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The map label for this gene is qor [C]

Identifier: 86360887

GI number: 86360887

Start: 165531

End: 166556

Strand: Direct

Name: qor [C]

Synonym: RHE_PF00156

Alternate gene names: 86360887

Gene position: 165531-166556 (Clockwise)

Preceding gene: 86360885

Following gene: 86360888

Centisome position: 25.76

GC content: 62.96

Gene sequence:

>1026_bases
ATGAAAGCCGTTGGATACAACAAACCCGCCCCGATTACCGATGATGCATCACTCCTCGACATCGAACTGCCGAAGCCCGC
GCCTGCCGGACATGACATCCTGGTCGAGGTGAAGGCGGTGTCGGTGAACCCGGTCGATTACAAGGTCCGCCGTAGCACCC
CCCCGGATGGCACAGACTGGAAGGTGATCGGCTATGATGCCGCCGGGATCGTCAGCGCCGTCGGCCCGGACGTCACGCTC
TTCCGACCCGGCGATGAAGTCTTCTACGCGGGCTCGATCATTCGGCCAGGCACCAACGCCGAATTCCACCTCGTGGATGA
GCGCATCGTCGGCCGCAAGCCGAAAACGCTGGACTGGGCCGAAGCTGCCGCCTTGCCGCTGACGTCGATCACGGCCTGGG
AAGCCTTCTTCGACCGGCTCGACGTGAATAAGCCGGTGCCTGGCGCGGCGCCAGCGATTCTGATCGTCGGCGGAGCCGGC
GGCGTCGGGTCGATCGCAGTCCAGATTGCCCGACAACGCACCGACCTTACCGTGATCGCCACGGCATCGCGTCCCGAGAC
GCAGGAGTGGGTTAAATCGCTGGGTGCGCATCATGTCATCGACCATTCCAAGCCGCTGGCGGCAGAAGTCGCCGCGCTGG
GACTGGGAGCGCCTGCCTTCGTGTTCTCGACGACGCACACCGACAAGCATGCGGCCGAAATCGCAGACCTCATCGCCCCG
CAGGGGCGGTTCTGCCTAATCGATGATCCCTCTGCTTTCGACATAATGCTGTTCAAGCGCAAGGCAGTGTCGATCCATCA
TGAACTGATGTTCACCCGCCCGATGTTCGGCACGCCGGACATGTCGGAGCAGGGCCGCCTTCTGAACGACGTCTCGCGCC
TGGTCGACGAGGGCAGGTTGCGCACGACGCTTACCAACCGGCTTTCGCCGATCAACGCCGCCAATCTAAAACAGGCTCAC
GCCCTAGTGGAGAGCGGCACCGCAAGAGGCAAGGTAGTGATCGAGGGTTTCGGGCTGCAACGCTGA

Upstream 100 bases:

>100_bases
CATAATGGTATCCTTTCTGATACTATAGGCAATTTTTGTGCGTATCGCGCAGAATTACAATACGAACTAACTGTGTCTCC
GGCAACCAGGAGATACTTTT

Downstream 100 bases:

>100_bases
TCCACGCTCCACGTCTTTTCGAACAAATCCAAGAAAGTCGAACGACCCCTCATCAAGGAGGCTCGCATGAGCACTGCACC
CGAATTCACGAAATCGATTT

Product: putative zinc-dependent alcohol dehydrogenase protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKAVGYNKPAPITDDASLLDIELPKPAPAGHDILVEVKAVSVNPVDYKVRRSTPPDGTDWKVIGYDAAGIVSAVGPDVTL
FRPGDEVFYAGSIIRPGTNAEFHLVDERIVGRKPKTLDWAEAAALPLTSITAWEAFFDRLDVNKPVPGAAPAILIVGGAG
GVGSIAVQIARQRTDLTVIATASRPETQEWVKSLGAHHVIDHSKPLAAEVAALGLGAPAFVFSTTHTDKHAAEIADLIAP
QGRFCLIDDPSAFDIMLFKRKAVSIHHELMFTRPMFGTPDMSEQGRLLNDVSRLVDEGRLRTTLTNRLSPINAANLKQAH
ALVESGTARGKVVIEGFGLQR

Sequences:

>Translated_341_residues
MKAVGYNKPAPITDDASLLDIELPKPAPAGHDILVEVKAVSVNPVDYKVRRSTPPDGTDWKVIGYDAAGIVSAVGPDVTL
FRPGDEVFYAGSIIRPGTNAEFHLVDERIVGRKPKTLDWAEAAALPLTSITAWEAFFDRLDVNKPVPGAAPAILIVGGAG
GVGSIAVQIARQRTDLTVIATASRPETQEWVKSLGAHHVIDHSKPLAAEVAALGLGAPAFVFSTTHTDKHAAEIADLIAP
QGRFCLIDDPSAFDIMLFKRKAVSIHHELMFTRPMFGTPDMSEQGRLLNDVSRLVDEGRLRTTLTNRLSPINAANLKQAH
ALVESGTARGKVVIEGFGLQR
>Mature_341_residues
MKAVGYNKPAPITDDASLLDIELPKPAPAGHDILVEVKAVSVNPVDYKVRRSTPPDGTDWKVIGYDAAGIVSAVGPDVTL
FRPGDEVFYAGSIIRPGTNAEFHLVDERIVGRKPKTLDWAEAAALPLTSITAWEAFFDRLDVNKPVPGAAPAILIVGGAG
GVGSIAVQIARQRTDLTVIATASRPETQEWVKSLGAHHVIDHSKPLAAEVAALGLGAPAFVFSTTHTDKHAAEIADLIAP
QGRFCLIDDPSAFDIMLFKRKAVSIHHELMFTRPMFGTPDMSEQGRLLNDVSRLVDEGRLRTTLTNRLSPINAANLKQAH
ALVESGTARGKVVIEGFGLQR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=344, Percent_Identity=30.2325581395349, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI194239674, Length=178, Percent_Identity=34.8314606741573, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI13236495, Length=178, Percent_Identity=34.8314606741573, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI194239676, Length=178, Percent_Identity=34.8314606741573, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI22538446, Length=353, Percent_Identity=25.7790368271955, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI22538444, Length=353, Percent_Identity=25.7790368271955, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71987554, Length=184, Percent_Identity=35.3260869565217, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=326, Percent_Identity=27.3006134969325, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36548; Mature: 36548

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGYNKPAPITDDASLLDIELPKPAPAGHDILVEVKAVSVNPVDYKVRRSTPPDGTDW
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCEEEECCCCCCCCCE
KVIGYDAAGIVSAVGPDVTLFRPGDEVFYAGSIIRPGTNAEFHLVDERIVGRKPKTLDWA
EEEEECHHHHHHHCCCCEEEECCCCCEEEECCEECCCCCCEEEEECHHHHCCCCCCCCHH
EAAALPLTSITAWEAFFDRLDVNKPVPGAAPAILIVGGAGGVGSIAVQIARQRTDLTVIA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEE
TASRPETQEWVKSLGAHHVIDHSKPLAAEVAALGLGAPAFVFSTTHTDKHAAEIADLIAP
ECCCCCHHHHHHHCCCCEECCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCC
QGRFCLIDDPSAFDIMLFKRKAVSIHHELMFTRPMFGTPDMSEQGRLLNDVSRLVDEGRL
CCCEEEEECCCCEEEEEEHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCH
RTTLTNRLSPINAANLKQAHALVESGTARGKVVIEGFGLQR
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MKAVGYNKPAPITDDASLLDIELPKPAPAGHDILVEVKAVSVNPVDYKVRRSTPPDGTDW
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCEEEECCCCCCCCCE
KVIGYDAAGIVSAVGPDVTLFRPGDEVFYAGSIIRPGTNAEFHLVDERIVGRKPKTLDWA
EEEEECHHHHHHHCCCCEEEECCCCCEEEECCEECCCCCCEEEEECHHHHCCCCCCCCHH
EAAALPLTSITAWEAFFDRLDVNKPVPGAAPAILIVGGAGGVGSIAVQIARQRTDLTVIA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEE
TASRPETQEWVKSLGAHHVIDHSKPLAAEVAALGLGAPAFVFSTTHTDKHAAEIADLIAP
ECCCCCHHHHHHHCCCCEECCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCC
QGRFCLIDDPSAFDIMLFKRKAVSIHHELMFTRPMFGTPDMSEQGRLLNDVSRLVDEGRL
CCCEEEEECCCCEEEEEEHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCH
RTTLTNRLSPINAANLKQAHALVESGTARGKVVIEGFGLQR
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]