCTCGCCAAGCTGCCGGTCGATCGCGTACCGTCA
CGTCGGGATTGGTCGCGGTTGTCGAGCGTGTGGGCAAAACGTATCGACCAACGCATAGCCGAGTTACAGCGCCTGCGGTC
CGGTCTTGGCGAATGCATCGGTTGCGGCTGCCTGTCGATCGACCGATGTCGCTTGGCGAACCCTGCCGACGTGGCAGGGC
GCAAAGGCCCGGGGGCGAGATATTGGCTGGGGTGA

Upstream 100 bases:

>100_bases
GATATTCGCCTGCATTGCGGTGCTCCTTCAATGGGTACGCCTAACTGCTACAAGTTCAAGTTAACTTGAAGTTAAGAGAG
CTTCGTGCTTTTATTTATGC

Downstream 100 bases:

>100_bases
ATGAGCCTGGATTTCGGATTTAGCCGCTACAGTCCGCCGCAGGCGATCTCCGAGTGTTTGTTACGAATTTCCGAAGGTCT
CGGTTCACCATCTCCCGAAC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MDPMLTITDVSRRSGVASSALRFYEERGLIASERAGSGHRRYHRSALRRIAFIVFAQRIGLTLEEIGAELAKLPVDRVPS
RRDWSRLSSVWAKRIDQRIAELQRLRSGLGECIGCGCLSIDRCRLANPADVAGRKGPGARYWLG

Sequences:

>Translated_144_residues
MDPMLTITDVSRRSGVASSALRFYEERGLIASERAGSGHRRYHRSALRRIAFIVFAQRIGLTLEEIGAELAKLPVDRVPS
RRDWSRLSSVWAKRIDQRIAELQRLRSGLGECIGCGCLSIDRCRLANPADVAGRKGPGARYWLG
>Mature_144_residues
MDPMLTITDVSRRSGVASSALRFYEERGLIASERAGSGHRRYHRSALRRIAFIVFAQRIGLTLEEIGAELAKLPVDRVPS
RRDWSRLSSVWAKRIDQRIAELQRLRSGLGECIGCGCLSIDRCRLANPADVAGRKGPGARYWLG

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=137, Percent_Identity=49.6350364963504, Blast_Score=126, Evalue=6e-31,
Organism=Escherichia coli, GI1786695, Length=106, Percent_Identity=34.9056603773585, Blast_Score=63, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16080; Mature: 16080

Theoretical pI: Translated: 11.20; Mature: 11.20

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPMLTITDVSRRSGVASSALRFYEERGLIASERAGSGHRRYHRSALRRIAFIVFAQRIG
CCCCEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
LTLEEIGAELAKLPVDRVPSRRDWSRLSSVWAKRIDQRIAELQRLRSGLGECIGCGCLSI
CCHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DRCRLANPADVAGRKGPGARYWLG
CHHCCCCCHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDPMLTITDVSRRSGVASSALRFYEERGLIASERAGSGHRRYHRSALRRIAFIVFAQRIG
CCCCEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
LTLEEIGAELAKLPVDRVPSRRDWSRLSSVWAKRIDQRIAELQRLRSGLGECIGCGCLSI
CCHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DRCRLANPADVAGRKGPGARYWLG
CHHCCCCCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9045804; 10984043 [H]