BacMap

Definition	Rhizobium etli CFN 42 plasmid p42f, complete sequence.
Accession	NC_007766
Length	642,517

Click here to switch to the map view.

The map label for this gene is vbsS

Identifier: 86361187

GI number: 86361187

Start: 513853

End: 517845

Strand: Reverse

Name: vbsS

Synonym: RHE_PF00457

Alternate gene names: 86361187

Gene position: 517845-513853 (Counterclockwise)

Preceding gene: 86361188

Following gene: 86361186

Centisome position: 80.6

GC content: 64.74

Gene sequence:

>3993_bases
ATGAACAAGCAGATCACCAATTTCGCCGATGCCCGTCCGACCGACGCAGTGGACGCCGTCTTCGAGAGCTTTCCGCTGAC
CATCGCGCAGAAGCGCATCTGGTCGCTGGAGCAGATCGGCAATTACACGGTCTTTCCCGCTCAGGTCATAGGGCTGCGGC
TGAGCGCCGCGATCGACGTCGAGACGATTGCCGGCGCCTGCCGCGCGCTCGTGGCGCAGAATCCATCGCTTGCCTTCCGC
TTCCGCCGGCTGGCGGGCGGCCGCATCGAGCAATATCGCGGCGCGTCGAGCGAAGTGCCGCTCGATATCCTCGGCAAGGA
CGGCGCGGCTCTTTCCGAGCCCGATGCCTTGGCCGCACGGAAAGCCTTCCGCGACAAGCGCTTCGATCTCCTGGAAGGGC
CAGGCGCACGCATCCAGATCATCCGGCTTGCCGATGGGCAGTCGCTGCTGACGATCATGCTGCATCCGATCATCTGCGAC
GACCGCGAAAAATCCGTTCTTGCCGGGTCGCTGGCCAGCATTCTCGATGGCGAACCCGCCGGCGATATGCAGCCGGTGGA
AATCGCCGCCGGGGCGCGCGAGGCCGATTGGCTGGAGACGGATGAGGCGCGGCAGGCGCTTGCCTACTGGCGCGATGCGA
TAGGTTTGGACTATGCGGCCTCGACCTTCCCGACCCGTTTCAACAGCGGTGGGCTGGCAGGCGTGGCGCGCGCCGAGCAT
CGGTTTTCGATCGCCCCCGAGCTCTGGAGCAAACTCGAACGGCATGCGAGGGGGAAGGGCGTTCACGTCGAGCGCGTGCT
TCACGCCGCCTTCTGCGCGCTTCTGGCGCGCTACAACGGCAACTATGCCCTGCTGACCGGCCTGCTTGTCGCGCGGCCCC
GCACCGAACATCTCGCCAGCCGCGGCCGCGCCGAGCAGGTTCTTCCCCTTGTGCTCTCGCTGACCTCGAGACACTCGCTC
GACGATGTCGTCGCGGCGATCTCGTCGGTGACGCAGGAGGGGCTTGCCCGCCTCGTGCCGCTGGAGCGCATCACGCAGGA
ACTTGTTGTCGACGAGGCAGCCGCCCAGGAGGCCGTGGTCAAGGCCTTGTTCGAATTCCGCGAACCTTATCCCGTCCCGA
GGCAGGCGACGAACCTGGAACCCTCAGGCGCACGCGCCGACAGCGAGCTCTCCCTAGTCGTCGAGGCTCGCACGGATGGC
GGCGCGTACGGGCTGATCGACTATGCCGGCGATCTCTATGACGACGCCCTGATTGCCCGTGTCTCCAGGCATTATTGCCT
GGTGCTGGAGCAGATCGTCGCCAAGCCCGATCTCAGGATCAGGGATATCGAACTCATGGGCAGCGACGAGCTCGACTGGC
TGTCGGCGCCCTATGAGGATGACGCCGTCAATGACGACCGGCCGGTGCACGAGCTGATCTCGGCCCATTCGCGCCGCACG
CCAGACAAGACCGCGATCGTCTATGGCGACGAGGAGTGGAGCCATGGCTGGCTGGAGGCGAGCACCAACCGCCTCGGTCA
TCGGCTGCGGCAACTCGGCGTTCGCGCCGAAGTGACGGTCGCAATCTTCATCAAGCGCTCGCCGGAGGCGATCGTCGGCA
TCCTCGCGACCTTGAAGGCCGGCGGCGCCTATATTCCCGTTGAGCCTGACCATCCGCCGGTGCGCAACCACCACATCCTG
CGCGATGGCGGCGTCAAGATCGTGCTCACCCATAGCTGGCTGCGCCACCGCCTGCCGGAAGAACTCGACGCGACCGTCCT
CGAACTCGACAAGCTCGATCTCGAGGGCGAGCCGGATACGCCGCTTTATGTTCCCACGCACAAGGACCAGCTCGCCTATG
TCATGTACACCTCGGGCTCGACGGGATTGCCGAAAGGCGTCGCCGTCGAGCACGGGCCGCTGACGCACCATCTGCAGAAT
ACCTCGCGCGTCTATGGCATGAGCTCGGAATCCCGCGAGCTGCCCTTCCTGCCCTTCAGTTCGGATGGCGGCCATGAGCG
GTGGATGAACCCGCTGATGGAAGGCGGCAGCATCATTCTTCCCGACCAGCCGCTCTGGACGCCTGAGGAGACGCTGACGG
CGATGCGCAAGCATGGCGCCAACAATGCGAGCATTCCCACAACCTATCTGCAGCAGCTGGCGGAATGGGCCGATAGCACT
GACAGCGCGCCGCCGATGCGGCTCTATTCCTTTGGCGGCGAGGGGCTGGCGCAAACGACCTTCGATCTTCTGTCGCGGGC
GCTGAAGTCGGAATGGCTGATCAACGGCTATGGTCCCACGGAAACGATCATGACGCCGATGGTCTGGAAGGTCAGGGCCG
GCACGAAGTTCCAGGGCGTCTATGCGCCGCTCGGCCGCGCGGTCGGGCTGCGGCGCGTCTATGTGCTCGATCCCGATCTC
AACCTGTGCCCGATCGGCGTGACCGGCGAACTCTATATTGGCGGCGAGGGCATCGCGCGCGGCTATCTCGGCAAAGCAGA
TGCGACCGCCGACCGTTTCATCCCCGACCCATTTTCCAAGAAGGGCGGCCGGCTCTATCGCTCCGGCGACCTGACACGTT
GGCGCGAGGACGGAACGGTCGAATTCGTCGGCCGCGTCGATCATCAGGTGAAGCTGCGGGGATACCGCATCGAACTCGGC
GAGGTCGAAGCCGCACTCCTCCAGCAGCCCGGCGTCGGCGAAGCCCTGGTCGTTCTGCGCGATGACGATGCCGGCGGCGA
AAAGGCGCTGGTCGCCTATGTCGTGCCGAAGAAGGATGAGAGGCTTGACGTCGAGACGGTGCGCGCCGGCCTCGAGCGCA
GCCTGCCATCCTATATGGTGCCGGCGGCCGTGGTCGAACTCGAGAAGATGCCGACCAATCCGAACAGCAAGCTCGACCGC
TTCGCGCTGCCCGCACCCCAGCCGGTCAAACGCGCAATCATCGAGCCGGCGACCGCGCTCGAAGAGGAGGTGCTGGATGT
CTGGCGCCGGGTTCTCAAGCTGGAAGCGATCAGCGTCGAGGATAATTTCTTTGCCATCGGCGGCAATTCGCTGGGCGCGA
TCCGCATCCTCACGCAGCTCAGGCAGCGCCGGCCGAAGATCCCGCTCACCGTCGCCGATATCTTCAACAACCCGACCATT
CGCGCCTTTGCCGGCGTGATGGAGCAGGGGGAGGAGCGCGATCTCTCCGAGGTGATCGTGCTGCGCGCCTCCGGCGCCAA
GCCGCGGCTCTATTGCTTCCCGGGGCTCCTCGTCAGCACCCGCGAATATGTGAAGCTCGTCGATTATCTCGGCGCCGATC
AGCCGGCGACCGGCTTCATTTGCCACTCGCTGTCCGAGAAGAAGGAAGTCGGGGCGCCTGTTGAAGAGATCATCGAGAGC
TATGTCGACTATATCAGGAAGCACAGCGGCGGCGCGCCCTGCACTTTCCTCGGTTGGTCCTGGGGCGGGCTCCTGGCTTA
CGAGGCCGCCCGCACCCTTGCTAACGAGGTCGACGTCAGGATGATGGCGATGGTCGATGTCTGCGACCTCGGATCGGAAT
TTGCCATCGGCGCCAAGCCGAGGTTCCGGCCCGGCGAACGCGACATGCTGCACCGGGACGTGCAGGCATGGCTGCAAAAG
ACGGCGATGCGGCCCGAATCGGACCGGCTGCTGTCGACGATGGACGCCGATACCTACGAGCAGTTCCTGCGCTTCGTCGG
CGACGAGAAGGATCCGCTTCCCACAGACGGGCCCGACATCAGCAGCCGCGAGCATACGTTCTGGGTGCTGATCGACAACG
CCCTGATCTTCCGCAAGCACCGGCTCGTTCCCCATGACGTGCCGATCTATCCCTGGGCGGCCGATGACAGCCTCAACCGC
GGCCTCAACCTGATCGATTGGCGCCGCCTGTCGCCGCGGGCTCGCGCGGCCGAAATCATCACCGGCACCAACCATCTGCA
CATGATCGGGTCTCCCGCCTTCCATTCAAGGCTTGCCCTGCGTCTCAAGGAAACAGAGAAGGATAACGCATGA

Upstream 100 bases:

>100_bases
CCTGGCCCATATCCGCGACGTGTGGACCGATCCCCGCCCGCTCTCCCTGCGCTCGGCGATGGCCGGCGATGCGCGTCTCT
GAAAACCTCTGGATGGCAAG

Downstream 100 bases:

>100_bases
CCGTCGCTTTTACCCGCAGGGATGCCCTCAACGAGCCGCTCGATCTTGCCGGCATCGGCATCGGTCCCTCCAATCTGAGC
CTTGCCTGCCTGCTGGAATC

Product: vicibactin biosynthesis non-ribosomal peptide synthase protein

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan/phenylalanine/tyrosine adenylase; Trp/Phe/TyrA; Tryptophan/phenylalanine/tyrosine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 1330; Mature: 1330

Protein sequence:

>1330_residues
MNKQITNFADARPTDAVDAVFESFPLTIAQKRIWSLEQIGNYTVFPAQVIGLRLSAAIDVETIAGACRALVAQNPSLAFR
FRRLAGGRIEQYRGASSEVPLDILGKDGAALSEPDALAARKAFRDKRFDLLEGPGARIQIIRLADGQSLLTIMLHPIICD
DREKSVLAGSLASILDGEPAGDMQPVEIAAGAREADWLETDEARQALAYWRDAIGLDYAASTFPTRFNSGGLAGVARAEH
RFSIAPELWSKLERHARGKGVHVERVLHAAFCALLARYNGNYALLTGLLVARPRTEHLASRGRAEQVLPLVLSLTSRHSL
DDVVAAISSVTQEGLARLVPLERITQELVVDEAAAQEAVVKALFEFREPYPVPRQATNLEPSGARADSELSLVVEARTDG
GAYGLIDYAGDLYDDALIARVSRHYCLVLEQIVAKPDLRIRDIELMGSDELDWLSAPYEDDAVNDDRPVHELISAHSRRT
PDKTAIVYGDEEWSHGWLEASTNRLGHRLRQLGVRAEVTVAIFIKRSPEAIVGILATLKAGGAYIPVEPDHPPVRNHHIL
RDGGVKIVLTHSWLRHRLPEELDATVLELDKLDLEGEPDTPLYVPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHHLQN
TSRVYGMSSESRELPFLPFSSDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWADST
DSAPPMRLYSFGGEGLAQTTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKFQGVYAPLGRAVGLRRVYVLDPDL
NLCPIGVTGELYIGGEGIARGYLGKADATADRFIPDPFSKKGGRLYRSGDLTRWREDGTVEFVGRVDHQVKLRGYRIELG
EVEAALLQQPGVGEALVVLRDDDAGGEKALVAYVVPKKDERLDVETVRAGLERSLPSYMVPAAVVELEKMPTNPNSKLDR
FALPAPQPVKRAIIEPATALEEEVLDVWRRVLKLEAISVEDNFFAIGGNSLGAIRILTQLRQRRPKIPLTVADIFNNPTI
RAFAGVMEQGEERDLSEVIVLRASGAKPRLYCFPGLLVSTREYVKLVDYLGADQPATGFICHSLSEKKEVGAPVEEIIES
YVDYIRKHSGGAPCTFLGWSWGGLLAYEAARTLANEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDMLHRDVQAWLQK
TAMRPESDRLLSTMDADTYEQFLRFVGDEKDPLPTDGPDISSREHTFWVLIDNALIFRKHRLVPHDVPIYPWAADDSLNR
GLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSRLALRLKETEKDNA

Sequences:

>Translated_1330_residues
MNKQITNFADARPTDAVDAVFESFPLTIAQKRIWSLEQIGNYTVFPAQVIGLRLSAAIDVETIAGACRALVAQNPSLAFR
FRRLAGGRIEQYRGASSEVPLDILGKDGAALSEPDALAARKAFRDKRFDLLEGPGARIQIIRLADGQSLLTIMLHPIICD
DREKSVLAGSLASILDGEPAGDMQPVEIAAGAREADWLETDEARQALAYWRDAIGLDYAASTFPTRFNSGGLAGVARAEH
RFSIAPELWSKLERHARGKGVHVERVLHAAFCALLARYNGNYALLTGLLVARPRTEHLASRGRAEQVLPLVLSLTSRHSL
DDVVAAISSVTQEGLARLVPLERITQELVVDEAAAQEAVVKALFEFREPYPVPRQATNLEPSGARADSELSLVVEARTDG
GAYGLIDYAGDLYDDALIARVSRHYCLVLEQIVAKPDLRIRDIELMGSDELDWLSAPYEDDAVNDDRPVHELISAHSRRT
PDKTAIVYGDEEWSHGWLEASTNRLGHRLRQLGVRAEVTVAIFIKRSPEAIVGILATLKAGGAYIPVEPDHPPVRNHHIL
RDGGVKIVLTHSWLRHRLPEELDATVLELDKLDLEGEPDTPLYVPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHHLQN
TSRVYGMSSESRELPFLPFSSDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWADST
DSAPPMRLYSFGGEGLAQTTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKFQGVYAPLGRAVGLRRVYVLDPDL
NLCPIGVTGELYIGGEGIARGYLGKADATADRFIPDPFSKKGGRLYRSGDLTRWREDGTVEFVGRVDHQVKLRGYRIELG
EVEAALLQQPGVGEALVVLRDDDAGGEKALVAYVVPKKDERLDVETVRAGLERSLPSYMVPAAVVELEKMPTNPNSKLDR
FALPAPQPVKRAIIEPATALEEEVLDVWRRVLKLEAISVEDNFFAIGGNSLGAIRILTQLRQRRPKIPLTVADIFNNPTI
RAFAGVMEQGEERDLSEVIVLRASGAKPRLYCFPGLLVSTREYVKLVDYLGADQPATGFICHSLSEKKEVGAPVEEIIES
YVDYIRKHSGGAPCTFLGWSWGGLLAYEAARTLANEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDMLHRDVQAWLQK
TAMRPESDRLLSTMDADTYEQFLRFVGDEKDPLPTDGPDISSREHTFWVLIDNALIFRKHRLVPHDVPIYPWAADDSLNR
GLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSRLALRLKETEKDNA
>Mature_1330_residues
MNKQITNFADARPTDAVDAVFESFPLTIAQKRIWSLEQIGNYTVFPAQVIGLRLSAAIDVETIAGACRALVAQNPSLAFR
FRRLAGGRIEQYRGASSEVPLDILGKDGAALSEPDALAARKAFRDKRFDLLEGPGARIQIIRLADGQSLLTIMLHPIICD
DREKSVLAGSLASILDGEPAGDMQPVEIAAGAREADWLETDEARQALAYWRDAIGLDYAASTFPTRFNSGGLAGVARAEH
RFSIAPELWSKLERHARGKGVHVERVLHAAFCALLARYNGNYALLTGLLVARPRTEHLASRGRAEQVLPLVLSLTSRHSL
DDVVAAISSVTQEGLARLVPLERITQELVVDEAAAQEAVVKALFEFREPYPVPRQATNLEPSGARADSELSLVVEARTDG
GAYGLIDYAGDLYDDALIARVSRHYCLVLEQIVAKPDLRIRDIELMGSDELDWLSAPYEDDAVNDDRPVHELISAHSRRT
PDKTAIVYGDEEWSHGWLEASTNRLGHRLRQLGVRAEVTVAIFIKRSPEAIVGILATLKAGGAYIPVEPDHPPVRNHHIL
RDGGVKIVLTHSWLRHRLPEELDATVLELDKLDLEGEPDTPLYVPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHHLQN
TSRVYGMSSESRELPFLPFSSDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWADST
DSAPPMRLYSFGGEGLAQTTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKFQGVYAPLGRAVGLRRVYVLDPDL
NLCPIGVTGELYIGGEGIARGYLGKADATADRFIPDPFSKKGGRLYRSGDLTRWREDGTVEFVGRVDHQVKLRGYRIELG
EVEAALLQQPGVGEALVVLRDDDAGGEKALVAYVVPKKDERLDVETVRAGLERSLPSYMVPAAVVELEKMPTNPNSKLDR
FALPAPQPVKRAIIEPATALEEEVLDVWRRVLKLEAISVEDNFFAIGGNSLGAIRILTQLRQRRPKIPLTVADIFNNPTI
RAFAGVMEQGEERDLSEVIVLRASGAKPRLYCFPGLLVSTREYVKLVDYLGADQPATGFICHSLSEKKEVGAPVEEIIES
YVDYIRKHSGGAPCTFLGWSWGGLLAYEAARTLANEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDMLHRDVQAWLQK
TAMRPESDRLLSTMDADTYEQFLRFVGDEKDPLPTDGPDISSREHTFWVLIDNALIFRKHRLVPHDVPIYPWAADDSLNR
GLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSRLALRLKETEKDNA

Specific function: Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D- Leu) an

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=586, Percent_Identity=21.8430034129693, Blast_Score=86, Evalue=3e-16,
Organism=Homo sapiens, GI187761345, Length=497, Percent_Identity=23.1388329979879, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI187761343, Length=497, Percent_Identity=23.1388329979879, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI42544132, Length=388, Percent_Identity=23.9690721649485, Blast_Score=73, Evalue=2e-12,
Organism=Homo sapiens, GI157311624, Length=476, Percent_Identity=23.3193277310924, Blast_Score=70, Evalue=2e-11,
Organism=Homo sapiens, GI157311622, Length=476, Percent_Identity=23.3193277310924, Blast_Score=70, Evalue=2e-11,
Organism=Homo sapiens, GI58082049, Length=480, Percent_Identity=23.3333333333333, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786801, Length=1203, Percent_Identity=25.2701579384871, Blast_Score=247, Evalue=4e-66,
Organism=Escherichia coli, GI145693145, Length=534, Percent_Identity=22.6591760299625, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1788107, Length=558, Percent_Identity=24.5519713261649, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17556356, Length=691, Percent_Identity=25.7597684515195, Blast_Score=156, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17550940, Length=551, Percent_Identity=23.2304900181488, Blast_Score=128, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=505, Percent_Identity=24.5544554455446, Blast_Score=108, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=543, Percent_Identity=22.8360957642726, Blast_Score=97, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=453, Percent_Identity=25.1655629139073, Blast_Score=93, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17531443, Length=513, Percent_Identity=22.2222222222222, Blast_Score=82, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=381, Percent_Identity=24.6719160104987, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560308, Length=381, Percent_Identity=22.0472440944882, Blast_Score=73, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=769, Percent_Identity=25.2275682704811, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319699, Length=352, Percent_Identity=24.4318181818182, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319264, Length=569, Percent_Identity=23.725834797891, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648676, Length=628, Percent_Identity=27.7070063694268, Blast_Score=167, Evalue=6e-41,
Organism=Drosophila melanogaster, GI18859661, Length=542, Percent_Identity=23.2472324723247, Blast_Score=98, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21355181, Length=541, Percent_Identity=22.9205175600739, Blast_Score=98, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24581924, Length=359, Percent_Identity=24.2339832869081, Blast_Score=71, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR023213
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 147036; Mature: 147036

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQITNFADARPTDAVDAVFESFPLTIAQKRIWSLEQIGNYTVFPAQVIGLRLSAAIDV
CCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHCCH
ETIAGACRALVAQNPSLAFRFRRLAGGRIEQYRGASSEVPLDILGKDGAALSEPDALAAR
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHH
KAFRDKRFDLLEGPGARIQIIRLADGQSLLTIMLHPIICDDREKSVLAGSLASILDGEPA
HHHHHCCCHHHCCCCCEEEEEEECCCCCEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
GDMQPVEIAAGAREADWLETDEARQALAYWRDAIGLDYAASTFPTRFNSGGLAGVARAEH
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCHHHHHCC
RFSIAPELWSKLERHARGKGVHVERVLHAAFCALLARYNGNYALLTGLLVARPRTEHLAS
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCHHHHHH
RGRAEQVLPLVLSLTSRHSLDDVVAAISSVTQEGLARLVPLERITQELVVDEAAAQEAVV
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KALFEFREPYPVPRQATNLEPSGARADSELSLVVEARTDGGAYGLIDYAGDLYDDALIAR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEHHHCCHHHHHHHHHH
VSRHYCLVLEQIVAKPDLRIRDIELMGSDELDWLSAPYEDDAVNDDRPVHELISAHSRRT
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
PDKTAIVYGDEEWSHGWLEASTNRLGHRLRQLGVRAEVTVAIFIKRSPEAIVGILATLKA
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHHC
GGAYIPVEPDHPPVRNHHILRDGGVKIVLTHSWLRHRLPEELDATVLELDKLDLEGEPDT
CCEEECCCCCCCCCCCCEEEECCCEEEEEECHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
PLYVPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHHLQNTSRVYGMSSESRELPFLPFS
CEEECCCCCCEEEEEEECCCCCCCCCCEECCCCCHHHHCCCHHEECCCCCCCCCCEECCC
SDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWADST
CCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
DSAPPMRLYSFGGEGLAQTTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKFQGV
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHCCCEEEEECCCEECCH
YAPLGRAVGLRRVYVLDPDLNLCPIGVTGELYIGGEGIARGYLGKADATADRFIPDPFSK
HHHHHHHCCCEEEEEECCCCCEEEECCCCEEEECCCCHHCCCCCCCCCCHHCCCCCCCCC
KGGRLYRSGDLTRWREDGTVEFVGRVDHQVKLRGYRIELGEVEAALLQQPGVGEALVVLR
CCCEEEECCCCCEECCCCCEEEEECCCCEEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEE
DDDAGGEKALVAYVVPKKDERLDVETVRAGLERSLPSYMVPAAVVELEKMPTNPNSKLDR
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHH
FALPAPQPVKRAIIEPATALEEEVLDVWRRVLKLEAISVEDNFFAIGGNSLGAIRILTQL
CCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEECCCCCHHHHHHHHH
RQRRPKIPLTVADIFNNPTIRAFAGVMEQGEERDLSEVIVLRASGAKPRLYCFPGLLVST
HHHCCCCCEEHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCHHHHH
REYVKLVDYLGADQPATGFICHSLSEKKEVGAPVEEIIESYVDYIRKHSGGAPCTFLGWS
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCC
WGGLLAYEAARTLANEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDMLHRDVQAWLQK
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHH
TAMRPESDRLLSTMDADTYEQFLRFVGDEKDPLPTDGPDISSREHTFWVLIDNALIFRKH
HHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEHHC
RLVPHDVPIYPWAADDSLNRGLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSRLAL
CCCCCCCCCCCCCCCCHHHCCCCCEECCCCCCHHHHHHEEECCCCEEEECCCHHHHHHHH
RLKETEKDNA
HHHCCCCCCC
>Mature Secondary Structure
MNKQITNFADARPTDAVDAVFESFPLTIAQKRIWSLEQIGNYTVFPAQVIGLRLSAAIDV
CCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHCCH
ETIAGACRALVAQNPSLAFRFRRLAGGRIEQYRGASSEVPLDILGKDGAALSEPDALAAR
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHH
KAFRDKRFDLLEGPGARIQIIRLADGQSLLTIMLHPIICDDREKSVLAGSLASILDGEPA
HHHHHCCCHHHCCCCCEEEEEEECCCCCEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
GDMQPVEIAAGAREADWLETDEARQALAYWRDAIGLDYAASTFPTRFNSGGLAGVARAEH
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCHHHHHCC
RFSIAPELWSKLERHARGKGVHVERVLHAAFCALLARYNGNYALLTGLLVARPRTEHLAS
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCHHHHHH
RGRAEQVLPLVLSLTSRHSLDDVVAAISSVTQEGLARLVPLERITQELVVDEAAAQEAVV
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KALFEFREPYPVPRQATNLEPSGARADSELSLVVEARTDGGAYGLIDYAGDLYDDALIAR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEHHHCCHHHHHHHHHH
VSRHYCLVLEQIVAKPDLRIRDIELMGSDELDWLSAPYEDDAVNDDRPVHELISAHSRRT
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
PDKTAIVYGDEEWSHGWLEASTNRLGHRLRQLGVRAEVTVAIFIKRSPEAIVGILATLKA
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHHC
GGAYIPVEPDHPPVRNHHILRDGGVKIVLTHSWLRHRLPEELDATVLELDKLDLEGEPDT
CCEEECCCCCCCCCCCCEEEECCCEEEEEECHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
PLYVPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHHLQNTSRVYGMSSESRELPFLPFS
CEEECCCCCCEEEEEEECCCCCCCCCCEECCCCCHHHHCCCHHEECCCCCCCCCCEECCC
SDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWADST
CCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
DSAPPMRLYSFGGEGLAQTTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKFQGV
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHCCCEEEEECCCEECCH
YAPLGRAVGLRRVYVLDPDLNLCPIGVTGELYIGGEGIARGYLGKADATADRFIPDPFSK
HHHHHHHCCCEEEEEECCCCCEEEECCCCEEEECCCCHHCCCCCCCCCCHHCCCCCCCCC
KGGRLYRSGDLTRWREDGTVEFVGRVDHQVKLRGYRIELGEVEAALLQQPGVGEALVVLR
CCCEEEECCCCCEECCCCCEEEEECCCCEEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEE
DDDAGGEKALVAYVVPKKDERLDVETVRAGLERSLPSYMVPAAVVELEKMPTNPNSKLDR
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHH
FALPAPQPVKRAIIEPATALEEEVLDVWRRVLKLEAISVEDNFFAIGGNSLGAIRILTQL
CCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEECCCCCHHHHHHHHH
RQRRPKIPLTVADIFNNPTIRAFAGVMEQGEERDLSEVIVLRASGAKPRLYCFPGLLVST
HHHCCCCCEEHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCHHHHH
REYVKLVDYLGADQPATGFICHSLSEKKEVGAPVEEIIESYVDYIRKHSGGAPCTFLGWS
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCC
WGGLLAYEAARTLANEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDMLHRDVQAWLQK
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHH
TAMRPESDRLLSTMDADTYEQFLRFVGDEKDPLPTDGPDISSREHTFWVLIDNALIFRKH
HHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEHHC
RLVPHDVPIYPWAADDSLNRGLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSRLAL
CCCCCCCCCCCCCCCCHHHCCCCCEECCCCCCHHHHHHEEECCCCEEEECCCHHHHHHHH
RLKETEKDNA
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA