Click here to switch to the map view.

The map label for this gene is adh [H]

Identifier: 85860870

GI number: 85860870

Start: 3031390

End: 3032502

Strand: Direct

Name: adh [H]

Synonym: SYN_01655

Alternate gene names: 85860870

Gene position: 3031390-3032502 (Clockwise)

Preceding gene: 85860868

Following gene: 85860871

Centisome position: 95.35

GC content: 50.31

Gene sequence:

>1113_bases
ATGGCTGACGTACCGAAAACGATCAAAACGTGGCAAATGGTAGCACCATGGAGAAAGAACAAGGAAACGGGAGAGAAAAT
CCCCGGTCAACTGCAATTAACGGAGATTCCTGTTCCTGAGCTGAAAGAGGGGGATGTTCTGGTAAAGATTGCGGGCTGCG
GTGTCTGCCACACCGATCTCGGCTTTTTCTTCGATGCCGTCCCGACCGTTACCAAACCCCCGTTGACGCTGGGCCATGAA
GTCAGTGGTACCGTCGTTGCGGGCGATCCAAAATGGATTGGGAAAGAAGTTTTAATTCCTGCCGTTTTGCCCTGCCGTAA
ATGTGAACTTTGTAAAACAGGTCGTGGAAACCGCTGCCTCAATCAGATGTTCATTGGCTGCAGTCATGGAATTTATGGCG
GTAATTCAGATTACATTCCCGTTCCCTCACTTGACCTTTGCGAAATCAAAAATCGTCCCAGCACTCGCCCCCTGGAAAAT
TACTCCGTTGCGTCCGATGCGGTCACAACGCCCTACCAGGCAATGATCAAGGCGAAGGTAGGAATTGGGGATAATGTCAT
TGTCATCGGAGCCACTGGCGGTGTCGGTCTTTATACGGCGCAGATCGCCAAGGCGATGGGCGCGGATGTCGTTATCGGAA
TCGACATCGCAGAACAGAAGCTTCAGAAGATGCTCAACTATGGGTGCGATTTCGTCATCATGAATAAGGACAAGAGCAAC
AAGGATGTCATGGGTGAATACCGCGCGATCTGCAAGGCCAATGCGCTGCCCAATTATGGCTGGAAGATCTTCGAAGTTTC
AGGGAACAAATTTGGTCAGGCCCTGGCCCTCGATCTGCTTTCCTTCACCGGGACCATGGTTCAAATCGGGTACGGGCTGG
GATCTATTGATTTCAATGTATCCAGGCTGATGGCGTTTGATGCACAGATTATCGGCACCTGGGCATGCCTGCCCGAGTAC
TATCCACATGTTCTCTCTCTGATCCATTCCGGAAAGATCCAGATCGATCCTTTCCTGGAAGTTCGGCCAATGAGCACAAT
CGCAGCAACCTATGATGAAGTTCACAAAGCCGGTTCTCCGGAAAAGAGAATTGTTTTGAAGCCTGATTTTTAG

Upstream 100 bases:

>100_bases
AAAGTTGAATTTATAATTTTTGAGGGGGTGATAAGAAAGAGGCGTCTGAATCATTAAGTATATTTCAATTTCTATATTAA
ATCTTTTATGGAGGTGTCTA

Downstream 100 bases:

>100_bases
AAAATCACCAAATAAAATAACGTATAAGGGGGATTAGTATGAGTTTAGATTGGATGCCAAGAGAACACGGGTTAAAGAAT
CACAGCCGACATACTGAACA

Product: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MADVPKTIKTWQMVAPWRKNKETGEKIPGQLQLTEIPVPELKEGDVLVKIAGCGVCHTDLGFFFDAVPTVTKPPLTLGHE
VSGTVVAGDPKWIGKEVLIPAVLPCRKCELCKTGRGNRCLNQMFIGCSHGIYGGNSDYIPVPSLDLCEIKNRPSTRPLEN
YSVASDAVTTPYQAMIKAKVGIGDNVIVIGATGGVGLYTAQIAKAMGADVVIGIDIAEQKLQKMLNYGCDFVIMNKDKSN
KDVMGEYRAICKANALPNYGWKIFEVSGNKFGQALALDLLSFTGTMVQIGYGLGSIDFNVSRLMAFDAQIIGTWACLPEY
YPHVLSLIHSGKIQIDPFLEVRPMSTIAATYDEVHKAGSPEKRIVLKPDF

Sequences:

>Translated_370_residues
MADVPKTIKTWQMVAPWRKNKETGEKIPGQLQLTEIPVPELKEGDVLVKIAGCGVCHTDLGFFFDAVPTVTKPPLTLGHE
VSGTVVAGDPKWIGKEVLIPAVLPCRKCELCKTGRGNRCLNQMFIGCSHGIYGGNSDYIPVPSLDLCEIKNRPSTRPLEN
YSVASDAVTTPYQAMIKAKVGIGDNVIVIGATGGVGLYTAQIAKAMGADVVIGIDIAEQKLQKMLNYGCDFVIMNKDKSN
KDVMGEYRAICKANALPNYGWKIFEVSGNKFGQALALDLLSFTGTMVQIGYGLGSIDFNVSRLMAFDAQIIGTWACLPEY
YPHVLSLIHSGKIQIDPFLEVRPMSTIAATYDEVHKAGSPEKRIVLKPDF
>Mature_369_residues
ADVPKTIKTWQMVAPWRKNKETGEKIPGQLQLTEIPVPELKEGDVLVKIAGCGVCHTDLGFFFDAVPTVTKPPLTLGHEV
SGTVVAGDPKWIGKEVLIPAVLPCRKCELCKTGRGNRCLNQMFIGCSHGIYGGNSDYIPVPSLDLCEIKNRPSTRPLENY
SVASDAVTTPYQAMIKAKVGIGDNVIVIGATGGVGLYTAQIAKAMGADVVIGIDIAEQKLQKMLNYGCDFVIMNKDKSNK
DVMGEYRAICKANALPNYGWKIFEVSGNKFGQALALDLLSFTGTMVQIGYGLGSIDFNVSRLMAFDAQIIGTWACLPEYY
PHVLSLIHSGKIQIDPFLEVRPMSTIAATYDEVHKAGSPEKRIVLKPDF

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=345, Percent_Identity=24.9275362318841, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI262073058, Length=274, Percent_Identity=27.7372262773723, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI71743840, Length=274, Percent_Identity=27.7372262773723, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI226510992, Length=329, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788407, Length=355, Percent_Identity=26.7605633802817, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082125, Length=326, Percent_Identity=26.6871165644172, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788075, Length=332, Percent_Identity=24.3975903614458, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790045, Length=335, Percent_Identity=24.7761194029851, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788073, Length=355, Percent_Identity=27.0422535211268, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786825, Length=220, Percent_Identity=27.7272727272727, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790718, Length=306, Percent_Identity=24.1830065359477, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787863, Length=224, Percent_Identity=26.7857142857143, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786552, Length=244, Percent_Identity=30.327868852459, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17562876, Length=316, Percent_Identity=28.1645569620253, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=215, Percent_Identity=31.1627906976744, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=222, Percent_Identity=29.7297297297297, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=365, Percent_Identity=26.3013698630137, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=370, Percent_Identity=25.4054054054054, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=355, Percent_Identity=25.6338028169014, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=203, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=358, Percent_Identity=26.8156424581006, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=358, Percent_Identity=26.536312849162, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=340, Percent_Identity=24.1176470588235, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=217, Percent_Identity=30.8755760368664, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=268, Percent_Identity=29.1044776119403, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=333, Percent_Identity=24.3243243243243, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=273, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=267, Percent_Identity=29.2134831460674, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737897, Length=221, Percent_Identity=28.5067873303167, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17137530, Length=311, Percent_Identity=26.0450160771704, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40228; Mature: 40097

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVPKTIKTWQMVAPWRKNKETGEKIPGQLQLTEIPVPELKEGDVLVKIAGCGVCHTDL
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEHHHH
GFFFDAVPTVTKPPLTLGHEVSGTVVAGDPKWIGKEVLIPAVLPCRKCELCKTGRGNRCL
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCCCCHHHHCCCCCHHH
NQMFIGCSHGIYGGNSDYIPVPSLDLCEIKNRPSTRPLENYSVASDAVTTPYQAMIKAKV
HHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEC
GIGDNVIVIGATGGVGLYTAQIAKAMGADVVIGIDIAEQKLQKMLNYGCDFVIMNKDKSN
CCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCEEEECCCCCC
KDVMGEYRAICKANALPNYGWKIFEVSGNKFGQALALDLLSFTGTMVQIGYGLGSIDFNV
CHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCH
SRLMAFDAQIIGTWACLPEYYPHVLSLIHSGKIQIDPFLEVRPMSTIAATYDEVHKAGSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHHHHHHCCCC
EKRIVLKPDF
CCEEEECCCC
>Mature Secondary Structure 
ADVPKTIKTWQMVAPWRKNKETGEKIPGQLQLTEIPVPELKEGDVLVKIAGCGVCHTDL
CCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEHHHH
GFFFDAVPTVTKPPLTLGHEVSGTVVAGDPKWIGKEVLIPAVLPCRKCELCKTGRGNRCL
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCCCCHHHHCCCCCHHH
NQMFIGCSHGIYGGNSDYIPVPSLDLCEIKNRPSTRPLENYSVASDAVTTPYQAMIKAKV
HHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEC
GIGDNVIVIGATGGVGLYTAQIAKAMGADVVIGIDIAEQKLQKMLNYGCDFVIMNKDKSN
CCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCEEEECCCCCC
KDVMGEYRAICKANALPNYGWKIFEVSGNKFGQALALDLLSFTGTMVQIGYGLGSIDFNV
CHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCH
SRLMAFDAQIIGTWACLPEYYPHVLSLIHSGKIQIDPFLEVRPMSTIAATYDEVHKAGSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHHHHHHCCCC
EKRIVLKPDF
CCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA