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The map label for this gene is mutM [H]

Identifier: 85860946

GI number: 85860946

Start: 3113121

End: 3114056

Strand: Direct

Name: mutM [H]

Synonym: SYN_00204

Alternate gene names: 85860946

Gene position: 3113121-3114056 (Clockwise)

Preceding gene: 85860942

Following gene: 85860947

Centisome position: 97.92

GC content: 55.56

Gene sequence:

>936_bases
ATGCTGGCAACTTTGAATGGAATGGCCGGTTTTTACGCGGGTCGCTTCTGCATGCGCGTCGACTTTCTCTGCCGCCCTGC
TGTCACTGTCAAACTCGAAAAGAGTGTGTCAGCGCCCGGATGGACAGACCGGACAAGAAAAGAGGAACACATGCCTGAAC
TCCCCGAAGTAGAAACCCTTTGCCGTCAACTGCGGCAGAAAGTACCTCATGCAAAGATCAAGGGAACTTTCATCCTTGAC
AGCAAACTGGGGAAGCTGGACAATCTGAAAGGCCGCGGCATCGCTTCCGTGACTCGTCTTGGGAAACGGATCGTCCTTGG
GCTGGATGACGGCAGATCGCTGGAAATTCACCTGAGAATGACAGGTCGGCTTCTCTGGCAGGAAAAACCGGATATCGGAG
AAAAGCCGCCGCACAGCCGCTTCATCCTCGATCTGACCCCCGGTCGGATCATTATCGTCGATCCCCGGCGTTTTGCCACG
TTGTCTCTTGTCGCGGATGCGGCAAAGGGGAACGCGGCTGTCGACGCCCTGAAGCCCGGATGCCCAGAGGCACTGAAAGA
AAAGGGATGCAACCGAAGTCGGTCCATTAAATCTTTTCTCATGGACCAGAGCATCATCGGCGGAATTGGTAATATTTATG
CCTGCGAAATCCTCTATCGAGCAGGATTGAATCCTCTCCGCAGGACGGCCGACCTGACTTCAGAGGACTGGCGGCGCGTC
GGAAGCGCCATGGTTGAGGTCCTTTCAAAGGCCGTTGTTTGCCGGGGAACGTCCATTTCCGACTGGCGCGATCTTTTTGG
CTGCAAAGGCGAGTATCAGAAGGAACTTCGCGTATATGGGCGCGAGGGGAAAAAGTGCCCGCACTGCGGAGGAATCATTC
AGCGAGTCCGCCTTTTGGGTCGGGGAACGTGGTTCTGTCCGAACTGCCAGGCTTGA

Upstream 100 bases:

>100_bases
GATTACGGGCGATGAAGTCGGGGAAAAGAAAGACAAACCGGTTCAAGATTCCATCATTGTCAATCCGGGGTGAAGCGTGC
TATATCTTCATGTCTTTCAG

Downstream 100 bases:

>100_bases
CTGCCCATCCCCTGGCCTACTTTGTACGAAAATTGAGAAATTTGACCTCGAGCGTCATGTGGGAATGCTTTATTGAATCA
GAATGAGGACACATTATGGG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLATLNGMAGFYAGRFCMRVDFLCRPAVTVKLEKSVSAPGWTDRTRKEEHMPELPEVETLCRQLRQKVPHAKIKGTFILD
SKLGKLDNLKGRGIASVTRLGKRIVLGLDDGRSLEIHLRMTGRLLWQEKPDIGEKPPHSRFILDLTPGRIIIVDPRRFAT
LSLVADAAKGNAAVDALKPGCPEALKEKGCNRSRSIKSFLMDQSIIGGIGNIYACEILYRAGLNPLRRTADLTSEDWRRV
GSAMVEVLSKAVVCRGTSISDWRDLFGCKGEYQKELRVYGREGKKCPHCGGIIQRVRLLGRGTWFCPNCQA

Sequences:

>Translated_311_residues
MLATLNGMAGFYAGRFCMRVDFLCRPAVTVKLEKSVSAPGWTDRTRKEEHMPELPEVETLCRQLRQKVPHAKIKGTFILD
SKLGKLDNLKGRGIASVTRLGKRIVLGLDDGRSLEIHLRMTGRLLWQEKPDIGEKPPHSRFILDLTPGRIIIVDPRRFAT
LSLVADAAKGNAAVDALKPGCPEALKEKGCNRSRSIKSFLMDQSIIGGIGNIYACEILYRAGLNPLRRTADLTSEDWRRV
GSAMVEVLSKAVVCRGTSISDWRDLFGCKGEYQKELRVYGREGKKCPHCGGIIQRVRLLGRGTWFCPNCQA
>Mature_311_residues
MLATLNGMAGFYAGRFCMRVDFLCRPAVTVKLEKSVSAPGWTDRTRKEEHMPELPEVETLCRQLRQKVPHAKIKGTFILD
SKLGKLDNLKGRGIASVTRLGKRIVLGLDDGRSLEIHLRMTGRLLWQEKPDIGEKPPHSRFILDLTPGRIIIVDPRRFAT
LSLVADAAKGNAAVDALKPGCPEALKEKGCNRSRSIKSFLMDQSIIGGIGNIYACEILYRAGLNPLRRTADLTSEDWRRV
GSAMVEVLSKAVVCRGTSISDWRDLFGCKGEYQKELRVYGREGKKCPHCGGIIQRVRLLGRGTWFCPNCQA

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=274, Percent_Identity=32.1167883211679, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786932, Length=276, Percent_Identity=24.6376811594203, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 34634; Mature: 34634

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLATLNGMAGFYAGRFCMRVDFLCRPAVTVKLEKSVSAPGWTDRTRKEEHMPELPEVETL
CCEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHCCCCCCCHHHH
CRQLRQKVPHAKIKGTFILDSKLGKLDNLKGRGIASVTRLGKRIVLGLDDGRSLEIHLRM
HHHHHHHCCCCEECEEEEECCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCEEEEEEEE
TGRLLWQEKPDIGEKPPHSRFILDLTPGRIIIVDPRRFATLSLVADAAKGNAAVDALKPG
ECEEEECCCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCHHHHCCCC
CPEALKEKGCNRSRSIKSFLMDQSIIGGIGNIYACEILYRAGLNPLRRTADLTSEDWRRV
CCHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHH
GSAMVEVLSKAVVCRGTSISDWRDLFGCKGEYQKELRVYGREGKKCPHCGGIIQRVRLLG
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
RGTWFCPNCQA
CCCCCCCCCCC
>Mature Secondary Structure
MLATLNGMAGFYAGRFCMRVDFLCRPAVTVKLEKSVSAPGWTDRTRKEEHMPELPEVETL
CCEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHCCCCCCCHHHH
CRQLRQKVPHAKIKGTFILDSKLGKLDNLKGRGIASVTRLGKRIVLGLDDGRSLEIHLRM
HHHHHHHCCCCEECEEEEECCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCEEEEEEEE
TGRLLWQEKPDIGEKPPHSRFILDLTPGRIIIVDPRRFATLSLVADAAKGNAAVDALKPG
ECEEEECCCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCHHHHCCCC
CPEALKEKGCNRSRSIKSFLMDQSIIGGIGNIYACEILYRAGLNPLRRTADLTSEDWRRV
CCHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHH
GSAMVEVLSKAVVCRGTSISDWRDLFGCKGEYQKELRVYGREGKKCPHCGGIIQRVRLLG
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
RGTWFCPNCQA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA