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The map label for this gene is serA [H]

Identifier: 86361109

GI number: 86361109

Start: 427557

End: 428531

Strand: Reverse

Name: serA [H]

Synonym: RHE_PF00379

Alternate gene names: 86361109

Gene position: 428531-427557 (Counterclockwise)

Preceding gene: 86361110

Following gene: 86361102

Centisome position: 66.7

GC content: 64.92

Gene sequence:

>975_bases
ATGAGCTTCATCTTTTCCACACATCCCCTGCACCCCGCGGCCAAGGCCATGCTTCAGGGAGCGGGTGATCTGCGTATCGC
GTCCGCGCCCGATCCCGAAACCTTGCTGCGAGAAGGACGGGGTGCGGGCATTGTCATCGTGCGCGCGCCGATCCCGCCGG
TTTTCTTCGAGGATGCGCCGGCGCTCCGTGCGGCGATCCGCCATGGTGCCGGCCTCGACATGGTGCCGATGGAGGCGGCG
ACCCGCGCCGGTGTGCTTGTCGCCAACGTGCCTGGTGTCAATGCGTCGACTGTCGCCGAACATGTGTTCCTGGTGACACT
GGCTCTGCTCAGGCGCTTCCGCCAGATGGACGGGGACCTGCGTCAGAACGGCTGGGCAGCAGGCCGCGCCCAGGCGGATG
CTGCCGTCGACCTCGGCGGCCGCACTATGGGTATCGTCGGCATGGGCAATGTCGGGAAGGCGATCTTCAAGATTGCAAAG
TTCGGCTTTGGCCTCGAGGTGGTCGCCACGAGCCGGTCGCCGGGAAGTGTGCCGGAGGGCGCGCGCTTCCTGACAATCGA
TGAGCTCGTCGCGCTGGCCGATATCCTTGTGCTTTGCTGCCCGCTGACGCCCGGGACAACTGGCTTGCTCCATGCCGGGC
GCATCGCTCGGATGAGGCCCGATGCCATTCTGGTCAACGTTTCGCGCGGTCCCGTGGTCGATGACGCGGCGCTGATCGAG
GCCTTGCGCGGCGGCCGCATCGGCGGAGCGGCGCTCGACGTCTTTGCTACGCAACCACTGCCGTTAGATCATCCCTATTT
CGGCTTTGCCAACGTCATCGTCACTCCGCATCTGGCTGGTCTGACGGAAGAGAGCATGATGCGCATGGGAACAGGCGCGG
CCAGCGAAGCGCTGCGCGTCATCAAAGGCGACCTGCCCGTCAATTTGCGGAATCCCGAAGTGGTAGAGCACTACCGCCGG
CGCTTTCCGACATAA

Upstream 100 bases:

>100_bases
TGATGAGCGCGCATCTTCAAGGTGCGCAAAGCTATTGGAAGGGTCTCATCGGCGGTCCGGCGGCGGCAGCTCGATAGGGA
GTAACCGGCGGGGAGGGCCG

Downstream 100 bases:

>100_bases
CGCGGCTGCGAGCGGGAAGGCCGGCTGCCATGCCACGCGCAGAGACATCTTTTTGTATGGAGCAGGTCAGACCGCATGCC
GCAGGCTTACCCCGCTGCCG

Product: putative phosphoglycerate dehydrogenase protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSFIFSTHPLHPAAKAMLQGAGDLRIASAPDPETLLREGRGAGIVIVRAPIPPVFFEDAPALRAAIRHGAGLDMVPMEAA
TRAGVLVANVPGVNASTVAEHVFLVTLALLRRFRQMDGDLRQNGWAAGRAQADAAVDLGGRTMGIVGMGNVGKAIFKIAK
FGFGLEVVATSRSPGSVPEGARFLTIDELVALADILVLCCPLTPGTTGLLHAGRIARMRPDAILVNVSRGPVVDDAALIE
ALRGGRIGGAALDVFATQPLPLDHPYFGFANVIVTPHLAGLTEESMMRMGTGAASEALRVIKGDLPVNLRNPEVVEHYRR
RFPT

Sequences:

>Translated_324_residues
MSFIFSTHPLHPAAKAMLQGAGDLRIASAPDPETLLREGRGAGIVIVRAPIPPVFFEDAPALRAAIRHGAGLDMVPMEAA
TRAGVLVANVPGVNASTVAEHVFLVTLALLRRFRQMDGDLRQNGWAAGRAQADAAVDLGGRTMGIVGMGNVGKAIFKIAK
FGFGLEVVATSRSPGSVPEGARFLTIDELVALADILVLCCPLTPGTTGLLHAGRIARMRPDAILVNVSRGPVVDDAALIE
ALRGGRIGGAALDVFATQPLPLDHPYFGFANVIVTPHLAGLTEESMMRMGTGAASEALRVIKGDLPVNLRNPEVVEHYRR
RFPT
>Mature_323_residues
SFIFSTHPLHPAAKAMLQGAGDLRIASAPDPETLLREGRGAGIVIVRAPIPPVFFEDAPALRAAIRHGAGLDMVPMEAAT
RAGVLVANVPGVNASTVAEHVFLVTLALLRRFRQMDGDLRQNGWAAGRAQADAAVDLGGRTMGIVGMGNVGKAIFKIAKF
GFGLEVVATSRSPGSVPEGARFLTIDELVALADILVLCCPLTPGTTGLLHAGRIARMRPDAILVNVSRGPVVDDAALIEA
LRGGRIGGAALDVFATQPLPLDHPYFGFANVIVTPHLAGLTEESMMRMGTGAASEALRVIKGDLPVNLRNPEVVEHYRRR
FPT

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=309, Percent_Identity=31.3915857605178, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI145580578, Length=269, Percent_Identity=34.2007434944238, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4557499, Length=269, Percent_Identity=34.2007434944238, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=34.1911764705882, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI61743967, Length=272, Percent_Identity=34.1911764705882, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580575, Length=269, Percent_Identity=34.2007434944238, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI6912396, Length=247, Percent_Identity=31.5789473684211, Blast_Score=128, Evalue=5e-30,
Organism=Escherichia coli, GI87082289, Length=265, Percent_Identity=33.5849056603774, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789279, Length=304, Percent_Identity=30.2631578947368, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1787645, Length=268, Percent_Identity=27.2388059701493, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081824, Length=241, Percent_Identity=28.6307053941909, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=30.2238805970149, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17532191, Length=247, Percent_Identity=27.1255060728745, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=251, Percent_Identity=31.4741035856574, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=261, Percent_Identity=31.0344827586207, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=302, Percent_Identity=28.476821192053, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=261, Percent_Identity=30.6513409961686, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=30.0578034682081, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=119, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646446, Length=277, Percent_Identity=33.9350180505415, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646448, Length=277, Percent_Identity=33.9350180505415, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646452, Length=277, Percent_Identity=33.9350180505415, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646450, Length=277, Percent_Identity=33.9350180505415, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI62472511, Length=277, Percent_Identity=33.9350180505415, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28571528, Length=249, Percent_Identity=31.7269076305221, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585514, Length=250, Percent_Identity=30, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574282, Length=250, Percent_Identity=30, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574284, Length=250, Percent_Identity=30, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=30, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=30, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=26.578073089701, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI28574286, Length=250, Percent_Identity=28.8, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24585516, Length=244, Percent_Identity=25.4098360655738, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34132; Mature: 34001

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIFSTHPLHPAAKAMLQGAGDLRIASAPDPETLLREGRGAGIVIVRAPIPPVFFEDAP
CCCCCCCCCCCHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCEEEEEECCCCCCEECCCH
ALRAAIRHGAGLDMVPMEAATRAGVLVANVPGVNASTVAEHVFLVTLALLRRFRQMDGDL
HHHHHHHCCCCCCCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
RQNGWAAGRAQADAAVDLGGRTMGIVGMGNVGKAIFKIAKFGFGLEVVATSRSPGSVPEG
HHCCCCCCCCCCCCEEECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
ARFLTIDELVALADILVLCCPLTPGTTGLLHAGRIARMRPDAILVNVSRGPVVDDAALIE
CEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHEECCCEEEEECCCCCCCCHHHHHH
ALRGGRIGGAALDVFATQPLPLDHPYFGFANVIVTPHLAGLTEESMMRMGTGAASEALRV
HHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHEECCCCCCCCHHHHHHHCCCCHHHHHHH
IKGDLPVNLRNPEVVEHYRRRFPT
HHCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SFIFSTHPLHPAAKAMLQGAGDLRIASAPDPETLLREGRGAGIVIVRAPIPPVFFEDAP
CCCCCCCCCCHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCEEEEEECCCCCCEECCCH
ALRAAIRHGAGLDMVPMEAATRAGVLVANVPGVNASTVAEHVFLVTLALLRRFRQMDGDL
HHHHHHHCCCCCCCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
RQNGWAAGRAQADAAVDLGGRTMGIVGMGNVGKAIFKIAKFGFGLEVVATSRSPGSVPEG
HHCCCCCCCCCCCCEEECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
ARFLTIDELVALADILVLCCPLTPGTTGLLHAGRIARMRPDAILVNVSRGPVVDDAALIE
CEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHEECCCEEEEECCCCCCCCHHHHHH
ALRGGRIGGAALDVFATQPLPLDHPYFGFANVIVTPHLAGLTEESMMRMGTGAASEALRV
HHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHEECCCCCCCCHHHHHHHCCCCHHHHHHH
IKGDLPVNLRNPEVVEHYRRRFPT
HHCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]